HumanLectome - Human Lectin Entry

NCBI Summary

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins, where ligand-receptor interactions can result in the activation of NK and T cells. The surface expression of these ligands is important for the recognition of stressed cells by the immune system, and thus this protein and its ligands are therapeutic targets for the treatment of immune diseases and cancers. Read-through transcription exists between this gene and the upstream KLRC4 (killer cell lectin-like receptor subfamily C, member 4) family member in the same cluster. [provided by RefSeq, Dec 2010].

Protein name

Killer cell lectin-like receptor K member 1

Synonym(s)

NKG2-D type II integral membrane protein (Killer cell lectin-like receptor subfamily K member 1) (NK cell receptor D) (NKG2-D-activating NK receptor) (CD antigen CD314)

HGNC gene name

KLRK1

HGNC name

killer cell lectin like receptor K1

Protein_CD_name

CD314

Lectin confidence

Low evidence

UniLectin class

C-type lectin

C-type classification

Undefined

Known lectin group

C-type - Natural Killer NK

Lectin fold

a/b mixed / C-type lectin-like

Glycan specificity

Complex N-glycans / Heparan

RefSeq accession

Gene ID

UniProt accession

Ensembl protein ID

UniRef cluster ID

LectomeXplore score

0.316

Reference

10.1016/j.bbrc.2009.06.101

Other links

neXtProt, PFAM, InterPro

Protein sequence and protein families (fasta) (216 amino acids) Download

MGWIRGRRSRHSWEMSEFHNYNLDLKKSDFSTRWQKQRCPVVKSKCRENASPFFFCCFIAVAMGIRFIIMVTIWSAVFLNSLFNQEVQIPLTESYCGPCPKNWICYKNNCYQFFDESKNWYESQASCMSQNASLLKVYSKEDQDLLKLVKSYHWMGLVHIPTNGSWQWEDGSILSPNLLTIIEMQKGDCALYASSFKGYIENCSTPNTYICMQRTV

Mol* PDB structure viewerUniLectin3D

Select a PDB entry:

Structural models

AlphaFold v2: AF-P26718-F1 Download

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Expression

Human Protein Atlas

GeneCards

mRNA expression in normal human tissues for KLRK1 Gene

ProteomicsDB

References

NCBI References (10 PubMed Identifiers)

Altered NK-cell compartment and dysfunctional NKG2D/NKG2D-ligand axis in patients with ataxia-telangiectasia. [34298181]

Tumor-derived NKG2D ligand sMIC reprograms NK cells to an inflammatory phenotype through CBM signalosome activation. [34294876]

Differential Effects of Histone Deacetylases on the Expression of NKG2D Ligands and NK Cell-Mediated Anticancer Immunity in Lung Cancer Cells. [34203519]

Roles of the NKG2D immunoreceptor and its ligands. [14523385]

An activating immunoreceptor complex formed by NKG2D and DAP10. [10426994]

Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. [10426993]

The genomic organization of NKG2C, E, F, and D receptor genes in the human natural killer gene complex. [9683661]

Sequence analysis of a 62-kb region overlapping the human KLRC cluster of genes. [9598306]

Cloning of NKG2-F, a new member of the NKG2 family of human natural killer cell receptor genes. [9394807]

DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells. [2007850]

UniProt Main References (19 PubMed Identifiers)

Conservation and variation in human and common chimpanzee CD94 and NKG2 genes. [11751968]

Complete sequencing and characterization of 21,243 full-length human cDNAs. [14702039]

The finished DNA sequence of human chromosome 12. [16541075]

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]

DAP10 and DAP12 form distinct, but functionally cooperative, receptor complexes in natural killer cells. [11015446]

Costimulation of CD8alphabeta T cells by NKG2D via engagement by MIC induced on virus-infected cells. [11224526]

UL16-binding proteins, novel MHC class I-related proteins, bind to NKG2D and activate multiple signaling pathways in primary NK cells. [11777960]

Lymphocyte activation via NKG2D: towards a new paradigm in immune recognition? [11973127]

Two human ULBP/RAET1 molecules with transmembrane regions are ligands for NKG2D. [15240696]

A Structural basis for the association of DAP12 with mouse, but not human, NKG2D. [15294961]

All isoforms of this gene containing a lectin domain

NP_001186734.1, NP_031386.2

RNA

RNA (Transcript ID: NM_007360.4)

