HumanLectome - Human Lectin Entry

NCBI Summary

CD302 is a C-type lectin receptor involved in cell adhesion and migration, as well as endocytosis and phagocytosis (Kato et al., 2007 [PubMed 17947679]).[supplied by OMIM, Aug 2008].

Protein name

CD302

Synonym(s)

CD302 antigen (C-type lectin BIMLEC) (C-type lectin domain family 13 member A) (DEC205-associated C-type lectin 1) (Type I transmembrane C-type lectin receptor DCL-1) (CD antigen CD302)

HGNC gene name

CD302

HGNC name

CD302 molecule

Protein_CD_name

CD302

Lectin confidence

Very low evidence

UniLectin class

C-type lectin

C-type classification

Undefined

Known lectin group

C-type - CTLD/acidic neck

Lectin fold

a/b mixed / C-type lectin-like

Glycan specificity

Uncharacterised

RefSeq accession

Gene ID

UniProt accession

Ensembl protein ID

UniRef cluster ID

LectomeXplore score

0.276

Reference

10.4049/jimmunol.179.9.6052

Other links

neXtProt, PFAM, InterPro

Protein sequence and protein families (fasta) (232 amino acids) Download

MLRAALPALLLPLLGLAAAAVADCPSSTWIQFQDSCYIFLQEAIKVESIEDVRNQCTDHGADMISIHNEEENAFILDTLKKQWKGPDDILLGMFYDTDDASFKWFDNSNMTFDKWTDQDDDEDLVDTCAFLHIKTGEWKKGNCEVSSVEGTLCKTAIPYKRKYLSDNHILISALVIASTVILTVLGAIIWFLYKKHSDSRFTTVFSTAPQSPYNEDCVLVVGEENEYPVQFD

Mol* PDB structure viewerUniLectin3D

Select a PDB entry:

Structural models

AlphaFold v2: AF-Q8IX05-F1 Download

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

AlphaFold_v2 structural model assessment through SWISS-MODEL tools.

Expression

Human Protein Atlas

GeneCards

mRNA expression in normal human tissues for CD302 Gene

References

NCBI References (7 PubMed Identifiers)

A reference map of the human binary protein interactome. [32296183]

Characterization of the Expression and Function of the C-Type Lectin Receptor CD302 in Mice and Humans Reveals a Role in Dendritic Cell Migration. [27316686]

New genetic associations detected in a host response study to hepatitis B vaccine. [20237496]

Defining the membrane proteome of NK cells. [19946888]

Characterization of DLC1-SAM equilibrium unfolding at the amino acid residue level. [19317456]

The novel endocytic and phagocytic C-Type lectin receptor DCL-1/CD302 on macrophages is colocalized with F-actin, suggesting a role in cell adhesion and migration. [17947679]

Hodgkin's lymphoma cell lines express a fusion protein encoded by intergenically spliced mRNA for the multilectin receptor DEC-205 (CD205) and a novel C-type lectin receptor DCL-1. [12824192]

UniProt Main References (5 PubMed Identifiers)

Complete sequencing and characterization of 21,243 full-length human cDNAs. [14702039]

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. [15815621]

Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. [7584026]

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]

1H, 13C and 15N resonance assignments of human DCL-1 (CD302) extracellular domain. [26725057]

All isoforms of this gene containing a lectin domain

NP_055695.2, NP_001185693.1, NP_001185692.1

RNA

RNA (Transcript ID: NM_014880.5)

RNA RefSeq ID

NM_014880.5

RNA name

CD302 molecule, transcript variant 1

Isoforms

All isoforms of CD302 containing a lectin domain

RNA Ensembl ID

ENST00000259053.6

Coding region

11..709 (or 159771851.. 159798198)

