NCBI Summary
The protein encoded by this gene is a soluble beta-galactoside binding lectin. The encoded protein is found as a homodimer and can bind to lymphotoxin-alpha. A single nucleotide polymorphism in an intron of this gene can alter the transcriptional level of the protein, with a resultant increased risk of myocardial infarction. [provided by RefSeq, Jul 2008].
Protein
Protein (NP_006489)
Galectin 2
Galectin-2 (Gal-2) (Beta-galactoside-binding lectin L-14-II) (HL14) (Lactose-binding lectin 2) (S-Lac lectin 2)
LGALS2
galectin 2
Undefined
Curated
Galectin
S-Type Lectins - Prototypical
b-sandwich / ConA-like
0.416
Protein sequence and protein families (fasta) (132 amino acids) Download
MTGELEVKNMDMKPGSTLKITGSIADGTDGFVINLGQGTDKLNLHFNPRFSESTIVCNSLDGSNWGQEQREDHLCFSPGSEVKFTVTFESDKFKVKLPDGHELTFPNRLGHSHLSYLSVRGGFNMSSFKLKE
Mol* PDB structure viewerUniLectin3D
Structural models
Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.


Ligand
Glycan ligands from structural data
bGal14Glc
Gal(b1-4)Glc
References
NCBI References (10 PubMed Identifiers)
  • Syndecan 4, galectin 2, and death receptor 3 (DR3) as novel proteins in pathophysiology of preeclampsia. [31608721]
  • Genome-wide CRISPR screen identifies LGALS2 as an oxidative stress-responsive gene with an inhibitory function on colon tumor growth. [33110234]
  • A reference map of the human binary protein interactome. [32296183]
  • Placental Galectin-2 Expression in Gestational Diabetes: A Systematic, Histological Analysis. [32244351]
  • Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations. [31515488]
  • X-ray crystal structure of the human dimeric S-Lac lectin, L-14-II, in complex with lactose at 2.9-A resolution. [8262940]
  • Crystallization and preliminary X-ray diffraction analysis of the human dimeric S-Lac lectin (L-14-II). [8411163]
  • Isolation and expression of a gene encoding L-14-II, a new human soluble lactose-binding lectin. [1375225]
  • Genomic sequence and organization of two members of a human lectin gene family. [1988031]
  • Evidence that a human soluble beta-galactoside-binding lectin is encoded by a family of genes. [3020551]
UniProt Main References (4 PubMed Identifiers)
  • A genome annotation-driven approach to cloning the human ORFeome. [15461802]
  • The DNA sequence of human chromosome 22. [10591208]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
  • The consensus coding sequences of human breast and colorectal cancers. [16959974]
RNA
RNA (Transcript ID: NM_006498.3)
galectin 2
m7G-5')ppp(5'-CUGUUUGUGCUGGGUACUGGGAGAUGCAGGCGGGGAGACACAAGGUAGAAGGGGCAAAGUCCUCACCUAGGACCUUGAGGGAGUUAAUGUGUAAUAUUCUAGGAUAUAAGCUUGACCACGAGUUGAGACCCUGAGCACAGGCCUCCAGGAGCCGCUGGGAGCUGCCGCCAGGAGCUGUCACCAUGACGGGGGAACUUGAGGUUAAGAACAUGGACAUGAAGCCGGGGUCAACCCUGAAGAUCACAGGCAGCAUCGCCGAUGGCACUGAUGGCUUUGUAAUUAAUCUGGGCCAGGGGACAGACAAGCUGAACCUGCAUUUCAACCCUCGCUUCAGCGAAUCCACCAUUGUCUGCAACUCAUUGGACGGCAGCAACUGGGGGCAAGAACAACGGGAAGAUCACCUGUGCUUCAGCCCAGGGUCAGAGGUCAAGUUCACAGUGACCUUUGAGAGUGACAAAUUCAAGGUGAAGCUGCCAGAUGGGCACGAGCUGACUUUUCCCAACAGGCUGGGUCACAGCCACCUGAGCUACCUGAGCGUAAGGGGCGGGUUCAACAUGUCCUCUUUCAAGUUAAAAGAAUAAAAGACUUCCAGCCGA-3'- Poly-A tail
  • Coding region
;
DNA
DNA (Gene ID: 3957)
galectin 2
strand -
HL14
NCBI CDS gene sequence (399 bp)
5'-ATGACGGGGGAACTTGAGGTTAAGAACATGGACATGAAGCCGGGGTCAACCCTGAAGATCACAGGCAGCATCGCCGATGGCACTGATGGCTTTGTAATTAATCTGGGCCAGGGGACAGACAAGCTGAACCTGCATTTCAACCCTCGCTTCAGCGAATCCACCATTGTCTGCAACTCATTGGACGGCAGCAACTGGGGGCAAGAACAACGGGAAGATCACCTGTGCTTCAGCCCAGGGTCAGAGGTCAAGTTCACAGTGACCTTTGAGAGTGACAAATTCAAGGTGAAGCTGCCAGATGGGCACGAGCTGACTTTTCCCAACAGGCTGGGTCACAGCCACCTGAGCTACCTGAGCGTAAGGGGCGGGTTCAACATGTCCTCTTTCAAGTTAAAAGAATAA-3'
NCBI CDS gene sequence with introns (location: 37570263.. 37579905) (9643 bp)Download
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 37570248.. 37580087) (9840 bp)Download
NCBI gene sequence (location: [37570248.. 37580087 + 1000]) (10840 bp)Download
How to cite: Schnider B., M'Rad Y., el Ahmadie J., de Brevern AG., Imberty A., Lisacek F., HumanLectome, an update of UniLectin for the annotation and prediction of human lectins, Nucleic Acids Reasearch doi.org/10.1093/nar/gkad905