NCBI Summary
This gene encodes a member of the lectican family of chondroitin sulfate proteoglycans that is specifically expressed in the central nervous system. This protein is developmentally regulated and may function in the formation of the brain extracellular matrix. This protein is highly expressed in gliomas and may promote the growth and cell motility of brain tumor cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011].
Protein
Protein (NP_068767)
Brevican
Brevican core protein (Brain-enriched hyaluronan-binding protein) (BEHAB) (Chondroitin sulfate proteoglycan 7)
BCAN
brevican
Undefined
Curated
C-type lectin
Undefined
C-type - Proteoglycans or lecticans
a/b mixed / C-type lectin-like
Hyaluronan
NP_068767
63827
Q96GW7
ENSP00000331210.4
Q96GW7
0.382
10.1083/jcb.125.2.495
neXtProt, PFAM, InterPro
Protein sequence and protein families (fasta) (911 amino acids) Download
MAQLFLPLLAALVLAQAPAALADVLEGDSSEDRAFRVRIAGDAPLQGVLGGALTIPCHVHYLRPPPSRRAVLGSPRVKWTFLSRGREAEVLVARGVRVKVNEAYRFRVALPAYPASLTDVSLALSELRPNDSGIYRCEVQHGIDDSSDAVEVKVKGVVFLYREGSARYAFSFSGAQEACARIGAHIATPEQLYAAYLGGYEQCDAGWLSDQTVRYPIQTPREACYGDMDGFPGVRNYGVVDPDDLYDVYCYAEDLNGELFLGDPPEKLTLEEARAYCQERGAEIATTGQLYAAWDGGLDHCSPGWLADGSVRYPIVTPSQRCGGGLPGVKTLFLFPNQTGFPNKHSRFNVYCFRDSAQPSAIPEASNPASNPASDGLEAIVTVTETLEELQLPQEATESESRGAIYSIPIMEDGGGGSSTPEDPAEAPRTLLEFETQSMVPPTGFSEEEGKALEEEEKYEDEEEKEEEEEEEEVEDEALWAWPSELSSPGPEASLPTEPAAQEESLSQAPARAVLQPGASPLPDGESEASRPPRVHGPPTETLPTPRERNLASPSPSTLVEAREVGEATGGPELSGVPRGESEETGSSEGAPSLLPATRAPEGTRELEAPSEDNSGRTAPAGTSVQAQPVLPTDSASRGGVAVVPASGDCVPSPCHNGGTCLEEEEGVRCLCLPGYGGDLCDVGLRFCNPGWDAFQGACYKHFSTRRSWEEAETQCRMYGAHLASISTPEEQDFINNRYREYQWIGLNDRTIEGDFLWSDGVPLLYENWNPGQPDSYFLSGENCVVMVWHDQGQWSDVPCNYHLSYTCKMGLVSCGPPPELPLAQVFGRPRLRYEVDTVLRYRCREGLAQRNLPLIRCQENGRWEAPQISCVPRRPARALHPEEDPEGRQGRLLGRWKALLIPPSSPMPGP
No structure currently available in the PDB RCSB Databank.
Structural models
AlphaFold v2: AF-Q96GW7-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

SWISS-MODEL structural models
SWISS-MODEL structural model
Modeller structural model (Homology modelling pipeline), Error: [1.4, 1.75] ÅDownload
The location of the lectin domain structural model is: 686-813
We infer [1.4, 1.75] Å as the interval of error of this structural model.
Template 1: 6PWS chain: A, E1BIQ4, XP_005198961.1, sequence identity: 39.1%, coverage: 97.7%, location in sequence: 174-302, (162-290 in PDB).
Template 2: 3WHD chain: C, Q8WXI8, NP_525126.2, sequence identity: 39.1%, coverage: 98.4%, location in sequence: 63-215, (63-215 in PDB).
Template 3: 6PY1 chain: A, Q8IUN9, NP_878910.1, sequence identity: 36.7%, coverage: 96.1%, location in sequence: 179-308, (179-308 in PDB).
Show the alignment used for the construction of the structural model, Download.
Show the plot of DOPE energy score, Download.
Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for BCAN Gene
ProteomicsDB
References
NCBI References (10 PubMed Identifiers)
  • Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains. [32814053]
  • The CNS-specific proteoglycan, brevican, and its ADAMTS4-cleaved fragment show differential serological levels in Alzheimer's disease, other types of dementia and non-demented controls: A cross-sectional study. [32559242]
  • The Role of BEHAB/Brevican in the Tumor Microenvironment: Mediating Glioma Cell Invasion and Motility. [32845505]
  • Genome-wide methylation screen in low-grade breast cancer identifies novel epigenetically altered genes as potential biomarkers for tumor diagnosis. [22930747]
  • Brevican, neurocan, tenascin-C and versican are mainly responsible for the invasiveness of low-grade astrocytoma. [21997179]
  • The proteoglycans aggrecan and Versican form networks with fibulin-2 through their lectin domain binding. [11038354]
  • Brevican is degraded by matrix metalloproteinases and aggrecanase-1 (ADAMTS4) at different sites. [10986281]
  • cDNA cloning, chromosomal localization, and expression analysis of human BEHAB/brevican, a brain specific proteoglycan regulated during cortical development and in glioma. [11054543]
  • The C-type lectin domains of lecticans, a family of aggregating chondroitin sulfate proteoglycans, bind tenascin-R by protein-protein interactions independent of carbohydrate moiety. [9294172]
  • Brevican, a chondroitin sulfate proteoglycan of rat brain, occurs as secreted and cell surface glycosylphosphatidylinositol-anchored isoforms. [7592978]
UniProt Main References (5 PubMed Identifiers)
  • The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. [12975309]
  • The DNA sequence and biological annotation of human chromosome 1. [16710414]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
  • Enrichment of glycopeptides for glycan structure and attachment site identification. [19838169]
  • Extracellular matrix component expression in human pluripotent stem cell-derived retinal organoids recapitulates retinogenesis in vivo and reveals an important role for IMPG1 and CD44 in the development of photoreceptors and interphotoreceptor matrix. [29777959]
All isoforms of this gene containing a lectin domain
NP_068767.3, XP_011508168.1, XP_016857536.1, NP_940819.1
RNA
