NCBI Summary
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. The expression of this gene is restricted to small intestine, colon, and rectum, and it is underexpressed in colorectal cancer. [provided by RefSeq, Jul 2008].
Protein
Protein (NP_006140)
Galectin 4
Galectin-4 (Gal-4) (Antigen NY-CO-27) (L-36 lactose-binding protein) (L36LBP) (Lactose-binding lectin 4)
LGALS4
galectin 4
Undefined
Curated
Galectin
S-Type Lectins - Tandem repeat
b-sandwich / ConA-like
Gal / Oligo LacNAc / Blood group A and B
NP_006140
3960
P56470
ENSP00000302100.3
P56470
0.486
10.1111/febs.13348
neXtProt, PFAM, InterPro, CFG data
Protein sequence and protein families (fasta) (323 amino acids) Download
MAYVPAPGYQPTYNPTLPYYQPIPGGLNVGMSVYIQGVASEHMKRFFVNFVVGQDPGSDVAFHFNPRFDGWDKVVFNTLQGGKWGSEERKRSMPFKKGAAFELVFIVLAEHYKVVVNGNPFYEYGHRLPLQMVTHLQVDGDLQLQSINFIGGQPLRPQGPPMMPPYPGPGHCHQQLNSLPTMEGPPTFNPPVPYFGRLQGGLTARRTIIIKGYVPPTGKSFAINFKVGSSGDIALHINPRMGNGTVVRNSLLNGSWGSEEKKITHNPFGPGQFFDLSIRCGLDRFKVYANGQHLFDFAHRLSAFQRVDTLEIQGDVTLSYVQI
Mol* PDB structure viewerUniLectin3D
Structural models
AlphaFold v2: AF-P56470-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

AlphaFold_v2 structural model assessment through SWISS-MODEL tools.

Ligand
Glycan ligands from structural data
bGal13bGlcNAc13bGal14GlcNAC
Gal(b1-3)GlcNAc(b1-3)Gal(b1-4)Glc
4YM0
4YM0
GlyConnect Structures
bGal14bGlcNAc13bGal14GlcNAC
Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)Glc
4YLZ
4YLZ
GlyConnect Structures
bGal14Glc
Gal(b1-4)Glc
4YM2, 4YM3, 5DUW, 5DUV, 5CBL
4YM2, 4YM3, 5DUW, 5DUV, 5CBL
GlyConnect Structures
aFuc12bGal14Glc
Fuc(a1-2)Gal(b1-4)Glc
4YM1, 5DUX
4YM1, 5DUX
GlyConnect Structures
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for LGALS4 Gene
ProteomicsDB
References
NCBI References (10 PubMed Identifiers)
  • Evaluation of Serum and Gene Expression of Galectin-4, Interleukin-27, and Complement-7 in Hepatitis C Virus-Infected Egyptian Patients. [33381596]
  • SLPI facilitates cell migration by regulating lamellipodia/ruffles and desmosomes, in which Galectin4 plays an important role. [33016205]
  • A reference map of the human binary protein interactome. [32296183]
  • How presence of a signal peptide affects human galectins-1 and -4: Clues to explain common absence of a leader sequence among adhesion/growth-regulatory galectins. [31678146]
  • LGALS4 as a Prognostic Factor in Urothelial Carcinoma of Bladder Affects Cell Functions. [31558111]
  • Galectin-4 binds to sulfated glycosphingolipids and carcinoembryonic antigen in patches on the cell surface of human colon adenocarcinoma cells. [15546874]
  • High-affinity binding of recombinant human galectin-4 to SO(3)(-)-->3Galbeta1-->3GalNAc pyranoside. [11971864]
  • Cloning and expression of the mRNA of human galectin-4, an S-type lectin down-regulated in colorectal cancer. [9310382]
  • Strikingly different localization of galectin-3 and galectin-4 in human colon adenocarcinoma T84 cells. Galectin-4 is localized at sites of cell adhesion. [9162064]
  • Galectins. Structure and function of a large family of animal lectins. [8063692]
UniProt Main References (1 PubMed Identifiers)
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
All isoforms of this gene containing a lectin domain
NP_006140.1, XP_011525275.1, XP_011525276.1
RNA
