NCBI Summary
This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.
Protein
Protein (NP_005743)
Cartilage-derived C-type lectin
C-type lectin domain family 3 member A (C-type lectin superfamily member 1) (Cartilage-derived C-type lectin)
CLEC3A
C-type lectin domain family 3 member A
Undefined
Very low evidence
C-type lectin
Undefined
C-type - Tetranectin
a/b mixed / C-type lectin-like
Uncharacterised
NP_005743
10143
O75596
ENSP00000299642.5
O75596
0.386
Undefined
neXtProt, PFAM, InterPro
Protein sequence and protein families (fasta) (197 amino acids) Download
MAKNGLVICILVITLLLDQTTSHTSRLKARKHSKRRVRDKDGDLKTQIEKLWTEVNALKEIQALQTVCLRGTKVHKKCYLASEGLKHFHEANEDCISKGGILVIPRNSDEINALQDYGKRSLPGVNDFWLGINDMVTEGKFVDVNGIAISFLNWDRAQPNGGKRENCVLFSQSAQGKWSDEACRSSKRYICEFTIPQ
No structure currently available in the PDB RCSB Databank.
Structural models
AlphaFold v2: AF-O75596-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

SWISS-MODEL structural models
SWISS-MODEL structural model
Modeller structural model (Homology modelling pipeline), Error: [1.54, 1.98] ÅDownload
The location of the lectin domain structural model is: 41-194
We infer [1.54, 1.98] Å as the interval of error of this structural model.
Template 1: 6BBD chain: A, Q9N1X4, NP_999275.1, sequence identity: 29.2%, coverage: 95.5%, location in sequence: 225-378, (205-358 in PDB).
Template 2: 4WRE chain: A, P08427, NP_001257574.1, sequence identity: 24.7%, coverage: 90.3%, location in sequence: 108-248, (88-228 in PDB).
Template 3: 4ZES chain: A, Q8WTT0, NP_569708.1, sequence identity: 20.8%, coverage: 90.9%, location in sequence: 67-213, (67-213 in PDB).
Show the alignment used for the construction of the structural model, Download.
Show the plot of DOPE energy score, Download.
Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for CLEC3A Gene
ProteomicsDB
References
NCBI References (6 PubMed Identifiers)
  • Suppression of CLEC3A inhibits osteosarcoma cell proliferation and promotes their chemosensitivity through the AKT1/mTOR/HIF1alpha signaling pathway. [32319617]
  • CLEC3A, MMP7, and LCN2 as novel markers for predicting recurrence in resected G1 and G2 pancreatic neuroendocrine tumors. [31129920]
  • Gene-alcohol interactions identify several novel blood pressure loci including a promising locus near SLC16A9. [24376456]
  • Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects. [19844255]
  • Matrilysin (MMP-7) cleaves C-type lectin domain family 3 member A (CLEC3A) on tumor cell surface and modulates its cell adhesion activity. [19173304]
  • The cartilage-derived, C-type lectin (CLECSF1): structure of the gene and chromosomal location. [10524194]
UniProt Main References (3 PubMed Identifiers)
  • The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. [12975309]
  • Complete sequencing and characterization of 21,243 full-length human cDNAs. [14702039]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
RNA
RNA (Transcript ID: NM_005752.6)
NM_005752.6
C-type lectin domain family 3 member A
All isoforms of CLEC3A containing a lectin domain
ENST00000299642.10
80..673 (or 78022627.. 78030841)
78022548.. 78032101
NCBI Matured mRNA sequence 1933 NTPDownload 
