HumanLectome - Human Lectin Entry

NCBI Summary

This gene encodes a member of the polycystin protein family. The encoded glycoprotein contains a large N-terminal extracellular region, multiple transmembrane domains and a cytoplasmic C-tail. It is an integral membrane protein that functions as a regulator of calcium permeable cation channels and intracellular calcium homoeostasis. It is also involved in cell-cell/matrix interactions and may modulate G-protein-coupled signal-transduction pathways. It plays a role in renal tubular development, and mutations in this gene cause autosomal dominant polycystic kidney disease type 1 (ADPKD1). ADPKD1 is characterized by the growth of fluid-filled cysts that replace normal renal tissue and result in end-stage renal failure. Splice variants encoding different isoforms have been noted for this gene. Also, six pseudogenes, closely linked in a known duplicated region on chromosome 16p, have been described. [provided by RefSeq, Oct 2008].

Protein

Protein (NP_001009944)

Protein name

Polycystin 1

Synonym(s)

Polycystin-1 (PC1) (Autosomal dominant polycystic kidney disease 1 protein)

HGNC gene name

PKD1

HGNC name

polycystin 1, transient receptor potential channel interacting

Protein_CD_name

Undefined

Lectin confidence

Very low evidence

UniLectin class

C-type lectin

C-type classification

Undefined

Known lectin group

C-type - Polycysti

Lectin fold

a/b mixed / C-type lectin-like

Glycan specificity

Uncharacterised

RefSeq accession

Gene ID

UniProt accession

Ensembl protein ID

UniRef cluster ID

LectomeXplore score

0.34

Reference

10.1007/s00894-007-0201-z

Other links

PFAM, InterPro, CPX-4001

Protein sequence and protein families (fasta) (4303 amino acids) Download

MPPAAPARLALALGLGLWLGALAGGPGRGCGPCEPPCLCGPAPGAACRVNCSGRGLRTLGPALRIPADATALDVSHNLLRALDVGLLANLSALAELDISNNKISTLEEGIFANLFNLSEINLSGNPFECDCGLAWLPRWAEEQQVRVVQPEAATCAGPGSLAGQPLLGIPLLDSGCGEEYVACLPDNSSGTVAAVSFSAAHEGLLQPEACSAFCFSTGQGLAALSEQGWCLCGAAQPSSASFACLSLCSGPPPPPAPTCRGPTLLQHVFPASPGATLVGPHGPLASGQLAAFHIAAPLPVTATRWDFGDGSAEVDAAGPAASHRYVLPGRYHVTAVLALGAGSALLGTDVQVEAAPAALELVCPSSVQSDESLDLSIQNRGGSGLEAAYSIVALGEEPARAVHPLCPSDTEIFPGNGHCYRLVVEKAAWLQAQEQCQAWAGAALAMVDSPAVQRFLVSRVTRSLDVWIGFSTVQGVEVGPAPQGEAFSLESCQNWLPGEPHPATAEHCVRLGPTGWCNTDLCSAPHSYVCELQPGGPVQDAENLLVGAPSGDLQGPLTPLAQQDGLSAPHEPVEVMVFPGLRLSREAFLTTAEFGTQELRRPAQLRLQVYRLLSTAGTPENGSEPESRSPDNRTQLAPACMPGGRWCPGANICLPLDASCHPQACANGCTSGPGLPGAPYALWREFLFSVPAGPPAQYSVTLHGQDVLMLPGDLVGLQHDAGPGALLHCSPAPGHPGPRAPYLSANASSWLPHLPAQLEGTWACPACALRLLAATEQLTVLLGLRPNPGLRLPGRYEVRAEVGNGVSRHNLSCSFDVVSPVAGLRVIYPAPRDGRLYVPTNGSALVLQVDSGANATATARWPGGSVSARFENVCPALVATFVPGCPWETNDTLFSVVALPWLSEGEHVVDVVVENSASRANLSLRVTAEEPICGLRATPSPEARVLQGVLVRYSPVVEAGSDMVFRWTINDKQSLTFQNVVFNVIYQSAAVFKLSLTASNHVSNVTVNYNVTVERMNRMQGLQVSTVPAVLSPNATLALTAGVLVDSAVEVAFLWTFGDGEQALHQFQPPYNESFPVPDPSVAQVLVEHNVMHTYAAPGEYLLTVLASNAFENLTQQVPVSVRASLPSVAVGVSDGVLVAGRPVTFYPHPLPSPGGVLYTWDFGDGSPVLTQSQPAANHTYASRGTYHVRLEVNNTVSGAAAQADVRVFEELRGLSVDMSLAVEQGAPVVVSAAVQTGDNITWTFDMGDGTVLSGPEATVEHVYLRAQNCTVTVGAASPAGHLARSLHVLVFVLEVLRVEPAACIPTQPDARLTAYVTGNPAHYLFDWTFGDGSSNTTVRGCPTVTHNFTRSGTFPLALVLSSRVNRAHYFTSICVEPEVGNVTLQPERQFVQLGDEAWLVACAWPPFPYRYTWDFGTEEAAPTRARGPEVTFIYRDPGSYLVTVTASNNISAANDSALVEVQEPVLVTSIKVNGSLGLELQQPYLFSAVGRGRPASYLWDLGDGGWLEGPEVTHAYNSTGDFTVRVAGWNEVSRSEAWLNVTVKRRVRGLVVNASRTVVPLNGSVSFSTSLEAGSDVRYSWVLCDRCTPIPGGPTISYTFRSVGTFNIIVTAENEVGSAQDSIFVYVLQLIEGLQVVGGGRYFPTNHTVQLQAVVRDGTNVSYSWTAWRDRGPALAGSGKGFSLTVLEAGTYHVQLRATNMLGSAWADCTMDFVEPVGWLMVAASPNPAAVNTSVTLSAELAGGSGVVYTWSLEEGLSWETSEPFTTHSFPTPGLHLVTMTAGNPLGSANATVEVDVQVPVSGLSIRASEPGGSFVAAGSSVPFWGQLATGTNVSWCWAVPGGSSKRGPHVTMVFPDAGTFSIRLNASNAVSWVSATYNLTAEEPIVGLVLWASSKVVAPGQLVHFQILLAAGSAVTFRLQVGGANPEVLPGPRFSHSFPRVGDHVVSVRGKNHVSWAQAQVRIVVLEAVSGLQVPNCCEPGIATGTERNFTARVQRGSRVAYAWYFSLQKVQGDSLVILSGRDVTYTPVAAGLLEIQVRAFNALGSENRTLVLEVQDAVQYVALQSGPCFTNRSAQFEAATSPSPRRVAYHWDFGDGSPGQDTDEPRAEHSYLRPGDYRVQVNASNLVSFFVAQATVTVQVLACREPEVDVVLPLQVLMRRSQRNYLEAHVDLRDCVTYQTEYRWEVYRTASCQRPGRPARVALPGVDVSRPRLVLPRLALPVGHYCFVFVVSFGDTPLTQSIQANVTVAPERLVPIIEGGSYRVWSDTRDLVLDGSESYDPNLEDGDQTPLSFHWACVASTQREAGGCALNFGPRGSSTVTIPRERLAAGVEYTFSLTVWKAGRKEEATNQTVLIRSGRVPIVSLECVSCKAQAVYEVSRSSYVYLEGRCLNCSSGSKRGRWAARTFSNKTLVLDETTTSTGSAGMRLVLRRGVLRDGEGYTFTLTVLGRSGEEEGCASIRLSPNRPPLGGSCRLFPLGAVHALTTKVHFECTGWHDAEDAGAPLVYALLLRRCRQGHCEEFCVYKGSLSSYGAVLPPGFRPHFEVGLAVVVQDQLGAAVVALNRSLAITLPEPNGSATGLTVWLHGLTASVLPGLLRQADPQHVIEYSLALVTVLNEYERALDVAAEPKHERQHRAQIRKNITETLVSLRVHTVDDIQQIAAALAQCMGPSRELVCRSCLKQTLHKLEAMMLILQAETTAGTVTPTAIGDSILNITGDLIHLASSDVRAPQPSELGAESPSRMVASQAYNLTSALMRILMRSRVLNEEPLTLAGEEIVAQGKRSDPRSLLCYGGAPGPGCHFSIPEAFSGALANLSDVVQLIFLVDSNPFPFGYISNYTVSTKVASMAFQTQAGAQIPIERLASERAITVKVPNNSDWAARGHRSSANSANSVVVQPQASVGAVVTLDSSNPAAGLHLQLNYTLLDGHYLSEEPEPYLAVYLHSEPRPNEHNCSASRRIRPESLQGADHRPYTFFISPGSRDPAGSYHLNLSSHFRWSALQVSVGLYTSLCQYFSEEDMVWRTEGLLPLEETSPRQAVCLTRHLTAFGASLFVPPSHVRFVFPEPTADVNYIVMLTCAVCLVTYMVMAAILHKLDQLDASRGRAIPFCGQRGRFKYEILVKTGWGRGSGTTAHVGIMLYGVDSRSGHRHLDGDRAFHRNSLDIFRIATPHSLGSVWKIRVWHDNKGLSPAWFLQHVIVRDLQTARSAFFLVNDWLSVETEANGGLVEKEVLAASDAALLRFRRLLVAELQRGFFDKHIWLSIWDRPPRSRFTRIQRATCCVLLICLFLGANAVWYGAVGDSAYSTGHVSRLSPLSVDTVAVGLVSSVVVYPVYLAILFLFRMSRSKVAGSPSPTPAGQQVLDIDSCLDSSVLDSSFLTFSGLHAEQAFVGQMKSDLFLDDSKSLVCWPSGEGTLSWPDLLSDPSIVGSNLRQLARGQAGHGLGPEEDGFSLASPYSPAKSFSASDEDLIQQVLAEGVSSPAPTQDTHMETDLLSSLSSTPGEKTETLALQRLGELGPPSPGLNWEQPQAARLSRTGLVEGLRKRLLPAWCASLAHGLSLLLVAVAVAVSGWVGASFPPGVSVAWLLSSSASFLASFLGWEPLKVLLEALYFSLVAKRLHPDEDDTLVESPAVTPVSARVPRVRPPHGFALFLAKEEARKVKRLHGMLRSLLVYMLFLLVTLLASYGDASCHGHAYRLQSAIKQELHSRAFLAITRSEELWPWMAHVLLPYVHGNQSSPELGPPRLRQVRLQEALYPDPPGPRVHTCSAAGGFSTSDYDVGWESPHNGSGTWAYSAPDLLGAWSWGSCAVYDSGGYVQELGLSLEESRDRLRFLQLHNWLDNRSRAVFLELTRYSPAVGLHAAVTLRLEFPAAGRALAALSVRPFALRRLSAGLSLPLLTSVCLLLFAVHFAVAEARTWHREGRWRVLRLGAWARWLLVALTAATALVRLAQLGAADRQWTRFVRGRPRRFTSFDQVAQLSSAARGLAASLLFLLLVKAAQQLRFVRQWSVFGKTLCRALPELLGVTLGLVVLGVAYAQLAILLVSSCVDSLWSVAQALLVLCPGTGLSTLCPAESWHLSPLLCVGLWALRLWGALRLGAVILRWRYHALRGELYRPAWEPQDYEMVELFLRRLRLWMGLSKVKEFRHKVRFEGMEPLPSRSSRGSKVSPDVPPPSAGSDASHPSTSSSQLDGLSVSLGRLGTRCEPEPSRLQAVFEALLTQFDRLNQATEDVYQLEQQLHSLQGRRSSRAPAGSSRGPSPGLRPALPSRLARASRGVDLATGPSRTPLRAKNKVHPSST

Mol* PDB structure viewer

Select a PDB entry:

Structural models

No AlphaFold model available for P98161.

