NCBI Summary
This gene is a type I subclass member of the Reg gene family. The Reg gene family is a multigene family grouped into four subclasses, types I, II, III and IV based on the primary structures of the encoded proteins. This gene encodes a protein secreted by the exocrine pancreas that is highly similar to the REG1A protein. The related REG1A protein is associated with islet cell regeneration and diabetogenesis, and may be involved in pancreatic lithogenesis. Reg family members REG1A, REGL, PAP and this gene are tandemly clustered on chromosome 2p12 and may have arisen from the same ancestral gene by gene duplication. [provided by RefSeq, Jul 2008].
Protein (NP_006498)
Lithostathine-1-beta (Pancreatic stone protein 2) (PSP-2) (Regenerating islet-derived protein 1-beta) (REG-1-beta) (Regenerating protein I beta)
regenerating family member 1 beta
Very low evidence
C-type lectin
C-type - Free C-type Lectin Domains CTLDs
a/b mixed / C-type lectin-like
Protein sequence and protein families (fasta) (166 amino acids) Download
No structure currently available in the PDB RCSB Databank.
Structural models
Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

SWISS-MODEL structural models
Modeller structural model (Homology modelling pipeline), Error: [1.61, 2.1] ÅDownload
The location of the lectin domain structural model is: 21-165
We infer [1.61, 2.1] Å as the interval of error of this structural model.
Template 1: 6JJJ chain: A, P70194, NP_058031.2, sequence identity: 24.1%, coverage: 95.2%, location in sequence: 393-543, (393-543 in PDB).
Template 2: 3L9J chain: C, P05452, NP_003269.2, sequence identity: 22.8%, coverage: 90.3%, location in sequence: 67-201, (46-180 in PDB).
Template 3: 3WHD chain: C, Q8WXI8, NP_525126.2, sequence identity: 22.1%, coverage: 96.6%, location in sequence: 63-215, (63-215 in PDB).
Show the alignment used for the construction of the structural model, Download.
Show the plot of DOPE energy score, Download.
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
NCBI References (10 PubMed Identifiers)
  • Faecal regenerating 1B protein concentration is not associated with child growth in rural Malawi. [33112481]
  • Prognostic role of regenerating gene-I in patients with stage-IV head and neck squamous cell carcinoma. [27539087]
  • Synergistic activations of REG I alpha and REG I beta promoters by IL-6 and Glucocorticoids through JAK/STAT pathway in human pancreatic beta cells. [25767811]
  • Variants in the 1q21 risk region are associated with a visual endophenotype of autism and schizophrenia. [24152035]
  • Validation of four candidate pancreatic cancer serological biomarkers that improve the performance of CA19.9. [24007603]
  • Isolation and characterization of human reg protein produced in Saccharomyces cerevisiae. [2226837]
  • Enhanced expression of an exocrine pancreatic protein in Alzheimer's disease and the developing human brain. [2394826]
  • Complete nucleotide sequence of human reg gene and its expression in normal and tumoral tissues. The reg protein, pancreatic stone protein, and pancreatic thread protein are one and the same product of the gene. [2332435]
  • Secretory pancreatic stone protein messenger RNA. Nucleotide sequence and expression in chronic calcifying pancreatitis. [2525567]
  • N-terminal sequence extension in the glycosylated forms of human pancreatic stone protein. The 5-oxoproline N-terminal chain is O-glycosylated on the 5th amino acid residue. [2493268]
UniProt Main References (4 PubMed Identifiers)
  • A gene homologous to the reg gene is expressed in the human pancreas. [8348956]
  • Isolation, structural determination and expression of a novel reg gene, human regI beta. [8110835]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
  • The glycan moiety of human pancreatic lithostathine. Structure characterization and possible pathophysiological implications. [7607222]
RNA (Transcript ID: NM_006507.4)
regenerating family member 1 beta
  • Coding region
DNA (Gene ID: 5968)
regenerating family member 1 beta
strand -
NCBI CDS gene sequence (501 bp)
NCBI CDS gene sequence with introns (location: 79085216.. 79087612) (2397 bp)Download
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 79085023.. 79087993) (2971 bp)Download
NCBI gene sequence (location: [79085023.. 79087993 + 1000]) (3971 bp)Download
How to cite: Schnider B., M'Rad Y., el Ahmadie J., de Brevern AG., Imberty A., Lisacek F., HumanLectome, an update of UniLectin for the annotation and prediction of human lectins, Nucleic Acids Reasearch