HumanLectome - Human Lectin Entry

NCBI Summary

The protein encoded by this gene is a cell-surface glycoprotein and type I membrane protein that was originally identified as a myeloid cell-specific marker. The encoded protein was once thought to be a receptor for C1q, but now is thought to instead be involved in intercellular adhesion and in the clearance of apoptotic cells. The intracellular cytoplasmic tail of this protein has been found to interact with moesin, a protein known to play a role in linking transmembrane proteins to the cytoskeleton and in the remodelling of the cytoskeleton. [provided by RefSeq, Jul 2008].

Protein name

CD93

Synonym(s)

Complement component C1q receptor (C1q/MBL/SPA receptor) (C1qR) (C1qR(p)) (C1qRp) (CDw93) (Complement component 1 q subcomponent receptor 1) (Matrix-remodeling-associated protein 4) (CD antigen CD93)

HGNC gene name

CD93

HGNC name

CD93 molecule

Protein_CD_name

CD93

Lectin confidence

Very low evidence

UniLectin class

C-type lectin

C-type classification

Undefined

Known lectin group

C-type - Endosialin

Lectin fold

a/b mixed / C-type lectin-like

Glycan specificity

Uncharacterised

RefSeq accession

Gene ID

UniProt accession

Ensembl protein ID

UniRef cluster ID

LectomeXplore score

0.228

Reference

10.1016/j.ijbiomac.2022.10.136

Other links

neXtProt, PFAM, InterPro

Protein sequence and protein families (fasta) (652 amino acids) Download

MATSMGLLLLLLLLLTQPGAGTGADTEAVVCVGTACYTAHSGKLSAAEAQNHCNQNGGNLATVKSKEEAQHVQRVLAQLLRREAALTARMSKFWIGLQREKGKCLDPSLPLKGFSWVGGGEDTPYSNWHKELRNSCISKRCVSLLLDLSQPLLPSRLPKWSEGPCGSPGSPGSNIEGFVCKFSFKGMCRPLALGGPGQVTYTTPFQTTSSSLEAVPFASAANVACGEGDKDETQSHYFLCKEKAPDVFDWGSSGPLCVSPKYGCNFNNGGCHQDCFEGGDGSFLCGCRPGFRLLDDLVTCASRNPCSSSPCRGGATCVLGPHGKNYTCRCPQGYQLDSSQLDCVDVDECQDSPCAQECVNTPGGFRCECWVGYEPGGPGEGACQDVDECALGRSPCAQGCTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLCDSLCFNTQGSFHCGCLPGWVLAPNGVSCTMGPVSLGPPSGPPDEEDKGEKEGSTVPRAATASPTRGPEGTPKATPTTSRPSLSSDAPITSAPLKMLAPSGSPGVWREPSIHHATAASGPQEPAGGDSSVATQNNDGTDGQKLLLFYILGTVVAILLLLALALGLLVYRKRRAKREEKKEKKPQNAADSYSWVPERAESRAMENQYSPTPGTDC

Mol* PDB structure viewerUniLectin3D

Select a PDB entry:

Structural models

AlphaFold v2: AF-Q9NPY3-F1 Download

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Expression

Human Protein Atlas

GeneCards

mRNA expression in normal human tissues for CD93 Gene

ProteomicsDB

References

NCBI References (10 PubMed Identifiers)

Genetic variance and plasma concentration of CD93 is associated with cardiovascular mortality: Results from a 6.7-year follow-up of a healthy community-living elderly population. [33173973]

Efficiency and Target Derepression of Anti-miR-92a: Results of a First in Human Study. [32707001]

CD93 hematopoietic stem cells improve diabetic wound healing by VEGF activation and downregulation of DAPK-1. [31549396]

CD93 is a cell surface lectin receptor involved in the control of the inflammatory response stimulated by exogenous DNA. [31335975]

CD93 is Selectively Expressed on Human Myeloma Cells but Not on B Lymphocytes. [31182688]

cDNA cloning and primary structure analysis of C1qR(P), the human C1q/MBL/SPA receptor that mediates enhanced phagocytosis in vitro. [9047234]

Identification of the zinc-dependent endothelial cell binding protein for high molecular weight kininogen and factor XII: identity with the receptor that binds to the globular 'heads' of C1q (gC1q-R). [8710908]

Calreticulin is released from activated neutrophils and binds to C1q and mannan-binding protein. [8062452]

Short amino acid sequences derived from C1q receptor (C1q-R) show homology with the alpha chains of fibronectin and vitronectin receptors and collagen type IV. [1377218]