SWISS-MODEL structural models

SWISS-MODEL structural model

Modeller structural model (Homology modelling pipeline), Error: [1.57, 2.03] Å Download

The location of the lectin domain structural model is: 394-536
We infer [1.57, 2.03] Å as the interval of error of this structural model.
Template 1: 6JJJ chain: A, P70194, NP_058031.2, sequence identity: 27.3%, coverage: 93.7%, location in sequence: 393-543, (393-543 in PDB).
Template 2: 5VYB chain: A, Q6EIG7, NP_001007034.1, sequence identity: 23.8%, coverage: 97.2%, location in sequence: 63-209, (63-209 in PDB).
Template 3: 3ZHG chain: A, Q8CJ91, NP_081248.4, sequence identity: 22.4%, coverage: 91.6%, location in sequence: 191-322, (191-322 in PDB).
Show the alignment used for the construction of the structural model, Download.
Show the plot of DOPE energy score, Download.

Oligomerization and Known Interactions

Component of the heterotetrameric polycystin channel complex with PKD2; the tetramer contains one PKD1 chain and three PKD2 chains (PubMed:30093605). Interacts with PKD2; the interaction is required for ciliary localization (PubMed:20881056). Interacts with PKD2L1 (By similarity). Interacts with PRKX; involved in differentiation and controlled morphogenesis of the kidney (PubMed:17980165). Interacts (via extracellular domain) with WNT3A, WNT4, WNT5A and WNT9B (PubMed:27214281). Interacts with DVL1 and DVL2 (PubMed:27214281). Interacts with NPHP1 (via SH3 domain) (PubMed:20856870). Interacts with BBS1, BBS4, BBS5 and TTC8 (PubMed:24939912). Interacts with RGS7 (PubMed:10339594). Interacts (via the PKD repeats in the N-terminal extracellular region) with EPCIP; the interaction is not dependent on N-glycosylation of either protein (PubMed:37681898)

Annotation

Ligand

Glycan ligands from structural data

No crystal structures of complexes with glycan ligand.

Expression

Human Protein Atlas

GeneCards

Functionality temporarily unavailable.

ProteomicsDB

References

NCBI References (10 PubMed Identifiers)

PKD1-Associated Arachnoid Cysts in Autosomal Dominant Polycystic Kidney Disease. [34175641]

Polycystin-1 Enhances Stemmness Potential of Umbilical Cord Blood-Derived Mesenchymal Stem Cells. [34064452]

Cross Talk Between Renal Transporters and Polycystin-1 as a Potential Molecular Target Involved in Autosomal Dominant Polycystic Kidney Disease. [33994377]

Polycystin-1 modulates RUNX2 activation and osteocalcin gene expression via ERK signalling in a human craniosynostosis cell model. [33656806]

A novel nonsense mutation in the PKD1 gene (C3817T) is associated with autosomal dominant polycystic kidney disease (ADPKD) in a large three-generation Italian family. [7581371]

The polycystic kidney disease 1 (PKD1) gene encodes a novel protein with multiple cell recognition domains. [7663510]

Analysis of the genomic sequence for the autosomal dominant polycystic kidney disease (PKD1) gene predicts the presence of a leucine-rich repeat. The American PKD1 Consortium (APKD1 Consortium). [7633406]

Congenital Hepatic Fibrosis Overview [20301743]

Polycystic Kidney Disease, Autosomal Dominant [20301424]

Studies of genetic linkage between adult polycystic kidney disease and three markers on chromosome 16. [2821260]

UniProt Main References (51 PubMed Identifiers)

Polycystic kidney disease: the complete structure of the PKD1 gene and its protein. The International Polycystic Kidney Disease Consortium. [7736581]

The sequence and analysis of duplication-rich human chromosome 16. [15616553]

The polycystic kidney disease 1 gene encodes a 14 kb transcript and lies within a duplicated region on chromosome 16. The European Polycystic Kidney Disease Consortium. [8004675]

The polycystic kidney disease 1 gene encodes a 14 kb transcript and lies within a duplicated region on chromosome 16. The European Polycystic Kidney Disease Consortium. [8069919]

Interaction between RGS7 and polycystin. [10339594]

Cleavage of polycystin-1 requires the receptor for egg jelly domain and is disrupted by human autosomal-dominant polycystic kidney disease 1-associated mutations. [12482949]

Characterization of cis-autoproteolysis of polycystin-1, the product of human polycystic kidney disease 1 gene. [17525154]

Protein kinase X (PRKX) can rescue the effects of polycystic kidney disease-1 gene (PKD1) deficiency. [17980165]

Protein kinase D-mediated phosphorylation of polycystin-2 (TRPP2) is essential for its effects on cell growth and calcium channel activity. [20881056]

Polycystin-1 surface localization is stimulated by polycystin-2 and cleavage at the G protein-coupled receptor proteolytic site. [20980620]

Bardet-Biedl syndrome proteins 1 and 3 regulate the ciliary trafficking of polycystic kidney disease 1 protein. [24939912]

Mutations in GANAB, Encoding the Glucosidase IIalpha Subunit, Cause Autosomal-Dominant Polycystic Kidney and Liver Disease. [27259053]

The polycystin complex mediates Wnt/Ca(2+) signalling. [27214281]

The structure of a PKD domain from polycystin-1: implications for polycystic kidney disease. [9889186]

Structure of the human PKD1-PKD2 complex. [30093605]

Polycystin channels and kidney disease. [11698076]

Screening the 3' region of the polycystic kidney disease 1 (PKD1) gene reveals six novel mutations. [8554072]

Identification of mutations in the duplicated region of the polycystic kidney disease 1 gene (PKD1) by a novel approach. [9199561]

New amino acid polymorphism, Ala/Val4058, in exon 45 of the polycystic kidney disease 1 gene: evolution of alleles. [9150733]

An unusual pattern of mutation in the duplicated portion of PKD1 is revealed by use of a novel strategy for mutation detection. [9285784]

Three novel mutations of the PKD1 gene in Italian families with autosomal dominant polycystic kidney disease. [9259200]

Novel and recurrent mutations in the PKD1 (polycystic kidney disease) gene. [9521593]

Loss of heterozygosity in polycystic kidney disease with a missense mutation in the repeated region of PKD1. [9921908]

Identification of mutations in the repeated part of the autosomal dominant polycystic kidney disease type 1 gene, PKD1, by long-range PCR. [10364515]

Mutation detection of PKD1 identifies a novel mutation common to three families with aneurysms and/or very-early-onset disease. [10577909]

DGGE screening of PKD1 gene reveals novel mutations in a large cohort of 146 unrelated patients. [10987650]

Novel mutations in the 3 region of the polycystic kidney disease 1 (PKD1) gene. [10647901]

Mutational analysis within the 3' region of the PKD1 gene. [10200984]

Novel mutations in the duplicated region of PKD1 gene. [10854095]

Novel mutations in the duplicated region of the polycystic kidney disease 1 (PKD1) gene provides supporting evidence for gene conversion. [11216660]

Screening of the PKD1 duplicated region reveals multiple single nucleotide polymorphisms and a de novo mutation in Hellenic polycystic kidney disease families. [10923040]

Novel splicing and missense mutations in autosomal dominant polycystic kidney disease 1 (PKD1) gene: expression of mutated genes. [11058904]

Thirteen novel mutations of the replicated region of PKD1 in an Asian population. [11012875]

Novel mutations of the PKD1 gene in Korean patients with autosomal dominant polycystic kidney disease. [10729710]

Mutation analysis of the entire PKD1 gene: genetic and diagnostic implications. [11115377]

Novel PKD1 deletions and missense variants in a cohort of Hellenic polycystic kidney disease families. [11571556]

Mutation analysis of the entire replicated portion of PKD1 using genomic DNA samples. [11316854]

Mutations of the PKD1 gene among Japanese autosomal dominant polycystic kidney disease patients, including one heterozygous mutation identified in members of the same family. [11558899]

Mutational analysis within the 3' region of the PKD1 gene in Japanese families. [11691639]

Three novel mutations of the PKD1 gene in Korean patients with autosomal dominant polycystic kidney disease. [12220456]

Mutation detection in the duplicated region of the polycystic kidney disease 1 (PKD1) gene in PKD1-linked Australian families. [11857740]

Mutation analysis in PKD1 of Japanese autosomal dominant polycystic kidney disease patients. [12007219]

Mutation screening of the PKD1 transcript by RT-PCR. [12070253]

A complete mutation screen of the ADPKD genes by DHPLC. [11967008]

Novel mutations of PKD1 gene in Chinese patients with autosomal dominant polycystic kidney disease. [11773467]

Association of mutation position in polycystic kidney disease 1 (PKD1) gene and development of a vascular phenotype. [12842373]

Genetics and phenotypic characteristics of autosomal dominant polycystic kidney disease in Finns. [15772804]

Novel method for genomic analysis of PKD1 and PKD2 mutations in autosomal dominant polycystic kidney disease. [18837007]

Novel PKD1 and PKD2 mutations in autosomal dominant polycystic kidney disease (ADPKD). [21115670]

Autosomal dominant polycystic kidney disease: comprehensive mutation analysis of PKD1 and PKD2 in 700 unrelated patients. [22508176]

All isoforms of this gene containing a lectin domain

XP_024306068.1, NP_001009944.3, NP_000287.4, XP_024306067.1, XP_011520830.1, XP_011520831.1, XP_024306066.1

RNA

RNA (Transcript ID: NM_001009944.3)

RNA RefSeq ID

NM_001009944.3

RNA name

polycystin 1, transient receptor potential channel interacting, transcript variant 1

