NCBI Summary
The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments.
Protein
Protein (NP_055200)
SIGLEC-7
Sialic acid-binding Ig-like lectin 7 (Siglec-7) (Adhesion inhibitory receptor molecule 1) (AIRM-1) (CDw328) (D-siglec) (QA79 membrane protein) (p75) (CD antigen CD328)
SIGLEC7
sialic acid binding Ig like lectin 7
CD328
Curated
I-type lectin
I-Type Lectins - CD33-related Siglecs
b-sandwich / Ig-like
NeuAc / Neu5Ac(a2-8)Neu5Ac(a2-3)Gal
NP_055200
27036
Q9Y286
ENSP00000323328.6
Q9Y286
0.534
10.1146/annurev-immunol-102419-035900
neXtProt, PFAM, InterPro, CFG data
Protein sequence and protein families (fasta) (467 amino acids) Download
MLLLLLLPLLWGRERVEGQKSNRKDYSLTMQSSVTVQEGMCVHVRCSFSYPVDSQTDSDPVHGYWFRAGNDISWKAPVATNNPAWAVQEETRDRFHLLGDPQTKNCTLSIRDARMSDAGRYFFRMEKGNIKWNYKYDQLSVNVTALTHRPNILIPGTLESGCFQNLTCSVPWACEQGTPPMISWMGTSVSPLHPSTTRSSVLTLIPQPQHHGTSLTCQVTLPGAGVTTNRTIQLNVSYPPQNLTVTVFQGEGTASTALGNSSSLSVLEGQSLRLVCAVDSNPPARLSWTWRSLTLYPSQPSNPLVLELQVHLGDEGEFTCRAQNSLGSQHVSLNLSLQQEYTGKMRPVSGVLLGAVGGAGATALVFLSFCVIFIVVRSCRKKSARPAADVGDIGMKDANTIRGSASQGNLTESWADDNPRHHGLAAHSSGEEREIQYAPLSFHKGEPQDLSGQEATNNEYSEIKIPK
Mol* PDB structure viewerUniLectin3D
Structural models
AlphaFold v2: AF-Q9Y286-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Ligand
Glycan ligands from structural data
Oxamido-NeuAc
NeuAc
2G5R
2G5R
GlyConnect Structures
aNeuAc23bGal13(aNeuAc26)GlcNAc
NeuAc(a2-3)Gal(b1-3)[NeuAc(a2-6)]GlcNAc
2DF3
2DF3
GlyConnect Structures
2
GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc
2HRL
2HRL
GlyConnect Structures
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for SIGLEC7 Gene
ProteomicsDB
References
NCBI References (10 PubMed Identifiers)
  • Genome-wide CRISPR screens reveal a specific ligand for the glycan-binding immune checkpoint receptor Siglec-7. [33495350]
  • The conserved arginine residue in all siglecs is essential for Siglec-7 binding to sialic acid. [33248687]
  • Identification and functional characterization of a Siglec-7 counter-receptor on K562 cells. [33640457]
  • Decidual glycodelin-A polarizes human monocytes into a decidual macrophage-like phenotype through Siglec-7. [32513821]
  • Discovery of a new sialic acid binding region that regulates Siglec-7. [32457377]
  • Engagement of p75/AIRM1 or CD33 inhibits the proliferation of normal or leukemic myeloid cells. [10611343]
  • Identification and characterization of a novel siglec, siglec-7, expressed by human natural killer cells and monocytes. [10567377]
  • TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction. [10514511]
  • Identification and molecular cloning of p75/AIRM1, a novel member of the sialoadhesin family that functions as an inhibitory receptor in human natural killer cells. [10499918]
  • SH3 domains of the adapter molecule Grb2 complex with two proteins in T cells: the guanine nucleotide exchange protein Sos and a 75-kDa protein that is a substrate for T cell antigen receptor-activated tyrosine kinases. [8188688]
UniProt Main References (8 PubMed Identifiers)
  • Siglec-7: a sialic acid-binding lectin of the immunoglobulin superfamily. [10764831]
