NCBI Summary
The protein encoded by this gene is a soluble beta-galactoside binding lectin. The encoded protein is found as a homodimer and can bind to lymphotoxin-alpha. A single nucleotide polymorphism in an intron of this gene can alter the transcriptional level of the protein, with a resultant increased risk of myocardial infarction. [provided by RefSeq, Jul 2008].
Protein
Protein (NP_006489)
Galectin 2
Galectin-2 (Gal-2) (Beta-galactoside-binding lectin L-14-II) (HL14) (Lactose-binding lectin 2) (S-Lac lectin 2)
LGALS2
galectin 2
Undefined
Curated
Galectin
S-Type Lectins - Prototypical
b-sandwich / ConA-like
Gal
NP_006489
3957
P05162
ENSP00000215886.4
P05162
0.416
10.1042/BSR20181787
neXtProt, PFAM, InterPro
Protein sequence and protein families (fasta) (132 amino acids) Download
MTGELEVKNMDMKPGSTLKITGSIADGTDGFVINLGQGTDKLNLHFNPRFSESTIVCNSLDGSNWGQEQREDHLCFSPGSEVKFTVTFESDKFKVKLPDGHELTFPNRLGHSHLSYLSVRGGFNMSSFKLKE
Mol* PDB structure viewerUniLectin3D
Structural models
AlphaFold v2: AF-P05162-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

AlphaFold_v2 structural model assessment through SWISS-MODEL tools.

Ligand
Glycan ligands from structural data
bGal14Glc
Gal(b1-4)Glc
1HLC, 5EWS, 5DG1, 5DG2
1HLC, 5EWS, 5DG1, 5DG2
GlyConnect Structures
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for LGALS2 Gene
ProteomicsDB
References
NCBI References (10 PubMed Identifiers)
  • Syndecan 4, galectin 2, and death receptor 3 (DR3) as novel proteins in pathophysiology of preeclampsia. [31608721]
  • Genome-wide CRISPR screen identifies LGALS2 as an oxidative stress-responsive gene with an inhibitory function on colon tumor growth. [33110234]
  • A reference map of the human binary protein interactome. [32296183]
  • Placental Galectin-2 Expression in Gestational Diabetes: A Systematic, Histological Analysis. [32244351]
  • Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations. [31515488]
  • X-ray crystal structure of the human dimeric S-Lac lectin, L-14-II, in complex with lactose at 2.9-A resolution. [8262940]
  • Crystallization and preliminary X-ray diffraction analysis of the human dimeric S-Lac lectin (L-14-II). [8411163]
  • Isolation and expression of a gene encoding L-14-II, a new human soluble lactose-binding lectin. [1375225]
  • Genomic sequence and organization of two members of a human lectin gene family. [1988031]
  • Evidence that a human soluble beta-galactoside-binding lectin is encoded by a family of genes. [3020551]
UniProt Main References (4 PubMed Identifiers)
  • A genome annotation-driven approach to cloning the human ORFeome. [15461802]
  • The DNA sequence of human chromosome 22. [10591208]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
  • The consensus coding sequences of human breast and colorectal cancers. [16959974]
RNA
RNA (Transcript ID: NM_006498.3)
NM_006498.3
galectin 2
All isoforms of LGALS2 containing a lectin domain
ENST00000215886.6
183..581 (or 37570263.. 37579905)
37570248.. 37580087
NCBI Matured mRNA sequence 596 NTPDownload 
m7G-5')ppp(5'-CUGUUUGUGCUGGGUACUGGGAGAUGCAGGCGGGGAGACACAAGGUAGAAGGGGCAAAGUCCUCACCUAGGACCUUGAGGGAGUUAAUGUGUAAUAUUCUAGGAUAUAAGCUUGACCACGAGUUGAGACCCUGAGCACAGGCCUCCAGGAGCCGCUGGGAGCUGCCGCCAGGAGCUGUCACCAUGACGGGGGAACUUGAGGUUAAGAACAUGGACAUGAAGCCGGGGUCAACCCUGAAGAUCACAGGCAGCAUCGCCGAUGGCACUGAUGGCUUUGUAAUUAAUCUGGGCCAGGGGACAGACAAGCUGAACCUGCAUUUCAACCCUCGCUUCAGCGAAUCCACCAUUGUCUGCAACUCAUUGGACGGCAGCAACUGGGGGCAAGAACAACGGGAAGAUCACCUGUGCUUCAGCCCAGGGUCAGAGGUCAAGUUCACAGUGACCUUUGAGAGUGACAAAUUCAAGGUGAAGCUGCCAGAUGGGCACGAGCUGACUUUUCCCAACAGGCUGGGUCACAGCCACCUGAGCUACCUGAGCGUAAGGGGCGGGUUCAACAUGUCCUCUUUCAAGUUAAAAGAAUAAAAGACUUCCAGCCGA-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
;
More about the NCBI sViewer.
DNA
DNA (Gene ID: 3957)
LGALS2
galectin 2
NC_000022.11
22  37570263.. 37579905
37570263.. 37579905
strand -
CCDS13950.1
MGI:895068
ClinVar, dbVar
ENSG00000100079
HL14
uc003ata.4
INSDC:
6562
150571
OTTHUMG00000150590
ENA, DDBJ, Monarch
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (399 bp)
5'-ATGACGGGGGAACTTGAGGTTAAGAACATGGACATGAAGCCGGGGTCAACCCTGAAGATCACAGGCAGCATCGCCGATGGCACTGATGGCTTTGTAATTAATCTGGGCCAGGGGACAGACAAGCTGAACCTGCATTTCAACCCTCGCTTCAGCGAATCCACCATTGTCTGCAACTCATTGGACGGCAGCAACTGGGGGCAAGAACAACGGGAAGATCACCTGTGCTTCAGCCCAGGGTCAGAGGTCAAGTTCACAGTGACCTTTGAGAGTGACAAATTCAAGGTGAAGCTGCCAGATGGGCACGAGCTGACTTTTCCCAACAGGCTGGGTCACAGCCACCTGAGCTACCTGAGCGTAAGGGGCGGGTTCAACATGTCCTCTTTCAAGTTAAAAGAATAA-3'
NCBI CDS gene sequence with introns (location: 37570263.. 37579905) (9643 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 37570248.. 37580087) (9840 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [37570248.. 37580087 + 1000]) (10840 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
How to cite: Schnider B., M'Rad Y., el Ahmadie J., de Brevern AG., Imberty A., Lisacek F., HumanLectome, an update of UniLectin for the annotation and prediction of human lectins, Nucleic Acids Reasearch doi.org/10.1093/nar/gkad905