Protein
Protein (NP_065137)
Endosialin
Endosialin (Tumor endothelial marker 1) (CD antigen CD248)
CD248
CD248 molecule
CD248
Low evidence
C-type lectin
Undefined
C-type - Endosialin
a/b mixed / C-type lectin-like
Lipopolysaccharide
NP_065137
57124
Q9HCU0
ENSP00000308117.3
Q9HCU0
0.257
10.1016/j.trsl.2021.03.009
PFAM, InterPro
Protein sequence and protein families (fasta) (757 amino acids) Download
MLLRLLLAWAAAGPTLGQDPWAAEPRAACGPSSCYALFPRRRTFLEAWRACRELGGDLATPRTPEEAQRVDSLVGAGPASRLLWIGLQRQARQCQLQRPLRGFTWTTGDQDTAFTNWAQPASGGPCPAQRCVALEASGEHRWLEGSCTLAVDGYLCQFGFEGACPALQDEAGQAGPAVYTTPFHLVSTEFEWLPFGSVAAVQCQAGRGASLLCVKQPEGGVGWSRAGPLCLGTGCSPDNGGCEHECVEEVDGHVSCRCTEGFRLAADGRSCEDPCAQAPCEQQCEPGGPQGYSCHCRLGFRPAEDDPHRCVDTDECQIAGVCQQMCVNYVGGFECYCSEGHELEADGISCSPAGAMGAQASQDLGDELLDDGEDEEDEDEAWKAFNGGWTEMPGILWMEPTQPPDFALAYRPSFPEDREPQIPYPEPTWPPPLSAPRVPYHSSVLSVTRPVVVSATHPTLPSAHQPPVIPATHPALSRDHQIPVIAANYPDLPSAYQPGILSVSHSAQPPAHQPPMISTKYPELFPAHQSPMFPDTRVAGTQTTTHLPGIPPNHAPLVTTLGAQLPPQAPDALVLRTQATQLPIIPTAQPSLTTTSRSPVSPAHQISVPAATQPAALPTLLPSQSPTNQTSPISPTHPHSKAPQIPREDGPSPKLALWLPSPAPTAAPTALGEAGLAEHSQRDDRWLLVALLVPTCVFLVVLLALGIVYCTRCGPHAPNKRITDCYRWVIHAGSKSPTEPMPPRGSLTGVQTCRTSV
No structure currently available in the PDB RCSB Databank.
Structural models
AlphaFold v2: AF-Q9HCU0-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

SWISS-MODEL structural models
SWISS-MODEL structural model
Modeller structural model (Homology modelling pipeline), Error: [1.59, 2.07] ÅDownload
The location of the lectin domain structural model is: 30-159
We infer [1.59, 2.07] Å as the interval of error of this structural model.
Template 1: 3L9J chain: C, P05452, NP_003269.2, sequence identity: 25.4%, coverage: 92.3%, location in sequence: 67-201, (46-180 in PDB).
Template 2: 4MTH chain: A, Q06141, NP_002571.1, sequence identity: 24.6%, coverage: 96.9%, location in sequence: 40-175, (40-175 in PDB).
Template 3: 3WH3 chain: A, Q9ULY5, NP_055173.1, sequence identity: 20.8%, coverage: 91.5%, location in sequence: 79-208, (79-208 in PDB).
Show the alignment used for the construction of the structural model, Download.
Show the plot of DOPE energy score, Download.
Oligomerization and Known Interactions
Interacts with PDGFRA; this interaction promotes PDGF receptor signaling pathway. Interacts with integrin beta-1/ITGB1. Interacts with insulin receptor/INSR; this interaction diminishes INSR autophosphorylation
Annotation
Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
Expression
Human Protein Atlas
GeneCards
Functionality temporarily unavailable.