Isoforms

All isoforms of PKD1 containing a lectin domain

RNA Ensembl ID

ENST00000262304.9

Coding region

210..13121 (or 2089727.. 2135689)

mRNA location

2088708.. 2135898

NCBI Matured mRNA sequence 14140 NTP Download

m⁷G-5')ppp(5'-GCACUGCAGCGCCAGCGUCCGAGCGGGCGGCCGAGCUCCCGGAGCGGCCUGGCCCCGAGCCCCGAGCGGGCGUCGCUCAGCAGCAGGUCGCGGCCGCAGCCCCAUCCAGCCCCGCGCCCGCCAUGCCGUCCGCGGGCCCCGCCUGAGCUGCGGCCUCCGCGCGCGGGCGGGCCUGGGGACGGCGGGGCCAUGCGCGCGCUGCCCUAACGAUGCCGCCCGCCGCGCCCGCCCGCCUGGCGCUGGCCCUGGGCCUGGGCCUGUGGCUCGGGGCGCUGGCGGGGGGCCCCGGGCGCGGCUGCGGGCCCUGCGAGCCCCCCUGCCUCUGCGGCCCAGCGCCCGGCGCCGCCUGCCGCGUCAACUGCUCGGGCCGCGGGCUGCGGACGCUCGGUCCCGCGCUGCGCAUCCCCGCGGACGCCACAGCGCUAGACGUCUCCCACAACCUGCUCCGGGCGCUGGACGUUGGGCUCCUGGCGAACCUCUCGGCGCUGGCAGAGCUGGAUAUAAGCAACAACAAGAUUUCUACGUUAGAAGAAGGAAUAUUUGCUAAUUUAUUUAAUUUAAGUGAAAUAAACCUGAGUGGGAACCCGUUUGAGUGUGACUGUGGCCUGGCGUGGCUGCCGCGAUGGGCGGAGGAGCAGCAGGUGCGGGUGGUGCAGCCCGAGGCAGCCACGUGUGCUGGGCCUGGCUCCCUGGCUGGCCAGCCUCUGCUUGGCAUCCCCUUGCUGGACAGUGGCUGUGGUGAGGAGUAUGUCGCCUGCCUCCCUGACAACAGCUCAGGCACCGUGGCAGCAGUGUCCUUUUCAGCUGCCCACGAAGGCCUGCUUCAGCCAGAGGCCUGCAGCGCCUUCUGCUUCUCCACCGGCCAGGGCCUCGCAGCCCUCUCGGAGCAGGGCUGGUGCCUGUGUGGGGCGGCCCAGCCCUCCAGUGCCUCCUUUGCCUGCCUGUCCCUCUGCUCCGGCCCCCCGCCACCUCCUGCCCCCACCUGUAGGGGCCCCACCCUCCUCCAGCACGUCUUCCCUGCCUCCCCAGGGGCCACCCUGGUGGGGCCCCACGGACCUCUGGCCUCUGGCCAGCUAGCAGCCUUCCACAUCGCUGCCCCGCUCCCUGUCACUGCCACACGCUGGGACUUCGGAGACGGCUCCGCCGAGGUGGAUGCCGCUGGGCCGGCUGCCUCGCAUCGCUAUGUGCUGCCUGGGCGCUAUCACGUGACGGCCGUGCUGGCCCUGGGGGCCGGCUCAGCCCUGCUGGGGACAGACGUGCAGGUGGAAGCGGCACCUGCCGCCCUGGAGCUCGUGUGCCCGUCCUCGGUGCAGAGUGACGAGAGCCUCGACCUCAGCAUCCAGAACCGCGGUGGUUCAGGCCUGGAGGCCGCCUACAGCAUCGUGGCCCUGGGCGAGGAGCCGGCCCGAGCGGUGCACCCGCUCUGCCCCUCGGACACGGAGAUCUUCCCUGGCAACGGGCACUGCUACCGCCUGGUGGUGGAGAAGGCGGCCUGGCUGCAGGCGCAGGAGCAGUGUCAGGCCUGGGCCGGGGCCGCCCUGGCAAUGGUGGACAGUCCCGCCGUGCAGCGCUUCCUGGUCUCCCGGGUCACCAGGAGCCUAGACGUGUGGAUCGGCUUCUCGACUGUGCAGGGGGUGGAGGUGGGCCCAGCGCCGCAGGGCGAGGCCUUCAGCCUGGAGAGCUGCCAGAACUGGCUGCCCGGGGAGCCACACCCAGCCACAGCCGAGCACUGCGUCCGGCUCGGGCCCACCGGGUGGUGUAACACCGACCUGUGCUCAGCGCCGCACAGCUACGUCUGCGAGCUGCAGCCCGGAGGCCCAGUGCAGGAUGCCGAGAACCUCCUCGUGGGAGCGCCCAGUGGGGACCUGCAGGGACCCCUGACGCCUCUGGCACAGCAGGACGGCCUCUCAGCCCCGCACGAGCCCGUGGAGGUCAUGGUAUUCCCGGGCCUGCGUCUGAGCCGUGAAGCCUUCCUCACCACGGCCGAAUUUGGGACCCAGGAGCUCCGGCGGCCCGCCCAGCUGCGGCUGCAGGUGUACCGGCUCCUCAGCACAGCAGGGACCCCGGAGAACGGCAGCGAGCCUGAGAGCAGGUCCCCGGACAACAGGACCCAGCUGGCCCCCGCGUGCAUGCCAGGGGGACGCUGGUGCCCUGGAGCCAACAUCUGCUUGCCGCUGGACGCCUCCUGCCACCCCCAGGCCUGCGCCAAUGGCUGCACGUCAGGGCCAGGGCUACCCGGGGCCCCCUAUGCGCUAUGGAGAGAGUUCCUCUUCUCCGUUCCCGCGGGGCCCCCCGCGCAGUACUCGGUCACCCUCCACGGCCAGGAUGUCCUCAUGCUCCCUGGUGACCUCGUUGGCUUGCAGCACGACGCUGGCCCUGGCGCCCUCCUGCACUGCUCGCCGGCUCCCGGCCACCCUGGUCCCCGGGCCCCGUACCUCUCCGCCAACGCCUCGUCAUGGCUGCCCCACUUGCCAGCCCAGCUGGAGGGCACUUGGGCCUGCCCUGCCUGUGCCCUGCGGCUGCUUGCAGCCACGGAACAGCUCACCGUGCUGCUGGGCUUGAGGCCCAACCCUGGACUGCGGCUGCCUGGGCGCUAUGAGGUCCGGGCAGAGGUGGGCAAUGGCGUGUCCAGGCACAACCUCUCCUGCAGCUUUGACGUGGUCUCCCCAGUGGCUGGGCUGCGGGUCAUCUACCCUGCCCCCCGCGACGGCCGCCUCUACGUGCCCACCAACGGCUCAGCCUUGGUGCUCCAGGUGGACUCUGGUGCCAACGCCACGGCCACGGCUCGCUGGCCUGGGGGCAGUGUCAGCGCCCGCUUUGAGAAUGUCUGCCCUGCCCUGGUGGCCACCUUCGUGCCCGGCUGCCCCUGGGAGACCAACGAUACCCUGUUCUCAGUGGUAGCACUGCCGUGGCUCAGUGAGGGGGAGCACGUGGUGGACGUGGUGGUGGAAAACAGCGCCAGCCGGGCCAACCUCAGCCUGCGGGUGACGGCGGAGGAGCCCAUCUGUGGCCUCCGCGCCACGCCCAGCCCCGAGGCCCGUGUACUGCAGGGAGUCCUAGUGAGGUACAGCCCCGUGGUGGAGGCCGGCUCGGACAUGGUCUUCCGGUGGACCAUCAACGACAAGCAGUCCCUGACCUUCCAGAACGUGGUCUUCAAUGUCAUUUAUCAGAGCGCGGCGGUCUUCAAGCUCUCACUGACGGCCUCCAACCACGUGAGCAACGUCACCGUGAACUACAACGUAACCGUGGAGCGGAUGAACAGGAUGCAGGGUCUGCAGGUCUCCACAGUGCCGGCCGUGCUGUCCCCCAAUGCCACGCUAGCACUGACGGCGGGCGUGCUGGUGGACUCGGCCGUGGAGGUGGCCUUCCUGUGGACCUUUGGGGAUGGGGAGCAGGCCCUCCACCAGUUCCAGCCUCCGUACAACGAGUCCUUCCCGGUUCCAGACCCCUCGGUGGCCCAGGUGCUGGUGGAGCACAAUGUCAUGCACACCUACGCUGCCCCAGGUGAGUACCUCCUGACCGUGCUGGCAUCUAAUGCCUUCGAGAACCUGACGCAGCAGGUGCCUGUGAGCGUGCGCGCCUCCCUGCCCUCCGUGGCUGUGGGUGUGAGUGACGGCGUCCUGGUGGCCGGCCGGCCCGUCACCUUCUACCCGCACCCGCUGCCCUCGCCUGGGGGUGUUCUUUACACGUGGGACUUCGGGGACGGCUCCCCUGUCCUGACCCAGAGCCAGCCGGCUGCCAACCACACCUAUGCCUCGAGGGGCACCUACCACGUGCGCCUGGAGGUCAACAACACGGUGAGCGGUGCGGCGGCCCAGGCGGAUGUGCGCGUCUUUGAGGAGCUCCGCGGACUCAGCGUGGACAUGAGCCUGGCCGUGGAGCAGGGCGCCCCCGUGGUGGUCAGCGCCGCGGUGCAGACGGGCGACAACAUCACGUGGACCUUCGACAUGGGGGACGGCACCGUGCUGUCGGGCCCGGAGGCAACAGUGGAGCAUGUGUACCUGCGGGCACAGAACUGCACAGUGACCGUGGGUGCGGCCAGCCCCGCCGGCCACCUGGCCCGGAGCCUGCACGUGCUGGUCUUCGUCCUGGAGGUGCUGCGCGUUGAACCCGCCGCCUGCAUCCCCACGCAGCCUGACGCGCGGCUCACGGCCUACGUCACCGGGAACCCGGCCCACUACCUCUUCGACUGGACCUUCGGGGAUGGCUCCUCCAACACGACCGUGCGGGGGUGCCCGACGGUGACACACAACUUCACGCGGAGCGGCACGUUCCCCCUGGCGCUGGUGCUGUCCAGCCGCGUGAACAGGGCGCAUUACUUCACCAGCAUCUGCGUGGAGCCAGAGGUGGGCAACGUCACCCUGCAGCCAGAGAGGCAGUUUGUGCAGCUCGGGGACGAGGCCUGGCUGGUGGCAUGUGCCUGGCCCCCGUUCCCCUACCGCUACACCUGGGACUUUGGCACCGAGGAAGCCGCCCCCACCCGUGCCAGGGGCCCUGAGGUGACGUUCAUCUACCGAGACCCAGGCUCCUAUCUUGUGACAGUCACCGCGUCCAACAACAUCUCUGCUGCCAAUGACUCAGCCCUGGUGGAGGUGCAGGAGCCCGUGCUGGUCACCAGCAUCAAGGUCAAUGGCUCCCUUGGGCUGGAGCUGCAGCAGCCGUACCUGUUCUCUGCUGUGGGCCGUGGGCGCCCCGCCAGCUACCUGUGGGAUCUGGGGGACGGUGGGUGGCUCGAGGGUCCGGAGGUCACCCACGCUUACAACAGCACAGGUGACUUCACCGUUAGGGUGGCCGGCUGGAAUGAGGUGAGCCGCAGCGAGGCCUGGCUCAAUGUGACGGUGAAGCGGCGCGUGCGGGGGCUCGUCGUCAAUGCAAGCCGCACGGUGGUGCCCCUGAAUGGGAGCGUGAGCUUCAGCACGUCGCUGGAGGCCGGCAGUGAUGUGCGCUAUUCCUGGGUGCUCUGUGACCGCUGCACGCCCAUCCCUGGGGGUCCUACCAUCUCUUACACCUUCCGCUCCGUGGGCACCUUCAAUAUCAUCGUCACGGCUGAGAACGAGGUGGGCUCCGCCCAGGACAGCAUCUUCGUCUAUGUCCUGCAGCUCAUAGAGGGGCUGCAGGUGGUGGGCGGUGGCCGCUACUUCCCCACCAACCACACGGUACAGCUGCAGGCCGUGGUUAGGGAUGGCACCAACGUCUCCUACAGCUGGACUGCCUGGAGGGACAGGGGCCCGGCCCUGGCCGGCAGCGGCAAAGGCUUCUCGCUCACCGUGCUCGAGGCCGGCACCUACCAUGUGCAGCUGCGGGCCACCAACAUGCUGGGCAGCGCCUGGGCCGACUGCACCAUGGACUUCGUGGAGCCUGUGGGGUGGCUGAUGGUGGCCGCCUCCCCGAACCCAGCUGCCGUCAACACAAGCGUCACCCUCAGUGCCGAGCUGGCUGGUGGCAGUGGUGUCGUAUACACUUGGUCCUUGGAGGAGGGGCUGAGCUGGGAGACCUCCGAGCCAUUUACCACCCAUAGCUUCCCCACACCCGGCCUGCACUUGGUCACCAUGACGGCAGGGAACCCGCUGGGCUCAGCCAACGCCACCGUGGAAGUGGAUGUGCAGGUGCCUGUGAGUGGCCUCAGCAUCAGGGCCAGCGAGCCCGGAGGCAGCUUCGUGGCGGCCGGGUCCUCUGUGCCCUUUUGGGGGCAGCUGGCCACGGGCACCAAUGUGAGCUGGUGCUGGGCUGUGCCCGGCGGCAGCAGCAAGCGUGGCCCUCAUGUCACCAUGGUCUUCCCGGAUGCUGGCACCUUCUCCAUCCGGCUCAAUGCCUCCAACGCAGUCAGCUGGGUCUCAGCCACGUACAACCUCACGGCGGAGGAGCCCAUCGUGGGCCUGGUGCUGUGGGCCAGCAGCAAGGUGGUGGCGCCCGGGCAGCUGGUCCAUUUUCAGAUCCUGCUGGCUGCCGGCUCAGCUGUCACCUUCCGCCUGCAGGUCGGCGGGGCCAACCCCGAGGUGCUCCCCGGGCCCCGUUUCUCCCACAGCUUCCCCCGCGUCGGAGACCACGUGGUGAGCGUGCGGGGCAAAAACCACGUGAGCUGGGCCCAGGCGCAGGUGCGCAUCGUGGUGCUGGAGGCCGUGAGUGGGCUGCAGGUGCCCAACUGCUGCGAGCCUGGCAUCGCCACGGGCACUGAGAGGAACUUCACAGCCCGCGUGCAGCGCGGCUCUCGGGUCGCCUACGCCUGGUACUUCUCGCUGCAGAAGGUCCAGGGCGACUCGCUGGUCAUCCUGUCGGGCCGCGACGUCACCUACACGCCCGUGGCCGCGGGGCUGUUGGAGAUCCAGGUGCGCGCCUUCAACGCCCUGGGCAGUGAGAACCGCACGCUGGUGCUGGAGGUUCAGGACGCCGUCCAGUAUGUGGCCCUGCAGAGCGGCCCCUGCUUCACCAACCGCUCGGCGCAGUUUGAGGCCGCCACCAGCCCCAGCCCCCGGCGUGUGGCCUACCACUGGGACUUUGGGGAUGGGUCGCCAGGGCAGGACACAGAUGAGCCCAGGGCCGAGCACUCCUACCUGAGGCCUGGGGACUACCGCGUGCAGGUGAACGCCUCCAACCUGGUGAGCUUCUUCGUGGCGCAGGCCACGGUGACCGUCCAGGUGCUGGCCUGCCGGGAGCCGGAGGUGGACGUGGUCCUGCCCCUGCAGGUGCUGAUGCGGCGAUCACAGCGCAACUACUUGGAGGCCCACGUUGACCUGCGCGACUGCGUCACCUACCAGACUGAGUACCGCUGGGAGGUGUAUCGCACCGCCAGCUGCCAGCGGCCGGGGCGCCCAGCGCGUGUGGCCCUGCCCGGCGUGGACGUGAGCCGGCCUCGGCUGGUGCUGCCGCGGCUGGCGCUGCCUGUGGGGCACUACUGCUUUGUGUUUGUCGUGUCAUUUGGGGACACGCCACUGACACAGAGCAUCCAGGCCAAUGUGACGGUGGCCCCCGAGCGCCUGGUGCCCAUCAUUGAGGGUGGCUCAUACCGCGUGUGGUCAGACACACGGGACCUGGUGCUGGAUGGGAGCGAGUCCUACGACCCCAACCUGGAGGACGGCGACCAGACGCCGCUCAGUUUCCACUGGGCCUGUGUGGCUUCGACACAGAGGGAGGCUGGCGGGUGUGCGCUGAACUUUGGGCCCCGCGGGAGCAGCACGGUCACCAUUCCACGGGAGCGGCUGGCGGCUGGCGUGGAGUACACCUUCAGCCUGACCGUGUGGAAGGCCGGCCGCAAGGAGGAGGCCACCAACCAGACGGUGCUGAUCCGGAGUGGCCGGGUGCCCAUUGUGUCCUUGGAGUGUGUGUCCUGCAAGGCACAGGCCGUGUACGAAGUGAGCCGCAGCUCCUACGUGUACUUGGAGGGCCGCUGCCUCAAUUGCAGCAGCGGCUCCAAGCGAGGGCGGUGGGCUGCACGUACGUUCAGCAACAAGACGCUGGUGCUGGAUGAGACCACCACAUCCACGGGCAGUGCAGGCAUGCGACUGGUGCUGCGGCGGGGCGUGCUGCGGGACGGCGAGGGAUACACCUUCACGCUCACGGUGCUGGGCCGCUCUGGCGAGGAGGAGGGCUGCGCCUCCAUCCGCCUGUCCCCCAACCGCCCGCCGCUGGGGGGCUCUUGCCGCCUCUUCCCACUGGGCGCUGUGCACGCCCUCACCACCAAGGUGCACUUCGAAUGCACGGGCUGGCAUGACGCGGAGGAUGCUGGCGCCCCGCUGGUGUACGCCCUGCUGCUGCGGCGCUGUCGCCAGGGCCACUGCGAGGAGUUCUGUGUCUACAAGGGCAGCCUCUCCAGCUACGGAGCCGUGCUGCCCCCGGGUUUCAGGCCACACUUCGAGGUGGGCCUGGCCGUGGUGGUGCAGGACCAGCUGGGAGCCGCUGUGGUCGCCCUCAACAGGUCUUUGGCCAUCACCCUCCCAGAGCCCAACGGCAGCGCAACGGGGCUCACAGUCUGGCUGCACGGGCUCACCGCUAGUGUGCUCCCAGGGCUGCUGCGGCAGGCCGAUCCCCAGCACGUCAUCGAGUACUCGUUGGCCCUGGUCACCGUGCUGAACGAGUACGAGCGGGCCCUGGACGUGGCGGCAGAGCCCAAGCACGAGCGGCAGCACCGAGCCCAGAUACGCAAGAACAUCACGGAGACUCUGGUGUCCCUGAGGGUCCACACUGUGGAUGACAUCCAGCAGAUCGCUGCUGCGCUGGCCCAGUGCAUGGGGCCCAGCAGGGAGCUCGUAUGCCGCUCGUGCCUGAAGCAGACGCUGCACAAGCUGGAGGCCAUGAUGCUCAUCCUGCAGGCAGAGACCACCGCGGGCACCGUGACGCCCACCGCCAUCGGAGACAGCAUCCUCAACAUCACAGGAGACCUCAUCCACCUGGCCAGCUCGGACGUGCGGGCACCACAGCCCUCAGAGCUGGGAGCCGAGUCACCAUCUCGGAUGGUGGCGUCCCAGGCCUACAACCUGACCUCUGCCCUCAUGCGCAUCCUCAUGCGCUCCCGCGUGCUCAACGAGGAGCCCCUGACGCUGGCGGGCGAGGAGAUCGUGGCCCAGGGCAAGCGCUCGGACCCGCGGAGCCUGCUGUGCUAUGGCGGCGCCCCAGGGCCUGGCUGCCACUUCUCCAUCCCCGAGGCUUUCAGCGGGGCCCUGGCCAACCUCAGUGACGUGGUGCAGCUCAUCUUUCUGGUGGACUCCAAUCCCUUUCCCUUUGGCUAUAUCAGCAACUACACCGUCUCCACCAAGGUGGCCUCGAUGGCAUUCCAGACACAGGCCGGCGCCCAGAUCCCCAUCGAGCGGCUGGCCUCAGAGCGCGCCAUCACCGUGAAGGUGCCCAACAACUCGGACUGGGCUGCCCGGGGCCACCGCAGCUCCGCCAACUCCGCCAACUCCGUUGUGGUCCAGCCCCAGGCCUCCGUCGGUGCUGUGGUCACCCUGGACAGCAGCAACCCUGCGGCCGGGCUGCAUCUGCAGCUCAACUAUACGCUGCUGGACGGCCACUACCUGUCUGAGGAACCUGAGCCCUACCUGGCAGUCUACCUACACUCGGAGCCCCGGCCCAAUGAGCACAACUGCUCGGCUAGCAGGAGGAUCCGCCCAGAGUCACUCCAGGGUGCUGACCACCGGCCCUACACCUUCUUCAUUUCCCCGGGGAGCAGAGACCCAGCGGGGAGUUACCAUCUGAACCUCUCCAGCCACUUCCGCUGGUCGGCGCUGCAGGUGUCCGUGGGCCUGUACACGUCCCUGUGCCAGUACUUCAGCGAGGAGGACAUGGUGUGGCGGACAGAGGGGCUGCUGCCCCUGGAGGAGACCUCGCCCCGCCAGGCCGUCUGCCUCACCCGCCACCUCACCGCCUUCGGCGCCAGCCUCUUCGUGCCCCCAAGCCAUGUCCGCUUUGUGUUUCCUGAGCCGACAGCGGAUGUAAACUACAUCGUCAUGCUGACAUGUGCUGUGUGCCUGGUGACCUACAUGGUCAUGGCCGCCAUCCUGCACAAGCUGGACCAGUUGGAUGCCAGCCGGGGCCGCGCCAUCCCUUUCUGUGGGCAGCGGGGCCGCUUCAAGUACGAGAUCCUCGUCAAGACAGGCUGGGGCCGGGGCUCAGGUACCACGGCCCACGUGGGCAUCAUGCUGUAUGGGGUGGACAGCCGGAGCGGCCACCGGCACCUGGACGGCGACAGAGCCUUCCACCGCAACAGCCUGGACAUCUUCCGGAUCGCCACCCCGCACAGCCUGGGUAGCGUGUGGAAGAUCCGAGUGUGGCACGACAACAAAGGGCUCAGCCCUGCCUGGUUCCUGCAGCACGUCAUCGUCAGGGACCUGCAGACGGCACGCAGCGCCUUCUUCCUGGUCAAUGACUGGCUUUCGGUGGAGACGGAGGCCAACGGGGGCCUGGUGGAGAAGGAGGUGCUGGCCGCGAGCGACGCAGCCCUUUUGCGCUUCCGGCGCCUGCUGGUGGCUGAGCUGCAGCGUGGCUUCUUUGACAAGCACAUCUGGCUCUCCAUAUGGGACCGGCCGCCUCGUAGCCGUUUCACUCGCAUCCAGAGGGCCACCUGCUGCGUUCUCCUCAUCUGCCUCUUCCUGGGCGCCAACGCCGUGUGGUACGGGGCUGUUGGCGACUCUGCCUACAGCACGGGGCAUGUGUCCAGGCUGAGCCCGCUGAGCGUCGACACAGUCGCUGUUGGCCUGGUGUCCAGCGUGGUUGUCUAUCCCGUCUACCUGGCCAUCCUUUUUCUCUUCCGGAUGUCCCGGAGCAAGGUGGCUGGGAGCCCGAGCCCCACACCUGCCGGGCAGCAGGUGCUGGACAUCGACAGCUGCCUGGACUCGUCCGUGCUGGACAGCUCCUUCCUCACGUUCUCAGGCCUCCACGCUGAGCAGGCCUUUGUUGGACAGAUGAAGAGUGACUUGUUUCUGGAUGAUUCUAAGAGUCUGGUGUGCUGGCCCUCCGGCGAGGGAACGCUCAGUUGGCCGGACCUGCUCAGUGACCCGUCCAUUGUGGGUAGCAAUCUGCGGCAGCUGGCACGGGGCCAGGCGGGCCAUGGGCUGGGCCCAGAGGAGGACGGCUUCUCCCUGGCCAGCCCCUACUCGCCUGCCAAAUCCUUCUCAGCAUCAGAUGAAGACCUGAUCCAGCAGGUCCUUGCCGAGGGGGUCAGCAGCCCAGCCCCUACCCAAGACACCCACAUGGAAACGGACCUGCUCAGCAGCCUGUCCAGCACUCCUGGGGAGAAGACAGAGACGCUGGCGCUGCAGAGGCUGGGGGAGCUGGGGCCACCCAGCCCAGGCCUGAACUGGGAACAGCCCCAGGCAGCGAGGCUGUCCAGGACAGGACUGGUGGAGGGUCUGCGGAAGCGCCUGCUGCCGGCCUGGUGUGCCUCCCUGGCCCACGGGCUCAGCCUGCUCCUGGUGGCUGUGGCUGUGGCUGUCUCAGGGUGGGUGGGUGCGAGCUUCCCCCCGGGCGUGAGUGUUGCGUGGCUCCUGUCCAGCAGCGCCAGCUUCCUGGCCUCAUUCCUCGGCUGGGAGCCACUGAAGGUCUUGCUGGAAGCCCUGUACUUCUCACUGGUGGCCAAGCGGCUGCACCCGGAUGAAGAUGACACCCUGGUAGAGAGCCCGGCUGUGACGCCUGUGAGCGCACGUGUGCCCCGCGUACGGCCACCCCACGGCUUUGCACUCUUCCUGGCCAAGGAAGAAGCCCGCAAGGUCAAGAGGCUACAUGGCAUGCUGCGGAGCCUCCUGGUGUACAUGCUUUUUCUGCUGGUGACCCUGCUGGCCAGCUAUGGGGAUGCCUCAUGCCAUGGGCACGCCUACCGUCUGCAAAGCGCCAUCAAGCAGGAGCUGCACAGCCGGGCCUUCCUGGCCAUCACGCGGUCUGAGGAGCUCUGGCCAUGGAUGGCCCACGUGCUGCUGCCCUACGUCCACGGGAACCAGUCCAGCCCAGAGCUGGGGCCCCCACGGCUGCGGCAGGUGCGGCUGCAGGAAGCACUCUACCCAGACCCUCCCGGCCCCAGGGUCCACACGUGCUCGGCCGCAGGAGGCUUCAGCACCAGCGAUUACGACGUUGGCUGGGAGAGUCCUCACAAUGGCUCGGGGACGUGGGCCUAUUCAGCGCCGGAUCUGCUGGGGGCAUGGUCCUGGGGCUCCUGUGCCGUGUAUGACAGCGGGGGCUACGUGCAGGAGCUGGGCCUGAGCCUGGAGGAGAGCCGCGACCGGCUGCGCUUCCUGCAGCUGCACAACUGGCUGGACAACAGGAGCCGCGCUGUGUUCCUGGAGCUCACGCGCUACAGCCCGGCCGUGGGGCUGCACGCCGCCGUCACGCUGCGCCUCGAGUUCCCGGCGGCCGGCCGCGCCCUGGCCGCCCUCAGCGUCCGCCCCUUUGCGCUGCGCCGCCUCAGCGCGGGCCUCUCGCUGCCUCUGCUCACCUCGGUGUGCCUGCUGCUGUUCGCCGUGCACUUCGCCGUGGCCGAGGCCCGUACUUGGCACAGGGAAGGGCGCUGGCGCGUGCUGCGGCUCGGAGCCUGGGCGCGGUGGCUGCUGGUGGCGCUGACGGCGGCCACGGCACUGGUACGCCUCGCCCAGCUGGGUGCCGCUGACCGCCAGUGGACCCGUUUCGUGCGCGGCCGCCCGCGCCGCUUCACUAGCUUCGACCAGGUGGCGCAGCUGAGCUCCGCAGCCCGUGGCCUGGCGGCCUCGCUGCUCUUCCUGCUUUUGGUCAAGGCUGCCCAGCAGCUACGCUUCGUGCGCCAGUGGUCCGUCUUUGGCAAGACAUUAUGCCGAGCUCUGCCAGAGCUCCUGGGGGUCACCUUGGGCCUGGUGGUGCUCGGGGUAGCCUACGCCCAGCUGGCCAUCCUGCUCGUGUCUUCCUGUGUGGACUCCCUCUGGAGCGUGGCCCAGGCCCUGUUGGUGCUGUGCCCUGGGACUGGGCUCUCUACCCUGUGUCCUGCCGAGUCCUGGCACCUGUCACCCCUGCUGUGUGUGGGGCUCUGGGCACUGCGGCUGUGGGGCGCCCUACGGCUGGGGGCUGUUAUUCUCCGCUGGCGCUACCACGCCUUGCGUGGAGAGCUGUACCGGCCGGCCUGGGAGCCCCAGGACUACGAGAUGGUGGAGUUGUUCCUGCGCAGGCUGCGCCUCUGGAUGGGCCUCAGCAAGGUCAAGGAGUUCCGCCACAAAGUCCGCUUUGAAGGGAUGGAGCCGCUGCCCUCUCGCUCCUCCAGGGGCUCCAAGGUAUCCCCGGAUGUGCCCCCACCCAGCGCUGGCUCCGAUGCCUCGCACCCCUCCACCUCCUCCAGCCAGCUGGAUGGGCUGAGCGUGAGCCUGGGCCGGCUGGGGACAAGGUGUGAGCCUGAGCCCUCCCGCCUCCAAGCCGUGUUCGAGGCCCUGCUCACCCAGUUUGACCGACUCAACCAGGCCACAGAGGACGUCUACCAGCUGGAGCAGCAGCUGCACAGCCUGCAAGGCCGCAGGAGCAGCCGGGCGCCCGCCGGAUCUUCCCGUGGCCCAUCCCCGGGCCUGCGGCCAGCACUGCCCAGCCGCCUUGCCCGGGCCAGUCGGGGUGUGGACCUGGCCACUGGCCCCAGCAGGACACCCCUUCGGGCCAAGAACAAGGUCCACCCCAGCAGCACUUAGUCCUCCUUCCUGGCGGGGGUGGGCCGUGGAGUCGGAGUGGACACCGCUCAGUAUUACUUUCUGCCGCUGUCAAGGCCGAGGGCCAGGCAGAAUGGCUGCACGUAGGUUCCCCAGAGAGCAGGCAGGGGCAUCUGUCUGUCUGUGGGCUUCAGCACUUUAAAGAGGCUGUGUGGCCAACCAGGACCCAGGGUCCCCUCCCCAGCUCCCUUGGGAAGGACACAGCAGUAUUGGACGGUUUCUAGCCUCUGAGAUGCUAAUUUAUUUCCCCGAGUCCUCAGGUACAGCGGGCUGUGCCCGGCCCCACCCCCUGGGCAGAUGUCCCCCACUGCUAAGGCUGCUGGCUUCAGGGAGGGUUAGCCUGCACCGCCGCCACCCUGCCCCUAAGUUAUUACCUCUCCAGUUCCUACCGUACUCCCUGCACCGUCUCACUGUGUGUCUCGUGUCAGUAAUUUAUAUGGUGUUAAAAUGUGUAUAUUUUUGUAUGUCACUAUUUUCACUAGGGCUGAGGGGCCUGCGCCCAGAGCUGGCCUCCCCCAACACCUGCUGCGCUUGGUAGGUGUGGUGGCGUUAUGGCAGCCCGGCUGCUGCUUGGAUGCGAGCUUGGCCUUGGGCCGGUGCUGGGGGCACAGCUGUCUGCCAGGCACUCUCAUCACCCCAGAGGCCUUGUCAUCCUCCCUUGCCCCAGGCCAGGUAGCAAGAGAGCAGCGCCCAGGCCUGCUGGCAUCAGGUCUGGGCAAGUAGCAGGACUAGGCAUGUCAGAGGACCCCAGGGUGGUUAGAGGAAAAGACUCCUCCUGGGGGCUGGCUCCCAGGGUGGAGGAAGGUGACUGUGUGUGUGUGUGUGUGCGCGCGCGCACGCGCGAGUGUGCUGUAUGGCCCAGGCAGCCUCAAGGCCCUCGGAGCUGGCUGUGCCUGCUUCUGUGUACCACUUCUGUGGGCAUGGCCGCUUCUAGAGCCUCGACACCCCCCCAACCCCCGCACCAAGCAGACAAAGUCAAUAAAAGAGCUGUCUGACUGCAA-3'- Poly-A tail

