NCBI Summary
The protein encoded by this gene is expressed only in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. It is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway. Mutations in this gene result in Birbeck granules deficiency or loss of sugar binding activity. [provided by RefSeq, Aug 2010].
Protein
Protein (NP_056532)
CLEC4K - Langerin
C-type lectin domain family 4 member K (Langerin) (CD antigen CD207)
CD207
CD207 molecule
Curated
C-type lectin
CLEK4K
C-type - Type II transmembrane receptors
a/b mixed / C-type lectin-like
0.49
Protein sequence and protein families (fasta) (328 amino acids) Download
MTVEKEAPDAHFTVDKQNISLWPREPPPKSGPSLVPGKTPTVRAALICLTLVLVASVLLQAVLYPRFMGTISDVKTNVQLLKGRVDNISTLDSEIKKNSDGMEAAGVQIQMVNESLGYVRSQFLKLKTSVEKANAQIQILTRSWEEVSTLNAQIPELKSDLEKASALNTKIRALQGSLENMSKLLKRQNDILQVVSQGWKYFKGNFYYFSLIPKTWYSAEQFCVSRNSHLTSVTSESEQEFLYKTAGGLIYWIGLTKAGMEGDWSWVDDTPFNKVQSVRFWIPGEPNNAGNNEHCGNIKAPSLQAWNDAPCDKTFLFICKRPYVPSEP
Mol* PDB structure viewerUniLectin3D
Structural models
Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Ligand
Glycan ligands from structural data
aGal13(aFuc12)Gal
Gal(a1-3)[Fuc(a1-2)]Gal
aGlc14Glc
Glc(a1-4)Glc
aMeGlcNAc, GlcNAc
GlcNAc
bGlc13Glc
Glc(b1-3)Glc
GlcNS6S
GlcN
bGal14GlcNAC- SO3
Gal(b1-4)GlcNAc
bGlcNAc13bGal14GlcbCH2CH2N3
GlcNAc(b1-3)Gal(b1-4)Glc
aMan13Man
Man(a1-3)Man
aMeMan, Man
Man
References
NCBI References (10 PubMed Identifiers)
  • The molecular basis for the pH-dependent calcium affinity of the pattern recognition receptor langerin. [33989634]
  • Langerin (CD207) represents a novel interferon-stimulated gene in Langerhans cells. [31607745]
  • A reference map of the human binary protein interactome. [32296183]
  • A Common Genetic Variation in Langerin (CD207) Compromises Cellular Uptake of Staphylococcus aureus. [31141812]
  • Polymorphisms in human langerin affect stability and sugar binding activity. [16567809]
  • Langerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells. [14991068]
  • Comparison of the expression of Langerin and 175 kD mannose receptor in antigen-presenting cells in normal human skin and basal cell carcinoma. [15222130]
  • Langerin/CD207 sheds light on formation of birbeck granules and their possible function in Langerhans cells. [14610287]
  • Diversity of receptors binding HIV on dendritic cell subsets. [12352970]
  • Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules. [10661407]
UniProt Main References (9 PubMed Identifiers)
  • Generation and annotation of the DNA sequences of human chromosomes 2 and 4. [15815621]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
  • Characterization of carbohydrate recognition by langerin, a C-type lectin of Langerhans cells. [12626394]
  • Langerin is a natural barrier to HIV-1 transmission by Langerhans cells. [17334373]
  • Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. [19690332]
  • Dual specificity of Langerin to sulfated and mannosylated glycans via a single C-type carbohydrate recognition domain. [20026605]
  • C-type lectin Langerin is a beta-glucan receptor on human Langerhans cells that recognizes opportunistic and pathogenic fungi. [20097424]
  • Structural studies of langerin and Birbeck granule: a macromolecular organization model. [19175323]
  • A lack of Birbeck granules in Langerhans cells is associated with a naturally occurring point mutation in the human Langerin gene. [15816828]
All isoforms of this gene containing a lectin domain
