Protein
Protein (NP_006084)
Bone marrow proteoglycan 3
Proteoglycan 3 (Eosinophil major basic protein homolog) (Prepro-major basic protein homolog) (Prepro-MBPH)
PRG3
proteoglycan 3, pro eosinophil major basic protein 2
Undefined
Very low evidence
C-type lectin
Undefined
C-type - CTLD/acidic neck
a/b mixed / C-type lectin-like
Uncharacterised
NP_006084
10394
Q9Y2Y8
ENSP00000287143.2
Q9Y2Y8
0.34
Undefined
neXtProt, PFAM, InterPro
Protein sequence and protein families (fasta) (225 amino acids) Download
MQCLLLLPFLLLGTVSALHLENDAPHLESLETQADLGQDLDSSKEQERDLALTEEVIQAEGEEVKASACQDNFEDEEAMESDPAALDKDFQCPREEDIVEVQGSPRCKICRYLLVRTPKTFAEAQNVCSRCYGGNLVSIHDFNFNYRIQCCTSTVNQAQVWIGGNLRGWFLWKRFCWTDGSHWNFAYWSPGQPGNGQGSCVALCTKGGYWRRAQCDKQLPFVCSF
No structure currently available in the PDB RCSB Databank.
Structural models
AlphaFold v2: AF-Q9Y2Y8-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

SWISS-MODEL structural models
SWISS-MODEL structural model
Modeller structural model (Homology modelling pipeline), Error: [1.65, 2.17] ÅDownload
The location of the lectin domain structural model is: 67-225
We infer [1.65, 2.17] Å as the interval of error of this structural model.
Template 1: 6BBD chain: A, Q9N1X4, NP_999275.1, sequence identity: 21.4%, coverage: 93.7%, location in sequence: 225-378, (205-358 in PDB).
Template 2: 6JJJ chain: A, P70194, NP_058031.2, sequence identity: 21.4%, coverage: 86.2%, location in sequence: 393-543, (393-543 in PDB).
Template 3: 4WRE chain: A, P08427, NP_001257574.1, sequence identity: 20.1%, coverage: 87.4%, location in sequence: 108-248, (88-228 in PDB).
Show the alignment used for the construction of the structural model, Download.
Show the plot of DOPE energy score, Download.
Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for PRG3 Gene
ProteomicsDB
References
NCBI References (8 PubMed Identifiers)
  • Proteomic characterization of human multiple myeloma bone marrow extracellular matrix. [28344315]
  • Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver. [25037231]
  • A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. [22412388]
  • Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph. [21048031]
  • Human eosinophil major basic protein 2: location of disulfide bonds and free sulfhydryl groups. [17136616]
  • The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. [12975309]
  • Comparative structure, proximal promoter elements, and chromosome location of the human eosinophil major basic protein genes. [11170744]
  • A novel and highly divergent homolog of human eosinophil granule major basic protein. [10318872]
UniProt Main References (2 PubMed Identifiers)
  • Human chromosome 11 DNA sequence and analysis including novel gene identification. [16554811]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
RNA
RNA (Transcript ID: NM_006093.4)
NM_006093.4
proteoglycan 3, pro eosinophil major basic protein 2
All isoforms of PRG3 containing a lectin domain
ENST00000287143.2
111..788 (or 57376850.. 57380708)
57376769.. 57381150
NCBI Matured mRNA sequence 869 NTPDownload 
m7G-5')ppp(5'-AGAGGCACUGAGAGUGGAGGUCUCAGACUCUUGGAAGGGGCUAUACUAGACACACAAAGACAGCCCCAAGAAGGACGGUGGAGUAGUGUCCUCGCUAAAAGACAGUAGAUAUGCAAUGCCUCUUGCUCCUGCCCUUUCUCCUGCUGGGAACAGUUUCUGCUCUUCAUCUGGAGAAUGAUGCCCCCCAUCUGGAGAGCCUAGAGACACAGGCAGACCUAGGCCAGGAUCUGGAUAGUUCAAAGGAGCAGGAGAGAGACUUGGCUCUGACGGAGGAGGUGAUUCAGGCAGAGGGAGAGGAGGUCAAGGCUUCUGCCUGUCAAGACAACUUUGAGGAUGAGGAAGCCAUGGAGUCGGACCCAGCUGCCUUAGACAAGGACUUCCAGUGCCCCAGGGAAGAAGACAUUGUUGAAGUGCAGGGAAGUCCAAGGUGCAAGAUCUGCCGCUACCUAUUGGUGCGGACUCCUAAAACUUUUGCAGAAGCUCAGAAUGUCUGCAGCAGAUGCUACGGAGGCAACCUUGUCUCUAUCCAUGACUUCAACUUCAACUAUCGCAUUCAGUGCUGCACUAGCACAGUCAACCAAGCCCAGGUCUGGAUUGGAGGCAACCUCAGGGGCUGGUUCCUGUGGAAGCGGUUUUGCUGGACUGAUGGGAGCCACUGGAAUUUUGCUUACUGGUCCCCAGGGCAACCUGGGAAUGGGCAAGGCUCCUGUGUGGCCCUAUGCACCAAAGGAGGUUAUUGGCGACGAGCUCAAUGCGACAAGCAACUGCCCUUCGUCUGCUCCUUCUAAGCCAGCGGCACGGAGACCCUGCCAGCAGCUCCCUCCCGUCCCCCAACCUCUCCUGCUCAUAAAUCCAGACUUCCCACAGCA-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
;
More about the NCBI sViewer.
DNA
DNA (Gene ID: 10394)
PRG3
proteoglycan 3, pro eosinophil major basic protein 2
NC_000011.10
11  57376850.. 57380708
57376850.. 57380708
strand -
CCDS7954.1
MGI:1858200
ClinVar, dbVar
ENSG00000156575
MBPH, MBP2
uc001njv.2
INSDC: AF132209
9363
606814
OTTHUMG00000167026
ENA, DDBJ, Monarch
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (678 bp)
5'-ATGCAATGCCTCTTGCTCCTGCCCTTTCTCCTGCTGGGAACAGTTTCTGCTCTTCATCTGGAGAATGATGCCCCCCATCTGGAGAGCCTAGAGACACAGGCAGACCTAGGCCAGGATCTGGATAGTTCAAAGGAGCAGGAGAGAGACTTGGCTCTGACGGAGGAGGTGATTCAGGCAGAGGGAGAGGAGGTCAAGGCTTCTGCCTGTCAAGACAACTTTGAGGATGAGGAAGCCATGGAGTCGGACCCAGCTGCCTTAGACAAGGACTTCCAGTGCCCCAGGGAAGAAGACATTGTTGAAGTGCAGGGAAGTCCAAGGTGCAAGATCTGCCGCTACCTATTGGTGCGGACTCCTAAAACTTTTGCAGAAGCTCAGAATGTCTGCAGCAGATGCTACGGAGGCAACCTTGTCTCTATCCATGACTTCAACTTCAACTATCGCATTCAGTGCTGCACTAGCACAGTCAACCAAGCCCAGGTCTGGATTGGAGGCAACCTCAGGGGCTGGTTCCTGTGGAAGCGGTTTTGCTGGACTGATGGGAGCCACTGGAATTTTGCTTACTGGTCCCCAGGGCAACCTGGGAATGGGCAAGGCTCCTGTGTGGCCCTATGCACCAAAGGAGGTTATTGGCGACGAGCTCAATGCGACAAGCAACTGCCCTTCGTCTGCTCCTTCTAA-3'
NCBI CDS gene sequence with introns (location: 57376850.. 57380708) (3859 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 57376769.. 57381150) (4382 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [57376769.. 57381150 + 1000]) (5382 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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