NCBI Summary
This gene encodes a member of the natural killer cell receptor C-type lectin family. The encoded protein inhibits osteoclast formation and contains a transmembrane domain near the N-terminus as well as the C-type lectin-like extracellular domain. Several alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Oct 2010].
Protein
Protein (NP_037401)
C-type lectin domain family 2 - OCIL
C-type lectin domain family 2 member D (Lectin-like NK cell receptor) (Lectin-like transcript 1) (LLT-1) (Osteoclast inhibitory lectin)
CLEC2D
C-type lectin domain family 2 member D
Undefined
Low evidence
C-type lectin
CELEC2D
C-type - Natural Killer NK
a/b mixed / C-type lectin-like
Heparin and chondrotin sulfate A
NP_037401
29121
Q9UHP7
ENSP00000290855.6
Q9UHP7
0.245
10.1074/jbc.M312518200
PFAM, InterPro
Protein sequence and protein families (fasta) (191 amino acids) Download
MHDSNNVEKDITPSELPANPGCLHSKEHSIKATLIWRLFFLIMFLTIIVCGMVAALSAIRANCHQEPSVCLQAACPESWIGFQRKCFYFSDDTKNWTSSQRFCDSQDADLAQVESFQELNFLLRYKGPSDHWIGLSREQGQPWKWINGTEWTRQFPILGAGECAYLNDKGASSARHYTERKWICSKSDIHV
Mol* PDB structure viewerUniLectin3D
Structural models
AlphaFold v2: AF-Q9UHP7-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Oligomerization and Known Interactions
Homodimer; disulfide-linked
Annotation
Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
Expression
Human Protein Atlas
GeneCards
Functionality temporarily unavailable.
ProteomicsDB
References
NCBI References (10 PubMed Identifiers)
  • Role of LLT1 and PCNA as Natural Killer Cell Immune Evasion Strategies of HCT 116 Cells. [33288556]
  • Docetaxel suppresses immunotherapy efficacy of natural killer cells toward castration-resistant prostate cancer cells via altering androgen receptor-lectin-like transcript 1 signals. [32449811]
  • Immune Sensing of Cell Death through Recognition of Histone Sequences by C-Type Lectin-Receptor-2d Causes Inflammation and Tissue Injury. [31859049]
  • Lectin-like transcript 1 (LLT1) expression is associated with nodal metastasis in patients with head and neck cutaneous squamous cell carcinoma. [30955082]
  • Biological and Clinical Significance of Human NKRP1A/LLT1 Receptor/Ligand Interactions. [31002602]
  • Missing self-recognition of Ocil/Clr-b by inhibitory NKR-P1 natural killer cell receptors. [14990792]
  • The LLT1 receptor induces IFN-gamma production by human natural killer cells. [15104121]
  • Isolation of a human homolog of osteoclast inhibitory lectin that inhibits the formation and function of osteoclasts. [14753741]
  • Genetically linked C-type lectin-related ligands for the NKRP1 family of natural killer cell receptors. [12858173]
