NCBI Summary
This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. This gene is expressed specifically in the brain, with highest expression in the cerebellum. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Protein
Protein (NP_068580)
CBM13-ppGalNAc-T9
Polypeptide N-acetylgalactosaminyltransferase 9 (EC 2.4.1.41) (Polypeptide GalNAc transferase 9) (GalNAc-T9) (pp-GaNTase 9) (Protein-UDP acetylgalactosaminyltransferase 9) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 9)
GALNT9
polypeptide N-acetylgalactosaminyltransferase 9
Undefined
Curated
Ricin-like
R-Type Lectins
b-trefoil
GalNAc / Mucin-type glycopeptide
NP_068580
50614
Q9HCQ5
Undefined
Q9HCQ5
Undefined
10.1074/jbc.M111.273722
neXtProt, PFAM, InterPro
Protein sequence and protein families (fasta) (237 amino acids) Download
MEVLPCSRVAHIERTRKPYNNDIDYYAKRNALRAAEVWMDDFKSHVYMAWNIPMSNPGVDFGDVSERLALRQRLKCRSFKWYLENVYPEMRVYNNTLTYGEVRNSKASAYCLDQGAEDGDRAILYPCHGMSSQLVRYSADGLLQLGPLGSTAFLPDSKCLVDDGTGRMPTLKKCEDVARPTQRLWDFTQSGPIVSRATGRCLEVEMSKDANFGLRLVVQRCSGQKWMIRNWIKHARH
No structure currently available in the PDB RCSB Databank.
Structural models
AlphaFold v2: AF-Q9HCQ5-F1DownloadSee the associated sequence to the AlphaFold v2 model, which is different to this entry(NCBI sequence).
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

SWISS-MODEL structural models
SWISS-MODEL structural model
Modeller structural model (Homology modelling pipeline), Error: [ err > 2 Å]Download
The location of the lectin domain structural model is: 157-209
We infer [ err > 2 Å] as the interval of error of this structural model.
Template: 1XHB chain: A, O08912, NP_001153876.1, sequence identity: 18.9%, coverage: 96.2%, location in sequence: 95-553, (95-553 in PDB).
Show the alignment used for the construction of the structural model, Download.
Show the plot of DOPE energy score, Download.
Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for GALNT9 Gene
ProteomicsDB
References
NCBI References (4 PubMed Identifiers)
  • GALNT9 gene expression is a prognostic marker in neuroblastoma patients. [23136245]
  • Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. [16712791]
  • Cloning and characterization of a new human UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase, designated pp-GalNAc-T13, that is specifically expressed in neurons and synthesizes GalNAc alpha-serine/threonine antigen. [12407114]
  • Brain-specific expression of a novel human UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T9). [10978536]
UniProt Main References (1 PubMed Identifiers)
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
All isoforms of this gene containing a lectin domain
NP_068580.2, NP_001116108.1
RNA
RNA (Transcript ID: NM_021808.3)
NM_021808.3
polypeptide N-acetylgalactosaminyltransferase 9, transcript variant B
All isoforms of GALNT9 containing a lectin domain
279..992 (or 132197107.. 132203669)
132196372.. 132206028
NCBI Matured mRNA sequence 1727 NTPDownload 
