NCBI Summary
The protein encoded by this gene is expressed only in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. It is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway. Mutations in this gene result in Birbeck granules deficiency or loss of sugar binding activity. [provided by RefSeq, Aug 2010].
Protein
Protein (NP_056532)
CLEC4K - Langerin
C-type lectin domain family 4 member K (Langerin) (CD antigen CD207)
CD207
CD207 molecule
CD207
Curated
C-type lectin
CLEK4K
C-type - Type II transmembrane receptors
a/b mixed / C-type lectin-like
Man
NP_056532
50489
Q9UJ71
ENSP00000386378.3
Q9UJ71
0.49
10.1016/j.jmb.2010.11.039
neXtProt, PFAM, InterPro, CFG data
Protein sequence and protein families (fasta) (328 amino acids) Download
MTVEKEAPDAHFTVDKQNISLWPREPPPKSGPSLVPGKTPTVRAALICLTLVLVASVLLQAVLYPRFMGTISDVKTNVQLLKGRVDNISTLDSEIKKNSDGMEAAGVQIQMVNESLGYVRSQFLKLKTSVEKANAQIQILTRSWEEVSTLNAQIPELKSDLEKASALNTKIRALQGSLENMSKLLKRQNDILQVVSQGWKYFKGNFYYFSLIPKTWYSAEQFCVSRNSHLTSVTSESEQEFLYKTAGGLIYWIGLTKAGMEGDWSWVDDTPFNKVQSVRFWIPGEPNNAGNNEHCGNIKAPSLQAWNDAPCDKTFLFICKRPYVPSEP
Mol* PDB structure viewerUniLectin3D
Structural models
AlphaFold v2: AF-Q9UJ71-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

AlphaFold_v2 structural model assessment through SWISS-MODEL tools.

Ligand
Glycan ligands from structural data
aGal13(aFuc12)Gal
Gal(a1-3)[Fuc(a1-2)]Gal
3P5G
3P5G
GlyConnect Structures
aGlc14Glc
Glc(a1-4)Glc
3P7H
3P7H
GlyConnect Structures
aMeGlcNAc, GlcNAc
GlcNAc
4N32, 4N34, 4N36
4N32, 4N34, 4N36
GlyConnect Structures
bGlc13Glc
Glc(b1-3)Glc
3P5H
3P5H
GlyConnect Structures
GlcNS6S
GlcN
5G6U
5G6U
GlyConnect Structures
bGal14GlcNAC- SO3
Gal(b1-4)GlcNAc
3P5I
3P5I
GlyConnect Structures
bGlcNAc13bGal14GlcbCH2CH2N3
GlcNAc(b1-3)Gal(b1-4)Glc
4N33, 4N35, 4N38
4N33, 4N35, 4N38
GlyConnect Structures
aMan13Man
Man(a1-3)Man
3P5D
3P5D
GlyConnect Structures
aMeMan, Man
Man
3P5E, 3P7G, 4N37
3P5E, 3P7G, 4N37
GlyConnect Structures
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for CD207 Gene
ProteomicsDB
References
NCBI References (10 PubMed Identifiers)
  • The molecular basis for the pH-dependent calcium affinity of the pattern recognition receptor langerin. [33989634]
  • Langerin (CD207) represents a novel interferon-stimulated gene in Langerhans cells. [31607745]
  • A reference map of the human binary protein interactome. [32296183]
  • A Common Genetic Variation in Langerin (CD207) Compromises Cellular Uptake of Staphylococcus aureus. [31141812]
  • Polymorphisms in human langerin affect stability and sugar binding activity. [16567809]
  • Langerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells. [14991068]
