HumanLectome - Human Lectin Entry

NCBI Summary

This gene is a member of the aggrecan/versican proteoglycan family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage. Mutations in this gene may be involved in skeletal dysplasia and spinal degeneration. Multiple alternatively spliced transcript variants that encode different protein isoforms have been observed in this gene. [provided by RefSeq, Jul 2008].

Protein name

CLEC4H1 - Aggrecan

Synonym(s)

Aggrecan core protein (Cartilage-specific proteoglycan core protein) (CSPCP) (Chondroitin sulfate proteoglycan core protein 1) (Chondroitin sulfate proteoglycan 1) [Cleaved into: Aggrecan core protein 2]

HGNC gene name

ACAN

HGNC name

aggrecan

Protein_CD_name

Undefined

Lectin confidence

Curated

UniLectin class

C-type lectin

C-type classification

CLEC4H1

Known lectin group

C-type - Proteoglycans or lecticans

Lectin fold

a/b mixed / C-type lectin-like

Glycan specificity

Hyaluronan

RefSeq accession

NP_037359

Gene ID

176

UniProt accession

P16112

Ensembl protein ID

Undefined

UniRef cluster ID

P16112

LectomeXplore score

0.383

Reference

10.1152/ajpcell.00081.2022

Either no PDB or existing PDB of non-glycosylated form

Structural models

AlphaFold v2: AF-P16112-F1 Download

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

SWISS-MODEL structural models

SWISS-MODEL structural model

Modeller structural model (Homology modelling pipeline), Error: [1.43, 1.79] Å Download

The location of the lectin domain structural model is: 2314-2445
We infer [1.43, 1.79] Å as the interval of error of this structural model.
Template 1: 6JJJ chain: A, P70194, NP_058031.2, sequence identity: 37.1%, coverage: 97.0%, location in sequence: 393-543, (393-543 in PDB).
Template 2: 6PWS chain: A, E1BIQ4, XP_005198961.1, sequence identity: 34.8%, coverage: 95.5%, location in sequence: 174-302, (162-290 in PDB).
Template 3: 3WHD chain: C, Q8WXI8, NP_525126.2, sequence identity: 34.8%, coverage: 98.5%, location in sequence: 63-215, (63-215 in PDB).
Show the alignment used for the construction of the structural model, Download.
Show the plot of DOPE energy score, Download.

Expression

Human Protein Atlas

GeneCards

mRNA expression in normal human tissues for ACAN Gene

ProteomicsDB

References

NCBI References (10 PubMed Identifiers)

[Clinical and genetic analysis of five Chinese pedigrees affected with short stature due to variants of ACAN gene]. [34625928]

Azilsartan prevented AGE-induced inflammatory response and degradation of aggrecan in human chondrocytes through inhibition of Sox4. [34051020]

A High Proportion of Novel ACAN Mutations and Their Prevalence in a Large Cohort of Chinese Short Stature Children. [33606014]

Aggrecan: a new biomarker for acute type A aortic dissection. [33990642]

Growth-Promoting Therapies May Be Useful In Short Stature Patients With Nonspecific Skeletal Abnormalities Caused By Acan Heterozygous Mutations: Six Chinese Cases And Literature Review. [33471655]

The interglobular domain of cartilage aggrecan is cleaved by PUMP, gelatinases, and cathepsin B. [1326552]

The structure of aggrecan fragments in human synovial fluid. Evidence for the involvement in osteoarthritis of a novel proteinase which cleaves the Glu 373-Ala 374 bond of the interglobular domain. [1569188]

Complete coding sequence and deduced primary structure of the human cartilage large aggregating proteoglycan, aggrecan. Human-specific repeats, and additional alternatively spliced forms. [1985970]

A new epidermal growth factor-like domain in the human core protein for the large cartilage-specific proteoglycan. Evidence for alternative splicing of the domain. [2789216]

Absence of proteoglycan core protein in cartilage from the cmd/cmd (cartilage matrix deficiency) mouse. [7240256]

UniProt Main References (12 PubMed Identifiers)

Analysis of the DNA sequence and duplication history of human chromosome 15. [16572171]

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]

Catabolism of aggrecan by explant cultures of human articular cartilage in the presence of retinoic acid. [7574678]

Analysis of aggrecan and tenascin gene expression in mouse skeletal tissues by northern and in situ hybridization using species specific cDNA probes. [7524681]

The structure of aggrecan fragments in human synovial fluid. Evidence that aggrecanase mediates cartilage degradation in inflammatory joint disease, joint injury, and osteoarthritis. [8216415]

Length variation in the keratan sulfate domain of mammalian aggrecan. [7827755]

Age-related changes in the content of the C-terminal region of aggrecan in human articular cartilage. [8611178]

A mutation in the variable repeat region of the aggrecan gene (AGC1) causes a form of spondyloepiphyseal dysplasia associated with severe, premature osteoarthritis. [16080123]

Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. [16335952]

Interaction of cartilage oligomeric matrix protein/thrombospondin 5 with aggrecan. [17588949]

All isoforms of this gene containing a lectin domain

XP_011519616.1, NP_001126.3, XP_011519615.1, NP_037359.3, NP_001356197.1

RNA

RNA (Transcript ID: NM_013227.4)