  • Binding specificity of siglec7 to disialogangliosides of renal cell carcinoma: possible role of disialogangliosides in tumor progression. [11389909]
  • An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. [24275569]
  • High resolution crystal structures of Siglec-7. Insights into ligand specificity in the Siglec family. [12438315]
  • Structure of the saccharide-binding domain of the human natural killer cell inhibitory receptor p75/AIRM1. [14747738]
  • The structure of siglec-7 in complex with sialosides: leads for rational structure-based inhibitor design. [16623661]
  • Siglec-7 undergoes a major conformational change when complexed with the alpha(2,8)-disialylganglioside GT1b. [16895906]
  • The consensus coding sequences of human breast and colorectal cancers. [16959974]
All isoforms of this gene containing a lectin domain
NP_055200.1, NP_057627.2, XP_011525023.1, NP_001264130.1
RNA
RNA (Transcript ID: NM_014385.4)
NM_014385.4
sialic acid binding Ig like lectin 7, transcript variant 1
All isoforms of SIGLEC7 containing a lectin domain
ENST00000317643.10
70..1473 (or 51142370.. 51153245)
51142301.. 51153526
NCBI Matured mRNA sequence 1754 NTPDownload 
m7G-5')ppp(5'-GCAGUUCCUGAGAGAAGAACCCUGAGGAACAGACGUUCCCUCGCGGCCCUGGCACCUCCAACCCCAGAUAUGCUGCUGCUGCUGCUGCUGCCCCUGCUCUGGGGGAGGGAGAGGGUGGAAGGACAGAAGAGUAACCGGAAGGAUUACUCGCUGACGAUGCAGAGUUCCGUGACCGUGCAAGAGGGCAUGUGUGUCCAUGUGCGCUGCUCCUUCUCCUACCCAGUGGACAGCCAGACUGACUCUGACCCAGUUCAUGGCUACUGGUUCCGGGCAGGGAAUGAUAUAAGCUGGAAGGCUCCAGUGGCCACAAACAACCCAGCUUGGGCAGUGCAGGAGGAAACUCGGGACCGAUUCCACCUCCUUGGGGACCCACAGACCAAAAAUUGCACCCUGAGCAUCAGAGAUGCCAGAAUGAGUGAUGCGGGGAGAUACUUCUUUCGUAUGGAGAAAGGAAAUAUAAAAUGGAAUUAUAAAUAUGACCAGCUCUCUGUGAACGUGACAGCCUUGACCCACAGGCCCAACAUCCUUAUCCCCGGUACCCUGGAGUCUGGCUGCUUCCAGAAUCUGACCUGCUCUGUGCCCUGGGCCUGUGAGCAGGGGACGCCCCCUAUGAUCUCCUGGAUGGGGACCUCUGUGUCCCCCCUGCACCCCUCCACCACCCGCUCCUCAGUGCUCACCCUCAUCCCACAGCCCCAGCACCACGGCACCAGCCUCACCUGUCAGGUGACCUUGCCUGGGGCCGGCGUGACCACGAACAGGACCAUCCAACUCAAUGUGUCCUACCCUCCUCAGAACUUGACUGUGACUGUCUUCCAAGGAGAAGGCACAGCAUCCACAGCUCUGGGGAACAGCUCAUCUCUUUCAGUCCUAGAGGGCCAGUCUCUGCGCUUGGUCUGUGCUGUUGACAGCAAUCCCCCUGCCAGGCUGAGCUGGACCUGGAGGAGUCUGACCCUGUACCCCUCACAGCCCUCAAACCCUCUGGUACUGGAGCUGCAAGUGCACCUGGGGGAUGAAGGGGAAUUCACCUGUCGAGCUCAGAACUCUCUGGGUUCCCAGCACGUUUCCCUGAACCUCUCCCUGCAACAGGAGUACACAGGCAAAAUGAGGCCUGUAUCAGGAGUGUUGCUGGGGGCGGUCGGGGGAGCUGGAGCCACAGCCCUGGUCUUCCUCUCCUUCUGUGUCAUCUUCAUUGUAGUGAGGUCCUGCAGGAAGAAAUCGGCAAGGCCAGCAGCGGACGUGGGAGACAUAGGCAUGAAGGAUGCAAACACCAUCAGGGGCUCAGCCUCUCAGGGUAACCUGACUGAGUCCUGGGCAGAUGAUAACCCCCGACACCAUGGCCUGGCUGCCCACUCCUCAGGGGAGGAAAGAGAGAUCCAGUAUGCACCCCUCAGCUUUCAUAAGGGGGAGCCUCAGGACCUAUCAGGACAAGAAGCCACCAACAAUGAGUACUCAGAGAUCAAGAUCCCCAAGUAAGAAAAUGCAGAGGCUCGGGCUUGUUUGAGGGUUCACGACCCCUCCAGCAAAGGAGUCUGAGGCUGAUUCCAGUAGAAUUAGCAGCCCUCAAUGCUGUGCAACAAGACAUCAGAACUUAUUCCUCUUGUCUAACUGAAAAUGCAUGCCUGAUGACCAAACUCUCCCUUUCCCCAUCCAAUCGGUCCACACUCCCCGCCCUGGCCUCUGGUACCCACCAUUCUCCUCUGUACUUCUCUAAGGAUGACUACUUUAGAUUCCGAAUAUAGUGAGAUUGUAACGUG-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
;
More about the NCBI sViewer.
