Protein
Protein (NP_060095)
Intelectin 1
Intelectin-1 (ITLN-1) (Endothelial lectin HL-1) (Galactofuranose-binding lectin) (Intestinal lactoferrin receptor) (Omentin)
ITLN1
intelectin 1
Undefined
Curated
Ficolin-like
X-Type Lectins
a/b mixed with b-sheet / Fibrinogen C-ter like
Galf
NP_060095
55600
Q8WWA0
ENSP00000323587.3
Q8WWA0
0.514
10.1038/nsmb.3053
neXtProt, PFAM, InterPro, CFG data
Protein sequence and protein families (fasta) (313 amino acids) Download
MNQLSFLLFLIATTRGWSTDEANTYFKEWTCSSSPSLPRSCKEIKDECPSAFDGLYFLRTENGVIYQTFCDMTSGGGGWTLVASVHENDMRGKCTVGDRWSSQQGSKAVYPEGDGNWANYNTFGSAEAATSDDYKNPGYYDIQAKDLGIWHVPNKSPMQHWRNSSLLRYRTDTGFLQTLGHNLFGIYQKYPVKYGEGKCWTDNGPVIPVVYDFGDAQKTASYYSPYGQREFTAGFVQFRVFNNERAANALCAGMRVTGCNTEHHCIGGGGYFPEASPQQCGDFSGFDWSGYGTHVGYSSSREITEAAVLLFYR
Mol* PDB structure viewerUniLectin3D
Structural models
AlphaFold v2: AF-Q8WWA0-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

AlphaFold_v2 structural model assessment through SWISS-MODEL tools.
Ligand
Glycan ligands from structural data
Allyl-b-D-Galf
Galf
4WMY
4WMY
GlyConnect Structures
D-glycero-D-talo-oct-2-ulosonic acid (KO)
KO
6USC
6USC
GlyConnect Structures
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for ITLN1 Gene
ProteomicsDB
References
NCBI References (10 PubMed Identifiers)
  • Expression of adipokines in children with primary nephrotic syndrome and its association with hyperlipidemia. [34511173]
  • Human intelectin-1 (ITLN1) genetic variation and intestinal expression. [34145348]
  • Association between the omentin-1 gene rs2274907 A>T polymorphism and colorectal cancer in the Chinese Han population: a case-control study. [33823642]
  • Tetrahydroxystilbene glycoside improves endothelial dysfunction and hypertension in obese rats: The role of omentin-1. [33647262]
  • Relationships between serum omentin-1 concentration, body composition and physical activity levels in older women. [33725883]
  • The Xenopus laevis cortical granule lectin: cDNA cloning, developmental expression, and identification of the eglectin family of lectins. [14720597]
  • The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. [12975309]
  • Molecular cloning and functional expression of a human intestinal lactoferrin receptor. [11747454]
  • Human intelectin is a novel soluble lectin that recognizes galactofuranose in carbohydrate chains of bacterial cell wall. [11313366]
  • Human homologs of the Xenopus oocyte cortical granule lectin XL35. [11181563]
UniProt Main References (7 PubMed Identifiers)
  • Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action. [16531507]
  • Complete sequencing and characterization of 21,243 full-length human cDNAs. [14702039]
  • The DNA sequence and biological annotation of human chromosome 1. [16710414]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
  • Differential structure and activity between human and mouse intelectin-1: human intelectin-1 is a disulfide-linked trimer, whereas mouse homologue is a monomer. [17621593]
  • A lactoferrin-receptor, intelectin 1, affects uptake, sub-cellular localization and release of immunochemically detectable lactoferrin by intestinal epithelial Caco-2 cells. [23921499]
