NCBI Summary
The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments.
Protein
Protein (NP_055256)
SIGLEC-9
Sialic acid-binding Ig-like lectin 9 (Siglec-9) (CDw329) (Protein FOAP-9) (CD antigen CD329)
SIGLEC9
sialic acid binding Ig like lectin 9
Undefined
Curated
I-type lectin
I-Type Lectins - CD33-related Siglecs
b-sandwich / Ig-like
NeuAc / Neu5Ac(a2-6)Gal(b1-4)[Fuc(a1-3)](6S)GlcNAc
NP_055256
27180
Q9Y336
ENSP00000250360.2
Q9Y336
0.519
10.1146/annurev-immunol-102419-035900
neXtProt, PFAM, InterPro, CFG data
Protein sequence and protein families (fasta) (463 amino acids) Download
MLLLLLPLLWGRERAEGQTSKLLTMQSSVTVQEGLCVHVPCSFSYPSHGWIYPGPVVHGYWFREGANTDQDAPVATNNPARAVWEETRDRFHLLGDPHTKNCTLSIRDARRSDAGRYFFRMEKGSIKWNYKHHRLSVNVTALTHRPNILIPGTLESGCPQNLTCSVPWACEQGTPPMISWIGTSVSPLDPSTTRSSVLTLIPQPQDHGTSLTCQVTFPGASVTTNKTVHLNVSYPPQNLTMTVFQGDGTVSTVLGNGSSLSLPEGQSLRLVCAVDAVDSNPPARLSLSWRGLTLCPSQPSNPGVLELPWVHLRDAAEFTCRAQNPLGSQQVYLNVSLQSKATSGVTQGVVGGAGATALVFLSFCVIFVVVRSCRKKSARPAAGVGDTGIEDANAVRGSASQGPLTEPWAEDSPPDQPPPASARSSVGEGELQYASLSFQMVKPWDSRGQEATDTEYSEIKIHR
No structure currently available in the PDB RCSB Databank.
Structural models
AlphaFold v2: AF-Q9Y336-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

SWISS-MODEL structural models
SWISS-MODEL structural model
Modeller structural model (Homology modelling pipeline), Error: [0.82, 1.1] ÅDownload
The location of the lectin domain structural model is: 20-146
We infer [0.82, 1.1] Å as the interval of error of this structural model.
Template 1: 2G5R chain: A, Q9Y286, NP_055200.1, sequence identity: 71.7%, coverage: 94.5%, location in sequence: 24-144, (24-144 in PDB).
Template 2: 2N7B chain: A, Q9NYZ4, NP_055257.2, sequence identity: 62.2%, coverage: 95.3%, location in sequence: 26-152, (10-136 in PDB).
Template 3: 6D4A chain: B, P20138, NP_001763.3, sequence identity: 56.7%, coverage: 96.1%, location in sequence: 18-141, (18-141 in PDB).
Show the alignment used for the construction of the structural model, Download.
Show the plot of DOPE energy score, Download.
Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for SIGLEC9 Gene
ProteomicsDB
References
NCBI References (10 PubMed Identifiers)
  • Modulation of immune cell reactivity with cis-binding Siglec agonists. [33431669]
  • Targeting glycosylated antigens on cancer cells using siglec-7/9-based CAR T-cells. [32391973]
  • The Roles of Siglec7 and Siglec9 on Natural Killer Cells in Virus Infection and Tumour Progression. [32322597]
  • A reference map of the human binary protein interactome. [32296183]
  • The membrane-proximal immunoreceptor tyrosine-based inhibitory motif is critical for the inhibitory signaling mediated by Siglecs-7 and -9, CD33-related Siglecs expressed on human monocytes and NK cells. [15557178]
  • Negative regulation of T cell receptor signaling by Siglec-7 (p70/AIRM) and Siglec-9. [15292262]
  • A uniquely human consequence of domain-specific functional adaptation in a sialic acid-binding receptor. [14693915]