ProteomicsDB
References
NCBI References (10 PubMed Identifiers)
  • Role of tumor endothelial marker 1 (Endosialin/CD248) lectin-like domain in lipopolysaccharide-induced macrophage activation and sepsis in mice. [33737161]
  • Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains. [32814053]
  • Modified TLR-mediated downregulation of miR-125b-5p enhances CD248 (endosialin)-induced metastasis and drug resistance in colorectal cancer cells. [31746054]
  • Linking myofibroblast generation and microvascular alteration: The role of CD248 from pathogenesis to therapeutic target (Review). [31257535]
  • Specific loss of adipocyte CD248 improves metabolic health via reduced white adipose tissue hypoxia, fibrosis and inflammation. [31221584]
  • Human endosialin (tumor endothelial marker 1) is abundantly expressed in highly malignant and invasive brain tumors. [15624764]
  • Molecular characterization of the mouse Tem1/endosialin gene regulated by cell density in vitro and expressed in normal tissues in vivo. [11489895]
  • Molecular cloning and characterization of endosialin, a C-type lectin-like cell surface receptor of tumor endothelium. [11084048]
  • Genes expressed in human tumor endothelium. [10947988]
  • Identification of endosialin, a cell surface glycoprotein of vascular endothelial cells in human cancer. [1438285]
UniProt Main References (6 PubMed Identifiers)
  • Complete sequencing and characterization of 21,243 full-length human cDNAs. [14702039]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
  • Characterization of cancer stroma markers: in silico analysis of an mRNA expression database for fibroblast activation protein and endosialin. [16076089]
  • Endosialin (TEM1, CD248) is a marker of stromal fibroblasts and is not selectively expressed on tumour endothelium. [15862292]
  • An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. [24275569]
  • The consensus coding sequences of human breast and colorectal cancers. [16959974]
RNA
RNA (Transcript ID: NM_020404.3)
NM_020404.3
CD248 molecule
All isoforms of CD248 containing a lectin domain
ENST00000311330.4
18..2291 (or 66314754.. 66317027)
66314494.. 66317044
NCBI Matured mRNA sequence 2551 NTPDownload 