RNA RefSeq ID

NM_007360.4

RNA name

killer cell lectin like receptor K1

Isoforms

All isoforms of KLRK1 containing a lectin domain

RNA Ensembl ID

ENST00000240618.11

Coding region

165..815 (or 10373114.. 10388810)

mRNA location

10372353.. 10390041

NCBI Matured mRNA sequence 1576 NTP Download

m⁷G-5')ppp(5'-ACUUUCAAUUCUAGAUCAGGAACUGAGGACAUAUCUAAAUUUUCUAGUUUUAUAGAAGGCUUUUAUCCACAAGAAUCAAGAUCUUCCCUCUCUGAGCAGGAAUCCUUUGUGCAUUGAAGACUUUAGAUUCCUCUCUGCGGUAGACGUGCACUUAUAAGUAUUUGAUGGGGUGGAUUCGUGGUCGGAGGUCUCGACACAGCUGGGAGAUGAGUGAAUUUCAUAAUUAUAACUUGGAUCUGAAGAAGAGUGAUUUUUCAACACGAUGGCAAAAGCAAAGAUGUCCAGUAGUCAAAAGCAAAUGUAGAGAAAAUGCAUCUCCAUUUUUUUUCUGCUGCUUCAUCGCUGUAGCCAUGGGAAUCCGUUUCAUUAUUAUGGUAACAAUAUGGAGUGCUGUAUUCCUAAACUCAUUAUUCAACCAAGAAGUUCAAAUUCCCUUGACCGAAAGUUACUGUGGCCCAUGUCCUAAAAACUGGAUAUGUUACAAAAAUAACUGCUACCAAUUUUUUGAUGAGAGUAAAAACUGGUAUGAGAGCCAGGCUUCUUGUAUGUCUCAAAAUGCCAGCCUUCUGAAAGUAUACAGCAAAGAGGACCAGGAUUUACUUAAACUGGUGAAGUCAUAUCAUUGGAUGGGACUAGUACACAUUCCAACAAAUGGAUCUUGGCAGUGGGAAGAUGGCUCCAUUCUCUCACCCAACCUACUAACAAUAAUUGAAAUGCAGAAGGGAGACUGUGCACUCUAUGCCUCGAGCUUUAAAGGCUAUAUAGAAAACUGUUCAACUCCAAAUACGUACAUCUGCAUGCAAAGGACUGUGUAAAGAUGAUCAACCAUCUCAAUAAAAGCCAGGAACAGAGAAGAGAUUACACCAGCGGUAACACUGCCAACUGAGACUAAAGGAAACAAACAAAAACAGGACAAAAUGACCAAAGACUGUCAGAUUUCUUAGACUCCACAGGACCAAACCAUAGAACAAUUUCACUGCAAACAUGCAUGAUUCUCCAAGACAAAAGAAGAGAGAUCCUAAAGGCAAUUCAGAUAUCCCCAAGGCUGCCUCUCCCACCACAAGCCCAGAGUGGAUGGGCUGGGGGAGGGGUGCUGUUUUAAUUUCUAAAGGUAGGACCAACACCCAGGGGAUCAGUGAAGGAAGAGAAGGCCAGCAGAUCACUGAGAGUGCAACCCCACCCUCCACAGGAAAUUGCCUCAUGGGCAGGGCCACAGCAGAGAGACACAGCAUGGGCAGUGCCUUCCCUGCCUGUGGGGGUCAUGCUGCCACUUUUAAUGGGUCCUCCACCCAACGGGGUCAGGGAGGUGGUGCUGCCCCAGUGGGCCAUGAUUAUCUUAAAGGCAUUAUUCUCCAGCCUUAAGUAAGAUCUUAGGACGUUUCCUUUGCUAUGAUUUGUACUUGCUUGAGUCCCAUGACUGUUUCUCUUCCUCUCUUUCUUCCUUUUGGAAUAGUAAUAUCCAUCCUAUGUUUGUCCCACUAUUGUAUUUUGGAAGCACAUAACUUGUUUGGUUUCACAGGUUCACAGUUAAGAAGGAAUUUUGCCUCUGAAUAAAUAGAAUCUUGAGUCUCAUGCA-3'- Poly-A tail

Coding region

NCBI Matured mRNA sequence viewer

;

More about the NCBI sViewer.

DNA

DNA (Gene ID: 22914)

HGNC Gene symbol

KLRK1

HGNC Gene name

killer cell lectin like receptor K1

Chr. RefSeq ID

NC_000012.12

Chromosome N°

12 10373114.. 10388810

CDS location

10373114.. 10388810

DNA strand

strand -

CCDS ID

CCDS8623.1

Mouse ortholog gene

MGI:1196250

Gene Variant

ClinVar, dbVar

DNA Ensembl ID

ENSG00000213809

HGNC other symbol

NKG2D, KLR, NKG2-D, CD314

UCSC ID

uc009zhj.4

GeneBank

INSDC: AJ001687

GeneCards

18788

MIM

611817

VEGA ID

OTTHUMG00000168574

How to cite: