NCBI Summary
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type II transmembrane protein interacts with dnax-activation protein 12 and may play a role in cell activation. Alternative splice variants have been described but their full-length sequence has not been determined. [provided by RefSeq, Jul 2008].
Protein
Protein (NP_037384)
MDL-1 - Myeloid DAP12-associating lectin 1
C-type lectin domain family 5 member A (C-type lectin superfamily member 5) (Myeloid DAP12-associating lectin 1) (MDL-1)
CLEC5A
C-type lectin domain containing 5A
Undefined
Low evidence
C-type lectin
CLEC5A
C-type - Natural Killer NK
a/b mixed / C-type lectin-like
Man, Fuc, GlcNAc
NP_037384
23601
Q9NY25
ENSP00000449999.1
Q9NY25
0.315
10.1074/jbc.M111.226142
PFAM, InterPro
Protein sequence and protein families (fasta) (188 amino acids) Download
MNWHMIISGLIVVVLKVVGMTLFLLYFPQIFNKSNDGFTTTRSYGTVSQIFGSSSPSPNGFITTRSYGTVCPKDWEFYQARCFFLSTSESSWNESRDFCKGKGSTLAIVNTPEKLKFLQDITDAEKYFIGLIYHREEKRWRWINNSVFNGNVTNQNQNFNCATIGLTKTFDAASCDISYRRICEKNAK
Mol* PDB structure viewerUniLectin3D
Structural models
AlphaFold v2: AF-Q9NY25-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Oligomerization and Known Interactions
Monomer (PubMed:21566123). Homodimer (PubMed:21566123). The majority of CLEC5A is expressed as a monomeric form on macrophages (PubMed:21566123). Interacts with TYROBP/DAP12 (PubMed:10449773). The interaction with TYROBP is required for CLEC5A cell surface expression (PubMed:10449773). Interacts with HCST/DAP10 (By similarity). Forms a CLEC5A/TYROBP/HCST trimolecular complex depending almost solely on TYROBP (By similarity)

(Microbial infection) Interacts with dengue virus envelope protein E (PubMed:18496526, PubMed:21566123)
Annotation
Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
Expression
Human Protein Atlas
GeneCards
Functionality temporarily unavailable.
ProteomicsDB
References
NCBI References (10 PubMed Identifiers)
  • CLEC5A expressed on myeloid cells as a M2 biomarker relates to immunosuppression and decreased survival in patients with glioma. [31591460]
  • Genetic association analysis of CLEC5A and CLEC7A gene single-nucleotide polymorphisms and Crohn's disease. [32476786]
  • CLEC5A promotes the proliferation of gastric cancer cells by activating the PI3K/AKT/mTOR pathway. [32033754]
  • CLEC5A: A Promiscuous Pattern Recognition Receptor to Microbes and Beyond. [32152943]
  • CLEC2 and CLEC5A: Pathogenic Host Factors in Acute Viral Infections. [31867016]
  • Crystallization and X-ray diffraction analysis of human CLEC5A (MDL-1), a dengue virus receptor. [20057064]
  • CLEC5A is critical for dengue-virus-induced lethal disease. [18496526]
  • Evolutionary analysis reveals collective properties and specificity in the C-type lectin and lectin-like domain superfamily. [12945048]
  • C-type lectin-like domains. [10508765]
