6QNS structure in UniLectin3D

Mol* PDB structure viewer

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Comments

Botulinum Neurotoxin type B mutant I1248W/V1249W in complex with human synaptotagmin 1 and GD1a receptors

Yin L, Masuyer G, Zhang S, Zhang J, Miyashita S, Burgin D, Lovelock L, Coker S, Fu T, Stenmark P, Dong M. Characterization of a membrane binding loop leads to engineering botulinum neurotoxin B with improved therapeutic efficacy. PLoS biology 2020

Matching protein

P10844 in UniLectin

Available structures

1EPW : no ligand
1F31 : aNeuAc23bGal14Glc
1I1E : Doxorubicin
4KBB : no ligand
6QNS : GD1-a hexasaccharide

Related proteins
> 50% identity

Ligand

Glycan composition

IUPAC condensed

GlycoCT

RES
1b:x-dglc-HEX-1:5
2b:b-dgal-HEX-1:5
3b:a-dgro-dgal-NON-2:6|1:a|2:keto|3:d
4s:n-acetyl
5b:b-dgal-HEX-1:5
6s:n-acetyl
7b:b-dgal-HEX-1:5
8b:a-dgro-dgal-NON-2:6|1:a|2:keto|3:d
9s:n-acetyl
LIN
1:1o(4+1)2d
2:2o(3+2)3d
3:3d(5+1)4n
4:2o(4+1)5d
5:5d(2+1)6n
6:5o(3+1)7d
7:7o(3+2)8d
8:8d(5+1)9n

PubMed DOI RCSB.ORG PDBeGlyTouCan (glycan information)SwissModel (ligand interactions)Glyconnect and SugarBind glycan superstructure(s)Uniprot

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