NCBI Summary
Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene has lysophospholipase activity. It is composed of two identical subunits which are held together by disulfide bonds. This protein has structural similarity to several members of the beta-galactoside-binding S-type lectin family. [provided by RefSeq, Jul 2008].
Protein
Protein (NP_037400)
Galectin 13
Galactoside-binding soluble lectin 13 (Galectin-13) (Gal-13) (Placental tissue protein 13) (PP13) (Placental protein 13)
LGALS13
galectin 13
Undefined
Low evidence
galectin-like
S-Type Lectins - Prototypical
b-sandwich / ConA-like
Only for mutated forms
NP_037400
29124
Q9UHV8
ENSP00000221797.3
Q9UHV8
0.408
10.1074/jbc.M709545200
neXtProt, PFAM, InterPro, CFG data
Protein sequence and protein families (fasta) (139 amino acids) Download
MSSLPVPYKLPVSLSVGSCVIIKGTPIHSFINDPQLQVDFYTDMDEDSDIAFRFRVHFGNHVVMNRREFGIWMLEETTDYVPFEDGKQFELCIYVHYNEYEIKVNGIRIYGFVHRIPPSFVKMVQVSRDISLTSVCVCN
Mol* PDB structure viewerUniLectin3D
Structural models
AlphaFold v2: AF-Q9UHV8-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Ligand
Glycan ligands from structural data
Gal(b1-4)Glc
6A62, 6A63, 6A64
6A62, 6A63, 6A64
GlyConnect Structures
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for LGALS13 Gene
ProteomicsDB
References
NCBI References (10 PubMed Identifiers)
  • A reference map of the human binary protein interactome. [32296183]
  • Placental Protein 13 (Galectin-13) Polarizes Neutrophils Toward an Immune Regulatory Phenotype. [32117288]
  • Galectin-13/placental protein 13: redox-active disulfides as switches for regulating structure, function and cellular distribution. [31584064]
  • Resetting the ligand binding site of placental protein 13/galectin-13 recovers its ability to bind lactose. [30413611]
  • Reduced placental protein 13 (PP13) in placental derived syncytiotrophoblast extracellular vesicles in preeclampsia - A novel tool to study the impaired cargo transmission of the placenta to the maternal organs. [29884298]
  • Homology modelling and molecular dynamics studies of human placental tissue protein 13 (galectin-13). [11742106]
  • Isolation and sequence analysis of a cDNA encoding human placental tissue protein 13 (PP13), a new lysophospholipase, homologue of human eosinophil Charcot-Leyden Crystal protein. [10527825]
  • DelGEF, an RCC1-related protein encoded by a gene on chromosome 11p14 critical for two forms of hereditary deafness. [10571079]
  • Mammalian lysophospholipases. [10395961]
  • Purification and characterization of two new soluble placental tissue proteins (PP13 and PP17). [6856484]
UniProt Main References (3 PubMed Identifiers)
  • A primate subfamily of galectins expressed at the maternal-fetal interface that promote immune cell death. [19497882]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
  • Galectin-13, a different prototype galectin, does not bind beta-galacto-sides and forms dimers via intermolecular disulfide bridges between Cys-136 and Cys-138. [29343868]
All isoforms of this gene containing a lectin domain
NP_037400.1, XP_024307242.1, XP_011525176.1, XP_016882204.1
RNA
RNA (Transcript ID: NM_013268.3)
NM_013268.3
galectin 13
All isoforms of LGALS13 containing a lectin domain
ENST00000221797.5
46..465 (or 39602569.. 39607339)
39602524.. 39607474
NCBI Matured mRNA sequence 600 NTPDownload 
m7G-5')ppp(5'-AGAAGACUGGACUCAAUUCUGAAGGUCGCCAAGAAGGAGAGAACAAUGUCUUCUUUACCCGUGCCAUACAAACUGCCUGUGUCUUUGUCUGUUGGUUCCUGCGUGAUAAUCAAAGGGACACCAAUCCACUCUUUUAUCAAUGACCCACAGCUGCAGGUGGAUUUCUACACUGACAUGGAUGAGGAUUCAGAUAUUGCCUUCCGUUUCCGAGUGCACUUUGGCAAUCAUGUGGUCAUGAACAGGCGUGAGUUUGGGAUAUGGAUGUUGGAGGAGACAACAGACUACGUGCCCUUUGAGGAUGGCAAACAAUUUGAGCUGUGCAUCUACGUACAUUACAAUGAGUAUGAGAUAAAGGUCAAUGGCAUACGCAUUUACGGCUUUGUCCAUCGAAUCCCGCCAUCAUUUGUGAAGAUGGUGCAAGUGUCGAGAGAUAUCUCCCUGACCUCAGUGUGUGUCUGCAAUUGAGGGAGAUGAUCACACUCCUCAUUGUUGAGGAAUCCCUCUUUCUACCUGACCAUGGGAUUCCCAGAACCUGCUAACAGAAUAAUCCCUGCUCACAUUUUCCCCUACACUUUGUCAUUAAAACAGCACGAAAACUCA-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
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More about the NCBI sViewer.
DNA
DNA (Gene ID: 29124)
LGALS13
galectin 13
NC_000019.10
19  39602569.. 39607339
39602569.. 39607339
strand +
CCDS33024.1
ClinVar, dbVar
ENSG00000105198
PP13, PLAC8
uc002omb.4
INSDC: AF117383
15449
608717
OTTHUMG00000183073
ENA, DDBJ, Monarch
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (420 bp)
5'-ATGTCTTCTTTACCCGTGCCATACAAACTGCCTGTGTCTTTGTCTGTTGGTTCCTGCGTGATAATCAAAGGGACACCAATCCACTCTTTTATCAATGACCCACAGCTGCAGGTGGATTTCTACACTGACATGGATGAGGATTCAGATATTGCCTTCCGTTTCCGAGTGCACTTTGGCAATCATGTGGTCATGAACAGGCGTGAGTTTGGGATATGGATGTTGGAGGAGACAACAGACTACGTGCCCTTTGAGGATGGCAAACAATTTGAGCTGTGCATCTACGTACATTACAATGAGTATGAGATAAAGGTCAATGGCATACGCATTTACGGCTTTGTCCATCGAATCCCGCCATCATTTGTGAAGATGGTGCAAGTGTCGAGAGATATCTCCCTGACCTCAGTGTGTGTCTGCAATTGA-3'
NCBI CDS gene sequence with introns (location: 39602569.. 39607339) (4771 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 39602524.. 39607474) (4951 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [39602524 - 1000].. 39607474) (5951 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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