  • Myeloid DAP12-associating lectin (MDL)-1 is a cell surface receptor involved in the activation of myeloid cells. [10449773]
UniProt Main References (4 PubMed Identifiers)
  • The DNA sequence of human chromosome 7. [12853948]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
  • Myeloid DAP12-associating lectin (MDL)-1 regulates synovial inflammation and bone erosion associated with autoimmune arthritis. [20212065]
  • Structural flexibility of the macrophage dengue virus receptor CLEC5A: implications for ligand binding and signaling. [21566123]
All isoforms of this gene containing a lectin domain
NP_037384.1, XP_011514297.1, NP_001288096.1, XP_016867404.1, XP_016867406.1, XP_016867405.1
RNA
RNA (Transcript ID: NM_013252.3)
NM_013252.3
C-type lectin domain containing 5A, transcript variant 1
All isoforms of CLEC5A containing a lectin domain
ENST00000546910.6
189..755 (or 141930104.. 141946292)
141927357.. 141946974
NCBI Matured mRNA sequence 3502 NTPDownload 
m7G-5')ppp(5'-GUAUUUCUUGGGGAUGCUACCAAGGCAGAGACUGUGAAGAAGGAAGAACGUUGCUUGGGCAAAAGGAGCAUAUUCUCAGGAGACGGGGCCCCUGCCUGCCACACCAAGCAUUAGGCCACCAGGAAGACCCCCAUCUGCAAGCAAGCCUAGCCUUCCAGGGAGAAAGAGGCCCCUGCAGCUCCUUCAUCAUGAACUGGCACAUGAUCAUCUCUGGGCUUAUUGUGGUAGUGCUUAAAGUUGUUGGAAUGACCUUAUUUCUACUUUAUUUCCCACAGAUUUUUAACAAAAGUAACGAUGGUUUCACCACCACCAGGAGCUAUGGAACAGUCUCACAGAUUUUUGGGAGCAGUUCCCCAAGUCCCAACGGCUUCAUUACCACAAGGAGCUAUGGAACAGUCUGCCCCAAAGACUGGGAAUUUUAUCAAGCAAGAUGUUUUUUCUUAUCCACUUCUGAAUCAUCUUGGAAUGAAAGCAGGGACUUUUGCAAAGGAAAAGGAUCCACAUUGGCAAUUGUCAACACGCCAGAGAAACUGAAGUUUCUUCAGGACAUAACUGAUGCUGAGAAGUAUUUUAUUGGCUUAAUUUACCAUCGUGAAGAGAAAAGGUGGCGUUGGAUCAACAACUCUGUGUUCAAUGGCAAUGUUACCAAUCAGAAUCAGAAUUUCAACUGUGCGACCAUUGGCCUAACAAAGACAUUUGAUGCUGCAUCAUGUGACAUCAGCUACCGCAGGAUCUGUGAGAAGAAUGCCAAAUGAUCACAGUUCCCUGUGACAAGAACUAUACUUGCAACUCUUUUUGAAUCCAUACAGGUCGUCUGGCCAAUGAUUCUUUUACUUACCUAUCUGUCUACCAGUAGCGGUCCUUGCCCAUUUGGGAAACUGAGCUUCUUUCUUCUGCACUGGGGGACUGGAUGCUAGCCAUCUCCAGGAGACAGGAUCAGUUUUACGGAAACAACUCAGUUAGUAUAGAGAUGAGGUCCGCUUCUGUAGUACUGAGCAUUUCUGACUGAUCAAAAAGGCCUAGUCUGUUGACAGGGUUUGUUUUAUUUUAGCCUCAGAGUAUACCAUACUACUAGGGAGUAACUGUAGAGUGAGAAAUUAUAAACAUUAUUUAGGGAUUACCAUGGUGGAAGAGGGAUAAACAUAGGUCCUGUGACUUCGUCUCUGUUCUCAAGGGAACCCCAUUCACAUGCCCCUCCUAACUCCACAAGCGAGGGUAGCAGAGGCUCUCCUCAGUCUGAACUAAGGCUUGGCCUUGGGGAGGGCUCCUAGUGCUGAGCUUGGAGCAGCACGGACAGCAGCAUUGUUUAUGGGAAUGGAGAGAGGUCUGGGCAGGAUAGGAACCUUCUUGGAGACCCCUUUGAAGAAAACCAGGCAGCCAAGGGAGCCAAACACACUAGAUUUCUGUUCUUCAGCAAAGCCCUGAAGAGACACUUAAGCUAAAAAUUCCCUUGUCAUAUUUCUGAAACUCCAUUAUAACAUAUGUAACUCCUUUGUAACCAAAAUUUAGGUAAGCAGGCUUCCUUUGCUCUGAAGGUUUUGAGUACCUGGCUGUAUUUGUUGAGUAUUUUUAAAAUUUUGGAUAGUCUCUUAGGCAACAAUAAUCACAAUAUAUUCAUCCCUUCAGUUCUGGAGAAAGCCUGAUACCAGGCACAGCCUACUGACCCCAAGGAGCCUGGCACUGAUUGGCAUCACAUUGAUCUAGAACUGGUCCAGCCGACGAAGAGUAGGAAAAGAGAAGGGCUGCUCAGGGAAACAUUGGCUGGGGGCACGGAAUAAGCACAUAGUAAAAAGGGAACAUCAGGGUCAAAUGGAAAUCACCUGAGACAGGAAACAGGGAGUUCAUUUGGCCACACUGGAAGAAAGGCAAGAAAGAGGAAGACAAGUCUUGGAGUACCCUGGCUGUUCUCCACACUCACAAGACAUCAGCUAUAUACUCUGCUUGGUGCAUAAGAAAGAGAAAAGAGAUGCCUUUUGUGUUUUGAGUAAGAAUAAUUAAACCAUAAGGAAGACCAUGUAUAAAACUGAUGGAAAUAAUAGUCACCAAAGUACAGCACAUACCAUUUUGUGUCUAAUAACAAUGUAGCACAGUAAUGACUGUACAUGUCAUUGUAUGUAUACCAAACAAGAUUGUUGUAAAUCAUAUUUUUUAUUACAACACUAAGUUCUGCUUCUGCAUUCCUAGGUUUCAUCAUUUUUGGCUCCUUAGCAUGGCCACUUACAAUUUUUUAACAUGAGAUAACACAUCAGGUGUCAGAACUUGCUUGAAGGGAAUUACCAGAAGUAAUUUGUGUUUGAGAUGGGGUGGAAAUUGGAAUUAUAUUAGUAGCCGGUGGAGAUACAAGUUCUCUGACUGUGUUGGGAAAGGAUAAGUGCUACCGUUGAGAAGGGAAGAAAGGCUGAGUCUAGGUGGAGAAAAAUAUCAACAGAACUCUAGCCAAAGGCAAGCCCCAGAACUCAGACAACAGAAAGGAAAUCCUAAUCCUUCUGUUUUGAGAAGAGAGAACUGUAGUUGCUUCACUUCCUAUUUCAUGACAGAAUAACUGCAAACUUUUAAGAUCAGGAAAUGUAGACAUCUAGUGAUUUCUUUAGUAGACAGUUUAAUUUCCCCCAAGAUUAGGAGACACUUCUGUGCAGGUUCUAAAAGGAGCCCAAUGGCCUGGGGUGGGAGUGGGGAGUAGAUAGGGAAUAUGUGGGAUUUGGUUUAAGUUCAUCAUUGGAAGAGUUCCUGGAUCCUUGCAAGCUUAGAUAAAUGUGAUCUUUAUUAGAUAGCAGUGGCAUGCUUUAAAAAAAAAAAAGGCAAUGAAAAUUUAGCAAGCCACUGAAUUUGAGUUUUCACUUUGUUUCUAAUAUGCUGUGUGAAUCAGUACAGUUUUCUUACCCUUUCUUGGUCUUAAUUUCCUUACUGAUAAAAUGGGGUAGUAAUACCUAUCUCAAAAAAUUAUUGCACAUAUUAAAUAACAUUCCUCUAUGUAUCUCAAUGGCAUUAGACAUUAGGAGAAGCAUUUUGUGGAGGAUUUGAAGUUGAGAUCUUCAUCCAAGAAGUAGCUUUUCAAUUUGCUAGAAGCUUAAUGUAGGCAAGCCACUUCAUUUUUCAGAACUUGUUUACUCAUUUAUAAUAUGGGAAUAAAAAUUUGUGCAAGUCAGAGAAGGGUGCCUUAAAAAUGUUGUGGCCAAGCCACAUGAGAUCAAAGACACACUUUUCAUGACCUCAAAUGUGGGCCCAGCCUAGGUCAGCCAACCCCCAUCCAACCCUUAGACUCACGAACAAAUCCACCUGAGAUCAGCAGAGCCACCCUAGAUCAGCUGAAACUCUAAGCACAAAAAUAAAAACUUAUCACUGUAUACCACUGGAGUUUUCUGGUUAUCUCUCGUAUAGCAAAAUCUAACUGAUGCAAUCUCCAUCUGGCCUUCAUCCUUCUCCCUUUAUUGUCCUUUCGUGUAUUGUUCAUCCAGCAACCAGGAUGAUCUUGUUAAAACAUUAAACAGAUUCUGUCACUCUU-3'- Poly-A tail
  • Coding region
mRNA-related data
DNA
DNA (Gene ID: 23601)
CLEC5A
C-type lectin domain containing 5A
NC_000007.14
7  141930104.. 141946292
141930104.. 141946292
strand -
CCDS5870.1
MGI:1345151
ClinVar, dbVar
ENSG00000258227
MDL-1
uc003vwv.1
INSDC:
2054
604987
OTTHUMG00000157173
ENA, DDBJ, Monarch
Gene-related data
NCBI CDS gene sequence (567 bp)
5'-ATGAACTGGCACATGATCATCTCTGGGCTTATTGTGGTAGTGCTTAAAGTTGTTGGAATGACCTTATTTCTACTTTATTTCCCACAGATTTTTAACAAAAGTAACGATGGTTTCACCACCACCAGGAGCTATGGAACAGTCTCACAGATTTTTGGGAGCAGTTCCCCAAGTCCCAACGGCTTCATTACCACAAGGAGCTATGGAACAGTCTGCCCCAAAGACTGGGAATTTTATCAAGCAAGATGTTTTTTCTTATCCACTTCTGAATCATCTTGGAATGAAAGCAGGGACTTTTGCAAAGGAAAAGGATCCACATTGGCAATTGTCAACACGCCAGAGAAACTGAAGTTTCTTCAGGACATAACTGATGCTGAGAAGTATTTTATTGGCTTAATTTACCATCGTGAAGAGAAAAGGTGGCGTTGGATCAACAACTCTGTGTTCAATGGCAATGTTACCAATCAGAATCAGAATTTCAACTGTGCGACCATTGGCCTAACAAAGACATTTGATGCTGCATCATGTGACATCAGCTACCGCAGGATCTGTGAGAAGAATGCCAAATGA-3'
NCBI CDS gene sequence with introns (location: 141930104.. 141946292) (16189 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 141927357.. 141946974) (19618 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [141927357.. 141946974 + 1000]) (20618 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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