m7G-5')ppp(5'-GGCGCUUCUGAAGACGGGUGGGCAGACGAUGGAGGACGAGGCUCUGUCCCGCCCCUGCAGAGCUUCCUUCGUUCCGGCCCCUUCCAGCGAAGGGCAGGGCUCCGAGCAGAGACAACAGACAGAAACCCAGAAACCACCUGCCACGAUGUGAACCUGAUGCAGAAACGCGGUUCGCUCCCUCGGGAUGCAAAGGCCAACUUCAGCCUGGCACGGCGGCGCCGCGGACUCCACCAUCCCGGGGAAGGAGCCGGACCCCUGUGUGGCAGUGUGGCGGCAGCAUGGAGGUGCUGCCCUGCUCCCGCGUGGCCCACAUCGAGCGCACCAGGAAGCCCUACAACAACGACAUUGACUACUAUGCCAAGCGCAACGCCCUGCGCGCCGCCGAGGUGUGGAUGGAUGACUUCAAGUCCCACGUGUACAUGGCCUGGAACAUCCCCAUGUCGAACCCAGGGGUGGACUUCGGGGACGUGUCUGAGAGGCUGGCCCUGCGUCAGAGGCUGAAGUGUCGCAGCUUCAAGUGGUACCUGGAGAACGUGUACCCGGAGAUGAGGGUCUACAACAACACCCUCACGUACGGAGAGGUGAGAAACAGCAAAGCCAGUGCCUACUGUCUGGACCAGGGAGCGGAGGACGGCGACCGGGCGAUCCUCUACCCCUGCCACGGGAUGUCCUCCCAGCUGGUGCGGUACAGCGCUGAUGGACUGCUGCAGCUGGGGCCUCUGGGCUCCACAGCCUUCUUGCCUGACUCCAAGUGUCUGGUGGAUGACGGCACGGGCCGCAUGCCCACCCUGAAGAAGUGUGAGGAUGUGGCGCGGCCAACACAGCGGCUGUGGGACUUCACCCAGAGUGGCCCCAUUGUGAGCCGGGCCACGGGCCGCUGCCUGGAGGUGGAGAUGUCCAAAGAUGCCAACUUUGGGCUCCGGCUGGUGGUACAGAGGUGCUCGGGGCAGAAGUGGAUGAUCAGAAACUGGAUCAAACACGCACGGCACUGACCCCACCUCCGCCCGGACCCCCACAGACCUCGGGAAGGCGCUGGGCCGAGCCAGUGUGGCUGAGUGACCGGGGUGUGCCCGGCAGACACAGCAGGACAGGGCUCUAUGUGCGGCCAGGACAGCAGAGGCUGAGGGGCCGGGGUGUGGCUGAGUGACCAGGGUGUCACCCACUGCAUCUGGAGUACAGCUUCUCCUAGGACAGGCGGCUCUACCCGAGGGAGGGCGUCUGGGGACAGUGAUGCCAACUCAAACACGUGCCUUCUCCACGGUAUCUCCUGGCCAGGCUGCUGGGACAGCCGCCGCCUCUGCAUGUACCACAGCCCCCCACGCCCCAUAGGGAGGCCAAGCCCCGGACCAUGCACCAGGCUGCACCCUGGUGUCUUCCACCCGCAGGCCUCCCAUGCUCCAAGCAGCCUCCCCCAGCACUUGCGGCCGCUCAGCCCUCCAACCAAGACCUAAGUCACACAUCAUAAUGCAGCUCCUUGUGGUCUGGUAAGAGGGGUGCUGGAGGACAUGGACAGCGACAAACCUGAGGCCGUGUCUAGGAGGCUGGCACGACUGCUUCAGCAGAGACCAAAUAAAGAGAGGAUUAGGCAGCAGCACUGUGUGUGUCUUCCUGGGAGCCGAGCUGGGGGUUGGGGCCCGGUCCCACCUCUUUCCCAGGCACCUGGGCCCUGCCGCAGCCCAGCCCCUUGCCUGUUUUAAUAAAUACAGUUUUAUUGGCGCCCAGCCACA-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
;
More about the NCBI sViewer.
DNA
DNA (Gene ID: 50614)
GALNT9
polypeptide N-acetylgalactosaminyltransferase 9
NC_000012.12
12  132197107.. 132203669
132197107.. 132203669
strand -
CCDS41866.1
MGI:2677965
ClinVar, dbVar
ENSG00000182870
GALNAC-T9
uc001ukc.5
INSDC: AB040672
4131
606251
OTTHUMG00000168256
ENA, DDBJ, Monarch
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (714 bp)
5'-ATGGAGGTGCTGCCCTGCTCCCGCGTGGCCCACATCGAGCGCACCAGGAAGCCCTACAACAACGACATTGACTACTATGCCAAGCGCAACGCCCTGCGCGCCGCCGAGGTGTGGATGGATGACTTCAAGTCCCACGTGTACATGGCCTGGAACATCCCCATGTCGAACCCAGGGGTGGACTTCGGGGACGTGTCTGAGAGGCTGGCCCTGCGTCAGAGGCTGAAGTGTCGCAGCTTCAAGTGGTACCTGGAGAACGTGTACCCGGAGATGAGGGTCTACAACAACACCCTCACGTACGGAGAGGTGAGAAACAGCAAAGCCAGTGCCTACTGTCTGGACCAGGGAGCGGAGGACGGCGACCGGGCGATCCTCTACCCCTGCCACGGGATGTCCTCCCAGCTGGTGCGGTACAGCGCTGATGGACTGCTGCAGCTGGGGCCTCTGGGCTCCACAGCCTTCTTGCCTGACTCCAAGTGTCTGGTGGATGACGGCACGGGCCGCATGCCCACCCTGAAGAAGTGTGAGGATGTGGCGCGGCCAACACAGCGGCTGTGGGACTTCACCCAGAGTGGCCCCATTGTGAGCCGGGCCACGGGCCGCTGCCTGGAGGTGGAGATGTCCAAAGATGCCAACTTTGGGCTCCGGCTGGTGGTACAGAGGTGCTCGGGGCAGAAGTGGATGATCAGAAACTGGATCAAACACGCACGGCACTGA-3'
NCBI CDS gene sequence with introns (location: 132197107.. 132203669) (6563 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 132196372.. 132206028) (9657 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [132196372.. 132206028 + 1000]) (10657 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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