P09382Uniprot
Fold
Class
Family
Origin
Species
Available structures
1GZW : bGal14Glc1W6M : Gal1W6N : no ligand1W6O : bGal14Glc1W6P : bGal14GlcNAc1W6Q : no ligand2KM2 : no ligand2ZKN : lactose3OY8 : lactobionic acid3OYW : thiodigalactoside3T2T : methyl 2-O-acetyl-3-O-(4-methy3W58 : no ligand3W59 : no ligand4Q1P : NB169 (LacNAc derivative)4Q1R : AN027 (LacNAc derivative)4Q26 : N-Acetyllactosamine4Q27 : activated N-acetyllactosamine4Q2F : Functionalized N-acetyllactosa4XBL : bGal13GlcNAc4Y1U : bGal14GlcNAc4Y1V : bGal13GlcNAc4Y1X : (6OSO3)bGal14GlcNAc4Y1Y : (6OSO3)bGal13GlcNAc4Y1Z : bGal14GlcANAc4Y20 : aNeuAc23bGal14Glc4Y22 : (3OSO3)bGal13GlcNAc4Y24 : 3,3'deoxy-3,3'-bis-(4-[m-fluor5MWT : no ligand5MWX : no ligand6B94 : no ligand6F83 : no ligand
Related proteins
> 50% identity
> 50% identity
PubMed
Kishor C, Ross R, Blanchard H.
Lactulose as a novel template for anticancer drug development targeting galectins. Chemical biology & drug design 2018
Lactulose as a novel template for anticancer drug development targeting galectins. Chemical biology & drug design 2018
PubMed
Peterson, A., Collins, P.M., Huang, X., Kahl-Knutsson, B., Essenn, S., Zetterberg, F.R., Oredson, S., Leffler, H., Blanchard, H., Nilsson, U.J.
Aromatic heterocycle galectin-1 interactions for selective single-digit nM affinity ligands RSC Advances 2018
Aromatic heterocycle galectin-1 interactions for selective single-digit nM affinity ligands RSC Advances 2018
PubMed
Bertleff-Zieschang N, Bechold J, Grimm C, Reutlinger M, Schneider P, Schneider G, Seibel J.
Exploring the Structural Space of the Galectin-1-Ligand Interaction. Chembiochem : a European journal of chemical biology 2017
Exploring the Structural Space of the Galectin-1-Ligand Interaction. Chembiochem : a European journal of chemical biology 2017
PubMed
Bertleff-Zieschang N, Bechold J, Grimm C, Reutlinger M, Schneider P, Schneider G, Seibel J.
Exploring the Structural Space of the Galectin-1-Ligand Interaction. Chembiochem : a European journal of chemical biology 2017
Exploring the Structural Space of the Galectin-1-Ligand Interaction. Chembiochem : a European journal of chemical biology 2017
PubMed
Bertleff-Zieschang N, Bechold J, Grimm C, Reutlinger M, Schneider P, Schneider G, Seibel J.
Exploring the Structural Space of the Galectin-1-Ligand Interaction. Chembiochem : a European journal of chemical biology 2017
Exploring the Structural Space of the Galectin-1-Ligand Interaction. Chembiochem : a European journal of chemical biology 2017
PubMed
Bertleff-Zieschang N, Bechold J, Grimm C, Reutlinger M, Schneider P, Schneider G, Seibel J.
Exploring the Structural Space of the Galectin-1-Ligand Interaction. Chembiochem : a European journal of chemical biology 2017
Exploring the Structural Space of the Galectin-1-Ligand Interaction. Chembiochem : a European journal of chemical biology 2017
PubMed
Bertleff-Zieschang N, Bechold J, Grimm C, Reutlinger M, Schneider P, Schneider G, Seibel J.
Exploring the Structural Space of the Galectin-1-Ligand Interaction. Chembiochem : a European journal of chemical biology 2017
Exploring the Structural Space of the Galectin-1-Ligand Interaction. Chembiochem : a European journal of chemical biology 2017
PubMed
Bertleff-Zieschang N, Bechold J, Grimm C, Reutlinger M, Schneider P, Schneider G, Seibel J.
Exploring the Structural Space of the Galectin-1-Ligand Interaction. Chembiochem : a European journal of chemical biology 2017
Exploring the Structural Space of the Galectin-1-Ligand Interaction. Chembiochem : a European journal of chemical biology 2017
PubMed
Bertleff-Zieschang N, Bechold J, Grimm C, Reutlinger M, Schneider P, Schneider G, Seibel J.