RNA RefSeq ID

NM_013227.4

RNA name

aggrecan, transcript variant 2

Isoforms

All isoforms of ACAN containing a lectin domain

RNA Ensembl ID

Coding region

382..7974 (or 88836207.. 88874481)

mRNA location

88803436.. 88875353

NCBI Matured mRNA sequence 8846 NTP Download

m⁷G-5')ppp(5'-GCCCGCCCACCUACCUCCCCGCCGCUCCAGAGGGGGCUCGCAGAGCUGAGGACGCGCGCAGCGCUGCUCAAGGUCUCUCUCUCUCAGCACCCUCGCCGGCCGGCGUCUGACGCGGGUGCCAGGGUCUCCGGGCACCUUUCAGUGUCCAUUCCCUCAGCCAGCCAGGACUCCGCAACCCAGCAGUUGCCGCUGCGGCCACAGCCCGAGGGGACCUGCGGACAGGACGCCGGCAGGAGGAGGGGUGCGCAGCGCCCGCGCAGAGCGUCUCCCUCGCUACGCAGCGAGACCCGGGCCUCCCGGCCCCAGGAGCCCCCAGCUGCCUCGCCAGGUGUGUGGGACUGAAGUUCUUGGAGAAGGGAGUCCAACUCUUCAAGGUGAACUAUGACCACUUUACUCUGGGUUUUCGUGACUCUGAGGGUCAUCACUGCAGCUGUCACUGUAGAAACUUCAGACCAUGACAACUCGCUGAGUGUCAGCAUCCCCCAACCGUCCCCGCUGAGGGUCCUCCUGGGGACCUCCCUCACCAUCCCCUGCUAUUUCAUCGACCCCAUGCACCCUGUGACCACCGCCCCUUCUACCGCCCCACUGGCCCCAAGAAUCAAGUGGAGCCGUGUGUCCAAGGAGAAGGAGGUAGUGCUGCUGGUGGCCACUGAAGGGCGCGUGCGGGUCAACAGUGCCUAUCAGGACAAGGUCUCACUGCCCAACUACCCGGCCAUCCCCAGUGACGCCACCUUGGAAGUCCAGAGCCUGCGCUCCAAUGACUCUGGGGUCUACCGCUGCGAGGUGAUGCAUGGCAUCGAGGACAGCGAGGCCACCCUGGAAGUCGUGGUGAAAGGCAUCGUGUUCCAUUACAGAGCCAUCUCUACACGCUACACCCUCGACUUUGACAGGGCGCAGCGGGCCUGCCUGCAGAACAGUGCCAUCAUUGCCACGCCUGAGCAGCUGCAGGCCGCCUACGAAGACGGCUUCCACCAGUGUGACGCCGGCUGGCUGGCUGACCAGACUGUCAGAUACCCCAUCCACACUCCCCGGGAAGGCUGCUAUGGAGACAAGGAUGAGUUUCCUGGUGUGAGGACGUAUGGCAUCCGAGACACCAACGAGACCUAUGAUGUGUACUGCUUCGCCGAGGAGAUGGAGGGUGAGGUCUUUUAUGCAACAUCUCCAGAGAAGUUCACCUUCCAGGAAGCAGCCAAUGAGUGCCGGCGGCUGGGUGCCCGGCUGGCCACCACGGGCCAGCUCUACCUGGCCUGGCAGGCUGGCAUGGACAUGUGCAGCGCCGGCUGGCUGGCCGACCGCAGCGUGCGCUACCCCAUCUCCAAGGCCCGGCCCAACUGCGGUGGCAACCUCCUGGGCGUGAGGACCGUCUACGUGCAUGCCAACCAGACGGGCUACCCCGACCCCUCAUCCCGCUACGACGCCAUCUGCUACACAGGUGAAGACUUUGUGGACAUCCCAGAAAACUUCUUUGGAGUGGGGGGUGAGGAGGACAUCACCGUCCAGACAGUGACCUGGCCUGACAUGGAGCUGCCACUGCCUCGAAACAUCACUGAGGGUGAAGCCCGAGGCAGCGUGAUCCUUACCGUAAAGCCCAUCUUCGAGGUCUCCCCCAGUCCCCUGGAACCCGAGGAGCCCUUCACGUUUGCCCCUGAAAUAGGGGCCACUGCCUUCGCUGAGGUUGAGAAUGAGACUGGAGAGGCCACCAGGCCCUGGGGCUUUCCCACACCUGGCCUGGGCCCUGCCACGGCAUUCACCAGUGAGGACCUCGUCGUGCAGGUGACCGCUGUCCCUGGGCAGCCGCAUUUGCCAGGGGGGGUCGUCUUCCACUACCGCCCGGGACCCACCCGCUACUCGCUGACCUUUGAGGAGGCACAGCAGGCCUGCCUGCGCACGGGGGCGGUCAUUGCCUCGCCGGAGCAGCUCCAGGCCGCCUACGAAGCAGGCUAUGAGCAGUGUGACGCCGGCUGGCUGCGGGACCAGACCGUCAGAUACCCCAUUGUGAGCCCCCGGACCCCAUGCGUGGGUGACAAGGACAGCAGCCCAGGGGUCAGGACCUAUGGCGUGCGCCCAUCAACAGAGACCUACGAUGUCUACUGCUUUGUAGACAGACUUGAGGGGGAGGUGUUCUUCGCCACACGCCUUGAGCAGUUCACCUUCCAGGAAGCACUGGAGUUCUGUGAAUCUCACAAUGCUACGCUGGCCACCACGGGCCAGCUCUACGCCGCCUGGAGCCGCGGCCUGGACAAGUGCUAUGCCGGCUGGCUGGCCGACGGCAGCCUCCGCUACCCCAUCGUCACCCCAAGGCCUGCCUGCGGUGGGGACAAGCCAGGCGUGAGAACGGUCUACCUCUACCCUAACCAGACGGGCCUCCCAGACCCACUGUCCCGGCACCAUGCCUUCUGCUUCCGAGGCAUUUCAGCGGUUCCUUCUCCAGGAGAAGAAGAGGGUGGCACACCCACAUCACCCUCUGGUGUGGAGGAGUGGAUCGUGACCCAAGUGGUUCCUGGUGUGGCUGCUGUCCCCGUAGAAGAGGAGACAACUGCUGUACCCUCAGGGGAGACUACUGCCAUCCUAGAGUUCACCACCGAGCCAGAAAACCAGACAGAAUGGGAACCAGCCUAUACCCCAGUGGGCACAUCCCCGCUGCCAGGGAUCCUUCCUACUUGGCCUCCCACUGGCGCAGCAACAGAGGAAAGUACAGAAGGCCCUUCUGCAACUGAAGUGCCCUCUGCCUCAGAGGAACCAUCCCCCUCAGAGGUGCCAUUCCCCUCAGAGGAGCCAUCCCCCUCAGAGGAACCAUUCCCCUCAGUGAGGCCAUUCCCCUCAGUGGAGCUGUUCCCCUCAGAGGAGCCAUUCCCCUCCAAGGAGCCAUCCCCCUCAGAGGAACCAUCAGCCUCGGAAGAGCCGUAUACACCUUCACCCCCCGUGCCCAGCUGGACUGAGCUGCCCAGCUCUGGGGAGGAAUCUGGGGCCCCUGAUGUCAGUGGUGACUUCACAGGCAGUGGAGAUGUUUCAGGACACCUUGACUUCAGUGGGCAGCUGUCAGGGGACAGGGCAAGUGGACUGCCCUCUGGAGACCUGGACUCCAGUGGUCUUACUUCCACAGUGGGCUCAGGCCUGCCUGUGGAAAGUGGACUACCCUCAGGGGAUGAAGAGAGAAUUGAGUGGCCCAGCACUCCUACGGUUGGUGAACUGCCCUCUGGAGCUGAGAUCCUAGAGGGCUCUGCCUCUGGAGUUGGGGAUCUCAGUGGACUUCCUUCUGGAGAAGUUCUAGAGACCUCUGCCUCUGGAGUAGGAGACCUCAGUGGGCUUCCUUCUGGAGAAGUUCUAGAGACCACUGCCCCUGGAGUAGAGGACAUCAGCGGGCUUCCUUCUGGAGAAGUUCUAGAGACCACUGCCCCUGGAGUAGAGGACAUCAGCGGGCUUCCUUCUGGAGAAGUUCUAGAGACCACUGCCCCUGGAGUAGAGGACAUCAGCGGGCUUCCUUCUGGAGAAGUUCUAGAGACCACUGCCCCUGGAGUAGAGGACAUCAGCGGGCUUCCUUCUGGAGAAGUUCUAGAGACCACUGCCCCUGGAGUAGAGGACAUCAGCGGGCUUCCUUCUGGAGAAGUUCUAGAGACCACUGCCCCUGGAGUAGAGGACAUCAGCGGGCUUCCUUCUGGAGAAGUUCUAGAGACCGCUGCCCCUGGAGUAGAGGACAUCAGCGGGCUUCCUUCUGGAGAAGUUCUAGAGACCGCUGCCCCUGGAGUAGAGGACAUCAGCGGGCUUCCUUCUGGAGAAGUUCUAGAGACCGCUGCCCCUGGAGUAGAGGACAUCAGCGGGCUUCCUUCUGGAGAAGUUCUAGAGACCGCUGCCCCUGGAGUAGAGGACAUCAGCGGGCUUCCUUCUGGAGAAGUUCUAGAGACCGCUGCCCCUGGAGUAGAGGACAUCAGCGGGCUUCCUUCUGGAGAAGUUCUAGAGACCGCUGCCCCUGGAGUAGAGGACAUCAGCGGGCUUCCUUCUGGAGAAGUUCUAGAGACCGCUGCCCCUGGAGUAGAGGACAUCAGCGGGCUUCCUUCUGGAGAAGUUCUAGAGACUGCUGCCCCUGGAGUAGAGGACAUCAGCGGGCUUCCUUCUGGAGAAGUUCUAGAGACUGCUGCCCCUGGAGUAGAGGACAUCAGCGGGCUUCCUUCUGGAGAAGUUCUAGAGACUGCUGCCCCUGGAGUAGAGGACAUCAGCGGGCUUCCUUCUGGAGAAGUUCUAGAGACUGCUGCCCCUGGAGUAGAGGACAUCAGCGGGCUUCCUUCUGGAGAAGUUCUAGAGACUGCUGCCCCUGGAGUAGAGGACAUCAGCGGGCUUCCUUCUGGAGAAGUUCUAGAGACUGCUGCCCCUGGAGUAGAGGACAUCAGCGGGCUUCCUUCUGGAGAAGUUCUAGAGACUGCUGCCCCUGGAGUAGAGGACAUCAGCGGGCUUCCUUCUGGAGAAGUUCUAGAGACUGCUGCCCCUGGAGUAGAGGACAUCAGCGGGCUUCCUUCUGGAGAAGUUCUAGAGACUGCUGCCCCUGGAGUAGAGGACAUCAGCGGGCUUCCUUCUGGAGAAGUUCUAGAGACUACUGCCCCUGGAGUAGAGGAGAUCAGCGGGCUUCCUUCUGGAGAAGUUCUAGAGACUACUGCCCCUGGAGUAGAUGAGAUCAGUGGGCUUCCUUCUGGAGAAGUUCUAGAGACUACUGCCCCUGGAGUAGAGGAGAUCAGCGGGCUUCCUUCUGGAGAAGUUCUAGAGACUUCUACCUCUGCGGUAGGGGACCUCAGUGGACUUCCUUCUGGAGGAGAAGUUCUAGAGAUUUCUGUCUCUGGAGUAGAGGACAUCAGUGGGCUUCCUUCUGGAGAGGUUGUAGAGACUUCUGCCUCUGGAAUAGAGGAUGUCAGUGAACUUCCUUCAGGAGAAGGUCUAGAGACCUCUGCUUCUGGAGUAGAGGACCUCAGCAGGCUCCCUUCUGGAGAAGAAGUUCUAGAGAUUUCUGCCUCUGGAUUUGGGGACCUCAGUGGACUUCCUUCUGGAGGAGAAGGUCUAGAGACCUCUGCUUCUGAAGUAGGGACUGACCUCAGUGGGCUUCCUUCUGGAAGGGAGGGUCUAGAGACUUCAGCUUCUGGAGCUGAGGACCUCAGUGGGUUGCCUUCUGGAAAAGAAGACUUGGUGGGGUCAGCUUCUGGAGACUUGGACUUGGGCAAACUGCCUUCUGGAACUCUAGGAAGUGGGCAAGCUCCAGAAACAAGUGGUCUUCCCUCUGGAUUUAGUGGUGAGUAUUCUGGGGUGGACCUUGGAAGUGGCCCACCCUCUGGCCUGCCUGACUUUAGUGGACUUCCAUCUGGAUUCCCAACUGUUUCCCUAGUGGAUUCUACAUUGGUGGAAGUGGUCACAGCCUCCACUGCAAGUGAACUGGAAGGGAGGGGAACCAUUGGCAUCAGUGGUGCAGGAGAAAUAUCUGGACUGCCCUCCAGUGAGCUGGACAUUAGUGGGAGAGCUAGUGGACUCCCUUCAGGAACUGAACUCAGUGGCCAAGCAUCUGGGUCUCCUGAUGUCAGUGGGGAAAUACCUGGACUCUUUGGUGUCAGUGGACAGCCAUCAGGGUUUCCUGACACUAGUGGGGAAACAUCUGGAGUGACUGAGCUUAGCGGGCUGUCCUCUGGACAACCAGGUAUUAGUGGAGAAGCAUCUGGAGUUCUUUAUGGCACUAGUCAACCCUUUGGCAUAACUGAUCUGAGUGGAGAAACAUCUGGGGUCCCUGAUCUCAGUGGGCAGCCUUCAGGGUUACCAGGGUUCAGUGGGGCAACAUCAGGAGUCCCUGACCUGGUUUCUGGUACCACGAGUGGCAGCGGUGAAUCUUCUGGGAUUACAUUUGUGGACACCAGUUUGGUUGAAGUGGCCCCUACUACAUUUAAAGAAGAAGAAGGCUUAGGGUCUGUGGAACUCAGUGGCCUCCCUUCCGGAGAGGCAGAUCUGUCAGGCAAAUCUGGGAUGGUGGAUGUCAGUGGACAGUUUUCUGGAACAGUCGAUUCCAGUGGGUUUACAUCCCAGACUCCGGAAUUCAGUGGCCUACCAAGUGGCAUAGCUGAGGUCAGUGGAGAAUCCUCCAGAGCUGAGAUUGGGAGCAGCCUGCCCUCGGGAGCAUAUUAUGGCAGUGGAACUCCAUCUAGUUUCCCCACUGUCUCUCUUGUAGACAGAACUUUGGUGGAAUCUGUAACCCAGGCUCCAACAGCCCAAGAGGCAGGAGAAGGGCCUUCUGGCAUUUUAGAACUCAGUGGUGCUCAUUCUGGAGCACCAGACAUGUCUGGGGAGCAUUCUGGAUUUCUGGACCUAAGUGGGCUGCAGUCCGGGCUGAUAGAGCCCAGCGGAGAGCCACCAGGUACUCCAUAUUUUAGUGGGGAUUUUGCCAGCACCACCAAUGUAAGUGGAGAAUCCUCUGUAGCCAUGGGCACCAGUGGAGAGGCCUCAGGACUUCCAGAAGUUACUUUAAUCACUUCUGAGUUCGUGGAGGGUGUUACUGAACCAACUAUUUCUCAGGAACUAGGCCAAAGGCCCCCUGUGACACACACACCCCAGCUUUUUGAGUCCAGUGGAAAAGUCUCCACAGCUGGGGACAUUAGUGGAGCUACCCCAGUGCUCCCUGGGUCUGGAGUAGAAGUAUCAUCAGUCCCAGAAUCUAGCAGUGAGACGUCCGCCUAUCCUGAAGCUGGGUUCGGGGCAUCUGCCGCCCCUGAGGCCAGCAGAGAAGAUUCUGGGUCCCCUGAUCUGAGUGAAACCACCUCUGCAUUCCACGAAGCUAACCUUGAGAGAUCCUCUGGCCUAGGAGUGAGCGGCAGCACUUUGACAUUUCAAGAAGGCGAGGCGUCCGCUGCCCCAGAAGUGAGUGGAGAAUCCACCACCACCAGUGAUGUGGGGACAGAGGCACCAGGCUUGCCUUCAGCCACUCCCACGGCUUCUGGAGACAGGACUGAAAUCAGCGGAGACCUGUCUGGUCACACCUCGCAGCUGGGCGUUGUCAUCAGCACCAGCAUCCCAGAGUCUGAGUGGACCCAGCAGACCCAGCGCCCUGCAGAGACGCAUCUAGAAAUUGAGUCCUCAAGCCUCCUGUACUCAGGAGAAGAGACUCACACAGUCGAAACAGCCACCUCCCCAACAGAUGCUUCCAUCCCAGCUUCUCCGGAAUGGAAACGUGAAUCAGAAUCAACUGCUGCAGCCCCCGCCAGGUCCUGUGCAGAGGAGCCCUGUGGAGCUGGGACCUGCAAGGAGACAGAGGGACACGUCAUAUGCCUGUGCCCCCCUGGCUACACUGGCGAGCACUGUAACAUAGACCAGGAGGUAUGUGAGGAGGGCUGGAACAAGUACCAGGGCCACUGUUACCGCCACUUCCCGGACCGCGAGACCUGGGUGGAUGCUGAGCGCCGGUGUCGGGAGCAGCAGUCACACCUGAGCAGCAUCGUCACCCCCGAGGAGCAGGAGUUUGUCAACAACAAUGCCCAAGACUACCAGUGGAUCGGCCUGAACGACAGGACCAUCGAAGGGGACUUCCGCUGGUCAGAUGGACACCCCAUGCAAUUUGAGAACUGGCGCCCCAACCAGCCUGACAACUUUUUUGCCGCUGGAGAGGACUGUGUGGUGAUGAUCUGGCACGAGAAGGGCGAGUGGAAUGAUGUUCCCUGCAAUUACCACCUCCCCUUCACGUGUAAAAAGGGCACAGUGGCCUGCGGAGAGCCCCCUGUGGUGGAGCAUGCCAGGACCUUCGGGCAGAAGAAGGACCGGUAUGAGAUCAAUUCCCUGGUGCGGUACCAGUGCACAGAGGGGUUUGUCCAGCGCCACAUGCCCACCAUCCGGUGCCAGCCCAGCGGGCACUGGGAGGAGCCUCAGAUCACCUGCACAGACCCCACCACCUACAAACGCAGACUACAGAAGCGGAGCUCACGGCACCCUCGGAGGAGCCGCCCCAGCACAGCCCACUGAGAAGAGCUUCCAGGACGCACCCAGGACGCUGAGCCCAGGAGCCUGCCAGGCUGACGUGCAUCCCACCCAGACGGUGUCCUCUUCUUGUCGCUUUUUGUCAUAUAAGGAAUCCCAUUAAAGAAGGAAAAAAAUAAAUCCCACAUUUGUGUAUGCACCCACUCACCCCUCCAAAUCAGCAAAACCGCAUCUAAUUUGUCCGCCGAAUGCCAAAGCAAAGCAAACUUAUUAUAACCCUUGGACUGAGUUUAGAGACAUUUCUUCAAUUUCCCAUCGUGCCUUUCCAGGGACCAGUGCAGGGACAGGGGGAGAAGGGGAGGGGUUAAGUUAAAUAAAGAAGAUUAUUUUUGUUUCCUGACUUUAUCCAAGAGCAGUGCAAUCGUUGGUUAUUUCACCUCCAGGGAGAGCUAGGGAGGAGGGAGGAGGGCUCCAAAGGAGCUGGAAGGAGCAGAGGCCUGAGAGCAGGAAGAACUCGGAACCGCAGCUGAAUGUAUUGGAUGAGAAGGAGCCAGGAGGGCUACACCAUCUGUAUGAGGGAAAAGCCUUGGGGGAGAGGGGUGGGUUCCUGCCUCCUGCCGAGGGUAAGCCGGCAGGAGAGAGCCAUCAGAGGGACCUCCGCUGCCUGGGAGUUGGGUUCCCUCCAAGGGUCCCUCUUUCAGUGUCCUCUCUCUCACCUGGGUCUGCCACCCUAACAGGUGGCAACUCGGCAGGGCUGCUGGGGGCACUUCCUGCCCAGUGGGGGGUGCCGCCCAACCUUCUCCCCUCCCCACCCCCGCCCCCGGGACCGUGCAGGCACCAGGGUUCCGUGCACCUAUUUAUAUUUUUGAAAACUGAAGAUUAUAAUAUUAUAAUAAUAAUAAAGACAUUGGAAGAGA-3'- Poly-A tail