  • Comparison of the expression of Langerin and 175 kD mannose receptor in antigen-presenting cells in normal human skin and basal cell carcinoma. [15222130]
  • Langerin/CD207 sheds light on formation of birbeck granules and their possible function in Langerhans cells. [14610287]
  • Diversity of receptors binding HIV on dendritic cell subsets. [12352970]
  • Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules. [10661407]
UniProt Main References (9 PubMed Identifiers)
  • Generation and annotation of the DNA sequences of human chromosomes 2 and 4. [15815621]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
  • Characterization of carbohydrate recognition by langerin, a C-type lectin of Langerhans cells. [12626394]
  • Langerin is a natural barrier to HIV-1 transmission by Langerhans cells. [17334373]
  • Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. [19690332]
  • Dual specificity of Langerin to sulfated and mannosylated glycans via a single C-type carbohydrate recognition domain. [20026605]
  • C-type lectin Langerin is a beta-glucan receptor on human Langerhans cells that recognizes opportunistic and pathogenic fungi. [20097424]
  • Structural studies of langerin and Birbeck granule: a macromolecular organization model. [19175323]
  • A lack of Birbeck granules in Langerhans cells is associated with a naturally occurring point mutation in the human Langerin gene. [15816828]
All isoforms of this gene containing a lectin domain
NP_056532.4, XP_011531176.1, XP_011531177.1, XP_011531178.1
RNA
RNA (Transcript ID: NM_015717.5)
NM_015717.5
CD207 molecule
All isoforms of CD207 containing a lectin domain
ENST00000410009.5
41..1027 (or 70831050.. 70835776)
70830211.. 70835816
NCBI Matured mRNA sequence 1866 NTPDownload 
m7G-5')ppp(5'-AGAAGCACCUGUGCUCCCAGGAUAAGGGUGAGCACUCAGGAUGACUGUGGAGAAGGAGGCCCCUGAUGCGCACUUCACUGUGGACAAACAGAACAUCUCCCUCUGGCCCCGAGAGCCUCCUCCCAAGUCCGGUCCAUCUCUGGUCCCGGGGAAAACACCCACAGUCCGUGCUGCAUUAAUCUGCCUGACGCUGGUCCUGGUCGCCUCCGUCCUGCUGCAGGCCGUCCUUUAUCCCCGGUUUAUGGGCACCAUAUCAGAUGUAAAGACCAAUGUCCAGUUGCUGAAAGGUCGUGUGGACAACAUCAGCACCCUGGAUUCUGAAAUUAAAAAGAAUAGUGACGGCAUGGAGGCAGCUGGCGUUCAGAUCCAGAUGGUGAAUGAGAGCCUGGGUUAUGUGCGUUCUCAGUUCCUGAAGUUAAAAACCAGUGUGGAGAAGGCCAACGCACAGAUCCAGAUCUUAACAAGAAGUUGGGAAGAAGUCAGUACCUUAAAUGCCCAAAUCCCAGAGUUAAAAAGUGAUUUGGAGAAAGCCAGUGCUUUAAAUACAAAGAUCCGGGCACUCCAGGGCAGCUUGGAGAAUAUGAGCAAGUUGCUCAAACGACAAAAUGAUAUUCUACAGGUGGUUUCUCAAGGCUGGAAGUACUUCAAGGGGAACUUCUAUUACUUUUCUCUCAUUCCAAAGACCUGGUAUAGUGCCGAGCAGUUCUGUGUGUCCAGGAAUUCACACCUGACCUCGGUGACCUCAGAGAGUGAGCAGGAGUUUCUGUAUAAAACAGCGGGGGGACUCAUCUACUGGAUUGGCCUGACUAAAGCAGGGAUGGAAGGGGACUGGUCCUGGGUGGAUGACACGCCAUUCAACAAGGUCCAAAGUGUGAGGUUCUGGAUUCCAGGUGAGCCCAACAAUGCUGGGAACAAUGAACACUGUGGCAAUAUAAAGGCUCCCUCACUUCAGGCCUGGAAUGAUGCCCCAUGUGACAAAACGUUUCUUUUCAUUUGUAAGCGACCCUAUGUCCCAUCAGAACCGUGACAGGACAGGCUCCCAAGCUCACUCUUUGAGCUCCAACGCUUGUUAAACAUGAGGAAAUGCCUCUUUCUUCCCCAGACUCCAGGAUGACUUUGCACGUUAAUUUUUCUUGCUUCAAAAUUGUCCCACAGUGGCAUUCUGGAGUCCGUCUGUCUUGGCUGGAAAUUCUCUGACGUCUUGGAGGCAGCUGGAAUGGAAAGGAGAAUUCAGGUUAAAGUGGGAGGGGUGGGUAGAGAGGAUUUAGAAGUUCCAAUUGCCCUGCUAAGGAGGAUCAAGACCCGUAAUCCGGCAUAACACCCUGGGGUUUUCCACUCUUUCAGAGAAACCUCAGCUUCAUCACAUCAAAGUUACUCCAGAGCAACCAAGCAAUUCUCCUGAUAUUGUCAUCCAGGGCUUUUCUUGGCCAAACCCCCUAGAAUUUCCAUGUCUCUGCUUAGCUGUGCUGGCAGCUAGCAGCUGGCUGUGUUUGCAGUGCAAAUAGCUCUGUUCUUGGAAAUCCUGCUCAUGGUAUGUCCCCAGUGGUUUCUUCAUCCACAUCAUCUAAAGCCUGAACCCGUUCUUCUCUGGUUCAAGUCAGUGGCUGACACGGACUUGUAUCUCCUUCAGAGCUCGGCUGGCACCCAGCCUCCCUUCUCCUUCCACUCCCUUAGUACACUGGAGUGCCGAGCCCUGCCUUCCACCCAGCGUCCAUCCAGCCCCUGUCCUCACCUCUCCGGCACCUCCUCCUCCUUCUGCAUUUCCUAUCUUCCUGUGUCUUGUGCAUGGGAAGCAGCCUUCAGUGCCUUCAUGAAUUCACCUUCCAGCUUCCUCAGAAUAAAAUGCUGCCUGGGUCAAGGACUCAC-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
;
More about the NCBI sViewer.
DNA
DNA (Gene ID: 50489)
CD207
CD207 molecule
NC_000002.12
2  70831050.. 70835776
70831050.. 70835776
strand -
CCDS74520.1
MGI:2180021
ClinVar, dbVar
ENSG00000116031
Langerin, CLEC4K
uc002shg.4
INSDC: AJ242859
17935
604862
OTTHUMG00000153176
ENA, DDBJ, Monarch
CD207
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (987 bp)
5'-ATGACTGTGGAGAAGGAGGCCCCTGATGCGCACTTCACTGTGGACAAACAGAACATCTCCCTCTGGCCCCGAGAGCCTCCTCCCAAGTCCGGTCCATCTCTGGTCCCGGGGAAAACACCCACAGTCCGTGCTGCATTAATCTGCCTGACGCTGGTCCTGGTCGCCTCCGTCCTGCTGCAGGCCGTCCTTTATCCCCGGTTTATGGGCACCATATCAGATGTAAAGACCAATGTCCAGTTGCTGAAAGGTCGTGTGGACAACATCAGCACCCTGGATTCTGAAATTAAAAAGAATAGTGACGGCATGGAGGCAGCTGGCGTTCAGATCCAGATGGTGAATGAGAGCCTGGGTTATGTGCGTTCTCAGTTCCTGAAGTTAAAAACCAGTGTGGAGAAGGCCAACGCACAGATCCAGATCTTAACAAGAAGTTGGGAAGAAGTCAGTACCTTAAATGCCCAAATCCCAGAGTTAAAAAGTGATTTGGAGAAAGCCAGTGCTTTAAATACAAAGATCCGGGCACTCCAGGGCAGCTTGGAGAATATGAGCAAGTTGCTCAAACGACAAAATGATATTCTACAGGTGGTTTCTCAAGGCTGGAAGTACTTCAAGGGGAACTTCTATTACTTTTCTCTCATTCCAAAGACCTGGTATAGTGCCGAGCAGTTCTGTGTGTCCAGGAATTCACACCTGACCTCGGTGACCTCAGAGAGTGAGCAGGAGTTTCTGTATAAAACAGCGGGGGGACTCATCTACTGGATTGGCCTGACTAAAGCAGGGATGGAAGGGGACTGGTCCTGGGTGGATGACACGCCATTCAACAAGGTCCAAAGTGTGAGGTTCTGGATTCCAGGTGAGCCCAACAATGCTGGGAACAATGAACACTGTGGCAATATAAAGGCTCCCTCACTTCAGGCCTGGAATGATGCCCCATGTGACAAAACGTTTCTTTTCATTTGTAAGCGACCCTATGTCCCATCAGAACCGTGA-3'
NCBI CDS gene sequence with introns (location: 70831050.. 70835776) (4727 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 70830211.. 70835816) (5606 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [70830211.. 70835816 + 1000]) (6606 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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