NCBI Summary
This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. The encoded protein is capable of glycosylating fibronectin peptide in vitro and is expressed in a fibroblast cell line, indicating that it may be involved in the synthesis of oncofetal fibronectin. [provided by RefSeq, Jul 2008].
Protein
Protein (NP_009141)
CBM13-ppGalNAc-T6
Polypeptide N-acetylgalactosaminyltransferase 6 (EC 2.4.1.41) (Polypeptide GalNAc transferase 6) (GalNAc-T6) (pp-GaNTase 6) (Protein-UDP acetylgalactosaminyltransferase 6) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 6)
GALNT6
polypeptide N-acetylgalactosaminyltransferase 6
Undefined
Curated
Ricin-like
R-Type Lectins
b-trefoil
GalNAc / Mucin-type glycopeptide
NP_009141
11226
Q8NCL4
ENSP00000348668.2
Q8NCL4
Undefined
10.1074/jbc.M111.273722
neXtProt, PFAM, InterPro
Protein sequence and protein families (fasta) (622 amino acids) Download
MRLLRRRHMPLRLAMVGCAFVLFLFLLHRDVSSREEATEKPWLKSLVSRKDHVLDLMLEAMNNLRDSMPKLQIRAPEAQQTLFSINQSCLPGFYTPAELKPFWERPPQDPNAPGADGKAFQKSKWTPLETQEKEEGYKKHCFNAFASDRISLQRSLGPDTRPPECVDQKFRRCPPLATTSVIIVFHNEAWSTLLRTVYSVLHTTPAILLKEIILVDDASTEEHLKEKLEQYVKQLQVVRVVRQEERKGLITARLLGASVAQAEVLTFLDAHCECFHGWLEPLLARIAEDKTVVVSPDIVTIDLNTFEFAKPVQRGRVHSRGNFDWSLTFGWETLPPHEKQRRKDETYPIKSPTFAGGLFSISKSYFEHIGTYDNQMEIWGGENVEMSFRVWQCGGQLEIIPCSVVGHVFRTKSPHTFPKGTSVIARNQVRLAEVWMDSYKKIFYRRNLQAAKMAQEKSFGDISERLQLREQLHCHNFSWYLHNVYPEMFVPDLTPTFYGAIKNLGTNQCLDVGENNRGGKPLIMYSCHGLGGNQYFEYTTQRDLRHNIAKQLCLHVSKGALGLGSCHFTGKNSQVPKDEEWELAQDQLIRNSGSGTCLTSQDKKPAMAPCNPSDPHQLWLFV
No structure currently available in the PDB RCSB Databank.
Structural models
AlphaFold v2: AF-Q8NCL4-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

SWISS-MODEL structural models
SWISS-MODEL structural model
Modeller structural model (Homology modelling pipeline), Error: [1.5, 1.91] ÅDownload
The location of the lectin domain structural model is: 496-622
We infer [1.5, 1.91] Å as the interval of error of this structural model.
Template: 1XHB chain: A, O08912, NP_001153876.1, sequence identity: 32.3%, coverage: 91.3%, location in sequence: 95-553, (95-553 in PDB).
Show the alignment used for the construction of the structural model, Download.
Show the plot of DOPE energy score, Download.
Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for GALNT6 Gene
ProteomicsDB
References
NCBI References (10 PubMed Identifiers)
  • Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains. [32814053]
  • GALNT6 promotes breast cancer metastasis by increasing mucin-type O-glycosylation of alpha2M. [32559179]
  • GALNT6 promotes invasion and metastasis of human lung adenocarcinoma cells through O-glycosylating chaperone protein GRP78. [32393740]
  • The GALNT6-LGALS3BP axis promotes breast cancer cell growth. [31894262]
  • The polypeptide GALNT6 Displays Redundant Functions upon Suppression of its Closest Homolog GALNT3 in Mediating Aberrant O-Glycosylation, Associated with Ovarian Cancer Progression. [31071912]
  • Polypeptide N-acetylgalactosaminyltransferase 6 disrupts mammary acinar morphogenesis through O-glycosylation of fibronectin. [21472136]
  • Expression of UDP-N-acetyl-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase-6 in gastric mucosa, intestinal metaplasia, and gastric carcinoma. [18854599]
  • Prognostic utility of glycosyltransferase expression in breast cancer. [19287074]
  • The cell-layer- and cell-type-specific distribution of GalNAc-transferases in the ocular surface epithelia is altered during keratinization. [12506059]
  • Cloning and characterization of a close homologue of human UDP-N-acetyl-alpha-D-galactosamine:Polypeptide N-acetylgalactosaminyltransferase-T3, designated GalNAc-T6. Evidence for genetic but not functional redundancy. [10464263]
UniProt Main References (2 PubMed Identifiers)
  • Complete sequencing and characterization of 21,243 full-length human cDNAs. [14702039]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
All isoforms of this gene containing a lectin domain
NP_009141.2, XP_005268664.1, XP_006719277.1, XP_011536121.1, XP_011536124.1, XP_016874234.1, XP_024304579.1, XP_024304580.1, XP_024304581.1, XP_024304582.1, XP_024304583.1, XP_024304584.1, XP_024304585.1