mRNA location

159768628.. 159798208

NCBI Matured mRNA sequence 3932 NTP Download

m⁷G-5')ppp(5'-ACCCGCCGUCAUGCUCCGGGCCGCGCUGCCCGCGCUCCUGCUGCCGUUGCUGGGCCUCGCCGCUGCUGCCGUCGCGGACUGUCCUUCAUCUACUUGGAUUCAGUUCCAAGACAGUUGUUACAUUUUUCUCCAAGAAGCCAUCAAAGUAGAAAGCAUAGAGGAUGUCAGAAAUCAGUGUACUGACCAUGGAGCGGACAUGAUAAGCAUACAUAAUGAAGAAGAAAAUGCUUUUAUACUGGAUACUUUGAAAAAGCAAUGGAAAGGCCCAGAUGAUAUCCUACUAGGCAUGUUUUAUGACACAGAUGAUGCGAGUUUCAAGUGGUUUGAUAAUUCAAAUAUGACAUUUGAUAAGUGGACAGACCAAGAUGAUGAUGAGGAUUUAGUUGACACCUGUGCUUUUCUGCACAUCAAGACAGGUGAAUGGAAAAAAGGAAAUUGUGAAGUUUCUUCUGUGGAAGGAACACUAUGCAAAACAGCUAUCCCAUACAAAAGGAAAUAUUUAUCAGAUAACCACAUUUUAAUAUCAGCAUUGGUGAUUGCUAGCACGGUAAUUUUGACAGUUUUGGGAGCAAUCAUUUGGUUCCUGUACAAAAAACAUUCUGAUUCUCGUUUCACCACAGUUUUUUCAACCGCACCCCAAUCACCUUAUAAUGAAGACUGUGUUUUGGUAGUUGGAGAAGAAAAUGAAUAUCCUGUUCAAUUUGACUAAGUUUUUGGUAAUCUUGCACUAAGACAUCAACAAAAUGCCCUGGCAGAGAUAACUUGGGAAAGAUUUUAAUAUAAAACUUGACAUUGGAUAUUAGAGCUUUAAUGGUAUUCCUUAUUCCAGUAACAUUUUUAUGUACUCAUCUGCUGUGAAAAGUCUUUAGGUUCAUUAAAAAAACAGGUUUUAGAAAUGAUCUUAGAUCUAAUAUAGUGAUUUUAAGCAUCCCGUCAAAGGCAGAAUCUGUCACUUGAAUGAAGGAAAGCUUAAAGCCCAAGCAGAUAAAAAUAAAAGCCCAGCCUAUUUGUCUUGCCUGCUGUAUCUUCCCUAUUUAGUUGACCCACUUUAGUUUAUAUGUUUAUUAGUAAACAUGAAAUGGGGAAUAAGUGAUUUUAAGUACAUCCCAUACAUUUAAAUAUCUUUGAUAAUUGUUAUUUUUUUGGCAGAUAAUUCCUCUAGAAUGUGUAUCUUUUUAUGAUUUAGAUGAAGAAAAUUUUACAACUUUUAACACCCCACACCAAUUUUAGUUUCAUUACUUUUACACACACCAUUUUAUCACAAAUGACUCAAGUUUUAAUGAAUGUUUAUAAAUUAUUUGAAACAAAAUAUGAUCGCUGUGUCCAGGAUGGCAUAGAGAAAGCUGGCAAUUAGGUUAACACUUACAUAUUAUAGUGCCCCUUUAAGGAUUUCUCUCUUGCCACCAUACCUUUUGUACUUUCCCCUAUACAAGAUGUAUCUCAUUCUCCUCAAGCAUUUAUAAAUUUUUCCUUCAAUGACAUGAAAACUGUGCAAGCAAAAACCGAAGAAAAACACUUAAGUACAACUGUAGUGACAGUGAUCAAAGUUUUCAGUGCAUUUAUUGUACAUUUUAAGAAAAAGGUGAAAAUCAUUUGGGGAGUAAAAAAAUGAAAAAGCUGAAACGAGUAAUUUUCCUCACCAUCAAUAAACCAAAAACAGGAAAGAUAAAGAAUGUAUAAAUUUCACGUAAAUUAGUCACGUAUCACUUAUCAAUGGGGAUACGUUCUAAGAAAUGCAUAGUUAGGGAAUCUUGUGUGAAAAUCAGCUUGUAUUUACACAAACCCAGAUGGUAGAGCCUAUUUUGUCCCAAACCUACACAGCAUGUUACUGUGCUGAAUACUGCAGACAAUUGUAACACAAUAUUUGUGUAUCUAAAUAUAGAAAAGGUACAGUAAAAAUAUGGUCUACUAAGGAAACACUGUUCUAUAUGUGGUCCAUUACUGACUGAAGUAUACUGUCUAGAAGUCUGAGGCUCAAAGAAAAGUAAUCCCUCUUCUGAAUCCACACCCCAUCAAUUAUCUUACUUUCUUCUGGGGAGAUAGAUAGAUAUACUAUCUCACUAGCUUGACUAAUGGCAACAAAGUUCCAGCUUGUGUAGUCUCUUUUUAUUGACCACAUGAAUCGAAAACACUCAUCACAAUUAAUGGCACUAUCAUUAAUGAGACAUGAGUAACUAAAAAGUGAUAGAAAACUAUUAACAGUGCGGCUACAUGGUACUGAAAAUGCAGGCAUUACACCAGCUGUUACACAAGCACAAGCAUGCUCUGUAAGAGCUUUACAUUUCUGAGAUUUUGUAUAGUGAUUGAGAUGUCUAUUUUAUUAUUGAUAGACUAUUACUAAUGUCAAUAUUGAACACUACCCUGGAAUUCCUGCCUGGUUUUCCUACCCAAAUUGUACCACUCCUUGAAGAACUACAGGCACAGUAAAAAAAAUAUGGCGUAUUAUGUGAACUAAAAGAGUUCUAAAGGAGUUCUUAAAGGAGUGGUAGAAUUUGGGUAGGAAAGUGAUUAAGUCCAACUUAAAACCAACAGUCUCAAACGUCUACAACUACAAUGUCCAAUGAGCCACUAGCCACAUGAGGCUAUUUAAGUAAAUUUAGUUUAAAAUCCAGUUUUCGAAUUACAUUAGCCACAUUGUCAAGUGUUCAAAUCACAGGUGGUUAGUGGCUACUGUACUGGGCAACAUACAUUAUAGAACAUUUUCAUUAUAGGAAGUUUUAUUGGGCAGUGCUGCUCUUAAAUCCUACCUUCCACUCAACUCCCAUACAACUUUCUUUUGUACAUUUUGAUACUUUCUACCUAAUGGCAGCUCUUCCAAAAUAGCUGCUUUAAACUCUGAUUUAAUUUUCAAUAUUUGGUUUCAUUUUUCAACAGGCCAAGAGGCCUCUGGUAAUGAAGUGCUAUAUAUAUAUAUAUGAUGGAGUCUCACUGUGCUGCCCAGGCUACAGUGCAGUGGCUCGAUCUUGGCUCUCUCCAAUCUCCGCCUUGCAGGUUUUCAAGCAAUUCUCCUGCCUCAGCCUCCUUAGUAGCUGGGACCACAGACAUCUGUCACCACACCCAGCUAACUUUUUGUAUUUUUGGUAGAGACGGGGUUUCGCCAUAUUGACUGGGCUGGUCUCAAACUCCUGACCUCAAGUGAUCCACCCACCUUGGUCUCCCAAAGUGCUGGGAUUACAUGCGUGAGCCACCACACUUGGCCUACAUUUUUUCUUUAUAUACCAGAACAUCUAUAACAGGCACCUUAUCUACUCAUUAGUGAAGAGAUAAUUGGAUUACACAGGCAGGCUUGUUUACUACAUCCAGAAUGUAGAAACUGCUUUCUUCAACAUCUUGGUUCUAGCUAGUAAUAACAAUAUAAUUCUUUGGCAGAUAUUCAGAAUAACAUUUUAAACUACAUUUUCUUAGAAAAUUGCAUUCUUGUAGUGAGCAGUGUAUGGUCUCUUUUGUUCAGAAUUUAAAACUGAUAACCAAUGAAAGCCUUUUCUCUUAUUCCUCUACCGUCAUUUACAUGAUAAUCUGAAGCUAAUAUGACAAUAUUUAAAUACUAAGUGGUACUAGGGAACUACAAGAAUACUGUAAAGCUUAAGCCAUUGUUAUCACUGUCAUUUAGCAUUUAAUAACAAAACUAUACAGAAUUAUGUGCAUACCAAUGAAUGUUUUGUACCAUCUAGUUAAAUUUUUUAAAUAAAGUUUUAUGGGUUAAGCAGAAGACAACUGUCAUACUGAAUUUUAUUAAAAGUAUAUAUACUUCAAAUUCAAAGCAUCCCUUAGGACCCACAGAAUAUAUUAAAACUACCACCCUUAAAUUUUAUAUUUUUGCUUUAAGACAGACAAUGCAAAGGUAACUGGCAAGAGGUGAGCAAAUGUUUUAGAACAUUUAUAUUAUUGCUUAAAAUGAGAUUUGAAAUUGUAAUAAAAUUCUUGGUUAUGAA-3'- Poly-A tail

Coding region

NCBI Matured mRNA sequence viewer

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More about the NCBI sViewer.

DNA

DNA (Gene ID: 9936)

HGNC Gene symbol

CD302

HGNC Gene name

CD302 molecule

Chr. RefSeq ID

NC_000002.12

Chromosome N°

2 159771851.. 159798198

CDS location

159771851.. 159798198

DNA strand

strand -

CCDS ID

CCDS33308.1

Mouse ortholog gene

MGI:1913455

Gene Variant

ClinVar, dbVar

DNA Ensembl ID

ENSG00000241399

HGNC other symbol

DCL-1, KIAA0022, BIMLEC, CLEC13A

UCSC ID

uc002uba.4

GeneBank

INSDC: AY314007

GeneCards

30843

MIM

612246

VEGA ID

OTTHUMG00000154080