8RVH structure in UniLectin3D

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Comments

BoNT A mutant Y1117V H1253K in complex with the GD1a ganglioside

Masuyer G, Rummel A, Stenmark P. Botulinum neurotoxin A mutants with enhanced ganglioside binding show improved potency and altered ganglioside selectivity. Communications chemistry 2025

Matching protein

P0DPI0 in UniLectin

Available structures

2VU9 : aNeuAc23bGal13bGalNAc14(aNeuAc
2VUA : no ligand
5TPB : no ligand
5TPC : GD1-a pentasaccharide
8RVG : Ganglioside GD1a
8RVH : Ganglioside GD1a
8RVI : Ganglioside GM1a

Related proteins
> 50% identity

Ligand

Glycan composition

IUPAC condensed

GlycoCT

RES
1b:x-dglc-HEX-1:5
2b:b-dgal-HEX-1:5
3b:a-dgro-dgal-NON-2:6|1:a|2:keto|3:d
4s:n-acetyl
5b:b-dgal-HEX-1:5
6s:n-acetyl
7b:b-dgal-HEX-1:5
8b:a-dgro-dgal-NON-2:6|1:a|2:keto|3:d
9s:n-acetyl
LIN
1:1o(4+1)2d
2:2o(3+2)3d
3:3d(5+1)4n
4:2o(4+1)5d
5:5d(2+1)6n
6:5o(3+1)7d
7:7o(3+2)8d
8:8d(5+1)9n

PubMed DOI RCSB.ORG PDBeGlyTouCan (glycan information)SwissModel (ligand interactions)Glyconnect and SugarBind glycan superstructure(s)Uniprot

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