NCBI Summary
This gene encodes a member of the C-lectin family, proteins that possess collagen-like sequences and carbohydrate recognition domains. The other members of this family are secreted proteins and bind to carbohydrate antigens on microorganisms facilitating their recognition and removal. This gene product is a cytosolic protein, a characteristic that suggests that it may have different biological functions than other C-lectins. [provided by RefSeq, Jul 2008].
Protein
Protein (NP_006429)
Collectin-L1
Collectin-10 (Collectin liver protein 1) (CL-L1) (Collectin-34) (CL-34)
COLEC10
collectin subfamily member 10
Undefined
Curated
C-type lectin
COLEC10
C-type - Collectins
a/b mixed / C-type lectin-like
Fuc, Man, GlcNAc
NP_006429
10584
Q9Y6Z7
ENSP00000332723.2
Q9Y6Z7
0.373
10.1016/j.imbio.2011.12.008
neXtProt, PFAM, InterPro
Protein sequence and protein families (fasta) (277 amino acids) Download
MNGFASLLRRNQFILLVLFLLQIQSLGLDIDSRPTAEVCATHTISPGPKGDDGEKGDPGEEGKHGKVGRMGPKGIKGELGDMGDQGNIGKTGPIGKKGDKGEKGLLGIPGEKGKAGTVCDCGRYRKFVGQLDISIARLKTSMKFVKNVIAGIRETEEKFYYIVQEEKNYRESLTHCRIRGGMLAMPKDEAANTLIADYVAKSGFFRVFIGVNDLEREGQYMFTDNTPLQNYSNWNEGEPSDPYGHEDCVEMLSSGRWNDTECHLTMYFVCEFIKKKK
No structure currently available in the PDB RCSB Databank.
Structural models
AlphaFold v2: AF-Q9Y6Z7-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

SWISS-MODEL structural models
SWISS-MODEL structural model
Modeller structural model (Homology modelling pipeline), Error: [1.54, 1.98] ÅDownload
The location of the lectin domain structural model is: 128-274
We infer [1.54, 1.98] Å as the interval of error of this structural model.
Template 1: 6BBD chain: A, Q9N1X4, NP_999275.1, sequence identity: 29.3%, coverage: 97.3%, location in sequence: 225-378, (205-358 in PDB).
Template 2: 4WRE chain: A, P08427, NP_001257574.1, sequence identity: 27.2%, coverage: 93.9%, location in sequence: 108-248, (88-228 in PDB).
Template 3: 5VYB chain: A, Q6EIG7, NP_001007034.1, sequence identity: 22.4%, coverage: 94.6%, location in sequence: 63-209, (63-209 in PDB).
Show the alignment used for the construction of the structural model, Download.
Show the plot of DOPE energy score, Download.
Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for COLEC10 Gene
ProteomicsDB
References
NCBI References (10 PubMed Identifiers)
  • Association of Polymorphisms of MASP1/3, COLEC10, and COLEC11 Genes with 3MC Syndrome. [32751929]
  • CL-L1 and CL-K1 Exhibit Widespread Tissue Distribution With High and Co-Localized Expression in Secretory Epithelia and Mucosa. [30108587]
  • COLEC10 is mutated in 3MC patients and regulates early craniofacial development. [28301481]
  • Collectin Liver 1 and Collectin Kidney 1 of the Lectin Complement Pathway Are Associated With Mortality After Kidney Transplantation. [27341702]
  • The pattern recognition molecule collectin-L1 in critically ill children. [27057739]
  • Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies. [19801982]
  • Multiple genetic loci for bone mineral density and fractures. [18445777]
  • The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. [12975309]
  • Molecular cloning of mouse collectin liver 1. [12450124]
  • Molecular cloning of a novel human collectin from liver (CL-L1). [10224141]
UniProt Main References (2 PubMed Identifiers)
  • Complete sequencing and characterization of 21,243 full-length human cDNAs. [14702039]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
All isoforms of this gene containing a lectin domain
NP_001311024.1, XP_005250813.1, NP_006429.2
RNA
RNA (Transcript ID: NM_006438.5)
NM_006438.5
collectin subfamily member 10, transcript variant 1
All isoforms of COLEC10 containing a lectin domain
ENST00000332843.3
36..869 (or 119067282.. 119106191)
119067247.. 119108455
NCBI Matured mRNA sequence 3133 NTPDownload 
m7G-5')ppp(5'-AUUUCUGGGAGACCCUUUUCUGAGGAACCACAGCAAUGAAUGGCUUUGCAUCCUUGCUUCGAAGAAACCAAUUUAUCCUCCUGGUACUAUUUCUUUUGCAAAUUCAGAGUCUGGGUCUGGAUAUUGAUAGCCGUCCUACCGCUGAAGUCUGUGCCACACACACAAUUUCACCAGGACCCAAAGGAGAUGAUGGUGAAAAAGGAGAUCCAGGAGAAGAGGGAAAGCAUGGCAAAGUGGGACGCAUGGGGCCGAAAGGAAUUAAAGGAGAACUGGGUGAUAUGGGAGAUCAGGGCAAUAUUGGCAAGACUGGGCCCAUUGGGAAGAAGGGUGACAAAGGGGAAAAAGGUUUGCUUGGAAUACCUGGAGAAAAAGGCAAAGCAGGUACUGUCUGUGAUUGUGGAAGAUACCGGAAAUUUGUUGGACAACUGGAUAUUAGUAUUGCUCGGCUCAAGACAUCUAUGAAGUUUGUCAAGAAUGUGAUAGCAGGGAUUAGGGAAACUGAAGAGAAAUUCUACUACAUCGUGCAGGAAGAGAAGAACUACAGGGAAUCCCUAACCCACUGCAGGAUUCGGGGUGGAAUGCUAGCCAUGCCCAAGGAUGAAGCUGCCAACACACUCAUCGCUGACUAUGUUGCCAAGAGUGGCUUCUUUCGGGUGUUCAUUGGCGUGAAUGACCUUGAAAGGGAGGGACAGUACAUGUUCACAGACAACACUCCACUGCAGAACUAUAGCAACUGGAAUGAGGGGGAACCCAGCGACCCCUAUGGUCAUGAGGACUGUGUGGAGAUGCUGAGCUCUGGCAGAUGGAAUGACACAGAGUGCCAUCUUACCAUGUACUUUGUCUGUGAGUUCAUCAAGAAGAAAAAGUAACUUCCCUCAUCCUACGUAUUUGCUAUUUUCCUGUGACCGUCAUUACAGUUAUUGUUAUCCAUCCUUUUUUUCCUGAUUGUACUACAUUUGAUCUGAGUCAACAUAGCUAGAAAAUGCUAAACUGAGGUAUGGAGCCUCCAUCAUCAUGCUCUUUUGUGAUGAUUUUCAUAUUUUCACACAUGGUAUAUUAUUGACCCAAUAACUCGCCAGGUUACAUGGGUCUUGAGAGAGAAUUUUAAUUACUAAUUGUGCACGAGAUAGUUGGUUGUCUAUAUGUCAAAUGAGUUGUUCUCUUGGUAUUUGCUCUACCAUCUCUCCCUAGAGCACUCUGUGUCUAUCCCAGUGGAUAAUUUCCCAGUUUACUGGUGAUGAUUAGGAAGGUUGUUGAUGGUUAGGCUAACCUGCCCUGGCCCAAAGCCAGACAUGUACAAGGGCUUUCUGUGAGCAAUGAUAAGAUCUUUGAAUCCAAGAUGCCCAGAUCUUUUACCAGUCACACCCUAUGGCCAUGGCUAUACUUGGAAGUUCUCCUUGUUGGCACAGACAUAGAAAUGCUUUAACCCCAAACCUUUAUAUGGGGGACUUCUAGCUUUGUGUCUUGUUUCAGACCAUGUGGAAUGAUAAAUACUCUUUUUGUGCUUCUGAUCUAUCGAUUUCACUAACAUAUACCAAGUAGGUGCUUUGAACCCCUUUCUGUAGGCUCACACCUUAAUCUCAGGCCCCUAUAUAGUCACACUUUGAUUUAAGAAAAAUGGAGCUCUUGAAAUCAAAAGAAAAAAAUGGGGAAUUGUUCACAAACAAUACUGGUUAUAGUUCUCUUGCUAAAUUGCCCACUGCUAUUAACUUAACUUCAUUUUUAUUUAUCUUAGGUUUACCUGCAUCAAUUUUAUUCACCUUAGGCAUAGGGAAUGAGGGAAGGAGUUUGUGAAGCCUUAAGAAAAUUCUGGAAGCUUCAAAGUGCUACCAACAUCAUCUCCAGGCCCCCUCAUCCUUGCCUCUAACAUAUCACUAAUGGUGACAUUUCAUGGGAGGCCUUUUACUCUUCAUAAAUAUAUGUCAUAGAAAUCCUACUGGAGAUGUCCCUUCUAAUACUCUGGCAUCACAGAAAUGUGUGAGGCACAGAAUUCGGAACAUGCUUAGAACUCACAUUUACUGAGCUGGUAAAAUUCUACCUUGAACUGUAGAUCAAACCUCAAAGCAGCUUUCACUUGGAAUUUAAAAAUAAACAGUUCAAAGAUACUCUAGAUUAUCACCCUAUAAACUUCUACUCCAGUUAUGGUUUCUGACAUAUGAUUAGACUGUUUCAAAUGCUGGCAAAAUGGUUAAUGAAGUAAGAGAAACAGAUCAACAACAUAUGUUCACCUUAAACCAUCUGUUCAUGAUUUCACCCGUGACUAACUGGUUAUGAGAUAGGACUUAAUUAGGUUAUUUCUGUGGGUUCAACAAGGGCCAUAAACUCAGAUCCUACAGGGGCCAGGCAGAUGACUUACCUAAAUGAAGUGGAACACGUGGGGACCCUAGUGCACUGAGCACAGCUUGCCCUUCCAAAGGAGCCAGCUGCUCCUCAGUGGCUGCUGCUGGUGCUAGGGAGGACCCAAUCUUGCUAAAUGUGCUGAUAUUUCAAGAGAAGUCAGAAAGCUGGGACUUUGUAACAUAAGCUCAUAUUUUAAUAUGUUGGCAACUAAUUAAUUUUUAACCCAAAUUUUAAGUGGGUUAAAAAUUAAUUAAAAUUAAAGAUUUGAGGUCAAAAGUCUUCUAGCUAAAGUUGUGAUCAUUUCAUUUCUUACUUCUGGAGGAAGGUUCAGAAGGUUCUAACCAAAUAGAAUGUCAUUAGGAUAUGAUGACAUGAAAGUCAAGAUAUCCCAUUAAUACCAUAUUCAAUUCAGCUUAAUAAUAGGAAUUUGUUAUAUGUUUGACAUUUAUCAGGUUACUAGUUAAACUCUUUUGAGAUGAUAGUACAUGACACUUUAAAGGCAGAAAAGCUUAAUAAAAAUUACAAAGUAGGACAUCAAACGCCAGUAUCCUUGGAUAGAAAGCCAUCCCAGAUCAUGAGGAAUGAAAACCUAGAAACACCUGUAGGAAAAUAAAGCUCAUAUGUAAGAAGAGAGGAAGGAGAGACAUGCAGCAAAUGUUGCCUACGGGCAACUUCAUGUUAAGGAUCCAUGUUCUGAUUUGUUCUAAGCCCCCAAAGUAUGAGUAUUUAUUGUGUGCACUGUUAGUGCUAUUAUUAUUUACUGUGAAUGUUAUAAUAAUAGUUCUCUCAAUGA-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
;
More about the NCBI sViewer.
DNA
DNA (Gene ID: 10584)
COLEC10
collectin subfamily member 10
NC_000008.11
8  119067282.. 119106191
119067282.. 119106191
strand +
CCDS6327.1
MGI:3606482
ClinVar, dbVar
ENSG00000184374
CL-L1, CL-10
uc003yoo.4
INSDC: AB002631
2220
607620
OTTHUMG00000164971
ENA, DDBJ, Monarch
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (834 bp)
5'-ATGAATGGCTTTGCATCCTTGCTTCGAAGAAACCAATTTATCCTCCTGGTACTATTTCTTTTGCAAATTCAGAGTCTGGGTCTGGATATTGATAGCCGTCCTACCGCTGAAGTCTGTGCCACACACACAATTTCACCAGGACCCAAAGGAGATGATGGTGAAAAAGGAGATCCAGGAGAAGAGGGAAAGCATGGCAAAGTGGGACGCATGGGGCCGAAAGGAATTAAAGGAGAACTGGGTGATATGGGAGATCAGGGCAATATTGGCAAGACTGGGCCCATTGGGAAGAAGGGTGACAAAGGGGAAAAAGGTTTGCTTGGAATACCTGGAGAAAAAGGCAAAGCAGGTACTGTCTGTGATTGTGGAAGATACCGGAAATTTGTTGGACAACTGGATATTAGTATTGCTCGGCTCAAGACATCTATGAAGTTTGTCAAGAATGTGATAGCAGGGATTAGGGAAACTGAAGAGAAATTCTACTACATCGTGCAGGAAGAGAAGAACTACAGGGAATCCCTAACCCACTGCAGGATTCGGGGTGGAATGCTAGCCATGCCCAAGGATGAAGCTGCCAACACACTCATCGCTGACTATGTTGCCAAGAGTGGCTTCTTTCGGGTGTTCATTGGCGTGAATGACCTTGAAAGGGAGGGACAGTACATGTTCACAGACAACACTCCACTGCAGAACTATAGCAACTGGAATGAGGGGGAACCCAGCGACCCCTATGGTCATGAGGACTGTGTGGAGATGCTGAGCTCTGGCAGATGGAATGACACAGAGTGCCATCTTACCATGTACTTTGTCTGTGAGTTCATCAAGAAGAAAAAGTAA-3'
NCBI CDS gene sequence with introns (location: 119067282.. 119106191) (38910 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 119067247.. 119108455) (41209 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [119067247 - 1000].. 119108455) (42209 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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