DNA
DNA (Gene ID: 27036)
SIGLEC7
sialic acid binding Ig like lectin 7
NC_000019.10
19  51142370.. 51153245
51142370.. 51153245
strand +
CCDS12826.1
MGI:1932475
ClinVar, dbVar
ENSG00000168995
SIGLEC-7, p75/AIRM1, QA79, CD328
uc002pvv.1
INSDC: AF170485
10876
604410
OTTHUMG00000182895
ENA, DDBJ, Monarch
CDw328
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (1404 bp)
5'-ATGCTGCTGCTGCTGCTGCTGCCCCTGCTCTGGGGGAGGGAGAGGGTGGAAGGACAGAAGAGTAACCGGAAGGATTACTCGCTGACGATGCAGAGTTCCGTGACCGTGCAAGAGGGCATGTGTGTCCATGTGCGCTGCTCCTTCTCCTACCCAGTGGACAGCCAGACTGACTCTGACCCAGTTCATGGCTACTGGTTCCGGGCAGGGAATGATATAAGCTGGAAGGCTCCAGTGGCCACAAACAACCCAGCTTGGGCAGTGCAGGAGGAAACTCGGGACCGATTCCACCTCCTTGGGGACCCACAGACCAAAAATTGCACCCTGAGCATCAGAGATGCCAGAATGAGTGATGCGGGGAGATACTTCTTTCGTATGGAGAAAGGAAATATAAAATGGAATTATAAATATGACCAGCTCTCTGTGAACGTGACAGCCTTGACCCACAGGCCCAACATCCTTATCCCCGGTACCCTGGAGTCTGGCTGCTTCCAGAATCTGACCTGCTCTGTGCCCTGGGCCTGTGAGCAGGGGACGCCCCCTATGATCTCCTGGATGGGGACCTCTGTGTCCCCCCTGCACCCCTCCACCACCCGCTCCTCAGTGCTCACCCTCATCCCACAGCCCCAGCACCACGGCACCAGCCTCACCTGTCAGGTGACCTTGCCTGGGGCCGGCGTGACCACGAACAGGACCATCCAACTCAATGTGTCCTACCCTCCTCAGAACTTGACTGTGACTGTCTTCCAAGGAGAAGGCACAGCATCCACAGCTCTGGGGAACAGCTCATCTCTTTCAGTCCTAGAGGGCCAGTCTCTGCGCTTGGTCTGTGCTGTTGACAGCAATCCCCCTGCCAGGCTGAGCTGGACCTGGAGGAGTCTGACCCTGTACCCCTCACAGCCCTCAAACCCTCTGGTACTGGAGCTGCAAGTGCACCTGGGGGATGAAGGGGAATTCACCTGTCGAGCTCAGAACTCTCTGGGTTCCCAGCACGTTTCCCTGAACCTCTCCCTGCAACAGGAGTACACAGGCAAAATGAGGCCTGTATCAGGAGTGTTGCTGGGGGCGGTCGGGGGAGCTGGAGCCACAGCCCTGGTCTTCCTCTCCTTCTGTGTCATCTTCATTGTAGTGAGGTCCTGCAGGAAGAAATCGGCAAGGCCAGCAGCGGACGTGGGAGACATAGGCATGAAGGATGCAAACACCATCAGGGGCTCAGCCTCTCAGGGTAACCTGACTGAGTCCTGGGCAGATGATAACCCCCGACACCATGGCCTGGCTGCCCACTCCTCAGGGGAGGAAAGAGAGATCCAGTATGCACCCCTCAGCTTTCATAAGGGGGAGCCTCAGGACCTATCAGGACAAGAAGCCACCAACAATGAGTACTCAGAGATCAAGATCCCCAAGTAA-3'
NCBI CDS gene sequence with introns (location: 51142370.. 51153245) (10876 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 51142301.. 51153526) (11226 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [51142301 - 1000].. 51153526) (12226 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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