  • Cloning of a new lectin-like receptor expressed on human NK cells. [10541800]
UniProt Main References (7 PubMed Identifiers)
  • Characterization of alternatively spliced transcript variants of CLEC2D gene. [20843815]
  • The finished DNA sequence of human chromosome 12. [16541075]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
  • Characterization of sugar binding by osteoclast inhibitory lectin. [15123656]
  • Cutting edge: lectin-like transcript-1 is a ligand for the inhibitory human NKR-P1A receptor. [16339513]
  • Four crystal structures of human LLT1, a ligand of human NKR-P1, in varied glycosylation and oligomerization states. [25760607]
  • Crystal structure of extracellular domain of human lectin-like transcript 1 (LLT1), the ligand for natural killer receptor-P1A. [25826155]
All isoforms of this gene containing a lectin domain
NP_001004419.1, NP_001184246.1, NP_037401.1, NP_001184248.1, NP_001184247.1
RNA
RNA (Transcript ID: NM_013269.6)
NM_013269.6
C-type lectin domain family 2 member D, transcript variant 1
All isoforms of CLEC2D containing a lectin domain
ENST00000290855.11
23..598 (or 9669735.. 9694874)
9669713.. 9699553
NCBI Matured mRNA sequence 5277 NTPDownload 
m7G-5')ppp(5'-ACUCAUAGAAACUGGAGGCAAAAUGCAUGACAGUAACAAUGUGGAGAAAGACAUUACACCAUCUGAAUUGCCUGCAAACCCAGGUUGUCUGCAUUCAAAAGAGCAUUCUAUUAAAGCUACCUUAAUUUGGCGCUUAUUUUUCUUAAUCAUGUUUCUGACAAUCAUAGUGUGUGGAAUGGUUGCUGCUUUAAGCGCAAUAAGAGCUAACUGCCAUCAAGAGCCAUCAGUAUGUCUUCAAGCUGCAUGCCCAGAAAGCUGGAUUGGUUUUCAAAGAAAGUGUUUCUAUUUUUCUGAUGACACCAAGAACUGGACAUCAAGUCAGAGGUUUUGUGACUCACAAGAUGCUGAUCUUGCUCAGGUUGAAAGCUUCCAGGAACUGAAUUUCCUGUUGAGAUAUAAAGGCCCAUCUGAUCACUGGAUUGGGCUGAGCAGAGAACAAGGCCAACCAUGGAAAUGGAUAAAUGGUACUGAAUGGACAAGACAGUUUCCUAUCCUGGGAGCAGGAGAGUGUGCCUAUUUGAAUGACAAAGGUGCCAGUAGUGCCAGGCACUACACAGAGAGGAAGUGGAUUUGUUCCAAAUCAGAUAUACAUGUCUAGAUGUUACAGCAAAGCCCCAACUAAUCUUUAGAAGCAUAUUGGAACUGAUAACUCCAUUUUAAAAUGAGCAAAGAAUUUAUUUCUUAUACCAACAGGUAUAUGAAAAUAUGCUCAAUAUCACUAAUAACUGGGAAAAUACAAAUCAAAAUCAUAGUAAAAUAUUACCUGUUUUCAUGGUGCUAAUAUUACCUGUUCUCCCACUGCUAAUGACAUACCCGAGACUGAGUAAUUUAUAAAUAAAAGAGAUUUAAUUGACUCAUAGUUCCACAUGGCUGGGGAGGUCUUGCAAUCAUGACAGAAGGCAAAUGGGAAGCAAAGUCAUGUCUUAUGUGGUGGCAGGCAGGGGGACUUGUGCACAGGAACUCCUAUUUAUACAACCAUCAGAUAUCUUGAGACAAGAACAGUAUGGGGCUCCCUGGUGUGAUUCCGUCCUGCGCGGCUGUUCUCUGGAGCAGCAUUCAUUUAUCUUCGUCUGCCUUGUCUCCUACCUAAGUGUGUGUCGCCACCCGAUGGAAGAUUCGAUGGACAUGGACAUGAGCCCCCUGAGGCCCCAGAACUAUCUUUUCAGUUGUGAACUAAAGGCCGACAAAGAUGAUCACUUUAAGGUGGAUAAUGAUGAAAAUGAGACCAGUUAUCUUUAAGAACGGUCAGCUCAGGGGCUGGUGCAAAGGAUGAACUGCACAUUGUUGAAGCAGAGGCCAUGAAUGACGAAGGCAGUCCAAUUAAAGUAACACUGGCAACUUUGAAAAUGUCUGUACAGCCAACGGUUUCUCUUGGGGGCUUUGAAAUAACACCACCAGUGGACUUAAGGUUGAAGUGUGGUUCAGGGCCAGUGCAUAUUAGUGGACAGCACUUAGUAGCUGUGAAGGAAGGUGCAGAGUCAGAAGAUGAAGAAGAGGAGGAUGUGAAACUCUUAAGUAUAUCUGGAAAGCAGUCUGCCCCUGGAGGUGGGCAGAAAAAAGUAAAACUUGCUGCUGCUGCUGAUGAUGAUGAUGAUGAAGAUGAUGAUGAUGAUGAUGACGAGGAAGCUGAAGAAAAAGCGCCAGUGAAGAAAUCUAUACGAGAUACUCCAGCCAAAAAUGCACAAAAGUCAAAUCAGAAUGGAAAAGACUCAAAACCAUCAUCAACACCAAGAUCAAAAGGACAAGAAUCCUUCAAAAAACAGGAAAAAUCUCCUAAAACACCAAAAGGAUCUAGUUCUGUAGAAGACAUUAAAGCAAAAAUGCAAGCAAGUAUAGAAAAACGUGGUUCUCUUCCCAAAGUGGAAACCAAGUUCAUCAAUUAUGUGAAGAAUUUCUUCUGGAUGACUGACCAAGAGGCUAUUCAAGAUCUCUGGCAGUGGAGGAAGUCUCUUUAAGAAAAUAGUUUAAACAAUUUGUUAAAAAUUUUCCAUCUUAUUUCAUUUCUGUAACAGUUGAUAUCUGGCUGUCCUUUUUAUAGUGCAGAGUGAGAACUUUCCCUACCAUGUUUGAUAAAUGUUGUCCAGGUUCUAUUGCCAAGAAUGUGUUGUCCAAAAUGCCUGUUUAGUUUUUAAAGAUGGAACUCCACCCUUUGCUUGGUUUUAAGUAUGUAUGGGAUGCUAUGAUAGGACAUAGUAGUAGCAGUGGUCAGACAUGGAAAUGGUGGGGAGACAAAAGUAUACACGUGAAAUAAAACUCAGUAUUUUAAUAAAGUAAAAAAAAAAAAAAAGGUAUGGGGAAAACUGCCCCCAUAAAGCAAUUGUCUCCACCUGGCCCUGCCCUUUGCAUGUGGAGAUUAUUACAAUUCAAGGUGAAAUUUGGGUGGAGACACAACCAAACCAUAUCAGAUGGCUAUAUCAAAAAGACAAGAAAUAACAAGCAUUGGUGAGAGUGUGGAGAAGACGGAACCCUUGUACACAGUUGGUGGGAACACAGUUUGGUGCAGCCAUUAUAGAAAACGUCAUGGAGGUUCCUAAAGAAAUUAAAAAGAGAACUACCAUAUGAGCCAGCAAUCCCUUUUCCAGAUAUACACCCAAAGGAAAUGAAAUCACCACCUCAUAAAGAUAUCUGCUUUCCUGUUUAUUAUAACACAUCUUUAUUCAUAAUAGCCAAGAUACGGAACUAACUGAAGUGACCAUUAACAGAUGAAUGGAUAAAGAAAUUGUCAUAUAUAUAAAACACACACAUUAUAUACAUACAUACAUAUAUAUAUAUAUAUAAAAAAUAGAAUAUUAUUCAGCCUUGUAAAAAGAAAUCCUGUUAUGUUGGGAACAAGCCCCCCAAAAUCUGGCCAUAAACUCACCCCAAAACUGGCCAUAAACAAAAUCUCUGCAGCACUGUGACAUGUUAGUGAUGGCCAUAACACCCACGCUGGAAGGUUGUGGGUUUAUGGGAAUGAGGGCAAGGAACACCUGGCCUGCCCAGGGUGGAAAACCACUUAAAGGCGUUCUUAAGCUACAAACAAUAGCAUGAGCGAUCUGUGCCUUAAGGACAUGUUCCUGCUGCAGUUAACUAGCCCAAUCUAUUCCUUUAAUUCGGCCCAUCCCUUCAUUUCCCAUAAGGGAUACUUUUAGUUAAUUUAAUAUCUAUAGAAACAAUGCUAAUGACUGGCUUGCUGUUAAUAAAUACAUGGGUAAAUCUCUGUUCUGGGCUCUCAGCUCUGAAGGCUGUGAGACCCCUGAUUUCCCACUUCACACCUCUAUAUUUCUGUGUGUGUGUCUUUAGUUCCUCUGGCGCUGCUGGGUUAGGAUCUACCCGACUGAGCUGGUCUCAGCACUGUUAUUUGAAACAAUGUAAAUAAACCUAUAGGGUUUAUUAUAUAUACUAAGUGAAAUAAGCCAGACACAGAAAAAAAAUGUUGCAUGAUCUCACUUAUAGUGAAACUUAAAAAAAAAACCCAAAUACAUAGAAAUAGAGUAGAAUGGUGGUUACCAGAGAUGAGGAAAAUACAGAGACACAGGUCAAAAGAUACAGAGUUGCAGUUACAAAGGGUGAGUAUGUCUAGAUAUCUAACAUACAGUAUGAGGACUAUAAUAGUAUUGCACUGUGUACUGAAAACUUGAUGACAGAUUUUAGAUAUUCUUACCACACAGACAAAAAGAAAUGUAAGUAUGUGAGAUGAAGCUUAUGUUAAUUAGAUUAAGUGUAUGUACAUAAAAACAUCACAUUAUACACAUCAAAUAUAUACAAUAAAAAAGCACAUUGGGAGAUACAUGAUAAAUUUCUAUCUGCAGUUGCUAUUUGCAUUUUUAAAGGAUAUUUUUAUUUUUUAAAUUUUUAGCUGACAACUGUAUAAUUAUGGAAUACAAUGUGAUGUUCUGAUAUAUGUGUACACUAUGGAAUGAUUAAAUCAAACUAACAUUUCAUCAUCUCACAUACUUAUCAUUUUCUGUGGUGAGAACAUUUGAAAUUUAUUCUCUUGACAAUUUUGAAAGAUCCAAUACACUAUUAUUAACUAUAGUCACUAUGCUGUGCAAUAGAUCUCAAAAGCUUAUUCCUCUUAACUGAAACCUACUACCCUGUGACAUGUGGGGAACAUCUCUCUAUUCCCCAGCCCCAGUCCCUAAAUGUUGAAUACACAAUGGGGAAAAAAUAGUCUUCAAUGAAUGGUGGUGGGAAAAUUGUAUAUCCACAUGCAGAAGAAUAAAAUUGGACCCUUACCUCCUACCAUAUAUAAAAACCAACUGAAAAUCGAUUAAAGACUUAAACUGUAAAACUACUAAAAGAAAAUAUAGGGAGAAAGCUUCACAACGUUGGUCUGGGCAAUAAUUUUUGGAUUUGACCUCAAAAGUAGAUGCAACCACAGUGAAAAUAAACAAAUGAAAUUGCAUAAAAUAAAAAAUGUUUCUGCACAGCAAAGGAAAUAAUUAAUGGAGUAAAGAGACAACUUACAGAUUGGGAGAAUAUAUUUCCAAACUAUUGUUGGGGCUCAGAAACGGAUACCCUAACAUAUAGUGAUUUGACAGGUGGAACUAAAGAAGACUCGAGGUCUCUCUGACCUCCUCCUCAACCUCUGUUUCUUAAUCCUCUGUUUUCCCAGAGCACAGGAGGAAGUUCUCUGAAGUUCCUUUAUCUGCUUUAAGUUCAGACUCACCAAAUAAGAAAACAGUUAAUUCUGGUGCCUUCCAUGGGUUUUCAUUAACUGAAGUCAUAUUGUAGGAAAAAGAAUGAAGUCUCUUAACCCACCUGGAUAGAUUUUUCUCACAAACCAUUGUCUUCUCUGCAAGCCCAGUAGACUUUGUCCCAGGCCAUUUAUGUGAUCUUCACCCCAUUAAGUUCUCCCCAAAUUAUUUACUCUUCCCCCAAAAUCACCCACACUUCCCCAUCUCCCUCUCCCCUAAGGACAAGGGUAUAUCACCAUCUAUACCCCAUUGCUUGGUGGGGUGAUCACUCUGAUUCUCUGCAUGCAUUUUUAUAGAUUUGUUUGCCAUUUAUCCUAUUAAUCUGCAUUCUGUCAAUUGUGGCAAGUUAUCAGCAUAUUUUUUAACUUUUAAUUAUUCUUAAUGGAAAGACACUUCUGUAUACACUGGAAAUCUCAGGAAAUUUCUUUUUUCCUUAAGCUUAAUUGAAAUGUUUACUUUUCAGUAAAAUUUCAAGCUUGAGUAAUGUUCAUGCCUGCUUUUCAUUGAAAUAGAAUGAAAAGGUUGCACAAUAUUAUUUUCAUGAAAUUACUUCUAGUAUAAUUCUGAAUAAACACUUUGAAAGGCAGUGAACUGUAAA-3'- Poly-A tail
  • Coding region
mRNA-related data
DNA
DNA (Gene ID: 29121)
CLEC2D
C-type lectin domain family 2 member D
NC_000012.12
12  9669735.. 9694874
9669735.. 9694874
strand +
CCDS8602.1
MGI:1918059;MGI:2135589;MGI:2136650;MGI:2136934;MGI:3028921;MGI:3522133
ClinVar, dbVar
ENSG00000069493
LLT1, CLAX, OCIL
uc001qwg.4
INSDC: AF133299
14351
605659
OTTHUMG00000168369
ENA, DDBJ, Monarch
Gene-related data
NCBI CDS gene sequence (576 bp)
5'-ATGCATGACAGTAACAATGTGGAGAAAGACATTACACCATCTGAATTGCCTGCAAACCCAGGTTGTCTGCATTCAAAAGAGCATTCTATTAAAGCTACCTTAATTTGGCGCTTATTTTTCTTAATCATGTTTCTGACAATCATAGTGTGTGGAATGGTTGCTGCTTTAAGCGCAATAAGAGCTAACTGCCATCAAGAGCCATCAGTATGTCTTCAAGCTGCATGCCCAGAAAGCTGGATTGGTTTTCAAAGAAAGTGTTTCTATTTTTCTGATGACACCAAGAACTGGACATCAAGTCAGAGGTTTTGTGACTCACAAGATGCTGATCTTGCTCAGGTTGAAAGCTTCCAGGAACTGAATTTCCTGTTGAGATATAAAGGCCCATCTGATCACTGGATTGGGCTGAGCAGAGAACAAGGCCAACCATGGAAATGGATAAATGGTACTGAATGGACAAGACAGTTTCCTATCCTGGGAGCAGGAGAGTGTGCCTATTTGAATGACAAAGGTGCCAGTAGTGCCAGGCACTACACAGAGAGGAAGTGGATTTGTTCCAAATCAGATATACATGTCTAG-3'
NCBI CDS gene sequence with introns (location: 9669735.. 9694874) (25140 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 9669713.. 9699553) (29841 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [9669713 - 1000].. 9699553) (30841 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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