m7G-5')ppp(5'-AGUCCGGGGGCAUCGCGAUGCUGCUGCGCCUGUUGCUGGCCUGGGCGGCCGCAGGGCCCACACUGGGCCAGGACCCCUGGGCUGCUGAGCCCCGUGCCGCCUGCGGCCCCAGCAGCUGCUACGCUCUCUUCCCACGGCGCCGCACCUUCCUGGAGGCCUGGCGGGCCUGCCGCGAGCUGGGGGGCGACCUGGCCACUCCUCGGACCCCCGAGGAGGCCCAGCGUGUGGACAGCCUGGUGGGUGCGGGCCCAGCCAGCCGGCUGCUGUGGAUCGGGCUGCAGCGGCAGGCCCGGCAAUGCCAGCUGCAGCGCCCACUGCGCGGCUUCACGUGGACCACAGGGGACCAGGACACGGCUUUCACCAACUGGGCCCAGCCAGCCUCUGGAGGCCCCUGCCCGGCCCAGCGCUGUGUGGCCCUGGAGGCAAGUGGCGAGCACCGCUGGCUGGAGGGCUCGUGCACGCUGGCUGUCGACGGCUACCUGUGCCAGUUUGGCUUCGAGGGCGCCUGCCCGGCGCUGCAAGAUGAGGCGGGCCAGGCCGGCCCAGCCGUGUAUACCACGCCCUUCCACCUGGUCUCCACAGAGUUUGAGUGGCUGCCCUUCGGCUCUGUGGCCGCUGUGCAGUGCCAGGCUGGCAGGGGAGCCUCUCUGCUCUGCGUGAAGCAGCCUGAGGGAGGUGUGGGCUGGUCACGGGCUGGGCCCCUGUGCCUGGGGACUGGCUGCAGCCCUGACAACGGGGGCUGCGAACACGAAUGUGUGGAGGAGGUGGAUGGUCACGUGUCCUGCCGCUGCACUGAGGGCUUCCGGCUGGCAGCAGACGGGCGCAGUUGCGAGGACCCCUGUGCCCAGGCUCCGUGCGAGCAGCAGUGUGAGCCCGGUGGGCCACAAGGCUACAGCUGCCACUGUCGCCUGGGUUUCCGGCCAGCGGAGGAUGAUCCGCACCGCUGUGUGGACACAGAUGAGUGCCAGAUUGCCGGUGUGUGCCAGCAGAUGUGUGUCAACUACGUUGGUGGCUUCGAGUGUUAUUGUAGCGAGGGACAUGAGCUGGAGGCUGAUGGCAUCAGCUGCAGCCCUGCAGGGGCCAUGGGUGCCCAGGCUUCCCAGGACCUCGGAGAUGAGUUGCUGGAUGACGGGGAGGAUGAGGAAGAUGAAGACGAGGCCUGGAAGGCCUUCAACGGUGGCUGGACGGAGAUGCCUGGGAUCCUGUGGAUGGAGCCUACGCAGCCGCCUGACUUUGCCCUGGCCUAUAGACCGAGCUUCCCAGAGGACAGAGAGCCACAGAUACCCUACCCGGAGCCCACCUGGCCACCCCCGCUCAGUGCCCCCAGGGUCCCCUACCACUCCUCAGUGCUCUCCGUCACCCGGCCUGUGGUGGUCUCUGCCACGCAUCCCACACUGCCUUCUGCCCACCAGCCUCCUGUGAUCCCUGCCACACACCCAGCUUUGUCCCGUGACCACCAGAUCCCCGUGAUCGCAGCCAACUAUCCAGAUCUGCCUUCUGCCUACCAACCCGGUAUUCUCUCUGUCUCUCAUUCAGCACAGCCUCCUGCCCACCAGCCCCCUAUGAUCUCAACCAAAUAUCCGGAGCUCUUCCCUGCCCACCAGUCCCCCAUGUUUCCAGACACCCGGGUCGCUGGCACCCAGACCACCACUCAUUUGCCUGGAAUCCCACCUAACCAUGCCCCUCUGGUCACCACCCUCGGUGCCCAGCUACCCCCUCAAGCCCCAGAUGCCCUUGUCCUCAGAACCCAGGCCACCCAGCUUCCCAUUAUCCCAACUGCCCAGCCCUCUCUGACCACCACCUCCAGGUCCCCUGUGUCUCCUGCCCAUCAAAUCUCUGUGCCUGCUGCCACCCAGCCCGCAGCCCUCCCCACCCUCCUGCCCUCUCAGAGCCCCACUAACCAGACCUCACCCAUCAGCCCUACACAUCCCCAUUCCAAAGCCCCCCAAAUCCCAAGGGAAGAUGGCCCCAGUCCCAAGUUGGCCCUGUGGCUGCCCUCACCAGCUCCCACAGCAGCCCCAACAGCCCUGGGGGAGGCUGGUCUUGCCGAGCACAGCCAGAGGGAUGACCGGUGGCUGCUGGUGGCACUCCUGGUGCCAACGUGUGUCUUUUUGGUGGUCCUGCUUGCACUGGGCAUCGUGUACUGCACCCGCUGUGGCCCCCAUGCACCCAACAAGCGCAUCACUGACUGCUAUCGCUGGGUCAUCCAUGCUGGGAGCAAGAGCCCAACAGAACCCAUGCCCCCCAGGGGCAGCCUCACAGGGGUGCAGACCUGCAGAACCAGCGUGUGAUGGGGUGCAGACCCCCCUCAUGGAGUAUGGGGCGCUGGACACAUGGCCGGGGCUGCACCAGGGACCCAUGGGGGCUGCCCAGCUGGACAGAUGGCUUCCUGCUCCCCAGGCCCAGCCAGGGUCCUCUCUCAACCACUAGACUUGGCUCUCAGGAACUCUGCUUCCUGGCCCAGCGCUCGUGACCAAGGAUACACCAAAGCCCUUAAGACCUCAGGGGGCGGGUGCUGGGGUCUUCUCCAAUAAAUGGGGUGUCAACCUUA-3'- Poly-A tail
  • Coding region
mRNA-related data
DNA
DNA (Gene ID: 57124)
CD248
CD248 molecule
NC_000011.10
11  66314754.. 66317027
66314754.. 66317027
strand -
CCDS8134.1
MGI:1917695
ClinVar, dbVar
ENSG00000174807
TEM1
uc001ohm.1
INSDC: AF279142
18219
606064
OTTHUMG00000167073
ENA, DDBJ, Monarch
CD248
Gene-related data
NCBI CDS gene sequence (2274 bp)
