NCBI Summary
The protein encoded by this gene is a membrane mannose-specific lectin that cycles between the endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment, and cis-Golgi, functioning as a cargo receptor for glycoprotein transport. The protein has an N-terminal signal sequence, a calcium-dependent and pH-sensitive carbohydrate recognition domain, a stalk region that functions in oligomerization, a transmembrane domain, and a short cytoplasmic domain required for organelle targeting. Allelic variants of this gene are associated with the autosomal recessive disorder combined factor V-factor VIII deficiency. [provided by RefSeq, Jul 2015].
Protein
Protein (NP_005561)
ERGIC-53 - lectin, mannose binding 1
Protein ERGIC-53 (ER-Golgi intermediate compartment 53 kDa protein) (Gp58) (Intracellular mannose-specific lectin MR60) (Lectin mannose-binding 1)
LMAN1
lectin, mannose binding 1
Undefined
Curated
ERGIC-VIP L-type
L-Type Lectins
b-sandwich / ConA-like
MAGSRQRGLRARVRPLFCALLLSLGRFVRGDGVGGDPAVALPHRRFEYKYSFKGPHLVQSDGTVPFWAHAGNAIPSSDQIRVAPSLKSQRGSVWTKTKAAFENWEVEVTFRVTGRGRIGADGLAIWYAENQGLEGPVFGSADLWNGVGIFFDSFDNDGKKNNPAIVIIGNNGQIHYDHQNDGASQALASCQRDFRNKPYPVRAKITYYQNTLTVMINNGFTPDKNDYEFCAKVENMIIPAQGHFGISAATGGLADDHDVLSFLTFQLTEPGKEPPTPDKEISEKEKEKYQEEFEHFQQELDKKKEEFQKGHPDLQGQPAEEIFESVGDRELRQVFEGQNRIHLEIKQLNRQLDMILDEQRRYVSSLTEEISKRGAGMPGQHGQITQQELDTVVKTQHEILRQVNEMKNSMSETVRLVSGMQHPGSAGGVYETTQHFIDIKEHLHIVKRDIDNLVQRNMPSNEKPKCPELPPFPSCLSTVHFIIFVVVQTVLFIGYIMYRSQQEAAAKKFF
Mol* PDB structure viewerUniLectin3D
Ligand
Glycan ligands from structural data
Man.png)
References
NCBI References (10 PubMed Identifiers)
- Mannan-Binding Lectin Suppresses Peptidoglycan-Induced TLR2 Activation and Inflammatory Responses. [30728747]
- Multiple coagulation factor deficiency protein 2 as a crucial component in metastasis of human oral cancer. [29679592]
- Combined deficiency of factors V and VIII by chance coinheritance of parahaemophilia and haemophilia A, but not by mutations of either LMAN1 or MCFD2, in a Japanese family. [29082580]
- Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics. [28675934]
