Protein
Protein (NP_071370)
CBM13-ppGalNAc-T11
Polypeptide N-acetylgalactosaminyltransferase 11 (EC 2.4.1.41) (Polypeptide GalNAc transferase 11) (GalNAc-T11) (pp-GaNTase 11) (Protein-UDP acetylgalactosaminyltransferase 11) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 11)
GALNT11
polypeptide N-acetylgalactosaminyltransferase 11
Undefined
Curated
Ricin-like
R-Type Lectins
b-trefoil
GalNAc / Mucin-type glycopeptide
NP_071370
63917
Q8NCW6
ENSP00000395122.2
Q8NCW6
Undefined
10.1074/jbc.M111.273722
neXtProt, PFAM, InterPro
Protein sequence and protein families (fasta) (608 amino acids) Download
MGSVTVRYFCYGCLFTSATWTVLLFVYFNFSEVTQPLKNVPVKGSGPHGPSPKKFYPRFTRGPSRVLEPQFKANKIDDVIDSRVEDPEEGHLKFSSELGMIFNERDQELRDLGYQKHAFNMLISDRLGYHRDVPDTRNAACKEKFYPPDLPAASVVICFYNEAFSALLRTVHSVIDRTPAHLLHEIILVDDDSDFDDLKGELDEYVQKYLPGKIKVIRNTKREGLIRGRMIGAAHATGEVLVFLDSHCEVNVMWLQPLLAAIREDRHTVVCPVIDIISADTLAYSSSPVVRGGFNWGLHFKWDLVPLSELGRAEGATAPIKSPTMAGGLFAMNRQYFHELGQYDSGMDIWGGENLEISFRIWMCGGKLFIIPCSRVGHIFRKRRPYGSPEGQDTMTHNSLRLAHVWLDEYKEQYFSLRPDLKTKSYGNISERVELRKKLGCKSFKWYLDNVYPEMQISGSHAKPQQPIFVNRGPKRPKVLQRGRLYHLQTNKCLVAQGRPSQKGGLVVLKACDYSDPNQIWIYNEEHELVLNSLLCLDMSETRSSDPPRLMKCHGSGGSQQWTFGKNNRLYQVSVGQCLRAVDPLGQKGSVAMAICDGSSSQQWHLEG
No structure currently available in the PDB RCSB Databank.
Structural models
AlphaFold v2: AF-Q8NCW6-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

SWISS-MODEL structural models
SWISS-MODEL structural model
Modeller structural model (Homology modelling pipeline), Error: [1.56, 2.01] ÅDownload
The location of the lectin domain structural model is: 476-607
We infer [1.56, 2.01] Å as the interval of error of this structural model.
Template: 1XHB chain: A, O08912, NP_001153876.1, sequence identity: 28.0%, coverage: 95.5%, location in sequence: 95-553, (95-553 in PDB).
Show the alignment used for the construction of the structural model, Download.
Show the plot of DOPE energy score, Download.
Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for GALNT11 Gene
ProteomicsDB
References
NCBI References (6 PubMed Identifiers)
  • Genome-wide association study of kidney function decline in individuals of European descent. [25493955]
  • GALNT11 as a new molecular marker in chronic lymphocytic leukemia. [24076351]
  • The heterotaxy gene GALNT11 glycosylates Notch to orchestrate cilia type and laterality. [24226769]
  • A Japanese-specific allele in the GALNT11 gene. [20547088]
  • Rescue of Drosophila Melanogaster l(2)35Aa lethality is only mediated by polypeptide GalNAc-transferase pgant35A, but not by the evolutionary conserved human ortholog GalNAc-transferase-T11. [20422447]
  • Functional conservation of subfamilies of putative UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferases in Drosophila, Caenorhabditis elegans, and mammals. One subfamily composed of l(2)35Aa is essential in Drosophila. [11925450]
UniProt Main References (4 PubMed Identifiers)
  • Complete sequencing and characterization of 21,243 full-length human cDNAs. [14702039]
  • The DNA sequence of human chromosome 7. [12853948]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
  • Rare copy number variations in congenital heart disease patients identify unique genes in left-right patterning. [21282601]
All isoforms of this gene containing a lectin domain
NP_001358397.1, NP_001358398.1, NP_001358399.1, NP_001291443.1, NP_001358404.1, NP_001358394.1, NP_001358395.1, NP_001358396.1, NP_001358387.1, NP_001358388.1, NP_001358389.1, NP_001358390.1, NP_001358391.1, NP_001358392.1, NP_071370.2, XP_006716146.1, XP_006716147.1, XP_024302625.1, XP_024302627.1, XP_024302628.1, XP_024302629.1, XP_024302630.1
RNA
RNA (Transcript ID: NM_022087.4)
NM_022087.4
polypeptide N-acetylgalactosaminyltransferase 11, transcript variant 1
All isoforms of GALNT11 containing a lectin domain
ENST00000430044.7
250..2076 (or 152094228.. 152121677)
152025674.. 152122340
NCBI Matured mRNA sequence 2739 NTPDownload 
m7G-5')ppp(5'-GCGGAGGCAGCGGCUCGGGGACUGGGCGAGGGCCCUGGGCCUGAGGAGGCGCGGCCGCCACUGCGCCCAGCGCCUGCGCGACGCCUGGCUGCUGGGCCCCGGGGCAGUUCAGCCCGCGCCGCUCCUGCGGGUCGGACUGGGGCUGUGGCGGGAGAGAAGAUGCCGCAGCCCGAGUCCCAGAAGGCGGCGAUCCUGGGCUGCGGGCAAGGCGGAAAUUGACAAUGGCCCUUCAGCUAUGCUAGGUCUAUAAUGGGAAGUGUCACAGUUCGGUAUUUCUGUUAUGGGUGCCUUUUUACAUCUGCGACCUGGACAGUUUUGCUUUUUGUUUAUUUCAACUUCAGUGAAGUGACUCAGCCACUUAAGAAUGUGCCCGUCAAGGGGUCUGGGCCCCACGGACCAUCUCCAAAAAAAUUCUAUCCCCGUUUCACUCGAGGCCCAAGUCGAGUGCUCGAGCCACAGUUCAAAGCAAACAAAAUUGACGAUGUGAUAGACAGUCGUGUUGAAGAUCCAGAAGAAGGCCACUUGAAAUUCUCUUCUGAAUUAGGUAUGAUUUUUAAUGAACGCGAUCAAGAGUUGAGAGACUUGGGCUAUCAGAAACAUGCUUUUAAUAUGCUUAUCAGUGACCGCUUGGGCUACCACAGAGAUGUGCCAGACACAAGGAAUGCAGCAUGUAAAGAAAAGUUCUACCCACCUGACCUGCCAGCUGCUAGUGUUGUUAUCUGUUUCUAUAAUGAAGCGUUUUCUGCCUUGCUUCGGACAGUGCACAGUGUCAUAGACCGCACGCCAGCACACCUGCUUCAUGAGAUCAUCCUUGUGGAUGAUGAUAGUGACUUUGAUGAUUUGAAAGGAGAACUAGAUGAAUAUGUCCAAAAAUACCUCCCUGGAAAAAUUAAAGUCAUAAGAAAUACAAAGCGUGAGGGGUUGAUUCGAGGGAGAAUGAUUGGCGCGGCCCACGCGACAGGAGAAGUCCUUGUGUUCCUGGACAGCCACUGUGAAGUGAAUGUGAUGUGGCUGCAGCCCUUGCUGGCCGCCAUCCGUGAGGACCGGCACACCGUGGUGUGCCCAGUGAUUGACAUCAUCAGCGCCGACACGCUGGCCUACAGCUCGUCCCCUGUCGUCCGCGGAGGGUUCAACUGGGGACUGCACUUCAAAUGGGAUCUUGUCCCCCUUUCUGAGCUAGGACGAGCGGAGGGAGCCACUGCACCAAUAAAGUCACCAACAAUGGCUGGAGGUUUGUUUGCCAUGAACAGACAGUAUUUCCAUGAACUUGGACAGUAUGAUAGUGGCAUGGAUAUCUGGGGAGGAGAAAAUUUGGAAAUAUCAUUUCGGAUCUGGAUGUGUGGCGGUAAGCUCUUCAUCAUCCCUUGCUCUAGAGUAGGACACAUUUUCCGAAAAAGGCGACCAUAUGGAUCUCCCGAAGGCCAGGACACCAUGACACACAACUCUUUGCGGCUGGCACAUGUCUGGUUGGAUGAAUACAAGGAGCAGUAUUUUUCCUUAAGACCUGACCUGAAGACGAAAAGCUAUGGCAAUAUCAGUGAGCGUGUGGAACUGAGAAAGAAGUUGGGCUGUAAAUCAUUUAAAUGGUAUUUGGAUAAUGUAUACCCAGAGAUGCAGAUAUCUGGGUCCCACGCCAAACCCCAACAACCCAUUUUUGUCAAUAGAGGGCCAAAACGACCCAAAGUCCUUCAACGUGGAAGGCUCUAUCACCUCCAGACCAACAAAUGCCUGGUGGCCCAGGGCCGCCCAAGUCAGAAGGGAGGUCUCGUGGUGCUUAAGGCCUGUGACUACAGUGACCCAAAUCAGAUCUGGAUCUAUAAUGAAGAGCAUGAAUUGGUUUUAAAUAGUCUCCUUUGUCUAGAUAUGUCAGAGACUCGCUCAUCAGACCCGCCACGGCUCAUGAAAUGCCACGGGUCAGGAGGAUCCCAGCAGUGGACCUUUGGGAAAAACAAUCGGCUAUACCAGGUGUCGGUUGGACAGUGCCUGAGAGCAGUGGAUCCCCUGGGUCAGAAGGGCUCUGUCGCCAUGGCGAUCUGCGAUGGCUCCUCUUCACAGCAGUGGCAUUUGGAAGGUUAAGGUGGAUGCUGUGGUGGGAACGUUGCUUCAUCAGGCGUUGCCUCCGGUGUGGAGUUUGGGGCUUUAGGAAAGCCUGGGUUGGGUGGAGCAGAACCAUCUUGGAGAAGAUGACAGUUCCCUGUCCUCCCGGAGAUGCCUGGGUGUGUUAGCAGAGGUGACACGUGUCUGACAGAGACGGGAGCUCUGAGUGUCCACGGGUGAAGAAGUGAGUGUCCACGGGUGAAGAAGUGAGUAUGUUUCACCUGGACAUUAAGGUGAUGUUUGAGCUGCUGUUAAGGAAUUUCUUGCUUAUAGAGGCAAACCACAGUAUCAUUUUAACUCUAGAAUUGGGCUUGUACAGAAGGAUAAAACCCAGGAAAAUGGAUAUUUCUAUUCAGAUUUAUUUAUGCCUCUUUUUAAUCCCCUUUAAUGAUGCAGUGGUUUUUAUCUGAUCAGGAACUUGUCAUGAUUUCCUUUCUUAGACUUCAUAGGAGAUAGUGCUUUAAAAAAAAAAAAAACUUCUAUUAUUUGUUUAGUAUGUUGUAAGUAGAUCAUUUUAAAAAACUGAAUCUAUAUUAUGUUUAACUUCAGAAGGCAUCAUUUAUAAGACAGUAUGGCAGUUAAUUAUAAAAUUAUUUUGAUGAAUUAUGAUACAAUCUACAUAAUAAAGAAUCCUUUUGAUUA-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
;
More about the NCBI sViewer.