RNA (Transcript ID: NM_006149.4)
NM_006149.4
galectin 4
All isoforms of LGALS4 containing a lectin domain
ENST00000307751.9
60..1031 (or 38801764.. 38812886)
38801674.. 38812945
NCBI Matured mRNA sequence 1121 NTPDownload 
m7G-5')ppp(5'-ACCAUCUCCCACUCCUGCAGCUCUUCUCACAGGACCAGCCACUAGCGCAGCCUCGAGCGAUGGCCUAUGUCCCCGCACCGGGCUACCAGCCCACCUACAACCCGACGCUGCCUUACUACCAGCCCAUCCCGGGCGGGCUCAACGUGGGAAUGUCUGUUUACAUCCAAGGAGUGGCCAGCGAGCACAUGAAGCGGUUCUUCGUGAACUUUGUGGUUGGGCAGGAUCCGGGCUCAGACGUCGCCUUCCACUUCAAUCCGCGGUUUGACGGCUGGGACAAGGUGGUCUUCAACACGUUGCAGGGCGGGAAGUGGGGCAGCGAGGAGAGGAAGAGGAGCAUGCCCUUCAAAAAGGGUGCCGCCUUUGAGCUGGUCUUCAUAGUCCUGGCUGAGCACUACAAGGUGGUGGUAAAUGGAAAUCCCUUCUAUGAGUACGGGCACCGGCUUCCCCUACAGAUGGUCACCCACCUGCAAGUGGAUGGGGAUCUGCAACUUCAAUCAAUCAACUUCAUCGGAGGCCAGCCCCUCCGGCCCCAGGGACCCCCGAUGAUGCCACCUUACCCUGGUCCCGGACAUUGCCAUCAACAGCUGAACAGCCUGCCCACCAUGGAAGGACCCCCAACCUUCAACCCGCCUGUGCCAUAUUUCGGGAGGCUGCAAGGAGGGCUCACAGCUCGAAGAACCAUCAUCAUCAAGGGCUAUGUGCCUCCCACAGGCAAGAGCUUUGCUAUCAACUUCAAGGUGGGCUCCUCAGGGGACAUAGCUCUGCACAUUAAUCCCCGCAUGGGCAACGGUACCGUGGUCCGGAACAGCCUUCUGAAUGGCUCGUGGGGAUCCGAGGAGAAGAAGAUCACCCACAACCCAUUUGGUCCCGGACAGUUCUUUGAUCUGUCCAUUCGCUGUGGCUUGGAUCGCUUCAAGGUUUACGCCAAUGGCCAGCACCUCUUUGACUUUGCCCAUCGCCUCUCGGCCUUCCAGAGGGUGGACACAUUGGAAAUCCAGGGUGAUGUCACCUUGUCCUAUGUCCAGAUCUAAUCUAUUCCUGGGGCCAUAACUCAUGGGAAAACAGAAUUAUCCCCUAGGACUCCUUUCUAAGCCCCUAAUAAAAUGUCUGAGGGUGUCUCA-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
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More about the NCBI sViewer.
DNA
DNA (Gene ID: 3960)
LGALS4
galectin 4
NC_000019.10
19  38801764.. 38812886
38801764.. 38812886
strand -
CCDS12521.1
MGI:107536
ClinVar, dbVar
ENSG00000171747
GAL4
uc002ojg.4
INSDC:
6565
602518
OTTHUMG00000182608
ENA, DDBJ, Monarch
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (972 bp)
5'-ATGGCCTATGTCCCCGCACCGGGCTACCAGCCCACCTACAACCCGACGCTGCCTTACTACCAGCCCATCCCGGGCGGGCTCAACGTGGGAATGTCTGTTTACATCCAAGGAGTGGCCAGCGAGCACATGAAGCGGTTCTTCGTGAACTTTGTGGTTGGGCAGGATCCGGGCTCAGACGTCGCCTTCCACTTCAATCCGCGGTTTGACGGCTGGGACAAGGTGGTCTTCAACACGTTGCAGGGCGGGAAGTGGGGCAGCGAGGAGAGGAAGAGGAGCATGCCCTTCAAAAAGGGTGCCGCCTTTGAGCTGGTCTTCATAGTCCTGGCTGAGCACTACAAGGTGGTGGTAAATGGAAATCCCTTCTATGAGTACGGGCACCGGCTTCCCCTACAGATGGTCACCCACCTGCAAGTGGATGGGGATCTGCAACTTCAATCAATCAACTTCATCGGAGGCCAGCCCCTCCGGCCCCAGGGACCCCCGATGATGCCACCTTACCCTGGTCCCGGACATTGCCATCAACAGCTGAACAGCCTGCCCACCATGGAAGGACCCCCAACCTTCAACCCGCCTGTGCCATATTTCGGGAGGCTGCAAGGAGGGCTCACAGCTCGAAGAACCATCATCATCAAGGGCTATGTGCCTCCCACAGGCAAGAGCTTTGCTATCAACTTCAAGGTGGGCTCCTCAGGGGACATAGCTCTGCACATTAATCCCCGCATGGGCAACGGTACCGTGGTCCGGAACAGCCTTCTGAATGGCTCGTGGGGATCCGAGGAGAAGAAGATCACCCACAACCCATTTGGTCCCGGACAGTTCTTTGATCTGTCCATTCGCTGTGGCTTGGATCGCTTCAAGGTTTACGCCAATGGCCAGCACCTCTTTGACTTTGCCCATCGCCTCTCGGCCTTCCAGAGGGTGGACACATTGGAAATCCAGGGTGATGTCACCTTGTCCTATGTCCAGATCTAA-3'
NCBI CDS gene sequence with introns (location: 38801764.. 38812886) (11123 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 38801674.. 38812945) (11272 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [38801674.. 38812945 + 1000]) (12272 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
How to cite: Schnider B., M'Rad Y., el Ahmadie J., de Brevern AG., Imberty A., Lisacek F., HumanLectome, an update of UniLectin for the annotation and prediction of human lectins, Nucleic Acids Reasearch doi.org/10.1093/nar/gkad905