- Crystal structure of the LMAN1-CRD/MCFD2 transport receptor complex provides insight into combined deficiency of factor V and factor VIII. [20138881]
- The locus for combined factor V-factor VIII deficiency (F5F8D) maps to 18q21, between D18S849 and D18S1103. [9245995]
- Mapping of the MR60/ERGIC-53 gene to human chromosome 18q21.3-18q22 by in situ hybridization. [8854877]
- ERGIC-53, a membrane protein of the endoplasmic reticulum-Golgi intermediate compartment, is identical to MR60, an intracellular mannose-specific lectin of myelomonocytic cells. [7876089]
- A putative novel class of animal lectins in the secretory pathway homologous to leguminous lectins. [8205612]
- ERGIC-53, a membrane protein of the ER-Golgi intermediate compartment, carries an ER retention motif. [8223692]
UniProt Main References (15 PubMed Identifiers)
- ERGIC-53 gene structure and mutation analysis in 19 combined factors V and VIII deficiency families. [10090935]
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
- Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. [12665801]
- Cluster analysis of an extensive human breast cancer cell line protein expression map database. [11840567]
- ER export of ERGIC-53 is controlled by cooperation of targeting determinants in all three of its domains. [13130098]
- Bleeding due to disruption of a cargo-specific ER-to-Golgi transport complex. [12717434]
- Oligomerization and interacellular localization of the glycoprotein receptor ERGIC-53 is independent of disulfide bonds. [16257008]
- Initial characterization of the human central proteome. [21269460]
- Protein interaction profiling of the p97 adaptor UBXD1 points to a role for the complex in modulating ERGIC-53 trafficking. [22337587]
- TMEM115 is an integral membrane protein of the Golgi complex involved in retrograde transport. [24806965] Show more
RNA
RNA (Transcript ID: NM_005570.4)