DNA
DNA (Gene ID: 63917)
GALNT11
polypeptide N-acetylgalactosaminyltransferase 11
NC_000007.14
7  152094228.. 152121677
152094228.. 152121677
strand +
CCDS5930.1
MGI:2444392
ClinVar, dbVar
ENSG00000178234
GalNAc-T11
uc010lqg.2
INSDC: AC006017
19875
615130
OTTHUMG00000157251
ENA, DDBJ, Monarch
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (1827 bp)
5'-ATGGGAAGTGTCACAGTTCGGTATTTCTGTTATGGGTGCCTTTTTACATCTGCGACCTGGACAGTTTTGCTTTTTGTTTATTTCAACTTCAGTGAAGTGACTCAGCCACTTAAGAATGTGCCCGTCAAGGGGTCTGGGCCCCACGGACCATCTCCAAAAAAATTCTATCCCCGTTTCACTCGAGGCCCAAGTCGAGTGCTCGAGCCACAGTTCAAAGCAAACAAAATTGACGATGTGATAGACAGTCGTGTTGAAGATCCAGAAGAAGGCCACTTGAAATTCTCTTCTGAATTAGGTATGATTTTTAATGAACGCGATCAAGAGTTGAGAGACTTGGGCTATCAGAAACATGCTTTTAATATGCTTATCAGTGACCGCTTGGGCTACCACAGAGATGTGCCAGACACAAGGAATGCAGCATGTAAAGAAAAGTTCTACCCACCTGACCTGCCAGCTGCTAGTGTTGTTATCTGTTTCTATAATGAAGCGTTTTCTGCCTTGCTTCGGACAGTGCACAGTGTCATAGACCGCACGCCAGCACACCTGCTTCATGAGATCATCCTTGTGGATGATGATAGTGACTTTGATGATTTGAAAGGAGAACTAGATGAATATGTCCAAAAATACCTCCCTGGAAAAATTAAAGTCATAAGAAATACAAAGCGTGAGGGGTTGATTCGAGGGAGAATGATTGGCGCGGCCCACGCGACAGGAGAAGTCCTTGTGTTCCTGGACAGCCACTGTGAAGTGAATGTGATGTGGCTGCAGCCCTTGCTGGCCGCCATCCGTGAGGACCGGCACACCGTGGTGTGCCCAGTGATTGACATCATCAGCGCCGACACGCTGGCCTACAGCTCGTCCCCTGTCGTCCGCGGAGGGTTCAACTGGGGACTGCACTTCAAATGGGATCTTGTCCCCCTTTCTGAGCTAGGACGAGCGGAGGGAGCCACTGCACCAATAAAGTCACCAACAATGGCTGGAGGTTTGTTTGCCATGAACAGACAGTATTTCCATGAACTTGGACAGTATGATAGTGGCATGGATATCTGGGGAGGAGAAAATTTGGAAATATCATTTCGGATCTGGATGTGTGGCGGTAAGCTCTTCATCATCCCTTGCTCTAGAGTAGGACACATTTTCCGAAAAAGGCGACCATATGGATCTCCCGAAGGCCAGGACACCATGACACACAACTCTTTGCGGCTGGCACATGTCTGGTTGGATGAATACAAGGAGCAGTATTTTTCCTTAAGACCTGACCTGAAGACGAAAAGCTATGGCAATATCAGTGAGCGTGTGGAACTGAGAAAGAAGTTGGGCTGTAAATCATTTAAATGGTATTTGGATAATGTATACCCAGAGATGCAGATATCTGGGTCCCACGCCAAACCCCAACAACCCATTTTTGTCAATAGAGGGCCAAAACGACCCAAAGTCCTTCAACGTGGAAGGCTCTATCACCTCCAGACCAACAAATGCCTGGTGGCCCAGGGCCGCCCAAGTCAGAAGGGAGGTCTCGTGGTGCTTAAGGCCTGTGACTACAGTGACCCAAATCAGATCTGGATCTATAATGAAGAGCATGAATTGGTTTTAAATAGTCTCCTTTGTCTAGATATGTCAGAGACTCGCTCATCAGACCCGCCACGGCTCATGAAATGCCACGGGTCAGGAGGATCCCAGCAGTGGACCTTTGGGAAAAACAATCGGCTATACCAGGTGTCGGTTGGACAGTGCCTGAGAGCAGTGGATCCCCTGGGTCAGAAGGGCTCTGTCGCCATGGCGATCTGCGATGGCTCCTCTTCACAGCAGTGGCATTTGGAAGGTTAA-3'
NCBI CDS gene sequence with introns (location: 152094228.. 152121677) (27450 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 152025674.. 152122340) (96667 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [152025674 - 1000].. 152122340) (97667 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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