  • Recognition of microbial glycans by human intelectin-1. [26148048]
RNA
RNA (Transcript ID: NM_017625.3)
NM_017625.3
intelectin 1
All isoforms of ITLN1 containing a lectin domain
ENST00000326245.4
127..1068 (or 160876664.. 160884877)
160876540.. 160885180
NCBI Matured mRNA sequence 1192 NTPDownload 
m7G-5')ppp(5'-AUUCCACAUCAGGAGCGUUUUUGGAGAAAGCUGCACUCUGUUGAGCUCCAGGGCGCAGUGGAGGGAGGGAGUGAAGGAGCUCUCUGUACCCAAGGAAAGUGCAGCUGAGACUCAGACAAGAUUACAAUGAACCAACUCAGCUUCCUGCUGUUUCUCAUAGCGACCACCAGAGGAUGGAGUACAGAUGAGGCUAAUACUUACUUCAAGGAAUGGACCUGUUCUUCGUCUCCAUCUCUGCCCAGAAGCUGCAAGGAAAUCAAAGACGAAUGUCCUAGUGCAUUUGAUGGCCUGUAUUUUCUCCGCACUGAGAAUGGUGUUAUCUACCAGACCUUCUGUGACAUGACCUCUGGGGGUGGCGGCUGGACCCUGGUGGCCAGCGUGCACGAGAAUGACAUGCGUGGGAAGUGCACGGUGGGCGAUCGCUGGUCCAGUCAGCAGGGCAGCAAAGCAGUCUACCCAGAGGGGGACGGCAACUGGGCCAACUACAACACCUUUGGAUCUGCAGAGGCGGCCACGAGCGAUGACUACAAGAACCCUGGCUACUACGACAUCCAGGCCAAGGACCUGGGCAUCUGGCACGUGCCCAAUAAGUCCCCCAUGCAGCACUGGAGAAACAGCUCCCUGCUGAGGUACCGCACGGACACUGGCUUCCUCCAGACACUGGGACAUAAUCUGUUUGGCAUCUACCAGAAAUAUCCAGUGAAAUAUGGAGAAGGAAAGUGUUGGACUGACAACGGCCCGGUGAUCCCUGUGGUCUAUGAUUUUGGCGACGCCCAGAAAACAGCAUCUUAUUACUCACCCUAUGGCCAGCGGGAAUUCACUGCGGGAUUUGUUCAGUUCAGGGUAUUUAAUAACGAGAGAGCAGCCAACGCCUUGUGUGCUGGAAUGAGGGUCACCGGAUGUAACACUGAGCACCACUGCAUUGGUGGAGGAGGAUACUUUCCAGAGGCCAGUCCCCAGCAGUGUGGAGAUUUUUCUGGUUUUGAUUGGAGUGGAUAUGGAACUCAUGUUGGUUACAGCAGCAGCCGUGAGAUAACUGAGGCAGCUGUGCUUCUAUUCUAUCGUUGAGAGUUUUGUGGGAGGGAACCCAGACCUCUCCUCCCAACCAUGAGAUCCCAAGGAUGGAGAACAACUUACCCAGUAGCUAGAAUGUUAAUGGCAGAAGAGAAAACAAUAAAUCAUAUUGACUCAA-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
;
More about the NCBI sViewer.
DNA
DNA (Gene ID: 55600)
ITLN1
intelectin 1
NC_000001.11
1  160876664.. 160884877
160876664.. 160884877
strand -
CCDS1211.1
MGI:1333831
ClinVar, dbVar
ENSG00000179914
ITLN, FLJ20022, LFR, HL-1, hIntL
uc001fxc.4
INSDC: AB036706
18259
609873
OTTHUMG00000028604
ENA, DDBJ, Monarch
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (942 bp)
5'-ATGAACCAACTCAGCTTCCTGCTGTTTCTCATAGCGACCACCAGAGGATGGAGTACAGATGAGGCTAATACTTACTTCAAGGAATGGACCTGTTCTTCGTCTCCATCTCTGCCCAGAAGCTGCAAGGAAATCAAAGACGAATGTCCTAGTGCATTTGATGGCCTGTATTTTCTCCGCACTGAGAATGGTGTTATCTACCAGACCTTCTGTGACATGACCTCTGGGGGTGGCGGCTGGACCCTGGTGGCCAGCGTGCACGAGAATGACATGCGTGGGAAGTGCACGGTGGGCGATCGCTGGTCCAGTCAGCAGGGCAGCAAAGCAGTCTACCCAGAGGGGGACGGCAACTGGGCCAACTACAACACCTTTGGATCTGCAGAGGCGGCCACGAGCGATGACTACAAGAACCCTGGCTACTACGACATCCAGGCCAAGGACCTGGGCATCTGGCACGTGCCCAATAAGTCCCCCATGCAGCACTGGAGAAACAGCTCCCTGCTGAGGTACCGCACGGACACTGGCTTCCTCCAGACACTGGGACATAATCTGTTTGGCATCTACCAGAAATATCCAGTGAAATATGGAGAAGGAAAGTGTTGGACTGACAACGGCCCGGTGATCCCTGTGGTCTATGATTTTGGCGACGCCCAGAAAACAGCATCTTATTACTCACCCTATGGCCAGCGGGAATTCACTGCGGGATTTGTTCAGTTCAGGGTATTTAATAACGAGAGAGCAGCCAACGCCTTGTGTGCTGGAATGAGGGTCACCGGATGTAACACTGAGCACCACTGCATTGGTGGAGGAGGATACTTTCCAGAGGCCAGTCCCCAGCAGTGTGGAGATTTTTCTGGTTTTGATTGGAGTGGATATGGAACTCATGTTGGTTACAGCAGCAGCCGTGAGATAACTGAGGCAGCTGTGCTTCTATTCTATCGTTGA-3'
NCBI CDS gene sequence with introns (location: 160876664.. 160884877) (8214 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 160876540.. 160885180) (8641 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [160876540.. 160885180 + 1000]) (9641 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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