NCBI Summary
This gene is predominantly expressed in placenta. The encoded protein belongs to the galectin (galaptin/S-lectin) family. The members of galectin family contain one or two carbohydrate recognition domains, which can bind beta-galactoside. Two alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008].
Protein
Protein (NP_064514)
Galectin 14
Placental protein 13-like (Charcot-Leyden crystal protein 2) (CLC2) (Galectin-14) (Gal-14)
LGALS14
galectin 14
Undefined
Low evidence
Galectin
S-Type Lectins - Prototypical
b-sandwich / ConA-like
Gal
NP_064514
56891
Q8TCE9
ENSP00000375905.2
Q8TCE9
0.394
10.1111/febs.15441
neXtProt, PFAM, InterPro
Protein sequence and protein families (fasta) (139 amino acids) Download
MSSLPVPYTLPVSLPVGSCVIITGTPILTFVKDPQLEVNFYTGMDEDSDIAFQFRLHFGHPAIMNSCVFGIWRYEEKCYYLPFEDGKPFELCIYVRHKEYKVMVNGQRIYNFAHRFPPASVKMLQVFRDISLTRVLISD
Mol* PDB structure viewerUniLectin3D
Structural models
AlphaFold v2: AF-Q8TCE9-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

AlphaFold_v2 structural model assessment through SWISS-MODEL tools.

Ligand
Glycan ligands from structural data
bGal14Glc
Gal(b1-4)Glc
6K2Z
6K2Z
GlyConnect Structures
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for LGALS14 Gene
ProteomicsDB
References
NCBI References (10 PubMed Identifiers)
  • Structure-function studies of galectin-14, an important effector molecule in embryology. [32525264]
  • Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains. [32814053]
  • A reference map of the human binary protein interactome. [32296183]
  • Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations. [31515488]
  • Pooled-matrix protein interaction screens using Barcode Fusion Genetics. [27107012]
  • A primate subfamily of galectins expressed at the maternal-fetal interface that promote immune cell death. [19497882]
  • Gene variants associated with ischemic stroke: the cardiovascular health study. [19023099]
  • Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. [17975119]
  • [siRNA-mediated silencing of ClC-2 gene inhibits proliferation of human U-87 glioma cells]. [16831268]
  • Cloning and expression of a novel human galectin cDNA, predominantly expressed in placenta(1). [11997112]
UniProt Main References (3 PubMed Identifiers)
  • Complete sequencing and characterization of 21,243 full-length human cDNAs. [14702039]
  • The DNA sequence and biology of human chromosome 19. [15057824]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
All isoforms of this gene containing a lectin domain
NP_064514.1, NP_982297.1
RNA
RNA (Transcript ID: NM_020129.3)
NM_020129.3
galectin 14, transcript variant 1
All isoforms of LGALS14 containing a lectin domain
ENST00000392052.8
49..468 (or 39704529.. 39709313)
39704481.. 39709444
NCBI Matured mRNA sequence 599 NTPDownload 
m7G-5')ppp(5'-ACAGAAGACUGGACACAAUUCCGAAGAGCUGCCCAGAAGGAGAGAACAAUGUCAUCACUACCCGUACCAUACACACUGCCUGUUUCCUUGCCUGUUGGUUCGUGCGUGAUAAUCACAGGGACACCGAUCCUCACUUUUGUCAAGGACCCACAGCUGGAGGUGAAUUUCUACACUGGGAUGGAUGAGGACUCAGAUAUUGCUUUCCAAUUCCGACUGCACUUUGGUCAUCCUGCAAUCAUGAACAGUUGUGUGUUUGGCAUAUGGAGAUAUGAGGAGAAAUGCUACUAUUUACCCUUUGAAGAUGGCAAACCAUUUGAGCUGUGCAUCUAUGUGCGUCACAAGGAAUACAAGGUAAUGGUAAAUGGCCAACGCAUUUACAACUUUGCCCAUCGAUUCCCGCCAGCAUCUGUGAAGAUGCUGCAAGUCUUCAGAGAUAUCUCCCUGACCAGAGUGCUUAUCAGCGAUUGAGGGAGAUGAUCAGACUCCUCAUUGUUGAGGAAUCCCUCUUUCUACCUGACCAUGGGAUUCCCAGAGCCUACUAACAGAAUAAUCCCUCCUCACCCCUUCCCCUACACUUGAUCAUUAAAACAGCACCAAAC-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
;
More about the NCBI sViewer.
DNA
DNA (Gene ID: 56891)
LGALS14
galectin 14
NC_000019.10
19  39704529.. 39709313
39704529.. 39709313
strand +
CCDS46073.1
ClinVar, dbVar
ENSG00000006659
PPL13, CLC2
uc002omf.4
INSDC: AF267852
30054
607260
OTTHUMG00000183143
ENA, DDBJ, Monarch
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (420 bp)
5'-ATGTCATCACTACCCGTACCATACACACTGCCTGTTTCCTTGCCTGTTGGTTCGTGCGTGATAATCACAGGGACACCGATCCTCACTTTTGTCAAGGACCCACAGCTGGAGGTGAATTTCTACACTGGGATGGATGAGGACTCAGATATTGCTTTCCAATTCCGACTGCACTTTGGTCATCCTGCAATCATGAACAGTTGTGTGTTTGGCATATGGAGATATGAGGAGAAATGCTACTATTTACCCTTTGAAGATGGCAAACCATTTGAGCTGTGCATCTATGTGCGTCACAAGGAATACAAGGTAATGGTAAATGGCCAACGCATTTACAACTTTGCCCATCGATTCCCGCCAGCATCTGTGAAGATGCTGCAAGTCTTCAGAGATATCTCCCTGACCAGAGTGCTTATCAGCGATTGA-3'
NCBI CDS gene sequence with introns (location: 39704529.. 39709313) (4785 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 39704481.. 39709444) (4964 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [39704481 - 1000].. 39709444) (5964 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
How to cite: Schnider B., M'Rad Y., el Ahmadie J., de Brevern AG., Imberty A., Lisacek F., HumanLectome, an update of UniLectin for the annotation and prediction of human lectins, Nucleic Acids Reasearch doi.org/10.1093/nar/gkad905