NCBI Summary
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type II transmembrane protein interacts with dnax-activation protein 12 and may play a role in cell activation. Alternative splice variants have been described but their full-length sequence has not been determined. [provided by RefSeq, Jul 2008].
Protein
Protein (NP_037384)
MDL-1 - Myeloid DAP12-associating lectin 1
C-type lectin domain family 5 member A (C-type lectin superfamily member 5) (Myeloid DAP12-associating lectin 1) (MDL-1)
CLEC5A
C-type lectin domain containing 5A
Undefined
Low evidence
C-type lectin
CLEC5A
C-type - Natural Killer NK
a/b mixed / C-type lectin-like
Man, Fuc, GlcNAc
NP_037384
23601
Q9NY25
ENSP00000449999.1
Q9NY25
0.315
10.1074/jbc.M111.226142
neXtProt, PFAM, InterPro
Protein sequence and protein families (fasta) (188 amino acids) Download
MNWHMIISGLIVVVLKVVGMTLFLLYFPQIFNKSNDGFTTTRSYGTVSQIFGSSSPSPNGFITTRSYGTVCPKDWEFYQARCFFLSTSESSWNESRDFCKGKGSTLAIVNTPEKLKFLQDITDAEKYFIGLIYHREEKRWRWINNSVFNGNVTNQNQNFNCATIGLTKTFDAASCDISYRRICEKNAK
Mol* PDB structure viewerUniLectin3D
Structural models
AlphaFold v2: AF-Q9NY25-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for CLEC5A Gene
ProteomicsDB
References
NCBI References (10 PubMed Identifiers)
  • CLEC5A expressed on myeloid cells as a M2 biomarker relates to immunosuppression and decreased survival in patients with glioma. [31591460]
  • Genetic association analysis of CLEC5A and CLEC7A gene single-nucleotide polymorphisms and Crohn's disease. [32476786]
  • CLEC5A promotes the proliferation of gastric cancer cells by activating the PI3K/AKT/mTOR pathway. [32033754]
  • CLEC5A: A Promiscuous Pattern Recognition Receptor to Microbes and Beyond. [32152943]
  • CLEC2 and CLEC5A: Pathogenic Host Factors in Acute Viral Infections. [31867016]
  • Crystallization and X-ray diffraction analysis of human CLEC5A (MDL-1), a dengue virus receptor. [20057064]
  • CLEC5A is critical for dengue-virus-induced lethal disease. [18496526]
  • Evolutionary analysis reveals collective properties and specificity in the C-type lectin and lectin-like domain superfamily. [12945048]
  • C-type lectin-like domains. [10508765]
  • Myeloid DAP12-associating lectin (MDL)-1 is a cell surface receptor involved in the activation of myeloid cells. [10449773]
UniProt Main References (4 PubMed Identifiers)
  • The DNA sequence of human chromosome 7. [12853948]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
  • Myeloid DAP12-associating lectin (MDL)-1 regulates synovial inflammation and bone erosion associated with autoimmune arthritis. [20212065]
  • Structural flexibility of the macrophage dengue virus receptor CLEC5A: implications for ligand binding and signaling. [21566123]