  • Siglec-9, a novel sialic acid binding member of the immunoglobulin superfamily expressed broadly on human blood leukocytes. [10801862]
  • Cloning, characterization, and phylogenetic analysis of siglec-9, a new member of the CD33-related group of siglecs. Evidence for co-evolution with sialic acid synthesis pathways. [10801860]
  • Identification and molecular characterization of a novel member of the siglec family (SIGLEC9). [10903842]
UniProt Main References (4 PubMed Identifiers)
  • The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. [12975309]
  • Complete sequencing and characterization of 21,243 full-length human cDNAs. [14702039]
  • The DNA sequence and biology of human chromosome 19. [15057824]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
All isoforms of this gene containing a lectin domain
XP_016882085.1, NP_055256.1, XP_011525034.1, XP_016882084.1, NP_001185487.1, XP_011525032.1, XP_006723209.1
RNA
RNA (Transcript ID: NM_014441.3)
NM_014441.3
sialic acid binding Ig like lectin 9, transcript variant 2
All isoforms of SIGLEC9 containing a lectin domain
ENST00000250360.8
70..1461 (or 51124975.. 51130079)
51124906.. 51130310
NCBI Matured mRNA sequence 1692 NTPDownload 
m7G-5')ppp(5'-GCAGUUCCUGAGAGAAGAACCCUGAGGAACAGACGUUCCCUCGCGGCCCUGGCACCUCUAACCCCAGACAUGCUGCUGCUGCUGCUGCCCCUGCUCUGGGGGAGGGAGAGGGCGGAAGGACAGACAAGUAAACUGCUGACGAUGCAGAGUUCCGUGACGGUGCAGGAAGGCCUGUGUGUCCAUGUGCCCUGCUCCUUCUCCUACCCCUCGCAUGGCUGGAUUUACCCUGGCCCAGUAGUUCAUGGCUACUGGUUCCGGGAAGGGGCCAAUACAGACCAGGAUGCUCCAGUGGCCACAAACAACCCAGCUCGGGCAGUGUGGGAGGAGACUCGGGACCGAUUCCACCUCCUUGGGGACCCACAUACCAAGAAUUGCACCCUGAGCAUCAGAGAUGCCAGAAGAAGUGAUGCGGGGAGAUACUUCUUUCGUAUGGAGAAAGGAAGUAUAAAAUGGAAUUAUAAACAUCACCGGCUCUCUGUGAAUGUGACAGCCUUGACCCACAGGCCCAACAUCCUCAUCCCAGGCACCCUGGAGUCCGGCUGCCCCCAGAAUCUGACCUGCUCUGUGCCCUGGGCCUGUGAGCAGGGGACACCCCCUAUGAUCUCCUGGAUAGGGACCUCCGUGUCCCCCCUGGACCCCUCCACCACCCGCUCCUCGGUGCUCACCCUCAUCCCACAGCCCCAGGACCAUGGCACCAGCCUCACCUGUCAGGUGACCUUCCCUGGGGCCAGCGUGACCACGAACAAGACCGUCCAUCUCAACGUGUCCUACCCGCCUCAGAACUUGACCAUGACUGUCUUCCAAGGAGACGGCACAGUAUCCACAGUCUUGGGAAAUGGCUCAUCUCUGUCACUCCCAGAGGGCCAGUCUCUGCGCCUGGUCUGUGCAGUUGAUGCAGUUGACAGCAAUCCCCCUGCCAGGCUGAGCCUGAGCUGGAGAGGCCUGACCCUGUGCCCCUCACAGCCCUCAAACCCGGGGGUGCUGGAGCUGCCUUGGGUGCACCUGAGGGAUGCAGCUGAAUUCACCUGCAGAGCUCAGAACCCUCUCGGCUCUCAGCAGGUCUACCUGAACGUCUCCCUGCAGAGCAAAGCCACAUCAGGAGUGACUCAGGGGGUGGUCGGGGGAGCUGGAGCCACAGCCCUGGUCUUCCUGUCCUUCUGCGUCAUCUUCGUUGUAGUGAGGUCCUGCAGGAAGAAAUCGGCAAGGCCAGCAGCGGGCGUGGGAGAUACGGGCAUAGAGGAUGCAAACGCUGUCAGGGGUUCAGCCUCUCAGGGGCCCCUGACUGAACCUUGGGCAGAAGACAGUCCCCCAGACCAGCCUCCCCCAGCUUCUGCCCGCUCCUCAGUGGGGGAAGGAGAGCUCCAGUAUGCAUCCCUCAGCUUCCAGAUGGUGAAGCCUUGGGACUCGCGGGGACAGGAGGCCACUGACACCGAGUACUCGGAGAUCAAGAUCCACAGAUGAGAAACUGCAGAGACUCACCCUGAUUGAGGGAUCACAGCCCCUCCAGGCAAGGGAGAAGUCAGAGGCUGAUUCUUGUAGAAUUAACAGCCCUCAACGUGAUGAGCUAUGAUAACACUAUGAAUUAUGUGCAGAGUGAAAAGCACACAGGCUUUAGAGUCAAAGUAUCUCAAACCUGAAUCCACACUGUGCCCUCCCUUUUAUUUUUUUAACUAAAAGACAGACAAAUUCCUA-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
;
More about the NCBI sViewer.