5'-ATGCTGCTGCGCCTGTTGCTGGCCTGGGCGGCCGCAGGGCCCACACTGGGCCAGGACCCCTGGGCTGCTGAGCCCCGTGCCGCCTGCGGCCCCAGCAGCTGCTACGCTCTCTTCCCACGGCGCCGCACCTTCCTGGAGGCCTGGCGGGCCTGCCGCGAGCTGGGGGGCGACCTGGCCACTCCTCGGACCCCCGAGGAGGCCCAGCGTGTGGACAGCCTGGTGGGTGCGGGCCCAGCCAGCCGGCTGCTGTGGATCGGGCTGCAGCGGCAGGCCCGGCAATGCCAGCTGCAGCGCCCACTGCGCGGCTTCACGTGGACCACAGGGGACCAGGACACGGCTTTCACCAACTGGGCCCAGCCAGCCTCTGGAGGCCCCTGCCCGGCCCAGCGCTGTGTGGCCCTGGAGGCAAGTGGCGAGCACCGCTGGCTGGAGGGCTCGTGCACGCTGGCTGTCGACGGCTACCTGTGCCAGTTTGGCTTCGAGGGCGCCTGCCCGGCGCTGCAAGATGAGGCGGGCCAGGCCGGCCCAGCCGTGTATACCACGCCCTTCCACCTGGTCTCCACAGAGTTTGAGTGGCTGCCCTTCGGCTCTGTGGCCGCTGTGCAGTGCCAGGCTGGCAGGGGAGCCTCTCTGCTCTGCGTGAAGCAGCCTGAGGGAGGTGTGGGCTGGTCACGGGCTGGGCCCCTGTGCCTGGGGACTGGCTGCAGCCCTGACAACGGGGGCTGCGAACACGAATGTGTGGAGGAGGTGGATGGTCACGTGTCCTGCCGCTGCACTGAGGGCTTCCGGCTGGCAGCAGACGGGCGCAGTTGCGAGGACCCCTGTGCCCAGGCTCCGTGCGAGCAGCAGTGTGAGCCCGGTGGGCCACAAGGCTACAGCTGCCACTGTCGCCTGGGTTTCCGGCCAGCGGAGGATGATCCGCACCGCTGTGTGGACACAGATGAGTGCCAGATTGCCGGTGTGTGCCAGCAGATGTGTGTCAACTACGTTGGTGGCTTCGAGTGTTATTGTAGCGAGGGACATGAGCTGGAGGCTGATGGCATCAGCTGCAGCCCTGCAGGGGCCATGGGTGCCCAGGCTTCCCAGGACCTCGGAGATGAGTTGCTGGATGACGGGGAGGATGAGGAAGATGAAGACGAGGCCTGGAAGGCCTTCAACGGTGGCTGGACGGAGATGCCTGGGATCCTGTGGATGGAGCCTACGCAGCCGCCTGACTTTGCCCTGGCCTATAGACCGAGCTTCCCAGAGGACAGAGAGCCACAGATACCCTACCCGGAGCCCACCTGGCCACCCCCGCTCAGTGCCCCCAGGGTCCCCTACCACTCCTCAGTGCTCTCCGTCACCCGGCCTGTGGTGGTCTCTGCCACGCATCCCACACTGCCTTCTGCCCACCAGCCTCCTGTGATCCCTGCCACACACCCAGCTTTGTCCCGTGACCACCAGATCCCCGTGATCGCAGCCAACTATCCAGATCTGCCTTCTGCCTACCAACCCGGTATTCTCTCTGTCTCTCATTCAGCACAGCCTCCTGCCCACCAGCCCCCTATGATCTCAACCAAATATCCGGAGCTCTTCCCTGCCCACCAGTCCCCCATGTTTCCAGACACCCGGGTCGCTGGCACCCAGACCACCACTCATTTGCCTGGAATCCCACCTAACCATGCCCCTCTGGTCACCACCCTCGGTGCCCAGCTACCCCCTCAAGCCCCAGATGCCCTTGTCCTCAGAACCCAGGCCACCCAGCTTCCCATTATCCCAACTGCCCAGCCCTCTCTGACCACCACCTCCAGGTCCCCTGTGTCTCCTGCCCATCAAATCTCTGTGCCTGCTGCCACCCAGCCCGCAGCCCTCCCCACCCTCCTGCCCTCTCAGAGCCCCACTAACCAGACCTCACCCATCAGCCCTACACATCCCCATTCCAAAGCCCCCCAAATCCCAAGGGAAGATGGCCCCAGTCCCAAGTTGGCCCTGTGGCTGCCCTCACCAGCTCCCACAGCAGCCCCAACAGCCCTGGGGGAGGCTGGTCTTGCCGAGCACAGCCAGAGGGATGACCGGTGGCTGCTGGTGGCACTCCTGGTGCCAACGTGTGTCTTTTTGGTGGTCCTGCTTGCACTGGGCATCGTGTACTGCACCCGCTGTGGCCCCCATGCACCCAACAAGCGCATCACTGACTGCTATCGCTGGGTCATCCATGCTGGGAGCAAGAGCCCAACAGAACCCATGCCCCCCAGGGGCAGCCTCACAGGGGTGCAGACCTGCAGAACCAGCGTGTGA-3'
NCBI CDS gene sequence with introns (location: 66314754.. 66317027) (2274 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 66314494.. 66317044) (2551 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [66314494.. 66317044 + 1000]) (3551 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
Cite How to cite