NCBI Summary
This gene encodes a mannose-binding type 1 transmembrane protein that contains an N-terminal lectin-like carbohydrate recognition domain. The encoded protein is similar in structure to lectins found in leguminous plants. This lectin is thought to transport newly synthesized glycoproteins from the endoplasmic reticulum (ER) to the ER-Golgi intermediate compartment. [provided by RefSeq, Jan 2017].
Protein
Protein (NP_068591)
Lectin, mannose-binding 1 like
Protein ERGIC-53-like (ERGIC53-like protein) (Lectin mannose-binding 1-like) (LMAN1-like protein)
LMAN1L
lectin, mannose binding 1 like
Undefined
Very low evidence
ERGIC-VIP L-type
L-Type Lectins
b-sandwich / ConA-like
Uncharacterised
NP_068591
79748
Q9HAT1
ENSP00000310431.5
Q9HAT1
0.592
Undefined
neXtProt, PFAM, InterPro
Protein sequence and protein families (fasta) (526 amino acids) Download
MPAVSGPGPLFCLLLLLLDPHSPETGCPPLRRFEYKLSFKGPRLALPGAGIPFWSHHGDAILGLEEVRLTPSMRNRSGAVWSRASVPFSAWEVEVQMRVTGLGRRGAQGMAVWYTRGRGHVGSVLGGLASWDGIGIFFDSPAEDTQDSPAIRVLASDGHIPSEQPGDGASQGLGSCHWDFRNRPHPFRARITYWGQRLRMSLNSGLTPSDPGEFCVDVGPLLLVPGGFFGVSAATGTLADDHDVLSFLTFSLSEPSPEVPPQPFLEMQQLRLARQLEGLWARLGLGTREDVTPKSDSEAQGEGERLFDLEETLGRHRRILQALRGLSKQLAQAERQWKKQLGPPGQARPDGGWALDASCQIPSTPGRGGHLSMSLNKDSAKVGALLHGQWTLLQALQEMRDAAVRMAAEAQVSYLPVGIEHHFLELDHILGLLQEELRGPAKAAAKAPRPPGQPPRASSCLQPGIFLFYLLIQTVGFFGYVHFRQELNKSLQECLSTGSLPLGPAPHTPRALGILRRQPLPASMPA
No structure currently available in the PDB RCSB Databank.
Structural models
AlphaFold v2: AF-Q9HAT1-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

SWISS-MODEL structural models
SWISS-MODEL structural model
Modeller structural model (Homology modelling pipeline), Error: [1.23, 1.5] ÅDownload
The location of the lectin domain structural model is: 29-255
We infer [1.23, 1.5] Å as the interval of error of this structural model.
Template 1: 1R1Z chain: A, Q62902, NP_446338.1, sequence identity: 50.2%, coverage: 99.6%, location in sequence: 28-277, (28-277 in PDB).
Template 2: 4GKY chain: A, P49257, NP_005561.1, sequence identity: 49.8%, coverage: 99.6%, location in sequence: 41-269, (41-269 in PDB).
Template 3: 2DUR chain: A, P49256, NP_001003258.1, sequence identity: 31.3%, coverage: 98.7%, location in sequence: 51-301, (51-301 in PDB).
Show the alignment used for the construction of the structural model, Download.
Show the plot of DOPE energy score, Download.
Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for LMAN1L Gene
ProteomicsDB
References
NCBI References (10 PubMed Identifiers)
  • Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics. [28675934]
  • Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption. [21490707]
  • New genetic associations detected in a host response study to hepatitis B vaccine. [20237496]
  • Genome-wide association study identifies eight loci associated with blood pressure. [19430483]
  • Identification of ERGIC-53 as an intracellular transport receptor of alpha1-antitrypsin. [18283111]
  • The sugar-binding ability of ERGIC-53 is enhanced by its interaction with MCFD2. [18056485]
  • Sequential steps and checkpoints in the early exocytic compartment during secretory IgM biogenesis. [17805346]
  • The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. [12975309]
  • Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma. [12880961]
  • ERGL, a novel gene related to ERGIC-53 that is highly expressed in normal and neoplastic prostate and several other tissues. [11255007]
UniProt Main References (2 PubMed Identifiers)
  • ERGL, a novel gene related to ERGIC-53 that is highly expressed in normal and neoplastic prostate and several other tissues. [11255007]
  • The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. [12975309]
RNA
RNA (Transcript ID: NM_021819.3)
NM_021819.3
lectin, mannose binding 1 like
All isoforms of LMAN1L containing a lectin domain
ENST00000309664.10
21..1601 (or 74812855.. 74825605)
74812835.. 74825754
NCBI Matured mRNA sequence 1750 NTPDownload 
m7G-5')ppp(5'-AGACUUCAGGCGCCUUCACGAUGCCGGCGGUCAGUGGUCCAGGUCCCUUAUUCUGCCUUCUCCUCCUGCUCCUGGACCCCCACAGCCCUGAGACGGGGUGUCCUCCUCUACGCAGGUUUGAGUACAAGCUCAGCUUCAAAGGCCCAAGGCUGGCAUUGCCUGGGGCUGGAAUACCCUUCUGGAGCCAUCAUGGAGACGCCAUCCUGGGCCUGGAGGAAGUGCGGCUGACGCCAUCCAUGAGGAACCGGAGUGGCGCCGUGUGGAGCAGGGCCUCUGUCCCCUUCUCUGCCUGGGAAGUAGAGGUGCAGAUGAGGGUGACGGGACUGGGGCGCCGGGGAGCCCAGGGCAUGGCCGUGUGGUACACCCGGGGCAGGGGCCAUGUAGGCUCUGUCCUUGGGGGGCUGGCUUCGUGGGACGGCAUCGGGAUCUUCUUUGACUCUCCGGCAGAGGAUACUCAGGACAGUCCUGCCAUCCGUGUGCUGGCCAGCGACGGGCACAUCCCCUCUGAGCAGCCUGGGGAUGGAGCUAGCCAAGGGCUGGGCUCCUGUCAUUGGGACUUCCGGAACCGGCCACACCCCUUCAGAGCACGGAUCACCUACUGGGGGCAGAGGCUGCGCAUGUCCUUGAACAGUGGCCUCACUCCCAGUGAUCCAGGUGAGUUCUGUGUGGAUGUGGGGCCCCUGCUUUUGGUCCCUGGAGGUUUCUUUGGGGUCUCAGCAGCCACCGGCACCCUGGCAGAUGAUCAUGAUGUCCUGUCCUUCCUGACCUUCAGCCUGAGUGAGCCCAGCCCAGAGGUUCCCCCUCAGCCCUUCCUGGAGAUGCAGCAGCUCCGCCUGGCGAGGCAGCUGGAAGGGCUGUGGGCAAGGCUGGGCUUGGGCACCAGGGAGGAUGUAACUCCAAAAUCAGACUCUGAAGCUCAAGGAGAAGGGGAAAGGCUCUUUGACCUGGAGGAGACGCUGGGCAGACACCGCCGGAUCCUGCAGGCUCUGCGGGGUCUCUCCAAGCAGCUGGCCCAGGCUGAGAGACAAUGGAAGAAGCAGCUGGGGCCCCCAGGCCAAGCCAGGCCUGACGGAGGCUGGGCCCUGGAUGCUUCCUGCCAGAUUCCAUCCACCCCAGGGAGGGGUGGCCACCUCUCCAUGUCACUCAAUAAGGACUCUGCCAAGGUCGGUGCCCUGCUCCAUGGACAGUGGACUCUGCUCCAGGCCCUGCAAGAGAUGAGGGAUGCAGCUGUCCGCAUGGCUGCAGAAGCCCAGGUCUCCUACCUGCCUGUGGGCAUUGAGCAUCAUUUCUUAGAGCUGGACCACAUCCUGGGCCUCCUGCAGGAGGAGCUUCGGGGCCCGGCGAAGGCAGCAGCCAAGGCCCCCCGCCCACCUGGCCAGCCCCCAAGGGCCUCCUCGUGCCUGCAGCCUGGCAUCUUCCUGUUCUACCUCCUCAUUCAGACUGUAGGCUUCUUCGGCUACGUGCACUUCAGGCAGGAGCUGAACAAGAGCCUUCAGGAGUGUCUGUCCACAGGCAGCCUUCCUCUGGGUCCUGCACCACACACCCCCAGGGCCCUGGGGAUUCUGAGGAGGCAGCCUCUCCCUGCCAGCAUGCCUGCCUGACCCACCUCAGAGCCUGCUUUGCAUCACUGGGAAGCAGGCAGUGUCUUGGGUGGGGGCUUGGUCAGUAUCCUCUCCGUCUGGGUGCCCAGCUCCCACGCACACCUGAGCUUUCGGCAUGCUCCCACCUCGUUAAAGGUGAUUUCCCUCUC-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
;
More about the NCBI sViewer.