m7G-5')ppp(5'-CUCCGCGUUCCAGAAUCCAAGAUGGCGGGAUCCAGGCAAAGGGGUCUCCGGGCCAGAGUUCGGCCGCUGUUCUGCGCCUUGCUGCUGUCACUCGGUCGCUUCGUCCGGGGCGACGGCGUGGGAGGAGACCCCGCGGUCGCGUUGCCACAUCGCCGUUUCGAGUACAAAUACAGCUUCAAGGGGCCGCACCUGGUGCAGAGCGACGGGACCGUGCCCUUCUGGGCCCACGCGGGGAAUGCUAUUCCAAGUUCAGAUCAAAUUCGAGUAGCACCAUCUUUAAAAAGCCAAAGAGGCUCAGUGUGGACAAAGACAAAAGCGGCCUUUGAGAACUGGGAAGUUGAGGUGACAUUUCGAGUGACUGGAAGAGGUCGAAUUGGAGCUGAUGGCCUAGCAAUUUGGUAUGCAGAAAAUCAAGGCUUGGAGGGCCCUGUGUUUGGAUCAGCUGAUCUGUGGAAUGGUGUUGGAAUAUUUUUUGAUUCUUUUGACAAUGAUGGAAAGAAAAAUAAUCCUGCUAUAGUAAUUAUAGGCAACAAUGGACAAAUCCAUUAUGACCAUCAAAAUGACGGGGCUAGUCAAGCUUUGGCAAGUUGCCAGAGGGACUUCCGCAACAAACCCUAUCCUGUCCGAGCAAAGAUUACCUAUUACCAGAACACACUGACAGUAAUGAUCAAUAAUGGCUUUACACCAGAUAAAAAUGAUUAUGAAUUUUGUGCCAAAGUGGAAAAUAUGAUUAUCCCUGCACAAGGGCAUUUUGGAAUAUCUGCUGCAACUGGAGGUCUUGCAGAUGACCAUGAUGUCCUUUCUUUUCUGACUUUCCAGUUGACUGAACCUGGAAAAGAGCCGCCCACACCAGAUAAAGAAAUUUCGGAAAAGGAAAAAGAAAAGUAUCAGGAGGAAUUUGAGCACUUUCAACAAGAAUUGGAUAAAAAAAAAGAGGAAUUCCAGAAGGGCCACCCCGACCUCCAAGGGCAGCCUGCGGAGGAAAUAUUUGAGAGUGUAGGAGAUCGAGAGCUAAGACAAGUCUUUGAAGGACAGAAUCGUAUUCAUCUUGAAAUCAAGCAGCUGAACCGGCAGUUAGAUAUGAUUCUUGAUGAACAGAGAAGAUAUGUCUCUUCCUUAACAGAGGAAAUCUCUAAAAGAGGAGCAGGAAUGCCUGGGCAGCAUGGGCAGAUUACUCAACAAGAACUGGAUACUGUUGUGAAAACUCAGCAUGAGAUUCUGAGACAAGUAAAUGAAAUGAAAAAUUCCAUGAGUGAAACCGUCAGACUGGUCAGUGGAAUGCAGCACCCUGGCUCUGCUGGAGGCGUCUAUGAGACAACACAGCACUUCAUUGACAUCAAAGAGCACCUGCACAUAGUAAAGAGGGACAUAGAUAACUUAGUGCAGCGAAAUAUGCCAUCAAAUGAAAAGCCGAAAUGCCCAGAACUACCACCAUUUCCAUCAUGUUUGUCUACGGUCCACUUCAUUAUAUUUGUUGUGGUGCAAACUGUAUUAUUCAUUGGUUAUAUCAUGUAUAGGUCUCAGCAAGAAGCAGCUGCCAAAAAAUUCUUUUGACUACCAUUUUCCUGUGUACUUCAUCUAUUUGUGUACAAAAUGAUGUCGUUUUGAGGGAAUUUAAGUAUUUAAAUUGCUUCAUAGUCUAAAUUAUUAAUUUUCUUAAUAAAAUAACUGUUUAAACAUUGAUUUGCAGUUAAGAAUAAACCUUAAAGCAAAGACAACCACAUUUUAAUUUGUUCACAGUAUGUAAAUCUGUCUAAAUUUCAGUGAAUUUCUGGUCAGUAUGAUGCAGCCUCUGAGCAGAAUAUUGACCAGUAAGAGGGUAAAUAAAGUGGGGGCAACCCCUGGAUAUGAAUGUUACCCCCUAAGUCUCCAAUAUUGCAGGUUUCCCUGUAUAACGUAAACACACUUGCCCUCAUGCCUCCCAGAAUAUGAGGUCUAAUUAAGAAGUCCCAUCAGGUUUAUUUUGUAACCAAAGUCUUUUUUAGAGGUCAGACUUCCUAAUCAAAGGCCUGGGCCUGCAGUCCUUUCAUCUUAAUGCAACUUCCUUUGAAAUCAAAGAAUAUUUUGUCUGAGAGCUUUAAGGAUCUGGUAAUAGACUUCAAAAUGUUAAGUGAAAUUUUUUUUUCCUCUAUUUAUCAAUGAUAUAUUUCACUUUUAAAGGAAAUUUUAGAGGAAAAUUAAUAGCUGCUUUUUGCCUAAAAAACCUUGUGGGUGGAAACAUUCCUCUGAGAAUGGCUUUUAUAGGUAUUUUGCCUGGUAAUGUAUUCAUUCAUGAUUGCCCAUAUUCUUGAAUGUCUUCAUUCCAAUGGGGUCAGGUCAAUAUUAUGAAAAUAAUUUUUAUAUUUAUAUUUGUAACUUAAGGAAUUUAUUUCUCCCUUUACUACAGCAUGUAAAUUCAGCUCAAAUUGCAUGAUCUGAGGAUUUAAAUUCACAAAACCUGCCACUACAUUCUGGUUUACAUUAGUUACUUCAUGCUGGCUGGGGUUAGUGACCAUUUGCAUACUCUUUUAAAUCAAGGAGGCUGUAGUAGAAGCAGUUUUAAGAUUCUUGAAGGCAAAAUUUGAAAAACAGUGAAUACUUCUAAUUGUUUCCUUUUAGUGCCAGAACUAAGGACAUUGUGAAGCACUUGUUAGUAAACUUAACCUUGAAAUGUCAGACUGGAAGGAGUUUUUAUAGUCUUUGUGCAUACUUCUAGGUAUUACAGAAACAGUCUGUAAAUGACAUUUUAAGAUGCAAAUUUAAUUCUGUUCACAGCUGAUUUAUACUGAUUUUUGCUGCCUUCAAAAUACUCUUUUACUUCUUUUAGCUAAAAUGGUUGUCUUUCAUUUGCCAUAGAAUUCCAAACAAUACUAUCUUAUAAAAUAGUACUGUUGAAUUAUUCCAAGCCUCCCUAGGUUUGCUCUCAAAUGUCAUUUACAGAUUGGGCUAACGACCUAAAAUCUAUAUAUAAAGACUUUCUGAAGAACUCUGUAUUAUAGCAAUACCAAACGAGUGCUGUGUGUGCAAACAGUCUGGCGUUGCUUUUUAUGUUGAUAUUUAUCCUAGAACACUGAAAGAGAAUAUGCCAGUGAUAACUCACUUUACUUCAGUCAUUUCAACACAGAAAAUGCUUCUCUAGCAUUUUUCUUUUGUAGUGUUAACAUUUUGAAAUUCAUGUUUCAGAGGCUUCAUCAUCACAGAAUUUACUCUUGCUCCAUGAAAAAAAAUUAAAUACCUUCAGAGGAAUAUUUAAGUUGUAAACUAUGAAACUUGAGAAAUCCUCUUGAGAUAAAAGGCUGCCAAAUCCAGUAUUAUAAAGUCCAUGGUCAUAUGUGCCUGUGCAUUAAAGGAAUACCAGAUCUAUGCAGUAUACAUUUUUCAGGCUGAAAUUCAAGGGGAAUCAUUCUGAUUAUUCUUACUACAAAUGGAGAUGGCUAUUAUGAAACAGCAUGAGCAUGAGCCUUUUAUCUUUUAUACUUAGUGAUAUACUUUGCUUGAAAAUCACUCAGCAAAGUAGUUCACAUGAUGUGUAUCAUAUUUGAAGUGUGGUUUUUCUCAAAAUCAUUGACUUUAAGGAGCUCAUUUCUGAACAAAAAGGUUUGCUCUGUGGAAAAAUCAAUCACUGCCAGGAUUCUUUCAUUUCUGUACUAUUUUGUAUAAUUGAAUUUGUUCACUUCUCUCACACCAGCAAGUGUUUUACAGGUGCCUUGGAUUAAAACAAAAUUGAUUUUAAAAUUUUUAUGUAAGUCAUUGUGUCUAUGAUGCCACUUUUAAAAGGAAAAUGCAAUUGCGUAAUGGCUUAUAUCCUUAUUUAAUGUACCUAUUUGUGUUCUAAUAAUUGUUUGAAUGUUUUAUUCAGCUUAAAACUUUACCAUGAAGUCAUAAACAGUAAACAAUGUUUUGUUAUGUAUUAAGGGGAUAUCAGUGUUUCUCAAAGUAUGAUCCAUGGACCAUCUGGGUCAUGGCGCCUGGUUUCAGACAACCUGAAUCAAAUCUUAGGGGUGGGGCUUUGGGAUGUCAUUGUUCAAUAGGCACCUCAGGAGAUUCUGAGCACACCAAUGUUUGAGAACCACUAAAAUGAGGAGUGGGAAAAAAAAAAUAGGUGUUUUGUUAAUUUAGAGCUGAGCUGAGAAGAUAAUAUAUUUUUAUUGUCAAUGACAUUAACAGAUAUGCACUGAUUCUUUUAUACCUACAAUUUACUUAAUGUUCCUUUUAUUAAAACGCGUGGUUCAUGAGCAACUACAGACUGAAUCCAGAUUAUUACCUGUUGCUUUCAGUAUUUUCGUGAUGGCUUUUAAUCUUAUGAAAUCAUCUUGAGAUCAUUCAUGGUCAAGCCAUGAAAACUCCCAUCUUCAAGCCUGCCUGCUAAAGCUUCUUUGCCUUCCUGAUUGUGAUUAUGGUAACAAUUUAUAUCAGACAGUUGUACUUUUUGAUAACUUAGGGAAAACAGAAAUGACUUGAACAAGGGAUUGCCUGCCUCACUGCAUUGCAGAGAUACAAUUUUUGUAAAGAACACAAAUAGCAGUUGUGAAUAUUAAGGUGUGAUUAUCUUUCCCUGUCCAUGUGCUUAUUGAAAGAAGAUAGUGAACAAAUGAUUAUAUUGAGGAUUUUUUUAAUUUAUAAGAUCUAAUGUGAAAUCCACACUUGGAACUUUUUAGAUCUGUCUGUUGCUUGUUUAAUAUAUUUCUUUUAUGACAUUACUUAAAGUUUAAAAGGGUUUUCUAUCCACUGUCAAUUUCAAUUGGAUAACAUUUUGUCAAGUUUUUUUUUUCCUGAUUAUUUGAUGCUAGCUGGAAUUCAAGAAAUGGCAUUGACCUUAUUCAAAUAAAGAAAUAUUUUAGUAAA-3'- Poly-A tail - Coding region
DNA
DNA (Gene ID: 3998)
lectin, mannose binding 1
strand -
MR60, ERGIC-53, ERGIC53, gp58, MCFD1, FMFD1
NCBI CDS gene sequence (1533 bp)
5'-ATGGCGGGATCCAGGCAAAGGGGTCTCCGGGCCAGAGTTCGGCCGCTGTTCTGCGCCTTGCTGCTGTCACTCGGTCGCTTCGTCCGGGGCGACGGCGTGGGAGGAGACCCCGCGGTCGCGTTGCCACATCGCCGTTTCGAGTACAAATACAGCTTCAAGGGGCCGCACCTGGTGCAGAGCGACGGGACCGTGCCCTTCTGGGCCCACGCGGGGAATGCTATTCCAAGTTCAGATCAAATTCGAGTAGCACCATCTTTAAAAAGCCAAAGAGGCTCAGTGTGGACAAAGACAAAAGCGGCCTTTGAGAACTGGGAAGTTGAGGTGACATTTCGAGTGACTGGAAGAGGTCGAATTGGAGCTGATGGCCTAGCAATTTGGTATGCAGAAAATCAAGGCTTGGAGGGCCCTGTGTTTGGATCAGCTGATCTGTGGAATGGTGTTGGAATATTTTTTGATTCTTTTGACAATGATGGAAAGAAAAATAATCCTGCTATAGTAATTATAGGCAACAATGGACAAATCCATTATGACCATCAAAATGACGGGGCTAGTCAAGCTTTGGCAAGTTGCCAGAGGGACTTCCGCAACAAACCCTATCCTGTCCGAGCAAAGATTACCTATTACCAGAACACACTGACAGTAATGATCAATAATGGCTTTACACCAGATAAAAATGATTATGAATTTTGTGCCAAAGTGGAAAATATGATTATCCCTGCACAAGGGCATTTTGGAATATCTGCTGCAACTGGAGGTCTTGCAGATGACCATGATGTCCTTTCTTTTCTGACTTTCCAGTTGACTGAACCTGGAAAAGAGCCGCCCACACCAGATAAAGAAATTTCGGAAAAGGAAAAAGAAAAGTATCAGGAGGAATTTGAGCACTTTCAACAAGAATTGGATAAAAAAAAAGAGGAATTCCAGAAGGGCCACCCCGACCTCCAAGGGCAGCCTGCGGAGGAAATATTTGAGAGTGTAGGAGATCGAGAGCTAAGACAAGTCTTTGAAGGACAGAATCGTATTCATCTTGAAATCAAGCAGCTGAACCGGCAGTTAGATATGATTCTTGATGAACAGAGAAGATATGTCTCTTCCTTAACAGAGGAAATCTCTAAAAGAGGAGCAGGAATGCCTGGGCAGCATGGGCAGATTACTCAACAAGAACTGGATACTGTTGTGAAAACTCAGCATGAGATTCTGAGACAAGTAAATGAAATGAAAAATTCCATGAGTGAAACCGTCAGACTGGTCAGTGGAATGCAGCACCCTGGCTCTGCTGGAGGCGTCTATGAGACAACACAGCACTTCATTGACATCAAAGAGCACCTGCACATAGTAAAGAGGGACATAGATAACTTAGTGCAGCGAAATATGCCATCAAATGAAAAGCCGAAATGCCCAGAACTACCACCATTTCCATCATGTTTGTCTACGGTCCACTTCATTATATTTGTTGTGGTGCAAACTGTATTATTCATTGGTTATATCATGTATAGGTCTCAGCAAGAAGCAGCTGCCAAAAAATTCTTTTGA-3'
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