All isoforms of this gene containing a lectin domain
NP_037384.1, XP_011514297.1, NP_001288096.1, XP_016867404.1, XP_016867406.1, XP_016867405.1
RNA
RNA (Transcript ID: NM_013252.3)
NM_013252.3
C-type lectin domain containing 5A, transcript variant 1
All isoforms of CLEC5A containing a lectin domain
ENST00000546910.6
189..755 (or 141930104.. 141946292)
141927357.. 141946974
NCBI Matured mRNA sequence 3502 NTPDownload 
m7G-5')ppp(5'-GUAUUUCUUGGGGAUGCUACCAAGGCAGAGACUGUGAAGAAGGAAGAACGUUGCUUGGGCAAAAGGAGCAUAUUCUCAGGAGACGGGGCCCCUGCCUGCCACACCAAGCAUUAGGCCACCAGGAAGACCCCCAUCUGCAAGCAAGCCUAGCCUUCCAGGGAGAAAGAGGCCCCUGCAGCUCCUUCAUCAUGAACUGGCACAUGAUCAUCUCUGGGCUUAUUGUGGUAGUGCUUAAAGUUGUUGGAAUGACCUUAUUUCUACUUUAUUUCCCACAGAUUUUUAACAAAAGUAACGAUGGUUUCACCACCACCAGGAGCUAUGGAACAGUCUCACAGAUUUUUGGGAGCAGUUCCCCAAGUCCCAACGGCUUCAUUACCACAAGGAGCUAUGGAACAGUCUGCCCCAAAGACUGGGAAUUUUAUCAAGCAAGAUGUUUUUUCUUAUCCACUUCUGAAUCAUCUUGGAAUGAAAGCAGGGACUUUUGCAAAGGAAAAGGAUCCACAUUGGCAAUUGUCAACACGCCAGAGAAACUGAAGUUUCUUCAGGACAUAACUGAUGCUGAGAAGUAUUUUAUUGGCUUAAUUUACCAUCGUGAAGAGAAAAGGUGGCGUUGGAUCAACAACUCUGUGUUCAAUGGCAAUGUUACCAAUCAGAAUCAGAAUUUCAACUGUGCGACCAUUGGCCUAACAAAGACAUUUGAUGCUGCAUCAUGUGACAUCAGCUACCGCAGGAUCUGUGAGAAGAAUGCCAAAUGAUCACAGUUCCCUGUGACAAGAACUAUACUUGCAACUCUUUUUGAAUCCAUACAGGUCGUCUGGCCAAUGAUUCUUUUACUUACCUAUCUGUCUACCAGUAGCGGUCCUUGCCCAUUUGGGAAACUGAGCUUCUUUCUUCUGCACUGGGGGACUGGAUGCUAGCCAUCUCCAGGAGACAGGAUCAGUUUUACGGAAACAACUCAGUUAGUAUAGAGAUGAGGUCCGCUUCUGUAGUACUGAGCAUUUCUGACUGAUCAAAAAGGCCUAGUCUGUUGACAGGGUUUGUUUUAUUUUAGCCUCAGAGUAUACCAUACUACUAGGGAGUAACUGUAGAGUGAGAAAUUAUAAACAUUAUUUAGGGAUUACCAUGGUGGAAGAGGGAUAAACAUAGGUCCUGUGACUUCGUCUCUGUUCUCAAGGGAACCCCAUUCACAUGCCCCUCCUAACUCCACAAGCGAGGGUAGCAGAGGCUCUCCUCAGUCUGAACUAAGGCUUGGCCUUGGGGAGGGCUCCUAGUGCUGAGCUUGGAGCAGCACGGACAGCAGCAUUGUUUAUGGGAAUGGAGAGAGGUCUGGGCAGGAUAGGAACCUUCUUGGAGACCCCUUUGAAGAAAACCAGGCAGCCAAGGGAGCCAAACACACUAGAUUUCUGUUCUUCAGCAAAGCCCUGAAGAGACACUUAAGCUAAAAAUUCCCUUGUCAUAUUUCUGAAACUCCAUUAUAACAUAUGUAACUCCUUUGUAACCAAAAUUUAGGUAAGCAGGCUUCCUUUGCUCUGAAGGUUUUGAGUACCUGGCUGUAUUUGUUGAGUAUUUUUAAAAUUUUGGAUAGUCUCUUAGGCAACAAUAAUCACAAUAUAUUCAUCCCUUCAGUUCUGGAGAAAGCCUGAUACCAGGCACAGCCUACUGACCCCAAGGAGCCUGGCACUGAUUGGCAUCACAUUGAUCUAGAACUGGUCCAGCCGACGAAGAGUAGGAAAAGAGAAGGGCUGCUCAGGGAAACAUUGGCUGGGGGCACGGAAUAAGCACAUAGUAAAAAGGGAACAUCAGGGUCAAAUGGAAAUCACCUGAGACAGGAAACAGGGAGUUCAUUUGGCCACACUGGAAGAAAGGCAAGAAAGAGGAAGACAAGUCUUGGAGUACCCUGGCUGUUCUCCACACUCACAAGACAUCAGCUAUAUACUCUGCUUGGUGCAUAAGAAAGAGAAAAGAGAUGCCUUUUGUGUUUUGAGUAAGAAUAAUUAAACCAUAAGGAAGACCAUGUAUAAAACUGAUGGAAAUAAUAGUCACCAAAGUACAGCACAUACCAUUUUGUGUCUAAUAACAAUGUAGCACAGUAAUGACUGUACAUGUCAUUGUAUGUAUACCAAACAAGAUUGUUGUAAAUCAUAUUUUUUAUUACAACACUAAGUUCUGCUUCUGCAUUCCUAGGUUUCAUCAUUUUUGGCUCCUUAGCAUGGCCACUUACAAUUUUUUAACAUGAGAUAACACAUCAGGUGUCAGAACUUGCUUGAAGGGAAUUACCAGAAGUAAUUUGUGUUUGAGAUGGGGUGGAAAUUGGAAUUAUAUUAGUAGCCGGUGGAGAUACAAGUUCUCUGACUGUGUUGGGAAAGGAUAAGUGCUACCGUUGAGAAGGGAAGAAAGGCUGAGUCUAGGUGGAGAAAAAUAUCAACAGAACUCUAGCCAAAGGCAAGCCCCAGAACUCAGACAACAGAAAGGAAAUCCUAAUCCUUCUGUUUUGAGAAGAGAGAACUGUAGUUGCUUCACUUCCUAUUUCAUGACAGAAUAACUGCAAACUUUUAAGAUCAGGAAAUGUAGACAUCUAGUGAUUUCUUUAGUAGACAGUUUAAUUUCCCCCAAGAUUAGGAGACACUUCUGUGCAGGUUCUAAAAGGAGCCCAAUGGCCUGGGGUGGGAGUGGGGAGUAGAUAGGGAAUAUGUGGGAUUUGGUUUAAGUUCAUCAUUGGAAGAGUUCCUGGAUCCUUGCAAGCUUAGAUAAAUGUGAUCUUUAUUAGAUAGCAGUGGCAUGCUUUAAAAAAAAAAAAGGCAAUGAAAAUUUAGCAAGCCACUGAAUUUGAGUUUUCACUUUGUUUCUAAUAUGCUGUGUGAAUCAGUACAGUUUUCUUACCCUUUCUUGGUCUUAAUUUCCUUACUGAUAAAAUGGGGUAGUAAUACCUAUCUCAAAAAAUUAUUGCACAUAUUAAAUAACAUUCCUCUAUGUAUCUCAAUGGCAUUAGACAUUAGGAGAAGCAUUUUGUGGAGGAUUUGAAGUUGAGAUCUUCAUCCAAGAAGUAGCUUUUCAAUUUGCUAGAAGCUUAAUGUAGGCAAGCCACUUCAUUUUUCAGAACUUGUUUACUCAUUUAUAAUAUGGGAAUAAAAAUUUGUGCAAGUCAGAGAAGGGUGCCUUAAAAAUGUUGUGGCCAAGCCACAUGAGAUCAAAGACACACUUUUCAUGACCUCAAAUGUGGGCCCAGCCUAGGUCAGCCAACCCCCAUCCAACCCUUAGACUCACGAACAAAUCCACCUGAGAUCAGCAGAGCCACCCUAGAUCAGCUGAAACUCUAAGCACAAAAAUAAAAACUUAUCACUGUAUACCACUGGAGUUUUCUGGUUAUCUCUCGUAUAGCAAAAUCUAACUGAUGCAAUCUCCAUCUGGCCUUCAUCCUUCUCCCUUUAUUGUCCUUUCGUGUAUUGUUCAUCCAGCAACCAGGAUGAUCUUGUUAAAACAUUAAACAGAUUCUGUCACUCUU-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
;
More about the NCBI sViewer.
DNA
DNA (Gene ID: 23601)
CLEC5A
C-type lectin domain containing 5A
NC_000007.14
7  141930104.. 141946292
141930104.. 141946292
strand -
CCDS5870.1
MGI:1345151
ClinVar, dbVar
ENSG00000258227
MDL-1
uc003vwv.1
INSDC:
2054
604987
OTTHUMG00000157173
ENA, DDBJ, Monarch
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (567 bp)
5'-ATGAACTGGCACATGATCATCTCTGGGCTTATTGTGGTAGTGCTTAAAGTTGTTGGAATGACCTTATTTCTACTTTATTTCCCACAGATTTTTAACAAAAGTAACGATGGTTTCACCACCACCAGGAGCTATGGAACAGTCTCACAGATTTTTGGGAGCAGTTCCCCAAGTCCCAACGGCTTCATTACCACAAGGAGCTATGGAACAGTCTGCCCCAAAGACTGGGAATTTTATCAAGCAAGATGTTTTTTCTTATCCACTTCTGAATCATCTTGGAATGAAAGCAGGGACTTTTGCAAAGGAAAAGGATCCACATTGGCAATTGTCAACACGCCAGAGAAACTGAAGTTTCTTCAGGACATAACTGATGCTGAGAAGTATTTTATTGGCTTAATTTACCATCGTGAAGAGAAAAGGTGGCGTTGGATCAACAACTCTGTGTTCAATGGCAATGTTACCAATCAGAATCAGAATTTCAACTGTGCGACCATTGGCCTAACAAAGACATTTGATGCTGCATCATGTGACATCAGCTACCGCAGGATCTGTGAGAAGAATGCCAAATGA-3'
NCBI CDS gene sequence with introns (location: 141930104.. 141946292) (16189 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 141927357.. 141946974) (19618 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [141927357.. 141946974 + 1000]) (20618 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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