NCBI Summary
The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments.
Protein
Protein (NP_055256)
SIGLEC-9
Sialic acid-binding Ig-like lectin 9 (Siglec-9) (CDw329) (Protein FOAP-9) (CD antigen CD329)
SIGLEC9
sialic acid binding Ig like lectin 9
Undefined
Curated
I-type lectin
I-Type Lectins - CD33-related Siglecs
b-sandwich / Ig-like
NeuAc / Neu5Ac(a2-6)Gal(b1-4)[Fuc(a1-3)](6S)GlcNAc
0.519
MLLLLLPLLWGRERAEGQTSKLLTMQSSVTVQEGLCVHVPCSFSYPSHGWIYPGPVVHGYWFREGANTDQDAPVATNNPARAVWEETRDRFHLLGDPHTKNCTLSIRDARRSDAGRYFFRMEKGSIKWNYKHHRLSVNVTALTHRPNILIPGTLESGCPQNLTCSVPWACEQGTPPMISWIGTSVSPLDPSTTRSSVLTLIPQPQDHGTSLTCQVTFPGASVTTNKTVHLNVSYPPQNLTMTVFQGDGTVSTVLGNGSSLSLPEGQSLRLVCAVDAVDSNPPARLSLSWRGLTLCPSQPSNPGVLELPWVHLRDAAEFTCRAQNPLGSQQVYLNVSLQSKATSGVTQGVVGGAGATALVFLSFCVIFVVVRSCRKKSARPAAGVGDTGIEDANAVRGSASQGPLTEPWAEDSPPDQPPPASARSSVGEGELQYASLSFQMVKPWDSRGQEATDTEYSEIKIHR
No structure currently available in the PDB RCSB Databank.
Structural models
SWISS-MODEL structural models
The location of the lectin domain structural model is: 20-146
We infer [0.82, 1.1] Å as the interval of error of this structural model.
Template 1: 2G5R chain: A, Q9Y286, NP_055200.1, sequence identity: 71.7%, coverage: 94.5%, location in sequence: 24-144, (24-144 in PDB).
Template 2: 2N7B chain: A, Q9NYZ4, NP_055257.2, sequence identity: 62.2%, coverage: 95.3%, location in sequence: 26-152, (10-136 in PDB).
Template 3: 6D4A chain: B, P20138, NP_001763.3, sequence identity: 56.7%, coverage: 96.1%, location in sequence: 18-141, (18-141 in PDB).
Show the alignment used for the construction of the structural model, Download.
Show the plot of DOPE energy score, Download.
We infer [0.82, 1.1] Å as the interval of error of this structural model.
Template 1: 2G5R chain: A, Q9Y286, NP_055200.1, sequence identity: 71.7%, coverage: 94.5%, location in sequence: 24-144, (24-144 in PDB).
Template 2: 2N7B chain: A, Q9NYZ4, NP_055257.2, sequence identity: 62.2%, coverage: 95.3%, location in sequence: 26-152, (10-136 in PDB).
Template 3: 6D4A chain: B, P20138, NP_001763.3, sequence identity: 56.7%, coverage: 96.1%, location in sequence: 18-141, (18-141 in PDB).
Show the alignment used for the construction of the structural model, Download.
Show the plot of DOPE energy score, Download.
Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
References
NCBI References (10 PubMed Identifiers)
- Modulation of immune cell reactivity with cis-binding Siglec agonists. [33431669]
- Targeting glycosylated antigens on cancer cells using siglec-7/9-based CAR T-cells. [32391973]
- The Roles of Siglec7 and Siglec9 on Natural Killer Cells in Virus Infection and Tumour Progression. [32322597]
- A reference map of the human binary protein interactome. [32296183]
- The membrane-proximal immunoreceptor tyrosine-based inhibitory motif is critical for the inhibitory signaling mediated by Siglecs-7 and -9, CD33-related Siglecs expressed on human monocytes and NK cells. [15557178]
- Negative regulation of T cell receptor signaling by Siglec-7 (p70/AIRM) and Siglec-9. [15292262]
- A uniquely human consequence of domain-specific functional adaptation in a sialic acid-binding receptor. [14693915]
- Siglec-9, a novel sialic acid binding member of the immunoglobulin superfamily expressed broadly on human blood leukocytes. [10801862]
- Cloning, characterization, and phylogenetic analysis of siglec-9, a new member of the CD33-related group of siglecs. Evidence for co-evolution with sialic acid synthesis pathways. [10801860]
- Identification and molecular characterization of a novel member of the siglec family (SIGLEC9). [10903842]
UniProt Main References (4 PubMed Identifiers)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. [12975309]
- Complete sequencing and characterization of 21,243 full-length human cDNAs. [14702039]
- The DNA sequence and biology of human chromosome 19. [15057824]
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
All isoforms of this gene containing a lectin domain
RNA
RNA (Transcript ID: NM_014441.3)
sialic acid binding Ig like lectin 9, transcript variant 2
m7G-5')ppp(5'-GCAGUUCCUGAGAGAAGAACCCUGAGGAACAGACGUUCCCUCGCGGCCCUGGCACCUCUAACCCCAGACAUGCUGCUGCUGCUGCUGCCCCUGCUCUGGGGGAGGGAGAGGGCGGAAGGACAGACAAGUAAACUGCUGACGAUGCAGAGUUCCGUGACGGUGCAGGAAGGCCUGUGUGUCCAUGUGCCCUGCUCCUUCUCCUACCCCUCGCAUGGCUGGAUUUACCCUGGCCCAGUAGUUCAUGGCUACUGGUUCCGGGAAGGGGCCAAUACAGACCAGGAUGCUCCAGUGGCCACAAACAACCCAGCUCGGGCAGUGUGGGAGGAGACUCGGGACCGAUUCCACCUCCUUGGGGACCCACAUACCAAGAAUUGCACCCUGAGCAUCAGAGAUGCCAGAAGAAGUGAUGCGGGGAGAUACUUCUUUCGUAUGGAGAAAGGAAGUAUAAAAUGGAAUUAUAAACAUCACCGGCUCUCUGUGAAUGUGACAGCCUUGACCCACAGGCCCAACAUCCUCAUCCCAGGCACCCUGGAGUCCGGCUGCCCCCAGAAUCUGACCUGCUCUGUGCCCUGGGCCUGUGAGCAGGGGACACCCCCUAUGAUCUCCUGGAUAGGGACCUCCGUGUCCCCCCUGGACCCCUCCACCACCCGCUCCUCGGUGCUCACCCUCAUCCCACAGCCCCAGGACCAUGGCACCAGCCUCACCUGUCAGGUGACCUUCCCUGGGGCCAGCGUGACCACGAACAAGACCGUCCAUCUCAACGUGUCCUACCCGCCUCAGAACUUGACCAUGACUGUCUUCCAAGGAGACGGCACAGUAUCCACAGUCUUGGGAAAUGGCUCAUCUCUGUCACUCCCAGAGGGCCAGUCUCUGCGCCUGGUCUGUGCAGUUGAUGCAGUUGACAGCAAUCCCCCUGCCAGGCUGAGCCUGAGCUGGAGAGGCCUGACCCUGUGCCCCUCACAGCCCUCAAACCCGGGGGUGCUGGAGCUGCCUUGGGUGCACCUGAGGGAUGCAGCUGAAUUCACCUGCAGAGCUCAGAACCCUCUCGGCUCUCAGCAGGUCUACCUGAACGUCUCCCUGCAGAGCAAAGCCACAUCAGGAGUGACUCAGGGGGUGGUCGGGGGAGCUGGAGCCACAGCCCUGGUCUUCCUGUCCUUCUGCGUCAUCUUCGUUGUAGUGAGGUCCUGCAGGAAGAAAUCGGCAAGGCCAGCAGCGGGCGUGGGAGAUACGGGCAUAGAGGAUGCAAACGCUGUCAGGGGUUCAGCCUCUCAGGGGCCCCUGACUGAACCUUGGGCAGAAGACAGUCCCCCAGACCAGCCUCCCCCAGCUUCUGCCCGCUCCUCAGUGGGGGAAGGAGAGCUCCAGUAUGCAUCCCUCAGCUUCCAGAUGGUGAAGCCUUGGGACUCGCGGGGACAGGAGGCCACUGACACCGAGUACUCGGAGAUCAAGAUCCACAGAUGAGAAACUGCAGAGACUCACCCUGAUUGAGGGAUCACAGCCCCUCCAGGCAAGGGAGAAGUCAGAGGCUGAUUCUUGUAGAAUUAACAGCCCUCAACGUGAUGAGCUAUGAUAACACUAUGAAUUAUGUGCAGAGUGAAAAGCACACAGGCUUUAGAGUCAAAGUAUCUCAAACCUGAAUCCACACUGUGCCCUCCCUUUUAUUUUUUUAACUAAAAGACAGACAAAUUCCUA-3'- Poly-A tail
- Coding region
DNA
DNA (Gene ID: 27180)
sialic acid binding Ig like lectin 9
strand +
NCBI CDS gene sequence (1392 bp)
5'-ATGCTGCTGCTGCTGCTGCCCCTGCTCTGGGGGAGGGAGAGGGCGGAAGGACAGACAAGTAAACTGCTGACGATGCAGAGTTCCGTGACGGTGCAGGAAGGCCTGTGTGTCCATGTGCCCTGCTCCTTCTCCTACCCCTCGCATGGCTGGATTTACCCTGGCCCAGTAGTTCATGGCTACTGGTTCCGGGAAGGGGCCAATACAGACCAGGATGCTCCAGTGGCCACAAACAACCCAGCTCGGGCAGTGTGGGAGGAGACTCGGGACCGATTCCACCTCCTTGGGGACCCACATACCAAGAATTGCACCCTGAGCATCAGAGATGCCAGAAGAAGTGATGCGGGGAGATACTTCTTTCGTATGGAGAAAGGAAGTATAAAATGGAATTATAAACATCACCGGCTCTCTGTGAATGTGACAGCCTTGACCCACAGGCCCAACATCCTCATCCCAGGCACCCTGGAGTCCGGCTGCCCCCAGAATCTGACCTGCTCTGTGCCCTGGGCCTGTGAGCAGGGGACACCCCCTATGATCTCCTGGATAGGGACCTCCGTGTCCCCCCTGGACCCCTCCACCACCCGCTCCTCGGTGCTCACCCTCATCCCACAGCCCCAGGACCATGGCACCAGCCTCACCTGTCAGGTGACCTTCCCTGGGGCCAGCGTGACCACGAACAAGACCGTCCATCTCAACGTGTCCTACCCGCCTCAGAACTTGACCATGACTGTCTTCCAAGGAGACGGCACAGTATCCACAGTCTTGGGAAATGGCTCATCTCTGTCACTCCCAGAGGGCCAGTCTCTGCGCCTGGTCTGTGCAGTTGATGCAGTTGACAGCAATCCCCCTGCCAGGCTGAGCCTGAGCTGGAGAGGCCTGACCCTGTGCCCCTCACAGCCCTCAAACCCGGGGGTGCTGGAGCTGCCTTGGGTGCACCTGAGGGATGCAGCTGAATTCACCTGCAGAGCTCAGAACCCTCTCGGCTCTCAGCAGGTCTACCTGAACGTCTCCCTGCAGAGCAAAGCCACATCAGGAGTGACTCAGGGGGTGGTCGGGGGAGCTGGAGCCACAGCCCTGGTCTTCCTGTCCTTCTGCGTCATCTTCGTTGTAGTGAGGTCCTGCAGGAAGAAATCGGCAAGGCCAGCAGCGGGCGTGGGAGATACGGGCATAGAGGATGCAAACGCTGTCAGGGGTTCAGCCTCTCAGGGGCCCCTGACTGAACCTTGGGCAGAAGACAGTCCCCCAGACCAGCCTCCCCCAGCTTCTGCCCGCTCCTCAGTGGGGGAAGGAGAGCTCCAGTATGCATCCCTCAGCTTCCAGATGGTGAAGCCTTGGGACTCGCGGGGACAGGAGGCCACTGACACCGAGTACTCGGAGATCAAGATCCACAGATGA-3'
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