Coding region

NCBI Matured mRNA sequence viewer

;

More about the NCBI sViewer.

DNA

DNA (Gene ID: 176)

HGNC Gene symbol

ACAN

HGNC Gene name

aggrecan

Chr. RefSeq ID

NC_000015.10

Chromosome N°

15 88836207.. 88874481

CDS location

88836207.. 88874481

DNA strand

strand +

CCDS ID

CCDS53970.1

Mouse ortholog gene

MGI:99602

Gene Variant

ClinVar, dbVar

DNA Ensembl ID

ENSG00000157766

HGNC other symbol

CSPGCP

UCSC ID

uc010upo.1

GeneBank

INSDC: M55172

GeneCards

319

MIM

155760

VEGA ID

OTTHUMG00000171989

Other links

ENA, DDBJ, Monarch

NCBI CDS Gene viewer

More about the NCBI sViewer.

NCBI CDS gene sequence (7593 bp)

5'-ATGACCACTTTACTCTGGGTTTTCGTGACTCTGAGGGTCATCACTGCAGCTGTCACTGTAGAAACTTCAGACCATGACAACTCGCTGAGTGTCAGCATCCCCCAACCGTCCCCGCTGAGGGTCCTCCTGGGGACCTCCCTCACCATCCCCTGCTATTTCATCGACCCCATGCACCCTGTGACCACCGCCCCTTCTACCGCCCCACTGGCCCCAAGAATCAAGTGGAGCCGTGTGTCCAAGGAGAAGGAGGTAGTGCTGCTGGTGGCCACTGAAGGGCGCGTGCGGGTCAACAGTGCCTATCAGGACAAGGTCTCACTGCCCAACTACCCGGCCATCCCCAGTGACGCCACCTTGGAAGTCCAGAGCCTGCGCTCCAATGACTCTGGGGTCTACCGCTGCGAGGTGATGCATGGCATCGAGGACAGCGAGGCCACCCTGGAAGTCGTGGTGAAAGGCATCGTGTTCCATTACAGAGCCATCTCTACACGCTACACCCTCGACTTTGACAGGGCGCAGCGGGCCTGCCTGCAGAACAGTGCCATCATTGCCACGCCTGAGCAGCTGCAGGCCGCCTACGAAGACGGCTTCCACCAGTGTGACGCCGGCTGGCTGGCTGACCAGACTGTCAGATACCCCATCCACACTCCCCGGGAAGGCTGCTATGGAGACAAGGATGAGTTTCCTGGTGTGAGGACGTATGGCATCCGAGACACCAACGAGACCTATGATGTGTACTGCTTCGCCGAGGAGATGGAGGGTGAGGTCTTTTATGCAACATCTCCAGAGAAGTTCACCTTCCAGGAAGCAGCCAATGAGTGCCGGCGGCTGGGTGCCCGGCTGGCCACCACGGGCCAGCTCTACCTGGCCTGGCAGGCTGGCATGGACATGTGCAGCGCCGGCTGGCTGGCCGACCGCAGCGTGCGCTACCCCATCTCCAAGGCCCGGCCCAACTGCGGTGGCAACCTCCTGGGCGTGAGGACCGTCTACGTGCATGCCAACCAGACGGGCTACCCCGACCCCTCATCCCGCTACGACGCCATCTGCTACACAGGTGAAGACTTTGTGGACATCCCAGAAAACTTCTTTGGAGTGGGGGGTGAGGAGGACATCACCGTCCAGACAGTGACCTGGCCTGACATGGAGCTGCCACTGCCTCGAAACATCACTGAGGGTGAAGCCCGAGGCAGCGTGATCCTTACCGTAAAGCCCATCTTCGAGGTCTCCCCCAGTCCCCTGGAACCCGAGGAGCCCTTCACGTTTGCCCCTGAAATAGGGGCCACTGCCTTCGCTGAGGTTGAGAATGAGACTGGAGAGGCCACCAGGCCCTGGGGCTTTCCCACACCTGGCCTGGGCCCTGCCACGGCATTCACCAGTGAGGACCTCGTCGTGCAGGTGACCGCTGTCCCTGGGCAGCCGCATTTGCCAGGGGGGGTCGTCTTCCACTACCGCCCGGGACCCACCCGCTACTCGCTGACCTTTGAGGAGGCACAGCAGGCCTGCCTGCGCACGGGGGCGGTCATTGCCTCGCCGGAGCAGCTCCAGGCCGCCTACGAAGCAGGCTATGAGCAGTGTGACGCCGGCTGGCTGCGGGACCAGACCGTCAGATACCCCATTGTGAGCCCCCGGACCCCATGCGTGGGTGACAAGGACAGCAGCCCAGGGGTCAGGACCTATGGCGTGCGCCCATCAACAGAGACCTACGATGTCTACTGCTTTGTAGACAGACTTGAGGGGGAGGTGTTCTTCGCCACACGCCTTGAGCAGTTCACCTTCCAGGAAGCACTGGAGTTCTGTGAATCTCACAATGCTACGCTGGCCACCACGGGCCAGCTCTACGCCGCCTGGAGCCGCGGCCTGGACAAGTGCTATGCCGGCTGGCTGGCCGACGGCAGCCTCCGCTACCCCATCGTCACCCCAAGGCCTGCCTGCGGTGGGGACAAGCCAGGCGTGAGAACGGTCTACCTCTACCCTAACCAGACGGGCCTCCCAGACCCACTGTCCCGGCACCATGCCTTCTGCTTCCGAGGCATTTCAGCGGTTCCTTCTCCAGGAGAAGAAGAGGGTGGCACACCCACATCACCCTCTGGTGTGGAGGAGTGGATCGTGACCCAAGTGGTTCCTGGTGTGGCTGCTGTCCCCGTAGAAGAGGAGACAACTGCTGTACCCTCAGGGGAGACTACTGCCATCCTAGAGTTCACCACCGAGCCAGAAAACCAGACAGAATGGGAACCAGCCTATACCCCAGTGGGCACATCCCCGCTGCCAGGGATCCTTCCTACTTGGCCTCCCACTGGCGCAGCAACAGAGGAAAGTACAGAAGGCCCTTCTGCAACTGAAGTGCCCTCTGCCTCAGAGGAACCATCCCCCTCAGAGGTGCCATTCCCCTCAGAGGAGCCATCCCCCTCAGAGGAACCATTCCCCTCAGTGAGGCCATTCCCCTCAGTGGAGCTGTTCCCCTCAGAGGAGCCATTCCCCTCCAAGGAGCCATCCCCCTCAGAGGAACCATCAGCCTCGGAAGAGCCGTATACACCTTCACCCCCCGTGCCCAGCTGGACTGAGCTGCCCAGCTCTGGGGAGGAATCTGGGGCCCCTGATGTCAGTGGTGACTTCACAGGCAGTGGAGATGTTTCAGGACACCTTGACTTCAGTGGGCAGCTGTCAGGGGACAGGGCAAGTGGACTGCCCTCTGGAGACCTGGACTCCAGTGGTCTTACTTCCACAGTGGGCTCAGGCCTGCCTGTGGAAAGTGGACTACCCTCAGGGGATGAAGAGAGAATTGAGTGGCCCAGCACTCCTACGGTTGGTGAACTGCCCTCTGGAGCTGAGATCCTAGAGGGCTCTGCCTCTGGAGTTGGGGATCTCAGTGGACTTCCTTCTGGAGAAGTTCTAGAGACCTCTGCCTCTGGAGTAGGAGACCTCAGTGGGCTTCCTTCTGGAGAAGTTCTAGAGACCACTGCCCCTGGAGTAGAGGACATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACCACTGCCCCTGGAGTAGAGGACATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACCACTGCCCCTGGAGTAGAGGACATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACCACTGCCCCTGGAGTAGAGGACATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACCACTGCCCCTGGAGTAGAGGACATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACCACTGCCCCTGGAGTAGAGGACATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACCGCTGCCCCTGGAGTAGAGGACATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACCGCTGCCCCTGGAGTAGAGGACATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACCGCTGCCCCTGGAGTAGAGGACATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACCGCTGCCCCTGGAGTAGAGGACATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACCGCTGCCCCTGGAGTAGAGGACATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACCGCTGCCCCTGGAGTAGAGGACATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACCGCTGCCCCTGGAGTAGAGGACATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACTGCTGCCCCTGGAGTAGAGGACATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACTGCTGCCCCTGGAGTAGAGGACATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACTGCTGCCCCTGGAGTAGAGGACATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACTGCTGCCCCTGGAGTAGAGGACATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACTGCTGCCCCTGGAGTAGAGGACATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACTGCTGCCCCTGGAGTAGAGGACATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACTGCTGCCCCTGGAGTAGAGGACATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACTGCTGCCCCTGGAGTAGAGGACATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACTGCTGCCCCTGGAGTAGAGGACATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACTACTGCCCCTGGAGTAGAGGAGATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACTACTGCCCCTGGAGTAGATGAGATCAGTGGGCTTCCTTCTGGAGAAGTTCTAGAGACTACTGCCCCTGGAGTAGAGGAGATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACTTCTACCTCTGCGGTAGGGGACCTCAGTGGACTTCCTTCTGGAGGAGAAGTTCTAGAGATTTCTGTCTCTGGAGTAGAGGACATCAGTGGGCTTCCTTCTGGAGAGGTTGTAGAGACTTCTGCCTCTGGAATAGAGGATGTCAGTGAACTTCCTTCAGGAGAAGGTCTAGAGACCTCTGCTTCTGGAGTAGAGGACCTCAGCAGGCTCCCTTCTGGAGAAGAAGTTCTAGAGATTTCTGCCTCTGGATTTGGGGACCTCAGTGGACTTCCTTCTGGAGGAGAAGGTCTAGAGACCTCTGCTTCTGAAGTAGGGACTGACCTCAGTGGGCTTCCTTCTGGAAGGGAGGGTCTAGAGACTTCAGCTTCTGGAGCTGAGGACCTCAGTGGGTTGCCTTCTGGAAAAGAAGACTTGGTGGGGTCAGCTTCTGGAGACTTGGACTTGGGCAAACTGCCTTCTGGAACTCTAGGAAGTGGGCAAGCTCCAGAAACAAGTGGTCTTCCCTCTGGATTTAGTGGTGAGTATTCTGGGGTGGACCTTGGAAGTGGCCCACCCTCTGGCCTGCCTGACTTTAGTGGACTTCCATCTGGATTCCCAACTGTTTCCCTAGTGGATTCTACATTGGTGGAAGTGGTCACAGCCTCCACTGCAAGTGAACTGGAAGGGAGGGGAACCATTGGCATCAGTGGTGCAGGAGAAATATCTGGACTGCCCTCCAGTGAGCTGGACATTAGTGGGAGAGCTAGTGGACTCCCTTCAGGAACTGAACTCAGTGGCCAAGCATCTGGGTCTCCTGATGTCAGTGGGGAAATACCTGGACTCTTTGGTGTCAGTGGACAGCCATCAGGGTTTCCTGACACTAGTGGGGAAACATCTGGAGTGACTGAGCTTAGCGGGCTGTCCTCTGGACAACCAGGTATTAGTGGAGAAGCATCTGGAGTTCTTTATGGCACTAGTCAACCCTTTGGCATAACTGATCTGAGTGGAGAAACATCTGGGGTCCCTGATCTCAGTGGGCAGCCTTCAGGGTTACCAGGGTTCAGTGGGGCAACATCAGGAGTCCCTGACCTGGTTTCTGGTACCACGAGTGGCAGCGGTGAATCTTCTGGGATTACATTTGTGGACACCAGTTTGGTTGAAGTGGCCCCTACTACATTTAAAGAAGAAGAAGGCTTAGGGTCTGTGGAACTCAGTGGCCTCCCTTCCGGAGAGGCAGATCTGTCAGGCAAATCTGGGATGGTGGATGTCAGTGGACAGTTTTCTGGAACAGTCGATTCCAGTGGGTTTACATCCCAGACTCCGGAATTCAGTGGCCTACCAAGTGGCATAGCTGAGGTCAGTGGAGAATCCTCCAGAGCTGAGATTGGGAGCAGCCTGCCCTCGGGAGCATATTATGGCAGTGGAACTCCATCTAGTTTCCCCACTGTCTCTCTTGTAGACAGAACTTTGGTGGAATCTGTAACCCAGGCTCCAACAGCCCAAGAGGCAGGAGAAGGGCCTTCTGGCATTTTAGAACTCAGTGGTGCTCATTCTGGAGCACCAGACATGTCTGGGGAGCATTCTGGATTTCTGGACCTAAGTGGGCTGCAGTCCGGGCTGATAGAGCCCAGCGGAGAGCCACCAGGTACTCCATATTTTAGTGGGGATTTTGCCAGCACCACCAATGTAAGTGGAGAATCCTCTGTAGCCATGGGCACCAGTGGAGAGGCCTCAGGACTTCCAGAAGTTACTTTAATCACTTCTGAGTTCGTGGAGGGTGTTACTGAACCAACTATTTCTCAGGAACTAGGCCAAAGGCCCCCTGTGACACACACACCCCAGCTTTTTGAGTCCAGTGGAAAAGTCTCCACAGCTGGGGACATTAGTGGAGCTACCCCAGTGCTCCCTGGGTCTGGAGTAGAAGTATCATCAGTCCCAGAATCTAGCAGTGAGACGTCCGCCTATCCTGAAGCTGGGTTCGGGGCATCTGCCGCCCCTGAGGCCAGCAGAGAAGATTCTGGGTCCCCTGATCTGAGTGAAACCACCTCTGCATTCCACGAAGCTAACCTTGAGAGATCCTCTGGCCTAGGAGTGAGCGGCAGCACTTTGACATTTCAAGAAGGCGAGGCGTCCGCTGCCCCAGAAGTGAGTGGAGAATCCACCACCACCAGTGATGTGGGGACAGAGGCACCAGGCTTGCCTTCAGCCACTCCCACGGCTTCTGGAGACAGGACTGAAATCAGCGGAGACCTGTCTGGTCACACCTCGCAGCTGGGCGTTGTCATCAGCACCAGCATCCCAGAGTCTGAGTGGACCCAGCAGACCCAGCGCCCTGCAGAGACGCATCTAGAAATTGAGTCCTCAAGCCTCCTGTACTCAGGAGAAGAGACTCACACAGTCGAAACAGCCACCTCCCCAACAGATGCTTCCATCCCAGCTTCTCCGGAATGGAAACGTGAATCAGAATCAACTGCTGCAGCCCCCGCCAGGTCCTGTGCAGAGGAGCCCTGTGGAGCTGGGACCTGCAAGGAGACAGAGGGACACGTCATATGCCTGTGCCCCCCTGGCTACACTGGCGAGCACTGTAACATAGACCAGGAGGTATGTGAGGAGGGCTGGAACAAGTACCAGGGCCACTGTTACCGCCACTTCCCGGACCGCGAGACCTGGGTGGATGCTGAGCGCCGGTGTCGGGAGCAGCAGTCACACCTGAGCAGCATCGTCACCCCCGAGGAGCAGGAGTTTGTCAACAACAATGCCCAAGACTACCAGTGGATCGGCCTGAACGACAGGACCATCGAAGGGGACTTCCGCTGGTCAGATGGACACCCCATGCAATTTGAGAACTGGCGCCCCAACCAGCCTGACAACTTTTTTGCCGCTGGAGAGGACTGTGTGGTGATGATCTGGCACGAGAAGGGCGAGTGGAATGATGTTCCCTGCAATTACCACCTCCCCTTCACGTGTAAAAAGGGCACAGTGGCCTGCGGAGAGCCCCCTGTGGTGGAGCATGCCAGGACCTTCGGGCAGAAGAAGGACCGGTATGAGATCAATTCCCTGGTGCGGTACCAGTGCACAGAGGGGTTTGTCCAGCGCCACATGCCCACCATCCGGTGCCAGCCCAGCGGGCACTGGGAGGAGCCTCAGATCACCTGCACAGACCCCACCACCTACAAACGCAGACTACAGAAGCGGAGCTCACGGCACCCTCGGAGGAGCCGCCCCAGCACAGCCCACTGA-3'

NCBI CDS gene sequence with introns (location: 88836207.. 88874481) (38275 bp)Download

NCBI Gene Viewer (CDS + introns)

NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 88803436.. 88875353) (71918 bp)Download

NCBI Gene Viewer (CDS + introns + Untranslated regions)

NCBI gene sequence (location: [88803436 - 1000].. 88875353) (72918 bp)Download

NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)

Either no PDB or existing PDB of non-glycosylated form

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