DNA
DNA (Gene ID: 27180)
SIGLEC9
sialic acid binding Ig like lectin 9
NC_000019.10
19  51124975.. 51130079
51124975.. 51130079
strand +
CCDS12825.1
MGI:1932475
ClinVar, dbVar
ENSG00000129450
CD329
uc002pvu.4
INSDC: AF135027
10878
605640
OTTHUMG00000182894
ENA, DDBJ, Monarch
CDw329
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (1392 bp)
5'-ATGCTGCTGCTGCTGCTGCCCCTGCTCTGGGGGAGGGAGAGGGCGGAAGGACAGACAAGTAAACTGCTGACGATGCAGAGTTCCGTGACGGTGCAGGAAGGCCTGTGTGTCCATGTGCCCTGCTCCTTCTCCTACCCCTCGCATGGCTGGATTTACCCTGGCCCAGTAGTTCATGGCTACTGGTTCCGGGAAGGGGCCAATACAGACCAGGATGCTCCAGTGGCCACAAACAACCCAGCTCGGGCAGTGTGGGAGGAGACTCGGGACCGATTCCACCTCCTTGGGGACCCACATACCAAGAATTGCACCCTGAGCATCAGAGATGCCAGAAGAAGTGATGCGGGGAGATACTTCTTTCGTATGGAGAAAGGAAGTATAAAATGGAATTATAAACATCACCGGCTCTCTGTGAATGTGACAGCCTTGACCCACAGGCCCAACATCCTCATCCCAGGCACCCTGGAGTCCGGCTGCCCCCAGAATCTGACCTGCTCTGTGCCCTGGGCCTGTGAGCAGGGGACACCCCCTATGATCTCCTGGATAGGGACCTCCGTGTCCCCCCTGGACCCCTCCACCACCCGCTCCTCGGTGCTCACCCTCATCCCACAGCCCCAGGACCATGGCACCAGCCTCACCTGTCAGGTGACCTTCCCTGGGGCCAGCGTGACCACGAACAAGACCGTCCATCTCAACGTGTCCTACCCGCCTCAGAACTTGACCATGACTGTCTTCCAAGGAGACGGCACAGTATCCACAGTCTTGGGAAATGGCTCATCTCTGTCACTCCCAGAGGGCCAGTCTCTGCGCCTGGTCTGTGCAGTTGATGCAGTTGACAGCAATCCCCCTGCCAGGCTGAGCCTGAGCTGGAGAGGCCTGACCCTGTGCCCCTCACAGCCCTCAAACCCGGGGGTGCTGGAGCTGCCTTGGGTGCACCTGAGGGATGCAGCTGAATTCACCTGCAGAGCTCAGAACCCTCTCGGCTCTCAGCAGGTCTACCTGAACGTCTCCCTGCAGAGCAAAGCCACATCAGGAGTGACTCAGGGGGTGGTCGGGGGAGCTGGAGCCACAGCCCTGGTCTTCCTGTCCTTCTGCGTCATCTTCGTTGTAGTGAGGTCCTGCAGGAAGAAATCGGCAAGGCCAGCAGCGGGCGTGGGAGATACGGGCATAGAGGATGCAAACGCTGTCAGGGGTTCAGCCTCTCAGGGGCCCCTGACTGAACCTTGGGCAGAAGACAGTCCCCCAGACCAGCCTCCCCCAGCTTCTGCCCGCTCCTCAGTGGGGGAAGGAGAGCTCCAGTATGCATCCCTCAGCTTCCAGATGGTGAAGCCTTGGGACTCGCGGGGACAGGAGGCCACTGACACCGAGTACTCGGAGATCAAGATCCACAGATGA-3'
NCBI CDS gene sequence with introns (location: 51124975.. 51130079) (5105 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 51124906.. 51130310) (5405 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [51124906 - 1000].. 51130310) (6405 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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