RNA
RNA (Transcript ID: NM_007210.4)
NM_007210.4
polypeptide N-acetylgalactosaminyltransferase 6
All isoforms of GALNT6 containing a lectin domain
ENST00000356317.8
312..2180 (or 51354379.. 51379781)
51351252.. 51391406
NCBI Matured mRNA sequence 5307 NTPDownload 
m7G-5')ppp(5'-CCCUCCUGCCUUCGCUCUCUGCUGGUCGCGGUGGCCUGUAGCUCCUCCCUCGGUAGGACCCCCCUCCACCUUGGCGCUUACGAGAUGAAUGAGGAGCCCAGACCUCUGGAACUUGGAGGGUUGUUCAGAUUCCCAGGCUGACAAAAAGGAGAAACAGCUUUUACUUGCAUCCAGGGCCAAUCAUCGCAGACCCAGACGUCUGCAGAGGGCUGAGGCCCCAGCUUGUGGCCACCACAACGUAUCAAGCUAUCUCCAGGGUUGGGCUCAGGACUCAGAGCUGACGCAGCUGGGGUGCCCCUUGGUUCUGGAGGAUGAGGCUCCUCCGCAGACGCCACAUGCCCCUGCGCCUGGCCAUGGUGGGCUGCGCCUUUGUGCUCUUCCUCUUCCUCCUGCAUAGGGAUGUGAGCAGCAGAGAGGAGGCCACAGAGAAGCCGUGGCUGAAGUCCCUGGUGAGCCGGAAGGAUCACGUCCUGGACCUCAUGCUGGAGGCCAUGAACAACCUUAGAGAUUCAAUGCCCAAGCUCCAAAUCAGGGCUCCAGAAGCCCAGCAGACUCUGUUCUCCAUAAACCAGUCCUGCCUCCCUGGGUUCUAUACCCCAGCUGAACUGAAGCCCUUCUGGGAACGGCCACCACAGGACCCCAAUGCCCCUGGGGCAGAUGGAAAAGCAUUUCAGAAGAGCAAGUGGACCCCCCUGGAGACCCAGGAAAAGGAAGAAGGCUAUAAGAAGCACUGUUUCAAUGCCUUUGCCAGCGACCGGAUCUCCCUGCAGAGGUCCCUGGGGCCAGACACCCGACCACCUGAGUGUGUGGACCAGAAGUUCCGGCGCUGCCCCCCACUGGCCACCACCAGCGUGAUCAUUGUGUUCCACAACGAAGCCUGGUCCACACUGCUGCGAACAGUGUACAGCGUCCUACACACCACCCCUGCCAUCUUGCUCAAGGAGAUCAUACUGGUGGAUGAUGCCAGCACAGAGGAGCACCUAAAGGAGAAGCUGGAGCAGUACGUGAAGCAGCUGCAGGUGGUGAGGGUGGUGCGGCAGGAGGAGCGGAAGGGGCUGAUCACCGCCCGGCUGCUGGGGGCCAGCGUGGCACAGGCGGAGGUGCUCACGUUCCUGGAUGCCCACUGUGAGUGCUUCCACGGCUGGCUGGAGCCCCUCCUGGCUCGAAUCGCUGAGGACAAGACAGUGGUGGUGAGCCCAGACAUCGUCACCAUCGACCUUAAUACUUUUGAGUUCGCCAAGCCCGUCCAGAGGGGCAGAGUCCAUAGCCGAGGCAACUUUGACUGGAGCCUGACCUUCGGCUGGGAAACACUUCCUCCACAUGAGAAGCAGAGGCGCAAGGAUGAAACCUACCCCAUCAAAUCCCCGACGUUUGCUGGUGGCCUCUUCUCCAUCUCCAAGUCCUACUUUGAGCACAUCGGUACCUAUGAUAAUCAGAUGGAGAUCUGGGGAGGGGAGAACGUGGAAAUGUCCUUCCGGGUGUGGCAGUGUGGGGGCCAGCUGGAGAUCAUCCCCUGCUCUGUCGUAGGCCAUGUGUUCCGGACCAAGAGCCCCCACACCUUCCCCAAGGGCACUAGUGUCAUUGCUCGCAAUCAAGUGCGCCUGGCAGAGGUCUGGAUGGACAGCUACAAGAAGAUUUUCUAUAGGAGAAAUCUGCAGGCAGCAAAGAUGGCCCAAGAGAAAUCCUUCGGUGACAUUUCGGAACGACUGCAGCUGAGGGAACAACUGCACUGUCACAACUUUUCCUGGUACCUGCACAAUGUCUACCCAGAGAUGUUUGUUCCUGACCUGACGCCCACCUUCUAUGGUGCCAUCAAGAACCUCGGCACCAACCAAUGCCUGGAUGUGGGUGAGAACAACCGCGGGGGGAAGCCCCUCAUCAUGUACUCCUGCCACGGCCUUGGCGGCAACCAGUACUUUGAGUACACAACUCAGAGGGACCUUCGCCACAACAUCGCAAAGCAGCUGUGUCUACAUGUCAGCAAGGGUGCUCUGGGCCUUGGGAGCUGUCACUUCACUGGCAAGAAUAGCCAGGUCCCCAAGGACGAGGAAUGGGAAUUGGCCCAGGAUCAGCUCAUCAGGAACUCAGGAUCUGGUACCUGCCUGACAUCCCAGGACAAAAAGCCAGCCAUGGCCCCCUGCAAUCCCAGUGACCCCCAUCAGUUGUGGCUCUUUGUCUAGGACCCAGAUCAUCCCCAGAGAGAGCCCCCACAAGCUCCUCAGGAAACAGGAUUGCUGAUGUCUGGGAACCUGAUCACCAGCUUCUCUGGAGGCCGUAAAGAUGGAUUUCUAAACCCACUGGGUGGCAAGGCAGGACCUUCCUAAUCCUUGCAACAACAUUGGGCCCAUUUUCUUUCCUUCACACCGAUGGAAGAGACCAUUAGGACAUAUAUUUAGCCUAGCGUUUUCCUGUUCUAGAAAUAGAGGCUCCCAAAGUAGGGAAGGCAGCUGGGGGAGGGUUCAGGGCAGCAAUGCUGAGUUCAAGAAAAGUACUUCAGGCUGGGCACAGUGGCUCAUGCCUGAAAUCCUAGCACUUUGGGAAGACAAUGUGGGAGAAUGGCUUGAGCCCAGGAGUUCAAGACCGGCCUGAGCAACAUAGUGAGGAUCCCAUCUCUACGCCCACCCUCCCCCCGGCAAAAAAAAAAAGCUGGGUAUGGUGGCUUAUGCCUGUAGUCGCAGCUACUCAGAAGGCUGAGGUGGGAGGAUUGCUUGUUCCCCGGAGGUUGAAGCUACAGUGAGCCUUGAUUGUGUCACUGCACUCCAGCCUGGGCAACAGGUAAGACUCUGUCUCAAAAAAAAACAAAAAAGAAGAAGAAAAGUACUUCUACAGCCAUGUCCUAUUCCUUGAUCAUCCAAAGCACCUGCAGAGUCCAGUGAAAUGAUAUAUUCUGGCUGGGCACAGUGGCUCACACCUGUAAUCCUAGCACUUUGGGAGGCCAAGGCAGGUGGAUCACCUGAGGUCAGAAGUUUGAAACCAGCCUGGACUACAUGGUGAAACUCCAUCUCUACUAAAAGUACAAAAAUUAGCUGGGCAUGAUGGCACGCACCUGCAGUCCCAGCUACUUGGGAGGCUGAGGCAGGAGAAUCACUCGAACCCAGGAGGCAGAGGUUGCAGUGAGCCAAGACAGCACCAUUGCACCCCAGCCUGAGCAACAAGAGCGAAACUCCAUCUCAGGAAAAAAAAAAAAAAAAAAAGUAUAUUCUAACAGACAGAUCAGAGGUCUAAGAGAUCCUCCCUUGCUAUUAUUACCUGAAGUCUGUAGAACUGUUUACAGAUAUCUCCUUGACAGGUGUCCUUUAUCUUACUUUAUCUGUACAGUAAUCCUGUGAGAAAGACAGGACAGAAACCACUGUGCCUAUUUUACAGAUACGAAAACUGAGACACAGGUAAAGGGGCUUGUCUGUAGUCCCAUAGCUAGCAGAUGGCUGGAGCCAAGACUGAGGCUCGUUCUUCAAUGCUGAGCCAGGGCUCCUUCCGCUGCACCACAAGAACGCUAGACCACUCGCCACCAGCCUUCUCAUUCCCUCUUCCUCCAUUCUAAUCAUUUCUAGCUGGCUGGCCUCCACAGAGCAUAGGAAAACAGCCAGGGCCGGGCACGGUGGCUCAUGCCUGUAAUCUCAACACUCUGGGAGGCCGAGCCGGGUGGAUAACCUGAGGUCAGGAAUUCGAGACCAGCCUGGCCAACAUGGUAAAACCCCAUCUCUACUAAAAAUAUAAAAAUUAGCCAGGCAUGGUGGCGCACACCUGUAAUCCCAGCUACUCAAGAGGCUGAGGCAGGAGAAUUGCUUAAAUCUGGGAGGCGGAAGUUGCAGUGAGCCAAGAUCGCGCCACUGAACUCCAGCCUAGGCAACAAGAGCAAAACUCCAUCUCCAAAAAAAAGAAAGGAAAAACAGGGCCAGGUAGCCAUUGUGGAGAGAGCACACUUAGGAAUCCUGGGAUGUUAGUGUUAAAAGAAAGCUCCUGGAGCCAGUGAUUCUCAGGUUUGUCCCAGAACCCUUUUUUCUAAGCCCCAUAUAAAAGGUAGAUUAAAAAAACAAAGUAGCAUGAGUGAAAUUGAGAGAGGGACAGGUAAUGCCUUCCAGCCCCUAACUUCUAACAAUCUGGAAGCACAACGUGAAAAUCACGUAGCCCAACCCUAUCAUUUUCAUAUUAUGAAACUGAGUCCAGGUAAGUGAAUCUGUCCAAGGUCACCCAGCAAGGUAUCAGUAGCCCUGAGGGUAAGGACUCUGAUAAGGCUCGGGAGGGUCCUGGAAAGCCUGAGGCGGCAGGAAGAGUGUGCAGAGUUGAGCGUGUCUGGAAGGCUGAUCCACUGCUGGGCCCACAUCAAAGCCCCCAUGGGGAGCAGACCCGACUGCACAUGGCUCUUUUGCUGGAAGAAGAGCAUGGCUGCGCAGAGGACUAAAAUUUCAUCUGGGAAGGCUUCUUUUGACUGUCAGUAGCAGGAUGUCACCAGAUGAGGGUGCUAUGGGACCACAGCUGUCUUUGUUCCCAUUGCAACUCAACCCUGCGGGAGGCCGCCUACAUCCCUGAGAGCCUUCUGGAGCCUACAGAGGAGACAUUGGCCAGCCAAAAGGAAAGGAGUGGCCAGGGUACGACCUGGAGUAGGGAAGGGAAAAAGUUCCCGGAAAGAAGAGAAUUGGAUGAGAGGUCUCAGUGGAAAUAAAGGUUUUCUGGCAUUGGUCAAGGAAACUCGCGUUGUGUUCUCUUACCUGUGUUGUCCCUUAGCUGAAUCAGUUGAUUUGGGCUAUGAAGAACCACACACAUCUGAAAAGUUCUGUUACAGCCACUGUCUCAUGUCCCCAAACAUUCUCUGGCCCUAAAUCUAGCUUAUGUAUUGUGUCAAGCACGUGGAGACGUGAGACGUCAAACGAGGUCCUGUCCCCGUGGAACUCACACGCUAAAUGUAAGCAAAUCAUAGCAAGCCUGGAGAUGCUCCAAGAGGUGCUGGAUGAGUUAGAAGGAGCAAUUCCUUCCACUUAGGGAAUCAGAUAAGGCCUCACAAAGAUGGCAAUGUUUGACCUAAGACCUCGGAAGAUGAGUCCUCAGAUGGGAAGGGCUCAAUAAGCAGAGUUGUUACACAGGCAGCAGCCUGGCAGGAGCAAAGCCACAGAGGACAUGUGGCCCCAGUGGGUCUGAGAAACCCAGAGGACAUUGGGGUGAGGGAGUGACUGGUGUAGAAGCUGGAAGAUCAGAGUUACAUCAUGAAUUUCAGGGGCCCUAGGCACUUUAGCCUUCACGGAGCUCUUGCUCCAUUCAAAAAAAAAUUAAUGUUAUGACUAUGUUGGUAUAAAGAUGAAUGUAAUCCAG-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
;
More about the NCBI sViewer.
DNA
DNA (Gene ID: 11226)
GALNT6
polypeptide N-acetylgalactosaminyltransferase 6
NC_000012.12
12  51354379.. 51379781
51354379.. 51379781
strand -
CCDS8813.1
MGI:1891640
ClinVar, dbVar
ENSG00000139629
GalNAc-T6
uc001ryl.2
INSDC: Y08565
4128
605148
OTTHUMG00000185181
ENA, DDBJ, Monarch
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (1869 bp)
5'-ATGAGGCTCCTCCGCAGACGCCACATGCCCCTGCGCCTGGCCATGGTGGGCTGCGCCTTTGTGCTCTTCCTCTTCCTCCTGCATAGGGATGTGAGCAGCAGAGAGGAGGCCACAGAGAAGCCGTGGCTGAAGTCCCTGGTGAGCCGGAAGGATCACGTCCTGGACCTCATGCTGGAGGCCATGAACAACCTTAGAGATTCAATGCCCAAGCTCCAAATCAGGGCTCCAGAAGCCCAGCAGACTCTGTTCTCCATAAACCAGTCCTGCCTCCCTGGGTTCTATACCCCAGCTGAACTGAAGCCCTTCTGGGAACGGCCACCACAGGACCCCAATGCCCCTGGGGCAGATGGAAAAGCATTTCAGAAGAGCAAGTGGACCCCCCTGGAGACCCAGGAAAAGGAAGAAGGCTATAAGAAGCACTGTTTCAATGCCTTTGCCAGCGACCGGATCTCCCTGCAGAGGTCCCTGGGGCCAGACACCCGACCACCTGAGTGTGTGGACCAGAAGTTCCGGCGCTGCCCCCCACTGGCCACCACCAGCGTGATCATTGTGTTCCACAACGAAGCCTGGTCCACACTGCTGCGAACAGTGTACAGCGTCCTACACACCACCCCTGCCATCTTGCTCAAGGAGATCATACTGGTGGATGATGCCAGCACAGAGGAGCACCTAAAGGAGAAGCTGGAGCAGTACGTGAAGCAGCTGCAGGTGGTGAGGGTGGTGCGGCAGGAGGAGCGGAAGGGGCTGATCACCGCCCGGCTGCTGGGGGCCAGCGTGGCACAGGCGGAGGTGCTCACGTTCCTGGATGCCCACTGTGAGTGCTTCCACGGCTGGCTGGAGCCCCTCCTGGCTCGAATCGCTGAGGACAAGACAGTGGTGGTGAGCCCAGACATCGTCACCATCGACCTTAATACTTTTGAGTTCGCCAAGCCCGTCCAGAGGGGCAGAGTCCATAGCCGAGGCAACTTTGACTGGAGCCTGACCTTCGGCTGGGAAACACTTCCTCCACATGAGAAGCAGAGGCGCAAGGATGAAACCTACCCCATCAAATCCCCGACGTTTGCTGGTGGCCTCTTCTCCATCTCCAAGTCCTACTTTGAGCACATCGGTACCTATGATAATCAGATGGAGATCTGGGGAGGGGAGAACGTGGAAATGTCCTTCCGGGTGTGGCAGTGTGGGGGCCAGCTGGAGATCATCCCCTGCTCTGTCGTAGGCCATGTGTTCCGGACCAAGAGCCCCCACACCTTCCCCAAGGGCACTAGTGTCATTGCTCGCAATCAAGTGCGCCTGGCAGAGGTCTGGATGGACAGCTACAAGAAGATTTTCTATAGGAGAAATCTGCAGGCAGCAAAGATGGCCCAAGAGAAATCCTTCGGTGACATTTCGGAACGACTGCAGCTGAGGGAACAACTGCACTGTCACAACTTTTCCTGGTACCTGCACAATGTCTACCCAGAGATGTTTGTTCCTGACCTGACGCCCACCTTCTATGGTGCCATCAAGAACCTCGGCACCAACCAATGCCTGGATGTGGGTGAGAACAACCGCGGGGGGAAGCCCCTCATCATGTACTCCTGCCACGGCCTTGGCGGCAACCAGTACTTTGAGTACACAACTCAGAGGGACCTTCGCCACAACATCGCAAAGCAGCTGTGTCTACATGTCAGCAAGGGTGCTCTGGGCCTTGGGAGCTGTCACTTCACTGGCAAGAATAGCCAGGTCCCCAAGGACGAGGAATGGGAATTGGCCCAGGATCAGCTCATCAGGAACTCAGGATCTGGTACCTGCCTGACATCCCAGGACAAAAAGCCAGCCATGGCCCCCTGCAATCCCAGTGACCCCCATCAGTTGTGGCTCTTTGTCTAG-3'
NCBI CDS gene sequence with introns (location: 51354379.. 51379781) (25403 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 51351252.. 51391406) (40155 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [51351252.. 51391406 + 1000]) (41155 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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