Platelet C1q receptor interactions with collagen- and C1q-coated surfaces. [2212670]

UniProt Main References (9 PubMed Identifiers)

Identification of human CD93 as the phagocytic C1q receptor (C1qRp) by expression cloning. [11781389]

The DNA sequence and comparative analysis of human chromosome 20. [11780052]

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]

Evidence that the two C1q binding membrane proteins, gC1q-R and cC1q-R, associate to form a complex. [9233640]

Human C1qRp is identical with CD93 and the mNI-11 antigen but does not bind C1q. [11994479]

C1qRP is a heavily O-glycosylated cell surface protein involved in the regulation of phagocytic activity. [10092817]

Interaction between complement receptor gC1qR and hepatitis C virus core protein inhibits T-lymphocyte proliferation. [11086025]

N-terminome analysis of the human mitochondrial proteome. [25944712]

The consensus coding sequences of human breast and colorectal cancers. [16959974]

RNA

RNA (Transcript ID: NM_012072.4)

RNA RefSeq ID

NM_012072.4

RNA name

CD93 molecule

Isoforms

All isoforms of CD93 containing a lectin domain

RNA Ensembl ID

ENST00000246006.5

Coding region

133..2091 (or 23083950.. 23086192)

mRNA location

23079360.. 23086324

NCBI Matured mRNA sequence 6681 NTP Download

m⁷G-5')ppp(5'-GUGUCCUUCUCUGCGCCGGAGUGGCUGCAGCUCACCCCUCAGCUCCCCUUGGGGCCCAGCUGGGAGCCGAGAUAGAAGCUCCUGUCGCCGCUGGGCUUCUCGCCUCCCGCAGAGGGCCACACAGAGACCGGGAUGGCCACCUCCAUGGGCCUGCUGCUGCUGCUGCUGCUGCUCCUGACCCAGCCCGGGGCGGGGACGGGAGCUGACACGGAGGCGGUGGUCUGCGUGGGGACCGCCUGCUACACGGCCCACUCGGGCAAGCUGAGCGCUGCCGAGGCCCAGAACCACUGCAACCAGAACGGGGGCAACCUGGCCACUGUGAAGAGCAAGGAGGAGGCCCAGCACGUCCAGCGAGUACUGGCCCAGCUCCUGAGGCGGGAGGCAGCCCUGACGGCGAGGAUGAGCAAGUUCUGGAUUGGGCUCCAGCGAGAGAAGGGCAAGUGCCUGGACCCUAGUCUGCCGCUGAAGGGCUUCAGCUGGGUGGGCGGGGGGGAGGACACGCCUUACUCUAACUGGCACAAGGAGCUCCGGAACUCGUGCAUCUCCAAGCGCUGUGUGUCUCUGCUGCUGGACCUGUCCCAGCCGCUCCUUCCCAGCCGCCUCCCCAAGUGGUCUGAGGGCCCCUGUGGGAGCCCAGGCUCCCCCGGAAGUAACAUUGAGGGCUUCGUGUGCAAGUUCAGCUUCAAAGGCAUGUGCCGGCCUCUGGCCCUGGGGGGCCCAGGUCAGGUGACCUACACCACCCCCUUCCAGACCACCAGUUCCUCCUUGGAGGCUGUGCCCUUUGCCUCUGCGGCCAAUGUAGCCUGUGGGGAAGGUGACAAGGACGAGACUCAGAGUCAUUAUUUCCUGUGCAAGGAGAAGGCCCCCGAUGUGUUCGACUGGGGCAGCUCGGGCCCCCUCUGUGUCAGCCCCAAGUAUGGCUGCAACUUCAACAAUGGGGGCUGCCACCAGGACUGCUUUGAAGGGGGGGAUGGCUCCUUCCUCUGCGGCUGCCGACCAGGAUUCCGGCUGCUGGAUGACCUGGUGACCUGUGCCUCUCGAAACCCUUGCAGCUCCAGCCCAUGUCGUGGGGGGGCCACGUGCGUCCUGGGACCCCAUGGGAAAAACUACACGUGCCGCUGCCCCCAAGGGUACCAGCUGGACUCGAGUCAGCUGGACUGUGUGGACGUGGAUGAAUGCCAGGACUCCCCCUGUGCCCAGGAGUGUGUCAACACCCCUGGGGGCUUCCGCUGCGAAUGCUGGGUUGGCUAUGAGCCGGGCGGUCCUGGAGAGGGGGCCUGUCAGGAUGUGGAUGAGUGUGCUCUGGGUCGCUCGCCUUGCGCCCAGGGCUGCACCAACACAGAUGGCUCAUUUCACUGCUCCUGUGAGGAGGGCUACGUCCUGGCCGGGGAGGACGGGACUCAGUGCCAGGACGUGGAUGAGUGUGUGGGCCCGGGGGGCCCCCUCUGCGACAGCUUGUGCUUCAACACACAAGGGUCCUUCCACUGUGGCUGCCUGCCAGGCUGGGUGCUGGCCCCAAAUGGGGUCUCUUGCACCAUGGGGCCUGUGUCUCUGGGACCACCAUCUGGGCCCCCCGAUGAGGAGGACAAAGGAGAGAAAGAAGGGAGCACCGUGCCCCGUGCUGCAACAGCCAGUCCCACAAGGGGCCCCGAGGGCACCCCCAAGGCUACACCCACCACAAGUAGACCUUCGCUGUCAUCUGACGCCCCCAUCACAUCUGCCCCACUCAAGAUGCUGGCCCCCAGUGGGUCCCCAGGCGUCUGGAGGGAGCCCAGCAUCCAUCACGCCACAGCUGCCUCUGGCCCCCAGGAGCCUGCAGGUGGGGACUCCUCCGUGGCCACACAAAACAACGAUGGCACUGACGGGCAAAAGCUGCUUUUAUUCUACAUCCUAGGCACCGUGGUGGCCAUCCUACUCCUGCUGGCCCUGGCUCUGGGGCUACUGGUCUAUCGCAAGCGGAGAGCGAAGAGGGAGGAGAAGAAGGAGAAGAAGCCCCAGAAUGCGGCAGACAGUUACUCCUGGGUUCCAGAGCGAGCUGAGAGCAGGGCCAUGGAGAACCAGUACAGUCCGACACCUGGGACAGACUGCUGAAAGUGAGGUGGCCCUAGAGACACUAGAGUCACCAGCCACCAUCCUCAGAGCUUUGAACUCCCCAUUCCAAAGGGGCACCCACAUUUUUUUGAAAGACUGGACUGGAAUCUUAGCAAACAAUUGUAAGUCUCCUCCUUAAAGGCCCCUUGGAACAUGCAGGUAUUUUCUACGGGUGUUUGAUGUUCCUGAAGUGGAAGCUGUGUGUUGGCGUGCCACGGUGGGGAUUUCGUGACUCUAUAAUGAUUGUUACUCCCCCUCCCUUUUCAAAUUCCAAUGUGACCAAUUCCGGAUCAGGGUGUGAGGAGGCCGGGGCUAAGGGGCUCCCCUGAAUAUCUUCUCUGCUCACUUCCACCAUCUAAGAGGAAAAGGUGAGUUGCUCAUGCUGAUUAGGAUUGAAAUGAUUUGUUUCUCUUCCUAGGAUGAAAACUAAAUCAAUUAAUUAUUCAAUUAGGUAAGAAGAUCUGGUUUUUUGGUCAAAGGGAACAUGUUCGGACUGGAAACAUUUCUUUACAUUUGCAUUCCUCCAUUUCGCCAGCACAAGUCUUGCUAAAUGUGAUACUGUUGACAUCCUCCAGAAUGGCCAGAAGUGCAAUUAACCUCUUAGGUGGCAAGGAGGCAGGAAGUGCCUCUUUAGUUCUUACAUUUCUAAUAGCCUUGGGUUUAUUUGCAAAGGAAGCUUGAAAAAUAUGAGAAAAGUUGCUUGAAGUGCAUUACAGGUGUUUGUGAAGUCACAUAAUCUACGGGGCUAGGGCGAGAGAGGCCAGGGAUUUGUUCACAGAUACUUGAAUUAAUUCAUCCAAAUGUACUGAGGUUACCACACACUUGACUACGGAUGUGAUCAACACUAACAAGGAAACAAAUUCAAGGACAACCUGUCUUUGAGCCAGGGCAGGCCUCAGACACCCUGCCUGUGGCCCCGCCUCCACUUCAUCCUGCCCGGAAUGCCAGUGCUCCGAGCUCAGACAGAGGAAGCCCUGCAGAAAGUUCCAUCAGGCUGUUUCCUAAAGGAUGUGUGAACGGGAGAUGAUGCACUGUGUUUUGAAAGUUGUCAUUUUAAAGCAUUUUAGCACAGUUCAUAGUCCACAGUUGAUGCAGCAUCCUGAGAUUUUAAAUCCUGAAGUGUGGGUGGCGCACACACCAAGUAGGGAGCUAGUCAGGCAGUUUGCUUAAGGAACUUUUGUUCUCUGUCUCUUUUCCUUAAAAUUGGGGGUAAGGAGGGAAGGAAGAGGGAAAGAGAUGACUAACUAAAAUCAUUUUUACAGCAAAAACUGCUCAAAGCCAUUUAAAUUAUAUCCUCAUUUUAAAAGUUACAUUUGCAAAUAUUUCUCCCUAUGAUAAUGUAGUCGAUAGUGUGCACUCUUUCUCUCUCUCUCUCUCUCUCACACACACACACACACACACACACACACACACAGAGACACGGCACCAUUCUGCCUGGGGCACUGGAACACAUUCCUGGGGGUCACCGAUGGUCAGAGUCACUAGAAGUUACCUGAGUAUCUCUGGGAGGCCUCAUGUCUCCUGUGGGCUUUUUACCACCACUGUGCAGGAGAACAGACAGAGGAAAUGUGUCUCCCUCCAAGGCCCCAAAGCCUCAGAGAAAGGGUGUUUCUGGUUUUGCCUUAGCAAUGCAUCGGUCUCUGAGGUGACACUCUGGAGUGGUUGAAGGGCCACAAGGUGCAGGGUUAAUACUCUUGCCAGUUUUGAAAUAUAGAUGCUAUGGUUCAGAUUGUUUUUAAUAGAAAACUAAAGGGGCAGGGGAAGUGAAAGGAAAGAUGGAGGUUUUGUGCGGCUCGAUGGGGCAUUUGGAACUUCUUUUUAAAGUCAUCUCAUGGUCUCCAGUUUUCAGUUGGAACUCUGGUGUUUAACACUUAAGGGAGACAAAGGCUGUGUCCAUUUGGCAAAACUUCCUUGGCCACGAGACUCUAGGUGAUGUGUGAAGCUGGGCAGUCUGUGGUGUGGAGAGCAGCCAUCUGUCUGGCCAUUCAGAGGAUUCUAAAGACAUGGCUGGAUGCGCUGCUGACCAACAUCAGCACUUAAAUAAAUGCAAAUGCAACAUUUCUCCCUCUGGGCCUUGAAAAUCCUUGCCCUUAUCAUUUGGGGUGAAGGAGACAUUUCUGUCCUUGGCUUCCCACAGCCCCAACGCAGUCUGUGUAUGAUUCCUGGGAUCCAACGAGCCCUCCUAUUUUCACAGUGUUCUGAUUGCUCUCACAGCCCAGGCCCAUCGUCUGUUCUCUGAAUGCAGCCCUGUUCUCAACAACAGGGAGGUCAUGGAACCCCUCUGUGGAACCCACAAGGGGAGAAAUGGGUGAUAAAGAAUCCAGUUCCUCAAAACCUUCCCUGGCAGGCUGGGUCCCUCUCCUGCUGGGUGGUGCUUUCUCUUGCACACCACUCCCACCACGGGGGGAGAGCCAGCAACCCAACCAGACAGCUCAGGUUGUGCAUCUGAUGGAAACCACUGGGCUCAAACACGUGCUUUAUUCUCCUGUUUAUUUUUGCUGUUACUUUGAAGCAUGGAAAUUCUUGUUUGGGGGAUCUUGGGGCUACAGUAGUGGGUAAACAAAUGCCCACCGGCCAAGAGGCCAUUAACAAAUCGUCCUUGUCCUGAGGGGCCCCAGCUUGCUCGGGCGUGGCACAGUGGGGAAUCCAAGGGUCACAGUAUGGGGAGAGGUGCACCCUGCCACCUGCUAACUUCUCGCUAGACACAGUGUUUCUGCCCAGGUGACCUGUUCAGCAGCAGAACAAGCCAGGGCCAUGGGGACGGGGGAAGUUUUCACUUGGAGAUGGACACCAAGACAAUGAAGAUUUGUUGUCCAAAUAGGUCAAUAAUUCUGGGAGACUCUUGGAAAAAACUGAAUAUAUUCAGGACCAACUCUCUCCCUCCCCUCAUCCCACAUCUCAAAGCAGACAAUGUAAAGAGAGAACAUCUCACACACCCAGCUCGCCAUGCCUACUCAUUCCUGAAUUUCAGGUGCCAUCACUGCUCUUUCUUUCUUCUUUGUCAUUUGAGAAAGGAUGCAGGAGGACAAUUCCCACAGAUAAUCUGAGGAAUGCAGAAAAACCAGGGCAGGACAGUUAUCGACAAUGCAUUAGAACUUGGUGAGCAUCCUCUGUAGAGGGACUCCACCCCUGCUCAACAGCUUGGCUUCCAGGCAAGACCAACCACAUCUGGUCUCUGCCUUCGGUGGCCCACACACCUAAGCGUCAUCGUCAUUGCCAUAGCAUCAUGAUGCAACACAUCUACGUGUAGCACUACGACGUUAUGUUUGGGUAAUGUGGGGAUGAACUGCAUGAGGCUCUGAUUAAGGAUGUGGGGAAGUGGGCUGCGGUCACUGUCGGCCUUGCAAGGCCACCUGGAGGCCUGUCUGUUAGCCAGUGGUGGAGGAGCAAGGCUUCAGGAAGGGCCAGCCACAUGCCAUCUUCCCUGCGAUCAGGCAAAAAAGUGGAAUUAAAAAGUCAAACCUUUAUAUGCAUGUGUUAUGUCCAUUUUGCAGGAUGAACUGAGUUUAAAAGAAUUUUUUUUUCUCUUCAAGUUGCUUUGUCUUUUCCAUCCUCAUCACAAGCCCUUGUUUGAGUGUCUUAUCCCUGAGCAAUCUUUCGAUGGAUGGAGAUGAUCAUUAGGUACUUUUGUUUCAACCUUUAUUCCUGUAAAUAUUUCUGUGAAAACUAGGAGAACAGAGAUGAGAUUUGACAAAAAAAAAUUGAAUUAAAAAUAACACAGUCUUUUUAAAACUAACAUAGGAAAGCCUUUCCUAUUAUUUCUCUUCUUAGCUUCUCCAUUGUCUAAAUCAGGAAAACAGGAAAACACAGCUUUCUAGCAGCUGCAAAAUGGUUUAAUGCCCCCUACAUAUUUCCAUCACCUUGAACAAUAGCUUUAGCUUGGGAAUCUGAGAUAUGAUCCCAGAAAACAUCUGUCUCUACUUCGGCUGCAAAACCCAUGGUUUAAAUCUAUAUGGUUUGUGCAUUUUCUCAACUAAAAAUAGAGAUGAUAAUCCGAAUUCUCCAUAUAUUCACUAAUCAAAGACACUAUUUUCAUACUAGAUUCCUGAGACAAAUACUCACUGAAGGGCUUGUUUAAAAAUAAAUUGUGUUUUGGUCUGUUCUUGUAGAUAAUGCCCUUCUAUUUUAGGUAGAAGCUCUGGAAUCCCUUUAUUGUGCUGUUGCUCUUAUCUGCAAGGUGGCAAGCAGUUCUUUUCAGCAGAUUUUGCCCACUAUUCCUCUGAGCUGAAGUUCUUUGCAUAGAUUUGGCUUAAGCUUGAAUUAGAUCCCUGCAAAGGCUUGCUCUGUGAUGUCAGAUGUAAUUGUAAAUGUCAGUAAUCACUUCAUGAAUGCUAAAUGAGAAUGUAAGUAUUUUUAAAUGUGUGUAUUUCAAAUUUGUUUGACUAAUUCUGGAAUUACAAGAUUUCUAUGCAGGAUUUACCUUCAUCCUGUGCAUGUUUCCCAAACUGUGAGGAGGGAAGGCUCAGAGAUCGAGCUUCUCCUCUGAGUUCUAACAAAAUGGUGCUUUGAGGGUCAGCCUUUAGGAAGGUGCAGCUUUGUUGUCCUUUGAGCUUUCUGUUAUGUGCCUAUCCUAAUAAACUCUUAAACACA-3'- Poly-A tail

Coding region

NCBI Matured mRNA sequence viewer

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More about the NCBI sViewer.

DNA

DNA (Gene ID: 22918)

HGNC Gene symbol

CD93

HGNC Gene name

CD93 molecule

Chr. RefSeq ID

NC_000020.11

Chromosome N°

20 23083950.. 23086192

CDS location

23083950.. 23086192

DNA strand

strand -

CCDS ID

CCDS13149.1

Mouse ortholog gene

MGI:106664

Gene Variant

ClinVar, dbVar

DNA Ensembl ID

ENSG00000125810

HGNC other symbol

C1qRP, C1qR(P), dJ737E23.1, CDw93, ECSM3

UCSC ID

uc002wsv.4

GeneBank

INSDC: U94333

GeneCards

15855

MIM

120577

VEGA ID

OTTHUMG00000032058

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