DNA
DNA (Gene ID: 79748)
LMAN1L
lectin, mannose binding 1 like
NC_000015.10
15  74812855.. 74825605
74812855.. 74825605
strand +
CCDS10270.1
MGI:2667537
ClinVar, dbVar
ENSG00000140506
ERGL, ERGIC-53L
uc002ayt.2
INSDC: AF303398
6632
609548
OTTHUMG00000142813
ENA, DDBJ, Monarch
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (1581 bp)
5'-ATGCCGGCGGTCAGTGGTCCAGGTCCCTTATTCTGCCTTCTCCTCCTGCTCCTGGACCCCCACAGCCCTGAGACGGGGTGTCCTCCTCTACGCAGGTTTGAGTACAAGCTCAGCTTCAAAGGCCCAAGGCTGGCATTGCCTGGGGCTGGAATACCCTTCTGGAGCCATCATGGAGACGCCATCCTGGGCCTGGAGGAAGTGCGGCTGACGCCATCCATGAGGAACCGGAGTGGCGCCGTGTGGAGCAGGGCCTCTGTCCCCTTCTCTGCCTGGGAAGTAGAGGTGCAGATGAGGGTGACGGGACTGGGGCGCCGGGGAGCCCAGGGCATGGCCGTGTGGTACACCCGGGGCAGGGGCCATGTAGGCTCTGTCCTTGGGGGGCTGGCTTCGTGGGACGGCATCGGGATCTTCTTTGACTCTCCGGCAGAGGATACTCAGGACAGTCCTGCCATCCGTGTGCTGGCCAGCGACGGGCACATCCCCTCTGAGCAGCCTGGGGATGGAGCTAGCCAAGGGCTGGGCTCCTGTCATTGGGACTTCCGGAACCGGCCACACCCCTTCAGAGCACGGATCACCTACTGGGGGCAGAGGCTGCGCATGTCCTTGAACAGTGGCCTCACTCCCAGTGATCCAGGTGAGTTCTGTGTGGATGTGGGGCCCCTGCTTTTGGTCCCTGGAGGTTTCTTTGGGGTCTCAGCAGCCACCGGCACCCTGGCAGATGATCATGATGTCCTGTCCTTCCTGACCTTCAGCCTGAGTGAGCCCAGCCCAGAGGTTCCCCCTCAGCCCTTCCTGGAGATGCAGCAGCTCCGCCTGGCGAGGCAGCTGGAAGGGCTGTGGGCAAGGCTGGGCTTGGGCACCAGGGAGGATGTAACTCCAAAATCAGACTCTGAAGCTCAAGGAGAAGGGGAAAGGCTCTTTGACCTGGAGGAGACGCTGGGCAGACACCGCCGGATCCTGCAGGCTCTGCGGGGTCTCTCCAAGCAGCTGGCCCAGGCTGAGAGACAATGGAAGAAGCAGCTGGGGCCCCCAGGCCAAGCCAGGCCTGACGGAGGCTGGGCCCTGGATGCTTCCTGCCAGATTCCATCCACCCCAGGGAGGGGTGGCCACCTCTCCATGTCACTCAATAAGGACTCTGCCAAGGTCGGTGCCCTGCTCCATGGACAGTGGACTCTGCTCCAGGCCCTGCAAGAGATGAGGGATGCAGCTGTCCGCATGGCTGCAGAAGCCCAGGTCTCCTACCTGCCTGTGGGCATTGAGCATCATTTCTTAGAGCTGGACCACATCCTGGGCCTCCTGCAGGAGGAGCTTCGGGGCCCGGCGAAGGCAGCAGCCAAGGCCCCCCGCCCACCTGGCCAGCCCCCAAGGGCCTCCTCGTGCCTGCAGCCTGGCATCTTCCTGTTCTACCTCCTCATTCAGACTGTAGGCTTCTTCGGCTACGTGCACTTCAGGCAGGAGCTGAACAAGAGCCTTCAGGAGTGTCTGTCCACAGGCAGCCTTCCTCTGGGTCCTGCACCACACACCCCCAGGGCCCTGGGGATTCTGAGGAGGCAGCCTCTCCCTGCCAGCATGCCTGCCTGA-3'
NCBI CDS gene sequence with introns (location: 74812855.. 74825605) (12751 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 74812835.. 74825754) (12920 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [74812835 - 1000].. 74825754) (13920 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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