Protein
Protein (NP_060095)
Intelectin 1
Intelectin-1 (ITLN-1) (Endothelial lectin HL-1) (Galactofuranose-binding lectin) (Intestinal lactoferrin receptor) (Omentin)
ITLN1
intelectin 1
Undefined
Curated
Ficolin-like
X-Type Lectins
a/b mixed with b-sheet / Fibrinogen C-ter like
Galf
NP_060095
55600
Q8WWA0
ENSP00000323587.3
Q8WWA0
0.514
10.1038/nsmb.3053
neXtProt, PFAM, InterPro, CFG data
Protein sequence and protein families (fasta) (313 amino acids) Download
MNQLSFLLFLIATTRGWSTDEANTYFKEWTCSSSPSLPRSCKEIKDECPSAFDGLYFLRTENGVIYQTFCDMTSGGGGWTLVASVHENDMRGKCTVGDRWSSQQGSKAVYPEGDGNWANYNTFGSAEAATSDDYKNPGYYDIQAKDLGIWHVPNKSPMQHWRNSSLLRYRTDTGFLQTLGHNLFGIYQKYPVKYGEGKCWTDNGPVIPVVYDFGDAQKTASYYSPYGQREFTAGFVQFRVFNNERAANALCAGMRVTGCNTEHHCIGGGGYFPEASPQQCGDFSGFDWSGYGTHVGYSSSREITEAAVLLFYR
Mol* PDB structure viewerUniLectin3D
Structural models
AlphaFold v2: AF-Q8WWA0-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

AlphaFold_v2 structural model assessment through SWISS-MODEL tools.

Ligand
Glycan ligands from structural data
Allyl-b-D-Galf
Galf
4WMY
4WMY
GlyConnect Structures
D-glycero-D-talo-oct-2-ulosonic acid (KO)
KO
6USC
6USC
GlyConnect Structures
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for ITLN1 Gene
ProteomicsDB
References
NCBI References (10 PubMed Identifiers)
  • Expression of adipokines in children with primary nephrotic syndrome and its association with hyperlipidemia. [34511173]
  • Human intelectin-1 (ITLN1) genetic variation and intestinal expression. [34145348]
  • Association between the omentin-1 gene rs2274907 A>T polymorphism and colorectal cancer in the Chinese Han population: a case-control study. [33823642]
  • Tetrahydroxystilbene glycoside improves endothelial dysfunction and hypertension in obese rats: The role of omentin-1. [33647262]
  • Relationships between serum omentin-1 concentration, body composition and physical activity levels in older women. [33725883]
  • The Xenopus laevis cortical granule lectin: cDNA cloning, developmental expression, and identification of the eglectin family of lectins. [14720597]
  • The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. [12975309]
  • Molecular cloning and functional expression of a human intestinal lactoferrin receptor. [11747454]
  • Human intelectin is a novel soluble lectin that recognizes galactofuranose in carbohydrate chains of bacterial cell wall. [11313366]
  • Human homologs of the Xenopus oocyte cortical granule lectin XL35. [11181563]
UniProt Main References (7 PubMed Identifiers)
  • Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action. [16531507]
  • Complete sequencing and characterization of 21,243 full-length human cDNAs. [14702039]
  • The DNA sequence and biological annotation of human chromosome 1. [16710414]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
  • Differential structure and activity between human and mouse intelectin-1: human intelectin-1 is a disulfide-linked trimer, whereas mouse homologue is a monomer. [17621593]
  • A lactoferrin-receptor, intelectin 1, affects uptake, sub-cellular localization and release of immunochemically detectable lactoferrin by intestinal epithelial Caco-2 cells. [23921499]
  • Recognition of microbial glycans by human intelectin-1. [26148048]
RNA
RNA (Transcript ID: NM_017625.3)
NM_017625.3