Coding region

mRNA-related data

DNA

DNA (Gene ID: 5310)

HGNC Gene symbol

PKD1

HGNC Gene name

polycystin 1, transient receptor potential channel interacting

Chr. RefSeq ID

NC_000016.10

Chromosome N°

16 2089727.. 2135689

CDS location

2089727.. 2135689

DNA strand

strand -

CCDS ID

CCDS32369.1

Mouse ortholog gene

MGI:97603

Gene Variant

ClinVar, dbVar

DNA Ensembl ID

ENSG00000008710

HGNC other symbol

PBP, Pc-1, TRPP1

UCSC ID

uc002cos.1

GeneBank

INSDC: L33243

GeneCards

9008

MIM

601313

VEGA ID

OTTHUMG00000155795

Other links

ENA, DDBJ, Monarch

Gene-related data

NCBI CDS gene sequence (12912 bp)

5'-ATGCCGCCCGCCGCGCCCGCCCGCCTGGCGCTGGCCCTGGGCCTGGGCCTGTGGCTCGGGGCGCTGGCGGGGGGCCCCGGGCGCGGCTGCGGGCCCTGCGAGCCCCCCTGCCTCTGCGGCCCAGCGCCCGGCGCCGCCTGCCGCGTCAACTGCTCGGGCCGCGGGCTGCGGACGCTCGGTCCCGCGCTGCGCATCCCCGCGGACGCCACAGCGCTAGACGTCTCCCACAACCTGCTCCGGGCGCTGGACGTTGGGCTCCTGGCGAACCTCTCGGCGCTGGCAGAGCTGGATATAAGCAACAACAAGATTTCTACGTTAGAAGAAGGAATATTTGCTAATTTATTTAATTTAAGTGAAATAAACCTGAGTGGGAACCCGTTTGAGTGTGACTGTGGCCTGGCGTGGCTGCCGCGATGGGCGGAGGAGCAGCAGGTGCGGGTGGTGCAGCCCGAGGCAGCCACGTGTGCTGGGCCTGGCTCCCTGGCTGGCCAGCCTCTGCTTGGCATCCCCTTGCTGGACAGTGGCTGTGGTGAGGAGTATGTCGCCTGCCTCCCTGACAACAGCTCAGGCACCGTGGCAGCAGTGTCCTTTTCAGCTGCCCACGAAGGCCTGCTTCAGCCAGAGGCCTGCAGCGCCTTCTGCTTCTCCACCGGCCAGGGCCTCGCAGCCCTCTCGGAGCAGGGCTGGTGCCTGTGTGGGGCGGCCCAGCCCTCCAGTGCCTCCTTTGCCTGCCTGTCCCTCTGCTCCGGCCCCCCGCCACCTCCTGCCCCCACCTGTAGGGGCCCCACCCTCCTCCAGCACGTCTTCCCTGCCTCCCCAGGGGCCACCCTGGTGGGGCCCCACGGACCTCTGGCCTCTGGCCAGCTAGCAGCCTTCCACATCGCTGCCCCGCTCCCTGTCACTGCCACACGCTGGGACTTCGGAGACGGCTCCGCCGAGGTGGATGCCGCTGGGCCGGCTGCCTCGCATCGCTATGTGCTGCCTGGGCGCTATCACGTGACGGCCGTGCTGGCCCTGGGGGCCGGCTCAGCCCTGCTGGGGACAGACGTGCAGGTGGAAGCGGCACCTGCCGCCCTGGAGCTCGTGTGCCCGTCCTCGGTGCAGAGTGACGAGAGCCTCGACCTCAGCATCCAGAACCGCGGTGGTTCAGGCCTGGAGGCCGCCTACAGCATCGTGGCCCTGGGCGAGGAGCCGGCCCGAGCGGTGCACCCGCTCTGCCCCTCGGACACGGAGATCTTCCCTGGCAACGGGCACTGCTACCGCCTGGTGGTGGAGAAGGCGGCCTGGCTGCAGGCGCAGGAGCAGTGTCAGGCCTGGGCCGGGGCCGCCCTGGCAATGGTGGACAGTCCCGCCGTGCAGCGCTTCCTGGTCTCCCGGGTCACCAGGAGCCTAGACGTGTGGATCGGCTTCTCGACTGTGCAGGGGGTGGAGGTGGGCCCAGCGCCGCAGGGCGAGGCCTTCAGCCTGGAGAGCTGCCAGAACTGGCTGCCCGGGGAGCCACACCCAGCCACAGCCGAGCACTGCGTCCGGCTCGGGCCCACCGGGTGGTGTAACACCGACCTGTGCTCAGCGCCGCACAGCTACGTCTGCGAGCTGCAGCCCGGAGGCCCAGTGCAGGATGCCGAGAACCTCCTCGTGGGAGCGCCCAGTGGGGACCTGCAGGGACCCCTGACGCCTCTGGCACAGCAGGACGGCCTCTCAGCCCCGCACGAGCCCGTGGAGGTCATGGTATTCCCGGGCCTGCGTCTGAGCCGTGAAGCCTTCCTCACCACGGCCGAATTTGGGACCCAGGAGCTCCGGCGGCCCGCCCAGCTGCGGCTGCAGGTGTACCGGCTCCTCAGCACAGCAGGGACCCCGGAGAACGGCAGCGAGCCTGAGAGCAGGTCCCCGGACAACAGGACCCAGCTGGCCCCCGCGTGCATGCCAGGGGGACGCTGGTGCCCTGGAGCCAACATCTGCTTGCCGCTGGACGCCTCCTGCCACCCCCAGGCCTGCGCCAATGGCTGCACGTCAGGGCCAGGGCTACCCGGGGCCCCCTATGCGCTATGGAGAGAGTTCCTCTTCTCCGTTCCCGCGGGGCCCCCCGCGCAGTACTCGGTCACCCTCCACGGCCAGGATGTCCTCATGCTCCCTGGTGACCTCGTTGGCTTGCAGCACGACGCTGGCCCTGGCGCCCTCCTGCACTGCTCGCCGGCTCCCGGCCACCCTGGTCCCCGGGCCCCGTACCTCTCCGCCAACGCCTCGTCATGGCTGCCCCACTTGCCAGCCCAGCTGGAGGGCACTTGGGCCTGCCCTGCCTGTGCCCTGCGGCTGCTTGCAGCCACGGAACAGCTCACCGTGCTGCTGGGCTTGAGGCCCAACCCTGGACTGCGGCTGCCTGGGCGCTATGAGGTCCGGGCAGAGGTGGGCAATGGCGTGTCCAGGCACAACCTCTCCTGCAGCTTTGACGTGGTCTCCCCAGTGGCTGGGCTGCGGGTCATCTACCCTGCCCCCCGCGACGGCCGCCTCTACGTGCCCACCAACGGCTCAGCCTTGGTGCTCCAGGTGGACTCTGGTGCCAACGCCACGGCCACGGCTCGCTGGCCTGGGGGCAGTGTCAGCGCCCGCTTTGAGAATGTCTGCCCTGCCCTGGTGGCCACCTTCGTGCCCGGCTGCCCCTGGGAGACCAACGATACCCTGTTCTCAGTGGTAGCACTGCCGTGGCTCAGTGAGGGGGAGCACGTGGTGGACGTGGTGGTGGAAAACAGCGCCAGCCGGGCCAACCTCAGCCTGCGGGTGACGGCGGAGGAGCCCATCTGTGGCCTCCGCGCCACGCCCAGCCCCGAGGCCCGTGTACTGCAGGGAGTCCTAGTGAGGTACAGCCCCGTGGTGGAGGCCGGCTCGGACATGGTCTTCCGGTGGACCATCAACGACAAGCAGTCCCTGACCTTCCAGAACGTGGTCTTCAATGTCATTTATCAGAGCGCGGCGGTCTTCAAGCTCTCACTGACGGCCTCCAACCACGTGAGCAACGTCACCGTGAACTACAACGTAACCGTGGAGCGGATGAACAGGATGCAGGGTCTGCAGGTCTCCACAGTGCCGGCCGTGCTGTCCCCCAATGCCACGCTAGCACTGACGGCGGGCGTGCTGGTGGACTCGGCCGTGGAGGTGGCCTTCCTGTGGACCTTTGGGGATGGGGAGCAGGCCCTCCACCAGTTCCAGCCTCCGTACAACGAGTCCTTCCCGGTTCCAGACCCCTCGGTGGCCCAGGTGCTGGTGGAGCACAATGTCATGCACACCTACGCTGCCCCAGGTGAGTACCTCCTGACCGTGCTGGCATCTAATGCCTTCGAGAACCTGACGCAGCAGGTGCCTGTGAGCGTGCGCGCCTCCCTGCCCTCCGTGGCTGTGGGTGTGAGTGACGGCGTCCTGGTGGCCGGCCGGCCCGTCACCTTCTACCCGCACCCGCTGCCCTCGCCTGGGGGTGTTCTTTACACGTGGGACTTCGGGGACGGCTCCCCTGTCCTGACCCAGAGCCAGCCGGCTGCCAACCACACCTATGCCTCGAGGGGCACCTACCACGTGCGCCTGGAGGTCAACAACACGGTGAGCGGTGCGGCGGCCCAGGCGGATGTGCGCGTCTTTGAGGAGCTCCGCGGACTCAGCGTGGACATGAGCCTGGCCGTGGAGCAGGGCGCCCCCGTGGTGGTCAGCGCCGCGGTGCAGACGGGCGACAACATCACGTGGACCTTCGACATGGGGGACGGCACCGTGCTGTCGGGCCCGGAGGCAACAGTGGAGCATGTGTACCTGCGGGCACAGAACTGCACAGTGACCGTGGGTGCGGCCAGCCCCGCCGGCCACCTGGCCCGGAGCCTGCACGTGCTGGTCTTCGTCCTGGAGGTGCTGCGCGTTGAACCCGCCGCCTGCATCCCCACGCAGCCTGACGCGCGGCTCACGGCCTACGTCACCGGGAACCCGGCCCACTACCTCTTCGACTGGACCTTCGGGGATGGCTCCTCCAACACGACCGTGCGGGGGTGCCCGACGGTGACACACAACTTCACGCGGAGCGGCACGTTCCCCCTGGCGCTGGTGCTGTCCAGCCGCGTGAACAGGGCGCATTACTTCACCAGCATCTGCGTGGAGCCAGAGGTGGGCAACGTCACCCTGCAGCCAGAGAGGCAGTTTGTGCAGCTCGGGGACGAGGCCTGGCTGGTGGCATGTGCCTGGCCCCCGTTCCCCTACCGCTACACCTGGGACTTTGGCACCGAGGAAGCCGCCCCCACCCGTGCCAGGGGCCCTGAGGTGACGTTCATCTACCGAGACCCAGGCTCCTATCTTGTGACAGTCACCGCGTCCAACAACATCTCTGCTGCCAATGACTCAGCCCTGGTGGAGGTGCAGGAGCCCGTGCTGGTCACCAGCATCAAGGTCAATGGCTCCCTTGGGCTGGAGCTGCAGCAGCCGTACCTGTTCTCTGCTGTGGGCCGTGGGCGCCCCGCCAGCTACCTGTGGGATCTGGGGGACGGTGGGTGGCTCGAGGGTCCGGAGGTCACCCACGCTTACAACAGCACAGGTGACTTCACCGTTAGGGTGGCCGGCTGGAATGAGGTGAGCCGCAGCGAGGCCTGGCTCAATGTGACGGTGAAGCGGCGCGTGCGGGGGCTCGTCGTCAATGCAAGCCGCACGGTGGTGCCCCTGAATGGGAGCGTGAGCTTCAGCACGTCGCTGGAGGCCGGCAGTGATGTGCGCTATTCCTGGGTGCTCTGTGACCGCTGCACGCCCATCCCTGGGGGTCCTACCATCTCTTACACCTTCCGCTCCGTGGGCACCTTCAATATCATCGTCACGGCTGAGAACGAGGTGGGCTCCGCCCAGGACAGCATCTTCGTCTATGTCCTGCAGCTCATAGAGGGGCTGCAGGTGGTGGGCGGTGGCCGCTACTTCCCCACCAACCACACGGTACAGCTGCAGGCCGTGGTTAGGGATGGCACCAACGTCTCCTACAGCTGGACTGCCTGGAGGGACAGGGGCCCGGCCCTGGCCGGCAGCGGCAAAGGCTTCTCGCTCACCGTGCTCGAGGCCGGCACCTACCATGTGCAGCTGCGGGCCACCAACATGCTGGGCAGCGCCTGGGCCGACTGCACCATGGACTTCGTGGAGCCTGTGGGGTGGCTGATGGTGGCCGCCTCCCCGAACCCAGCTGCCGTCAACACAAGCGTCACCCTCAGTGCCGAGCTGGCTGGTGGCAGTGGTGTCGTATACACTTGGTCCTTGGAGGAGGGGCTGAGCTGGGAGACCTCCGAGCCATTTACCACCCATAGCTTCCCCACACCCGGCCTGCACTTGGTCACCATGACGGCAGGGAACCCGCTGGGCTCAGCCAACGCCACCGTGGAAGTGGATGTGCAGGTGCCTGTGAGTGGCCTCAGCATCAGGGCCAGCGAGCCCGGAGGCAGCTTCGTGGCGGCCGGGTCCTCTGTGCCCTTTTGGGGGCAGCTGGCCACGGGCACCAATGTGAGCTGGTGCTGGGCTGTGCCCGGCGGCAGCAGCAAGCGTGGCCCTCATGTCACCATGGTCTTCCCGGATGCTGGCACCTTCTCCATCCGGCTCAATGCCTCCAACGCAGTCAGCTGGGTCTCAGCCACGTACAACCTCACGGCGGAGGAGCCCATCGTGGGCCTGGTGCTGTGGGCCAGCAGCAAGGTGGTGGCGCCCGGGCAGCTGGTCCATTTTCAGATCCTGCTGGCTGCCGGCTCAGCTGTCACCTTCCGCCTGCAGGTCGGCGGGGCCAACCCCGAGGTGCTCCCCGGGCCCCGTTTCTCCCACAGCTTCCCCCGCGTCGGAGACCACGTGGTGAGCGTGCGGGGCAAAAACCACGTGAGCTGGGCCCAGGCGCAGGTGCGCATCGTGGTGCTGGAGGCCGTGAGTGGGCTGCAGGTGCCCAACTGCTGCGAGCCTGGCATCGCCACGGGCACTGAGAGGAACTTCACAGCCCGCGTGCAGCGCGGCTCTCGGGTCGCCTACGCCTGGTACTTCTCGCTGCAGAAGGTCCAGGGCGACTCGCTGGTCATCCTGTCGGGCCGCGACGTCACCTACACGCCCGTGGCCGCGGGGCTGTTGGAGATCCAGGTGCGCGCCTTCAACGCCCTGGGCAGTGAGAACCGCACGCTGGTGCTGGAGGTTCAGGACGCCGTCCAGTATGTGGCCCTGCAGAGCGGCCCCTGCTTCACCAACCGCTCGGCGCAGTTTGAGGCCGCCACCAGCCCCAGCCCCCGGCGTGTGGCCTACCACTGGGACTTTGGGGATGGGTCGCCAGGGCAGGACACAGATGAGCCCAGGGCCGAGCACTCCTACCTGAGGCCTGGGGACTACCGCGTGCAGGTGAACGCCTCCAACCTGGTGAGCTTCTTCGTGGCGCAGGCCACGGTGACCGTCCAGGTGCTGGCCTGCCGGGAGCCGGAGGTGGACGTGGTCCTGCCCCTGCAGGTGCTGATGCGGCGATCACAGCGCAACTACTTGGAGGCCCACGTTGACCTGCGCGACTGCGTCACCTACCAGACTGAGTACCGCTGGGAGGTGTATCGCACCGCCAGCTGCCAGCGGCCGGGGCGCCCAGCGCGTGTGGCCCTGCCCGGCGTGGACGTGAGCCGGCCTCGGCTGGTGCTGCCGCGGCTGGCGCTGCCTGTGGGGCACTACTGCTTTGTGTTTGTCGTGTCATTTGGGGACACGCCACTGACACAGAGCATCCAGGCCAATGTGACGGTGGCCCCCGAGCGCCTGGTGCCCATCATTGAGGGTGGCTCATACCGCGTGTGGTCAGACACACGGGACCTGGTGCTGGATGGGAGCGAGTCCTACGACCCCAACCTGGAGGACGGCGACCAGACGCCGCTCAGTTTCCACTGGGCCTGTGTGGCTTCGACACAGAGGGAGGCTGGCGGGTGTGCGCTGAACTTTGGGCCCCGCGGGAGCAGCACGGTCACCATTCCACGGGAGCGGCTGGCGGCTGGCGTGGAGTACACCTTCAGCCTGACCGTGTGGAAGGCCGGCCGCAAGGAGGAGGCCACCAACCAGACGGTGCTGATCCGGAGTGGCCGGGTGCCCATTGTGTCCTTGGAGTGTGTGTCCTGCAAGGCACAGGCCGTGTACGAAGTGAGCCGCAGCTCCTACGTGTACTTGGAGGGCCGCTGCCTCAATTGCAGCAGCGGCTCCAAGCGAGGGCGGTGGGCTGCACGTACGTTCAGCAACAAGACGCTGGTGCTGGATGAGACCACCACATCCACGGGCAGTGCAGGCATGCGACTGGTGCTGCGGCGGGGCGTGCTGCGGGACGGCGAGGGATACACCTTCACGCTCACGGTGCTGGGCCGCTCTGGCGAGGAGGAGGGCTGCGCCTCCATCCGCCTGTCCCCCAACCGCCCGCCGCTGGGGGGCTCTTGCCGCCTCTTCCCACTGGGCGCTGTGCACGCCCTCACCACCAAGGTGCACTTCGAATGCACGGGCTGGCATGACGCGGAGGATGCTGGCGCCCCGCTGGTGTACGCCCTGCTGCTGCGGCGCTGTCGCCAGGGCCACTGCGAGGAGTTCTGTGTCTACAAGGGCAGCCTCTCCAGCTACGGAGCCGTGCTGCCCCCGGGTTTCAGGCCACACTTCGAGGTGGGCCTGGCCGTGGTGGTGCAGGACCAGCTGGGAGCCGCTGTGGTCGCCCTCAACAGGTCTTTGGCCATCACCCTCCCAGAGCCCAACGGCAGCGCAACGGGGCTCACAGTCTGGCTGCACGGGCTCACCGCTAGTGTGCTCCCAGGGCTGCTGCGGCAGGCCGATCCCCAGCACGTCATCGAGTACTCGTTGGCCCTGGTCACCGTGCTGAACGAGTACGAGCGGGCCCTGGACGTGGCGGCAGAGCCCAAGCACGAGCGGCAGCACCGAGCCCAGATACGCAAGAACATCACGGAGACTCTGGTGTCCCTGAGGGTCCACACTGTGGATGACATCCAGCAGATCGCTGCTGCGCTGGCCCAGTGCATGGGGCCCAGCAGGGAGCTCGTATGCCGCTCGTGCCTGAAGCAGACGCTGCACAAGCTGGAGGCCATGATGCTCATCCTGCAGGCAGAGACCACCGCGGGCACCGTGACGCCCACCGCCATCGGAGACAGCATCCTCAACATCACAGGAGACCTCATCCACCTGGCCAGCTCGGACGTGCGGGCACCACAGCCCTCAGAGCTGGGAGCCGAGTCACCATCTCGGATGGTGGCGTCCCAGGCCTACAACCTGACCTCTGCCCTCATGCGCATCCTCATGCGCTCCCGCGTGCTCAACGAGGAGCCCCTGACGCTGGCGGGCGAGGAGATCGTGGCCCAGGGCAAGCGCTCGGACCCGCGGAGCCTGCTGTGCTATGGCGGCGCCCCAGGGCCTGGCTGCCACTTCTCCATCCCCGAGGCTTTCAGCGGGGCCCTGGCCAACCTCAGTGACGTGGTGCAGCTCATCTTTCTGGTGGACTCCAATCCCTTTCCCTTTGGCTATATCAGCAACTACACCGTCTCCACCAAGGTGGCCTCGATGGCATTCCAGACACAGGCCGGCGCCCAGATCCCCATCGAGCGGCTGGCCTCAGAGCGCGCCATCACCGTGAAGGTGCCCAACAACTCGGACTGGGCTGCCCGGGGCCACCGCAGCTCCGCCAACTCCGCCAACTCCGTTGTGGTCCAGCCCCAGGCCTCCGTCGGTGCTGTGGTCACCCTGGACAGCAGCAACCCTGCGGCCGGGCTGCATCTGCAGCTCAACTATACGCTGCTGGACGGCCACTACCTGTCTGAGGAACCTGAGCCCTACCTGGCAGTCTACCTACACTCGGAGCCCCGGCCCAATGAGCACAACTGCTCGGCTAGCAGGAGGATCCGCCCAGAGTCACTCCAGGGTGCTGACCACCGGCCCTACACCTTCTTCATTTCCCCGGGGAGCAGAGACCCAGCGGGGAGTTACCATCTGAACCTCTCCAGCCACTTCCGCTGGTCGGCGCTGCAGGTGTCCGTGGGCCTGTACACGTCCCTGTGCCAGTACTTCAGCGAGGAGGACATGGTGTGGCGGACAGAGGGGCTGCTGCCCCTGGAGGAGACCTCGCCCCGCCAGGCCGTCTGCCTCACCCGCCACCTCACCGCCTTCGGCGCCAGCCTCTTCGTGCCCCCAAGCCATGTCCGCTTTGTGTTTCCTGAGCCGACAGCGGATGTAAACTACATCGTCATGCTGACATGTGCTGTGTGCCTGGTGACCTACATGGTCATGGCCGCCATCCTGCACAAGCTGGACCAGTTGGATGCCAGCCGGGGCCGCGCCATCCCTTTCTGTGGGCAGCGGGGCCGCTTCAAGTACGAGATCCTCGTCAAGACAGGCTGGGGCCGGGGCTCAGGTACCACGGCCCACGTGGGCATCATGCTGTATGGGGTGGACAGCCGGAGCGGCCACCGGCACCTGGACGGCGACAGAGCCTTCCACCGCAACAGCCTGGACATCTTCCGGATCGCCACCCCGCACAGCCTGGGTAGCGTGTGGAAGATCCGAGTGTGGCACGACAACAAAGGGCTCAGCCCTGCCTGGTTCCTGCAGCACGTCATCGTCAGGGACCTGCAGACGGCACGCAGCGCCTTCTTCCTGGTCAATGACTGGCTTTCGGTGGAGACGGAGGCCAACGGGGGCCTGGTGGAGAAGGAGGTGCTGGCCGCGAGCGACGCAGCCCTTTTGCGCTTCCGGCGCCTGCTGGTGGCTGAGCTGCAGCGTGGCTTCTTTGACAAGCACATCTGGCTCTCCATATGGGACCGGCCGCCTCGTAGCCGTTTCACTCGCATCCAGAGGGCCACCTGCTGCGTTCTCCTCATCTGCCTCTTCCTGGGCGCCAACGCCGTGTGGTACGGGGCTGTTGGCGACTCTGCCTACAGCACGGGGCATGTGTCCAGGCTGAGCCCGCTGAGCGTCGACACAGTCGCTGTTGGCCTGGTGTCCAGCGTGGTTGTCTATCCCGTCTACCTGGCCATCCTTTTTCTCTTCCGGATGTCCCGGAGCAAGGTGGCTGGGAGCCCGAGCCCCACACCTGCCGGGCAGCAGGTGCTGGACATCGACAGCTGCCTGGACTCGTCCGTGCTGGACAGCTCCTTCCTCACGTTCTCAGGCCTCCACGCTGAGCAGGCCTTTGTTGGACAGATGAAGAGTGACTTGTTTCTGGATGATTCTAAGAGTCTGGTGTGCTGGCCCTCCGGCGAGGGAACGCTCAGTTGGCCGGACCTGCTCAGTGACCCGTCCATTGTGGGTAGCAATCTGCGGCAGCTGGCACGGGGCCAGGCGGGCCATGGGCTGGGCCCAGAGGAGGACGGCTTCTCCCTGGCCAGCCCCTACTCGCCTGCCAAATCCTTCTCAGCATCAGATGAAGACCTGATCCAGCAGGTCCTTGCCGAGGGGGTCAGCAGCCCAGCCCCTACCCAAGACACCCACATGGAAACGGACCTGCTCAGCAGCCTGTCCAGCACTCCTGGGGAGAAGACAGAGACGCTGGCGCTGCAGAGGCTGGGGGAGCTGGGGCCACCCAGCCCAGGCCTGAACTGGGAACAGCCCCAGGCAGCGAGGCTGTCCAGGACAGGACTGGTGGAGGGTCTGCGGAAGCGCCTGCTGCCGGCCTGGTGTGCCTCCCTGGCCCACGGGCTCAGCCTGCTCCTGGTGGCTGTGGCTGTGGCTGTCTCAGGGTGGGTGGGTGCGAGCTTCCCCCCGGGCGTGAGTGTTGCGTGGCTCCTGTCCAGCAGCGCCAGCTTCCTGGCCTCATTCCTCGGCTGGGAGCCACTGAAGGTCTTGCTGGAAGCCCTGTACTTCTCACTGGTGGCCAAGCGGCTGCACCCGGATGAAGATGACACCCTGGTAGAGAGCCCGGCTGTGACGCCTGTGAGCGCACGTGTGCCCCGCGTACGGCCACCCCACGGCTTTGCACTCTTCCTGGCCAAGGAAGAAGCCCGCAAGGTCAAGAGGCTACATGGCATGCTGCGGAGCCTCCTGGTGTACATGCTTTTTCTGCTGGTGACCCTGCTGGCCAGCTATGGGGATGCCTCATGCCATGGGCACGCCTACCGTCTGCAAAGCGCCATCAAGCAGGAGCTGCACAGCCGGGCCTTCCTGGCCATCACGCGGTCTGAGGAGCTCTGGCCATGGATGGCCCACGTGCTGCTGCCCTACGTCCACGGGAACCAGTCCAGCCCAGAGCTGGGGCCCCCACGGCTGCGGCAGGTGCGGCTGCAGGAAGCACTCTACCCAGACCCTCCCGGCCCCAGGGTCCACACGTGCTCGGCCGCAGGAGGCTTCAGCACCAGCGATTACGACGTTGGCTGGGAGAGTCCTCACAATGGCTCGGGGACGTGGGCCTATTCAGCGCCGGATCTGCTGGGGGCATGGTCCTGGGGCTCCTGTGCCGTGTATGACAGCGGGGGCTACGTGCAGGAGCTGGGCCTGAGCCTGGAGGAGAGCCGCGACCGGCTGCGCTTCCTGCAGCTGCACAACTGGCTGGACAACAGGAGCCGCGCTGTGTTCCTGGAGCTCACGCGCTACAGCCCGGCCGTGGGGCTGCACGCCGCCGTCACGCTGCGCCTCGAGTTCCCGGCGGCCGGCCGCGCCCTGGCCGCCCTCAGCGTCCGCCCCTTTGCGCTGCGCCGCCTCAGCGCGGGCCTCTCGCTGCCTCTGCTCACCTCGGTGTGCCTGCTGCTGTTCGCCGTGCACTTCGCCGTGGCCGAGGCCCGTACTTGGCACAGGGAAGGGCGCTGGCGCGTGCTGCGGCTCGGAGCCTGGGCGCGGTGGCTGCTGGTGGCGCTGACGGCGGCCACGGCACTGGTACGCCTCGCCCAGCTGGGTGCCGCTGACCGCCAGTGGACCCGTTTCGTGCGCGGCCGCCCGCGCCGCTTCACTAGCTTCGACCAGGTGGCGCAGCTGAGCTCCGCAGCCCGTGGCCTGGCGGCCTCGCTGCTCTTCCTGCTTTTGGTCAAGGCTGCCCAGCAGCTACGCTTCGTGCGCCAGTGGTCCGTCTTTGGCAAGACATTATGCCGAGCTCTGCCAGAGCTCCTGGGGGTCACCTTGGGCCTGGTGGTGCTCGGGGTAGCCTACGCCCAGCTGGCCATCCTGCTCGTGTCTTCCTGTGTGGACTCCCTCTGGAGCGTGGCCCAGGCCCTGTTGGTGCTGTGCCCTGGGACTGGGCTCTCTACCCTGTGTCCTGCCGAGTCCTGGCACCTGTCACCCCTGCTGTGTGTGGGGCTCTGGGCACTGCGGCTGTGGGGCGCCCTACGGCTGGGGGCTGTTATTCTCCGCTGGCGCTACCACGCCTTGCGTGGAGAGCTGTACCGGCCGGCCTGGGAGCCCCAGGACTACGAGATGGTGGAGTTGTTCCTGCGCAGGCTGCGCCTCTGGATGGGCCTCAGCAAGGTCAAGGAGTTCCGCCACAAAGTCCGCTTTGAAGGGATGGAGCCGCTGCCCTCTCGCTCCTCCAGGGGCTCCAAGGTATCCCCGGATGTGCCCCCACCCAGCGCTGGCTCCGATGCCTCGCACCCCTCCACCTCCTCCAGCCAGCTGGATGGGCTGAGCGTGAGCCTGGGCCGGCTGGGGACAAGGTGTGAGCCTGAGCCCTCCCGCCTCCAAGCCGTGTTCGAGGCCCTGCTCACCCAGTTTGACCGACTCAACCAGGCCACAGAGGACGTCTACCAGCTGGAGCAGCAGCTGCACAGCCTGCAAGGCCGCAGGAGCAGCCGGGCGCCCGCCGGATCTTCCCGTGGCCCATCCCCGGGCCTGCGGCCAGCACTGCCCAGCCGCCTTGCCCGGGCCAGTCGGGGTGTGGACCTGGCCACTGGCCCCAGCAGGACACCCCTTCGGGCCAAGAACAAGGTCCACCCCAGCAGCACTTAG-3'

NCBI CDS gene sequence with introns (location: 2089727.. 2135689) (45963 bp)Download

NCBI Gene Viewer (CDS + introns)

NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 2088708.. 2135898) (47191 bp)Download

NCBI Gene Viewer (CDS + introns + Untranslated regions)

NCBI gene sequence (location: [2088708.. 2135898 + 1000]) (48191 bp)Download

NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)

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