m7G-5')ppp(5'-AAGAUGUAGCUGUGUAGUCUCCUUCCAUAGCUGCUCUAAGGGGGCUGGCAACAUGGCUCAGCAGGCUUGCCCCAGAGCCAUGGCAAAGAAUGGACUUGUAAUUUGCAUCCUGGUGAUCACCUUACUCCUGGACCAGACCACCAGCCACACAUCCAGAUUAAAAGCCAGGAAGCACAGCAAACGUCGAGUGAGAGACAAGGAUGGAGAUCUGAAGACUCAAAUUGAAAAGCUCUGGACAGAAGUCAAUGCCUUGAAGGAAAUUCAAGCCCUGCAGACAGUCUGUCUCCGAGGCACUAAAGUUCACAAGAAAUGCUACCUUGCUUCAGAAGGUUUGAAGCAUUUCCAUGAGGCCAAUGAAGACUGCAUUUCCAAAGGAGGAAUCCUGGUUAUCCCCAGGAACUCCGACGAAAUCAACGCCCUCCAAGACUAUGGUAAAAGGAGCCUGCCAGGUGUCAAUGACUUUUGGCUGGGCAUCAAUGACAUGGUCACGGAAGGCAAGUUUGUUGACGUCAACGGAAUCGCUAUCUCCUUCCUCAACUGGGACCGUGCACAGCCUAACGGUGGCAAGCGAGAAAACUGUGUCCUGUUCUCCCAAUCAGCUCAGGGCAAGUGGAGUGAUGAGGCCUGUCGCAGCAGCAAGAGAUACAUAUGCGAGUUCACCAUCCCUCAAUAGGUCUUUCUCCAAUGUGUCCUCCAAGCAAGAUUCAUCAUAACUUAUAGGUUCAUGAUCUCUAAGAUCAAGUAAAAAUCAUAAUUUUUACUUAUUAAAAAAUUGCAACACAAGAUCAAUGUCCAUAGCAAUAUGAUAGCAUCAGCCAAUUUUGCUAACACAUUUCUUUGGGAUUUUGCCCUUCCUGGGGUAUAGGGGAUCAGAAAUAUUGAUCCAUGUGCACGCAGAUAAAAUGGCUUCUGCUAAACAGACUAAAAUCUUUCUCUCUAGUCUUUCUCACUUGUACAAACCCAGUUUGUUUUCAAAAAAUCACAGUAGCAAUGCAACUCAUCACUCUAGAAAAGCAAGCUUAGGCUACCUGAAAGAUUUUCCCUUGGAAGUUUAGCGUAUGUUUGACUAACAAAAAUUCCCUACAUCAGAGACUCUAGGUGCUAUAUAAUCCAAAAACUUUUCAGCCUGUUGCUCAUUCUGUCCCAUGCUGGCAAUAAUACCUUGUCAGCCCAUUACCCUUAUUUUGAAUUGCUCCAUCUCCUGGUGGGACUUGUAUCUUGUCUGCCAUAUCAGAACACAAACCCCUGAAGAGGUUCUGAUUUGAUUUUUUUUUUUUCUUCAUGCCUACCCUUUUUUUGGAAGUUUCCAGCCGCAAUUUGAAAUGAAAUGACAAGGUGUAUAUUUGAUCAAUUUUCAUUCCCACCAUUGCAUUACAACCUCUAACUUAAAUGGGUAACCCUAAGGCAUAUCAAAGAAGCAGAUUGCAUGAUAAACGGAAACAGAAAAAAAGAACCUACAUUUAUUUUGCUUUAGCAUCCUUACUCUCACCUUUUAUGAGAUUGAGAGUGGACUUACAUUUCCUUUUUUACAUUUUCGUAUACUUAUUUUUUUUAGCCAUCAUUAUAUGUUUAAGUCUAUUAUGGGCAACCAAUCUUUGGAAGCUGAAAACUGAAUUUAAAGAAUGCUAUCUUGGAAAAUUGCAUACGUCUGUGCAAUUUUUUAUUCUGCCUAGUGCUAUUCUGCUUGUUUAACUAGAUUGUACAAAAUAACUUCAUUGCUUAAUAUCAAAUUACAAAGUUUAGACUUGGAGGGAAAUGGGCUUUUUAGAAGCAAACAAUUUUAAAUAUAUUUUGUUCUUCAAAUAAAUAGUGUUUAAACAUUGAAUGUGUUUUGUGAACAAUAUCCCACUUUGCAAACUUUAACUACACAUGCUUGGAAUUAAGUUUUAGCUGUUUUCAUUGCUCAAUAAUAAAGCCUGAAUUCUGAUCAAUA-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
;
More about the NCBI sViewer.
DNA
DNA (Gene ID: 10143)
CLEC3A
C-type lectin domain family 3 member A
NC_000016.10
16  78022627.. 78030841
78022627.. 78030841
strand +
CCDS10927.2
MGI:2685642
ClinVar, dbVar
ENSG00000166509
uc002ffh.6
INSDC: AF077345
2052
613588
OTTHUMG00000137620
ENA, DDBJ, Monarch
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (594 bp)
5'-ATGGCAAAGAATGGACTTGTAATTTGCATCCTGGTGATCACCTTACTCCTGGACCAGACCACCAGCCACACATCCAGATTAAAAGCCAGGAAGCACAGCAAACGTCGAGTGAGAGACAAGGATGGAGATCTGAAGACTCAAATTGAAAAGCTCTGGACAGAAGTCAATGCCTTGAAGGAAATTCAAGCCCTGCAGACAGTCTGTCTCCGAGGCACTAAAGTTCACAAGAAATGCTACCTTGCTTCAGAAGGTTTGAAGCATTTCCATGAGGCCAATGAAGACTGCATTTCCAAAGGAGGAATCCTGGTTATCCCCAGGAACTCCGACGAAATCAACGCCCTCCAAGACTATGGTAAAAGGAGCCTGCCAGGTGTCAATGACTTTTGGCTGGGCATCAATGACATGGTCACGGAAGGCAAGTTTGTTGACGTCAACGGAATCGCTATCTCCTTCCTCAACTGGGACCGTGCACAGCCTAACGGTGGCAAGCGAGAAAACTGTGTCCTGTTCTCCCAATCAGCTCAGGGCAAGTGGAGTGATGAGGCCTGTCGCAGCAGCAAGAGATACATATGCGAGTTCACCATCCCTCAATAG-3'
NCBI CDS gene sequence with introns (location: 78022627.. 78030841) (8215 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 78022548.. 78032101) (9554 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [78022548 - 1000].. 78032101) (10554 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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