intelectin 1
All isoforms of ITLN1 containing a lectin domain
ENST00000326245.4
127..1068 (or 160876664.. 160884877)
160876540.. 160885180
NCBI Matured mRNA sequence 1192 NTPDownload 
m7G-5')ppp(5'-AUUCCACAUCAGGAGCGUUUUUGGAGAAAGCUGCACUCUGUUGAGCUCCAGGGCGCAGUGGAGGGAGGGAGUGAAGGAGCUCUCUGUACCCAAGGAAAGUGCAGCUGAGACUCAGACAAGAUUACAAUGAACCAACUCAGCUUCCUGCUGUUUCUCAUAGCGACCACCAGAGGAUGGAGUACAGAUGAGGCUAAUACUUACUUCAAGGAAUGGACCUGUUCUUCGUCUCCAUCUCUGCCCAGAAGCUGCAAGGAAAUCAAAGACGAAUGUCCUAGUGCAUUUGAUGGCCUGUAUUUUCUCCGCACUGAGAAUGGUGUUAUCUACCAGACCUUCUGUGACAUGACCUCUGGGGGUGGCGGCUGGACCCUGGUGGCCAGCGUGCACGAGAAUGACAUGCGUGGGAAGUGCACGGUGGGCGAUCGCUGGUCCAGUCAGCAGGGCAGCAAAGCAGUCUACCCAGAGGGGGACGGCAACUGGGCCAACUACAACACCUUUGGAUCUGCAGAGGCGGCCACGAGCGAUGACUACAAGAACCCUGGCUACUACGACAUCCAGGCCAAGGACCUGGGCAUCUGGCACGUGCCCAAUAAGUCCCCCAUGCAGCACUGGAGAAACAGCUCCCUGCUGAGGUACCGCACGGACACUGGCUUCCUCCAGACACUGGGACAUAAUCUGUUUGGCAUCUACCAGAAAUAUCCAGUGAAAUAUGGAGAAGGAAAGUGUUGGACUGACAACGGCCCGGUGAUCCCUGUGGUCUAUGAUUUUGGCGACGCCCAGAAAACAGCAUCUUAUUACUCACCCUAUGGCCAGCGGGAAUUCACUGCGGGAUUUGUUCAGUUCAGGGUAUUUAAUAACGAGAGAGCAGCCAACGCCUUGUGUGCUGGAAUGAGGGUCACCGGAUGUAACACUGAGCACCACUGCAUUGGUGGAGGAGGAUACUUUCCAGAGGCCAGUCCCCAGCAGUGUGGAGAUUUUUCUGGUUUUGAUUGGAGUGGAUAUGGAACUCAUGUUGGUUACAGCAGCAGCCGUGAGAUAACUGAGGCAGCUGUGCUUCUAUUCUAUCGUUGAGAGUUUUGUGGGAGGGAACCCAGACCUCUCCUCCCAACCAUGAGAUCCCAAGGAUGGAGAACAACUUACCCAGUAGCUAGAAUGUUAAUGGCAGAAGAGAAAACAAUAAAUCAUAUUGACUCAA-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
;
More about the NCBI sViewer.
DNA
DNA (Gene ID: 55600)
ITLN1
intelectin 1
NC_000001.11
1  160876664.. 160884877
160876664.. 160884877
strand -
CCDS1211.1
MGI:1333831
ClinVar, dbVar
ENSG00000179914
ITLN, FLJ20022, LFR, HL-1, hIntL
uc001fxc.4
INSDC: AB036706
18259
609873
OTTHUMG00000028604
ENA, DDBJ, Monarch
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (942 bp)
5'-ATGAACCAACTCAGCTTCCTGCTGTTTCTCATAGCGACCACCAGAGGATGGAGTACAGATGAGGCTAATACTTACTTCAAGGAATGGACCTGTTCTTCGTCTCCATCTCTGCCCAGAAGCTGCAAGGAAATCAAAGACGAATGTCCTAGTGCATTTGATGGCCTGTATTTTCTCCGCACTGAGAATGGTGTTATCTACCAGACCTTCTGTGACATGACCTCTGGGGGTGGCGGCTGGACCCTGGTGGCCAGCGTGCACGAGAATGACATGCGTGGGAAGTGCACGGTGGGCGATCGCTGGTCCAGTCAGCAGGGCAGCAAAGCAGTCTACCCAGAGGGGGACGGCAACTGGGCCAACTACAACACCTTTGGATCTGCAGAGGCGGCCACGAGCGATGACTACAAGAACCCTGGCTACTACGACATCCAGGCCAAGGACCTGGGCATCTGGCACGTGCCCAATAAGTCCCCCATGCAGCACTGGAGAAACAGCTCCCTGCTGAGGTACCGCACGGACACTGGCTTCCTCCAGACACTGGGACATAATCTGTTTGGCATCTACCAGAAATATCCAGTGAAATATGGAGAAGGAAAGTGTTGGACTGACAACGGCCCGGTGATCCCTGTGGTCTATGATTTTGGCGACGCCCAGAAAACAGCATCTTATTACTCACCCTATGGCCAGCGGGAATTCACTGCGGGATTTGTTCAGTTCAGGGTATTTAATAACGAGAGAGCAGCCAACGCCTTGTGTGCTGGAATGAGGGTCACCGGATGTAACACTGAGCACCACTGCATTGGTGGAGGAGGATACTTTCCAGAGGCCAGTCCCCAGCAGTGTGGAGATTTTTCTGGTTTTGATTGGAGTGGATATGGAACTCATGTTGGTTACAGCAGCAGCCGTGAGATAACTGAGGCAGCTGTGCTTCTATTCTATCGTTGA-3'
NCBI CDS gene sequence with introns (location: 160876664.. 160884877) (8214 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 160876540.. 160885180) (8641 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [160876540.. 160885180 + 1000]) (9641 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
How to cite: Schnider B., M'Rad Y., el Ahmadie J., de Brevern AG., Imberty A., Lisacek F., HumanLectome, an update of UniLectin for the annotation and prediction of human lectins, Nucleic Acids Reasearch doi.org/10.1093/nar/gkad905