Q9NNX6 protein in UniLectin3D

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Class

Family

Origin

Species

Available structures

1K9I : bGlcNAc12aMan13(bGlcNAc12aMan1 1SL4 : aMan16(aMan13)aMan16Man 1SL5 : bGal14(aFuc13)bGlcNAc13bGal14G 2B6B : no ligand 2IT5 : aMan12aMan13aMan 2IT6 : aMan12aMan 2XR5 : Di-mannoside mimic 2XR6 : synthetic analog of trimannosi 6GHV : Di-mannoside mimic 7NL6 : triazole-based glycomimetic li 7NL7 : triazole-based glycomimetic li

Related proteins
> 50% identity

ProtVista PDB viewer

Reference of
7NL7 structure
2021
PubMed

Cramer J, Lakkaichi A, Aliu B, Jakob R, Klein S, Cattaneo I, Jiang X, Rabbani S, Schwardt O, Zimmer G, Ciancaglini M, Abreu Mota T, Maier T, Ernst B.
Sweet Drugs for Bad Bugs: A Glycomimetic Strategy against the DC-SIGN-Mediated Dissemination of SARS-CoV-2. Journal of the American Chemical Society 2021

Reference of
7NL6 structure
2021
PubMed

Reference of
6GHV structure
2019
PubMed

Medve L, Achilli S, Guzman-Caldentey J, Thépaut M, Senaldi L, Le Roy A, Sattin S, Ebel C, Vivès C, Martin-Santamaria S, Bernardi A, Fieschi F.
Enhancing Potency and Selectivity of a DC-SIGN Glycomimetic Ligand by Fragment-Based Design: Structural Basis. Chemistry (Weinheim an der Bergstrasse, Germany) 2019

Reference of
2XR6 structure
2014
PubMed

Sutkeviciute I, Thepaut M, Sattin S, Berzi A, McGeagh J, Grudinin S, Weiser J, Le Roy A, Reina JJ, Rojo J, Clerici M, Bernardi A, Ebel C, Fieschi F
Unique DC-SIGN Clustering Activity of a Small Glycomimetic: A Lesson for Ligand Design. ACS Chem. Biol. 2014

Reference of
2XR5 structure
2013
PubMed

Thépaut M, Guzzi C, Sutkeviciute I, Sattin S, Ribeiro-Viana R, Varga N, Chabrol E, Rojo J, Bernardi A, Angulo J, Nieto P, Fieschi F.
Structure of a glycomimetic ligand in the carbohydrate recognition domain of C-type lectin DC-SIGN. Structural requirements for selectivity and ligand design. Journal of the American Chemical Society 2013

Reference of
2IT5 structure
2007
PubMed

Feinberg H, Castelli R, Drickamer K, Seeberger PH, Weiss WI
Multiple modes of binding enhance the affinity of dc-sign for high-mannose N-linked glycans found on viral glycoproteins J. Biol. Chem. 2007

Reference of
2IT6 structure
2007
PubMed

Reference of
2B6B structure
2006
PubMed

Pokidysheva E, Zhang Y, Battisti AJ, Bator-Kelly CM, Chipman PR, Xiao C, Gregorio GG, Hendrickson WA, Kuhn RJ, Rossmann MG.
Cryo-EM reconstruction of dengue virus in complex with the carbohydrate recognition domain of DC-SIGN Cell. 2006

Reference of
1SL4 structure
2004
PubMed

Guo Y, Feinberg H, Conroy E, Mitchell DA, Alvarez R, Blixt O, Taylor ME, Weis WI, Drickamer K
Structural basis for distinct ligand-binding and targeting properties of the receptors DC-SIGN and DC-SIGNR Nature Struct. Mol. Biol. 2004

Reference of
1SL5 structure
2004
PubMed

Reference of
1K9I structure
2001
PubMed

Feinberg, H., Mitchell, D.A., Drickamer, K., Weis, W.I.
Structural basis for selective recognition of oligosaccharides by DC-SIGN and DC-SIGNR Science 2001

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