Exploring the Structural Space of the Galectin-1-Ligand Interaction. Chembiochem : a European journal of chemical biology 2017
Exploring the Structural Space of the Galectin-1-Ligand Interaction. Chembiochem : a European journal of chemical biology 2017
PubMed
Hsieh T, Lin H, Tu Z, Lin T, Wu S, Tseng Y, Liu F, Hsu S, Lin C.
Dual thio-digalactoside-binding modes of human galectins as the structural basis for the design of potent and selective inhibitors. Scientific reports 2016
Dual thio-digalactoside-binding modes of human galectins as the structural basis for the design of potent and selective inhibitors. Scientific reports 2016
PubMed
Hsieh T, Lin H, Tu Z, Huang B, Wu S, Lin C.
Structural Basis Underlying the Binding Preference of Human Galectins-1, -3 and -7 for Galbeta1-3,4GlcNAc. PloS one 2015
Structural Basis Underlying the Binding Preference of Human Galectins-1, -3 and -7 for Galbeta1-3,4GlcNAc. PloS one 2015
PubMed
Lin, H.Y., Hsieh, T.J., Tu, Z., Huang, B.S., Wu, S.C., Chien, C.T., Hsu, S.T., Lin, C.H.
To be published. Structural basis of human galectin-1 inhibition with Ki values in the micro- to nanomolar range 2015
To be published. Structural basis of human galectin-1 inhibition with Ki values in the micro- to nanomolar range 2015
PubMed
Lin, H.Y., Hsieh, T.J., Tu, Z., Huang, B.S., Wu, S.C., Chien, C.T., Hsu, S.T., Lin, C.H.
To be published. Structural basis of human galectin-1 inhibition with Ki values in the micro- to nanomolar range 2015
To be published. Structural basis of human galectin-1 inhibition with Ki values in the micro- to nanomolar range 2015
PubMed
Lin, H.Y., Hsieh, T.J., Tu, Z., Huang, B.S., Wu, S.C., Chien, C.T., Hsu, S.T., Lin, C.H.
To be published. Structural basis of human galectin-1 inhibition with Ki values in the micro- to nanomolar range To be published. 2015
To be published. Structural basis of human galectin-1 inhibition with Ki values in the micro- to nanomolar range To be published. 2015
PubMed
Lin, H.Y., Hsieh, T.J., Tu, Z., Huang, B.S., Wu, S.C., Chien, C.T., Hsu, S.T., Lin, C.H.
To be published. Structural basis of human galectin-1 inhibition with Ki values in the micro- to nanomolar range To be published. 2015
To be published. Structural basis of human galectin-1 inhibition with Ki values in the micro- to nanomolar range To be published. 2015
PubMed
Collins PM, Oberg CT, Leffler H, Nilsson UJ, Blanchard H.
Taloside Inhibitors of Galectin-1 and Galectin-3. Chem. Biol. Drug Des. 2012
Taloside Inhibitors of Galectin-1 and Galectin-3. Chem. Biol. Drug Des. 2012
PubMed
Nesmelova IV, Ermakova E, Daragan VA, Pang M, Menendez M, Lagartera L, Solis D, Baum LG, Mayo KH
Lactose binding to galectin-1 modulates structural dynamics, increases conformational entropy, and occurs with apparent negative cooperativity. J. Mol. Biol. 2010
Lactose binding to galectin-1 modulates structural dynamics, increases conformational entropy, and occurs with apparent negative cooperativity. J. Mol. Biol. 2010
PubMed
Stannard KA, Collins PM, Ito K, Sullivan EM, Scott SA, Gabutero E, Darren Grice I, Low P, Nilsson UJ, Leffler H, Blanchard H, Ralph SJ.
Galectin inhibitory disaccharides promote tumour immunity in a breast cancer model. Cancer Lett. 2010
Galectin inhibitory disaccharides promote tumour immunity in a breast cancer model. Cancer Lett. 2010
PubMed
Stannard KA, Collins PM, Ito K, Sullivan EM, Scott SA, Gabutero E, Darren Grice I, Low P, Nilsson UJ, Leffler H, Blanchard H, Ralph SJ.