RNA (Transcript ID: NM_021948.5)
NM_021948.5
brevican, transcript variant 1
All isoforms of BCAN containing a lectin domain
ENST00000329117.10
168..2903 (or 156646055.. 156659134)
156642117.. 156659528
NCBI Matured mRNA sequence 3297 NTPDownload 
m7G-5')ppp(5'-CUCUUCCGAAUGUCCUGCGGCCCCAGCCUCUCCUCACGCUCGCGCAGUCUCCGCCGCAGUCUCAGCUGCAGCUGCAGGACUGAGCCGUGCACCCGGAGGAGACCCCCGGAGGAGGCGACAAACUUCGCAGUGCCGCGACCCAACCCCAGCCCUGGGUAGCCUGCAGCAUGGCCCAGCUGUUCCUGCCCCUGCUGGCAGCCCUGGUCCUGGCCCAGGCUCCUGCAGCUUUAGCAGAUGUUCUGGAAGGAGACAGCUCAGAGGACCGCGCUUUUCGCGUGCGCAUCGCGGGCGACGCGCCACUGCAGGGCGUGCUCGGCGGCGCCCUCACCAUCCCUUGCCACGUCCACUACCUGCGGCCACCGCCGAGCCGCCGGGCUGUGCUGGGCUCUCCGCGGGUCAAGUGGACUUUCCUGUCCCGGGGCCGGGAGGCAGAGGUGCUGGUGGCGCGGGGAGUGCGCGUCAAGGUGAACGAGGCCUACCGGUUCCGCGUGGCACUGCCUGCGUACCCAGCGUCGCUCACCGACGUCUCCCUGGCGCUGAGCGAGCUGCGCCCCAACGACUCAGGUAUCUAUCGCUGUGAGGUCCAGCACGGCAUCGAUGACAGCAGCGACGCUGUGGAGGUCAAGGUCAAAGGGGUCGUCUUUCUCUACCGAGAGGGCUCUGCCCGCUAUGCUUUCUCCUUUUCUGGGGCCCAGGAGGCCUGUGCCCGCAUUGGAGCCCACAUCGCCACCCCGGAGCAGCUCUAUGCCGCCUACCUUGGGGGCUAUGAGCAAUGUGAUGCUGGCUGGCUGUCGGAUCAGACCGUGAGGUAUCCCAUCCAGACCCCACGAGAGGCCUGUUACGGAGACAUGGAUGGCUUCCCCGGGGUCCGGAACUAUGGUGUGGUGGACCCGGAUGACCUCUAUGAUGUGUACUGUUAUGCUGAAGACCUAAAUGGAGAACUGUUCCUGGGUGACCCUCCAGAGAAGCUGACAUUGGAGGAAGCACGGGCGUACUGCCAGGAGCGGGGUGCAGAGAUUGCCACCACGGGCCAACUGUAUGCAGCCUGGGAUGGUGGCCUGGACCACUGCAGCCCAGGGUGGCUAGCUGAUGGCAGUGUGCGCUACCCCAUCGUCACACCCAGCCAGCGCUGUGGUGGGGGCUUGCCUGGUGUCAAGACUCUCUUCCUCUUCCCCAACCAGACUGGCUUCCCCAAUAAGCACAGCCGCUUCAACGUCUACUGCUUCCGAGACUCGGCCCAGCCUUCUGCCAUCCCUGAGGCCUCCAACCCAGCCUCCAACCCAGCCUCUGAUGGACUAGAGGCUAUCGUCACAGUGACAGAGACCCUGGAGGAACUGCAGCUGCCUCAGGAAGCCACAGAGAGUGAAUCCCGUGGGGCCAUCUACUCCAUCCCCAUCAUGGAGGACGGAGGAGGUGGAAGCUCCACUCCAGAAGACCCAGCAGAGGCCCCUAGGACGCUCCUAGAAUUUGAAACACAAUCCAUGGUACCGCCCACGGGGUUCUCAGAAGAGGAAGGUAAGGCAUUGGAGGAAGAAGAGAAAUAUGAAGAUGAAGAAGAGAAAGAGGAGGAAGAAGAAGAGGAGGAGGUGGAGGAUGAGGCUCUGUGGGCAUGGCCCAGCGAGCUCAGCAGCCCGGGCCCUGAGGCCUCUCUCCCCACUGAGCCAGCAGCCCAGGAGGAGUCACUCUCCCAGGCGCCAGCAAGGGCAGUCCUGCAGCCUGGUGCAUCACCACUUCCUGAUGGAGAGUCAGAAGCUUCCAGGCCUCCAAGGGUCCAUGGACCACCUACUGAGACUCUGCCCACUCCCAGGGAGAGGAACCUAGCAUCCCCAUCACCUUCCACUCUGGUUGAGGCAAGAGAGGUGGGGGAGGCAACUGGUGGUCCUGAGCUAUCUGGGGUCCCUCGAGGAGAGAGCGAGGAGACAGGAAGCUCCGAGGGUGCCCCUUCCCUGCUUCCAGCCACACGGGCCCCUGAGGGUACCAGGGAGCUGGAGGCCCCCUCUGAAGAUAAUUCUGGAAGAACUGCCCCAGCAGGGACCUCAGUGCAGGCCCAGCCAGUGCUGCCCACUGACAGCGCCAGCCGAGGUGGAGUGGCCGUGGUCCCCGCAUCAGGUGACUGUGUCCCCAGCCCCUGCCACAAUGGUGGGACAUGCUUGGAGGAGGAGGAAGGGGUCCGCUGCCUAUGUCUGCCUGGCUAUGGGGGGGACCUGUGCGAUGUUGGCCUCCGCUUCUGCAACCCCGGCUGGGACGCCUUCCAGGGCGCCUGCUACAAGCACUUUUCCACACGAAGGAGCUGGGAGGAGGCAGAGACCCAGUGCCGGAUGUACGGCGCGCAUCUGGCCAGCAUCAGCACACCCGAGGAACAGGACUUCAUCAACAACCGGUACCGGGAGUACCAGUGGAUCGGACUCAACGACAGGACCAUCGAAGGCGACUUCUUGUGGUCGGAUGGCGUCCCCCUGCUCUAUGAGAACUGGAACCCUGGGCAGCCUGACAGCUACUUCCUGUCUGGAGAGAACUGCGUGGUCAUGGUGUGGCAUGAUCAGGGACAAUGGAGUGACGUGCCCUGCAACUACCACCUGUCCUACACCUGCAAGAUGGGGCUGGUGUCCUGUGGGCCGCCACCGGAGCUGCCCCUGGCUCAAGUGUUCGGCCGCCCACGGCUGCGCUAUGAGGUGGACACUGUGCUUCGCUACCGGUGCCGGGAAGGACUGGCCCAGCGCAAUCUGCCGCUGAUCCGAUGCCAAGAGAACGGUCGUUGGGAGGCCCCCCAGAUCUCCUGUGUGCCCAGAAGACCUGCCCGAGCUCUGCACCCAGAGGAGGACCCAGAAGGACGUCAGGGGAGGCUACUGGGACGCUGGAAGGCGCUGUUGAUCCCCCCUUCCAGCCCCAUGCCAGGUCCCUAGGGGGCAAGGCCUUGAACACUGCCGGCCACAGCACUGCCCUGUCACCCAAAUUUUCCCUCACACCCUGCGCUCCCGCCACCACAGGAAGUGACAACAUGACGAGGGGUGGUACUGGAGUCCAGGUGACAGUUCCUGAAGGGGCUUCUGGGAAAUACCUAGGAGGCUCCAGCCCAGCCCAGGCCCUCUCCCCCUACCCUGGGCACCAGAUCUUCCAUCAGGGCCGGAGUAAAUCCCUAAGUGCCUCAACUGCCCUCUCCCUGGCAGCCAUCUUGUCCCCUCUAUUCCUCUAGGGAGCACUGUGCCCACUCUUUCUGGGUUUUCCAAGGGAAUGGGCUUGCAGGAUGGAGUGUCUGUAAAAUCAACAGGAAAUAAAACUGUGUAUGAGCCCAGGCAA-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
;
More about the NCBI sViewer.
DNA
DNA (Gene ID: 63827)
BCAN
brevican
NC_000001.11
1  156646055.. 156659134
156646055.. 156659134
strand +
CCDS1149.1
MGI:1096385
ClinVar, dbVar
ENSG00000132692
BEHAB, MGC13038, CSPG7
uc001fpp.4
INSDC: BC027971
23059
600347
OTTHUMG00000033322
ENA, DDBJ, Monarch
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (2736 bp)
5'-ATGGCCCAGCTGTTCCTGCCCCTGCTGGCAGCCCTGGTCCTGGCCCAGGCTCCTGCAGCTTTAGCAGATGTTCTGGAAGGAGACAGCTCAGAGGACCGCGCTTTTCGCGTGCGCATCGCGGGCGACGCGCCACTGCAGGGCGTGCTCGGCGGCGCCCTCACCATCCCTTGCCACGTCCACTACCTGCGGCCACCGCCGAGCCGCCGGGCTGTGCTGGGCTCTCCGCGGGTCAAGTGGACTTTCCTGTCCCGGGGCCGGGAGGCAGAGGTGCTGGTGGCGCGGGGAGTGCGCGTCAAGGTGAACGAGGCCTACCGGTTCCGCGTGGCACTGCCTGCGTACCCAGCGTCGCTCACCGACGTCTCCCTGGCGCTGAGCGAGCTGCGCCCCAACGACTCAGGTATCTATCGCTGTGAGGTCCAGCACGGCATCGATGACAGCAGCGACGCTGTGGAGGTCAAGGTCAAAGGGGTCGTCTTTCTCTACCGAGAGGGCTCTGCCCGCTATGCTTTCTCCTTTTCTGGGGCCCAGGAGGCCTGTGCCCGCATTGGAGCCCACATCGCCACCCCGGAGCAGCTCTATGCCGCCTACCTTGGGGGCTATGAGCAATGTGATGCTGGCTGGCTGTCGGATCAGACCGTGAGGTATCCCATCCAGACCCCACGAGAGGCCTGTTACGGAGACATGGATGGCTTCCCCGGGGTCCGGAACTATGGTGTGGTGGACCCGGATGACCTCTATGATGTGTACTGTTATGCTGAAGACCTAAATGGAGAACTGTTCCTGGGTGACCCTCCAGAGAAGCTGACATTGGAGGAAGCACGGGCGTACTGCCAGGAGCGGGGTGCAGAGATTGCCACCACGGGCCAACTGTATGCAGCCTGGGATGGTGGCCTGGACCACTGCAGCCCAGGGTGGCTAGCTGATGGCAGTGTGCGCTACCCCATCGTCACACCCAGCCAGCGCTGTGGTGGGGGCTTGCCTGGTGTCAAGACTCTCTTCCTCTTCCCCAACCAGACTGGCTTCCCCAATAAGCACAGCCGCTTCAACGTCTACTGCTTCCGAGACTCGGCCCAGCCTTCTGCCATCCCTGAGGCCTCCAACCCAGCCTCCAACCCAGCCTCTGATGGACTAGAGGCTATCGTCACAGTGACAGAGACCCTGGAGGAACTGCAGCTGCCTCAGGAAGCCACAGAGAGTGAATCCCGTGGGGCCATCTACTCCATCCCCATCATGGAGGACGGAGGAGGTGGAAGCTCCACTCCAGAAGACCCAGCAGAGGCCCCTAGGACGCTCCTAGAATTTGAAACACAATCCATGGTACCGCCCACGGGGTTCTCAGAAGAGGAAGGTAAGGCATTGGAGGAAGAAGAGAAATATGAAGATGAAGAAGAGAAAGAGGAGGAAGAAGAAGAGGAGGAGGTGGAGGATGAGGCTCTGTGGGCATGGCCCAGCGAGCTCAGCAGCCCGGGCCCTGAGGCCTCTCTCCCCACTGAGCCAGCAGCCCAGGAGGAGTCACTCTCCCAGGCGCCAGCAAGGGCAGTCCTGCAGCCTGGTGCATCACCACTTCCTGATGGAGAGTCAGAAGCTTCCAGGCCTCCAAGGGTCCATGGACCACCTACTGAGACTCTGCCCACTCCCAGGGAGAGGAACCTAGCATCCCCATCACCTTCCACTCTGGTTGAGGCAAGAGAGGTGGGGGAGGCAACTGGTGGTCCTGAGCTATCTGGGGTCCCTCGAGGAGAGAGCGAGGAGACAGGAAGCTCCGAGGGTGCCCCTTCCCTGCTTCCAGCCACACGGGCCCCTGAGGGTACCAGGGAGCTGGAGGCCCCCTCTGAAGATAATTCTGGAAGAACTGCCCCAGCAGGGACCTCAGTGCAGGCCCAGCCAGTGCTGCCCACTGACAGCGCCAGCCGAGGTGGAGTGGCCGTGGTCCCCGCATCAGGTGACTGTGTCCCCAGCCCCTGCCACAATGGTGGGACATGCTTGGAGGAGGAGGAAGGGGTCCGCTGCCTATGTCTGCCTGGCTATGGGGGGGACCTGTGCGATGTTGGCCTCCGCTTCTGCAACCCCGGCTGGGACGCCTTCCAGGGCGCCTGCTACAAGCACTTTTCCACACGAAGGAGCTGGGAGGAGGCAGAGACCCAGTGCCGGATGTACGGCGCGCATCTGGCCAGCATCAGCACACCCGAGGAACAGGACTTCATCAACAACCGGTACCGGGAGTACCAGTGGATCGGACTCAACGACAGGACCATCGAAGGCGACTTCTTGTGGTCGGATGGCGTCCCCCTGCTCTATGAGAACTGGAACCCTGGGCAGCCTGACAGCTACTTCCTGTCTGGAGAGAACTGCGTGGTCATGGTGTGGCATGATCAGGGACAATGGAGTGACGTGCCCTGCAACTACCACCTGTCCTACACCTGCAAGATGGGGCTGGTGTCCTGTGGGCCGCCACCGGAGCTGCCCCTGGCTCAAGTGTTCGGCCGCCCACGGCTGCGCTATGAGGTGGACACTGTGCTTCGCTACCGGTGCCGGGAAGGACTGGCCCAGCGCAATCTGCCGCTGATCCGATGCCAAGAGAACGGTCGTTGGGAGGCCCCCCAGATCTCCTGTGTGCCCAGAAGACCTGCCCGAGCTCTGCACCCAGAGGAGGACCCAGAAGGACGTCAGGGGAGGCTACTGGGACGCTGGAAGGCGCTGTTGATCCCCCCTTCCAGCCCCATGCCAGGTCCCTAG-3'
NCBI CDS gene sequence with introns (location: 156646055.. 156659134) (13080 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 156642117.. 156659528) (17412 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [156642117 - 1000].. 156659528) (18412 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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