NP_056532.4, XP_011531176.1, XP_011531177.1, XP_011531178.1
RNA
RNA (Transcript ID: NM_015717.5)
CD207 molecule
m7G-5')ppp(5'-AGAAGCACCUGUGCUCCCAGGAUAAGGGUGAGCACUCAGGAUGACUGUGGAGAAGGAGGCCCCUGAUGCGCACUUCACUGUGGACAAACAGAACAUCUCCCUCUGGCCCCGAGAGCCUCCUCCCAAGUCCGGUCCAUCUCUGGUCCCGGGGAAAACACCCACAGUCCGUGCUGCAUUAAUCUGCCUGACGCUGGUCCUGGUCGCCUCCGUCCUGCUGCAGGCCGUCCUUUAUCCCCGGUUUAUGGGCACCAUAUCAGAUGUAAAGACCAAUGUCCAGUUGCUGAAAGGUCGUGUGGACAACAUCAGCACCCUGGAUUCUGAAAUUAAAAAGAAUAGUGACGGCAUGGAGGCAGCUGGCGUUCAGAUCCAGAUGGUGAAUGAGAGCCUGGGUUAUGUGCGUUCUCAGUUCCUGAAGUUAAAAACCAGUGUGGAGAAGGCCAACGCACAGAUCCAGAUCUUAACAAGAAGUUGGGAAGAAGUCAGUACCUUAAAUGCCCAAAUCCCAGAGUUAAAAAGUGAUUUGGAGAAAGCCAGUGCUUUAAAUACAAAGAUCCGGGCACUCCAGGGCAGCUUGGAGAAUAUGAGCAAGUUGCUCAAACGACAAAAUGAUAUUCUACAGGUGGUUUCUCAAGGCUGGAAGUACUUCAAGGGGAACUUCUAUUACUUUUCUCUCAUUCCAAAGACCUGGUAUAGUGCCGAGCAGUUCUGUGUGUCCAGGAAUUCACACCUGACCUCGGUGACCUCAGAGAGUGAGCAGGAGUUUCUGUAUAAAACAGCGGGGGGACUCAUCUACUGGAUUGGCCUGACUAAAGCAGGGAUGGAAGGGGACUGGUCCUGGGUGGAUGACACGCCAUUCAACAAGGUCCAAAGUGUGAGGUUCUGGAUUCCAGGUGAGCCCAACAAUGCUGGGAACAAUGAACACUGUGGCAAUAUAAAGGCUCCCUCACUUCAGGCCUGGAAUGAUGCCCCAUGUGACAAAACGUUUCUUUUCAUUUGUAAGCGACCCUAUGUCCCAUCAGAACCGUGACAGGACAGGCUCCCAAGCUCACUCUUUGAGCUCCAACGCUUGUUAAACAUGAGGAAAUGCCUCUUUCUUCCCCAGACUCCAGGAUGACUUUGCACGUUAAUUUUUCUUGCUUCAAAAUUGUCCCACAGUGGCAUUCUGGAGUCCGUCUGUCUUGGCUGGAAAUUCUCUGACGUCUUGGAGGCAGCUGGAAUGGAAAGGAGAAUUCAGGUUAAAGUGGGAGGGGUGGGUAGAGAGGAUUUAGAAGUUCCAAUUGCCCUGCUAAGGAGGAUCAAGACCCGUAAUCCGGCAUAACACCCUGGGGUUUUCCACUCUUUCAGAGAAACCUCAGCUUCAUCACAUCAAAGUUACUCCAGAGCAACCAAGCAAUUCUCCUGAUAUUGUCAUCCAGGGCUUUUCUUGGCCAAACCCCCUAGAAUUUCCAUGUCUCUGCUUAGCUGUGCUGGCAGCUAGCAGCUGGCUGUGUUUGCAGUGCAAAUAGCUCUGUUCUUGGAAAUCCUGCUCAUGGUAUGUCCCCAGUGGUUUCUUCAUCCACAUCAUCUAAAGCCUGAACCCGUUCUUCUCUGGUUCAAGUCAGUGGCUGACACGGACUUGUAUCUCCUUCAGAGCUCGGCUGGCACCCAGCCUCCCUUCUCCUUCCACUCCCUUAGUACACUGGAGUGCCGAGCCCUGCCUUCCACCCAGCGUCCAUCCAGCCCCUGUCCUCACCUCUCCGGCACCUCCUCCUCCUUCUGCAUUUCCUAUCUUCCUGUGUCUUGUGCAUGGGAAGCAGCCUUCAGUGCCUUCAUGAAUUCACCUUCCAGCUUCCUCAGAAUAAAAUGCUGCCUGGGUCAAGGACUCAC-3'- Poly-A tail
  • Coding region
;
DNA
DNA (Gene ID: 50489)
CD207 molecule
strand -
Langerin, CLEC4K
NCBI CDS gene sequence (987 bp)
5'-ATGACTGTGGAGAAGGAGGCCCCTGATGCGCACTTCACTGTGGACAAACAGAACATCTCCCTCTGGCCCCGAGAGCCTCCTCCCAAGTCCGGTCCATCTCTGGTCCCGGGGAAAACACCCACAGTCCGTGCTGCATTAATCTGCCTGACGCTGGTCCTGGTCGCCTCCGTCCTGCTGCAGGCCGTCCTTTATCCCCGGTTTATGGGCACCATATCAGATGTAAAGACCAATGTCCAGTTGCTGAAAGGTCGTGTGGACAACATCAGCACCCTGGATTCTGAAATTAAAAAGAATAGTGACGGCATGGAGGCAGCTGGCGTTCAGATCCAGATGGTGAATGAGAGCCTGGGTTATGTGCGTTCTCAGTTCCTGAAGTTAAAAACCAGTGTGGAGAAGGCCAACGCACAGATCCAGATCTTAACAAGAAGTTGGGAAGAAGTCAGTACCTTAAATGCCCAAATCCCAGAGTTAAAAAGTGATTTGGAGAAAGCCAGTGCTTTAAATACAAAGATCCGGGCACTCCAGGGCAGCTTGGAGAATATGAGCAAGTTGCTCAAACGACAAAATGATATTCTACAGGTGGTTTCTCAAGGCTGGAAGTACTTCAAGGGGAACTTCTATTACTTTTCTCTCATTCCAAAGACCTGGTATAGTGCCGAGCAGTTCTGTGTGTCCAGGAATTCACACCTGACCTCGGTGACCTCAGAGAGTGAGCAGGAGTTTCTGTATAAAACAGCGGGGGGACTCATCTACTGGATTGGCCTGACTAAAGCAGGGATGGAAGGGGACTGGTCCTGGGTGGATGACACGCCATTCAACAAGGTCCAAAGTGTGAGGTTCTGGATTCCAGGTGAGCCCAACAATGCTGGGAACAATGAACACTGTGGCAATATAAAGGCTCCCTCACTTCAGGCCTGGAATGATGCCCCATGTGACAAAACGTTTCTTTTCATTTGTAAGCGACCCTATGTCCCATCAGAACCGTGA-3'
NCBI CDS gene sequence with introns (location: 70831050.. 70835776) (4727 bp)Download
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 70830211.. 70835816) (5606 bp)Download
NCBI gene sequence (location: [70830211.. 70835816 + 1000]) (6606 bp)Download
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