Galectin inhibitory disaccharides promote tumour immunity in a breast cancer model. Cancer Lett. 2010
Galectin inhibitory disaccharides promote tumour immunity in a breast cancer model. Cancer Lett. 2010
PubMed
Nishi N, Abe A, Iwaki J, Yoshida H, Itoh A, Shoji H, Kamitori S, Hirabayashi J, Nakamura T
Functional and structural bases of a cysteine-less mutant as a long-lasting substitute for galectin-1 Glycobiology 2008
Functional and structural bases of a cysteine-less mutant as a long-lasting substitute for galectin-1 Glycobiology 2008
PubMed
Lopez-Lucendo MF, Solis D, Andre S, Hirabayashi J, Kasai K, Kaltner H, Gabius HJ, Romero A
Growth-regulatory human galectin-1: crystallographic characterisation of the structural changes induced by single-site mutations and their impact on the thermodynamics of ligand binding J. Mol. Biol. 2004
Growth-regulatory human galectin-1: crystallographic characterisation of the structural changes induced by single-site mutations and their impact on the thermodynamics of ligand binding J. Mol. Biol. 2004
PubMed
Lopez-Lucendo MF, Solis D, Andre S, Hirabayashi J, Kasai K, Kaltner H, Gabius HJ, Romero A
Growth-regulatory human galectin-1: crystallographic characterisation of the structural changes induced by single-site mutations and their impact on the thermodynamics of ligand binding J. Mol. Biol. 2004
Growth-regulatory human galectin-1: crystallographic characterisation of the structural changes induced by single-site mutations and their impact on the thermodynamics of ligand binding J. Mol. Biol. 2004
PubMed
Lopez-Lucendo MF, Solis D, Andre S, Hirabayashi J, Kasai K, Kaltner H, Gabius HJ, Romero A
Growth-regulatory human galectin-1: crystallographic characterisation of the structural changes induced by single-site mutations and their impact on the thermodynamics of ligand binding J. Mol. Biol. 2004
Growth-regulatory human galectin-1: crystallographic characterisation of the structural changes induced by single-site mutations and their impact on the thermodynamics of ligand binding J. Mol. Biol. 2004
PubMed
Lopez-Lucendo MF, Solis D, Andre S, Hirabayashi J, Kasai K, Kaltner H, Gabius HJ, Romero A
Growth-regulatory human galectin-1: crystallographic characterisation of the structural changes induced by single-site mutations and their impact on the thermodynamics of ligand binding J. Mol. Biol. 2004
Growth-regulatory human galectin-1: crystallographic characterisation of the structural changes induced by single-site mutations and their impact on the thermodynamics of ligand binding J. Mol. Biol. 2004
PubMed
Lopez-Lucendo MF, Solis D, Andre S, Hirabayashi J, Kasai K, Kaltner H, Gabius HJ, Romero A
Growth-regulatory human galectin-1: crystallographic characterisation of the structural changes induced by single-site mutations and their impact on the thermodynamics of ligand binding J. Mol. Biol. 2004
Growth-regulatory human galectin-1: crystallographic characterisation of the structural changes induced by single-site mutations and their impact on the thermodynamics of ligand binding J. Mol. Biol. 2004
PubMed
Lopez-Lucendo MF, Solis D, Andre S, Hirabayashi J, Kasai K, Kaltner H, Gabius HJ, Romero A
Growth-regulatory human galectin-1: crystallographic characterisation of the structural changes induced by single-site mutations and their impact on the thermodynamics of ligand binding J. Mol. Biol. 2004
Growth-regulatory human galectin-1: crystallographic characterisation of the structural changes induced by single-site mutations and their impact on the thermodynamics of ligand binding J. Mol. Biol. 2004
PubMed
Lin, H.Y., Hsieh, T.J., Tu, Z., Huang, B.S., Wu, S.C., Chien, C.T., Hsu, S.T., Lin, C.H.
To be published. Structural basis of human galectin-1 inhibition with Ki values in the micro- to nanomolar range 0
To be published. Structural basis of human galectin-1 inhibition with Ki values in the micro- to nanomolar range 0
PubMed
Lin, H.Y., Hsieh, T.J., Tu, Z., Huang, B.S., Wu, S.C., Chien, C.T., Hsu, S.T., Lin, C.H.
To be published. Structural basis of human galectin-1 inhibition with Ki values in the micro- to nanomolar range 0
To be published. Structural basis of human galectin-1 inhibition with Ki values in the micro- to nanomolar range 0
PubMed
Lin, H.Y., Hsieh, T.J., Tu, Z., Huang, B.S., Wu, S.C., Chien, C.T., Hsu, S.T., Lin, C.H.
To be published. Structural basis of human galectin-1 inhibition with Ki values in the micro- to nanomolar range 0
To be published. Structural basis of human galectin-1 inhibition with Ki values in the micro- to nanomolar range 0
PubMed
Saburi, H., Tanaka, T., Kunishima, N.
Crystal structure of Galectin-1 in the lactose-unbound state To be published. 0
Crystal structure of Galectin-1 in the lactose-unbound state To be published. 0
PubMed
Saburi, H., Tanaka, T., Kunishima, N.
Crystal structure of Galectin-1 in the lactose-unbound state To be published. 0
Crystal structure of Galectin-1 in the lactose-unbound state To be published. 0
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