NCBI Summary
This gene encodes a member of the glycosyltransferase 2 protein family. Members of this family initiate mucin-type O-glycoslation of peptides in the Golgi apparatus. The encoded protein may be involved in O-linked glycosylation of the immunoglobulin A1 hinge region. This gene may influence triglyceride levels, and may be involved Type 2 diabetes, as well as several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014].
Protein
Protein (NP_004472)
CBM13-ppGalNAc-T2
Polypeptide N-acetylgalactosaminyltransferase 2 (EC 2.4.1.41) (Polypeptide GalNAc transferase 2) (GalNAc-T2) (pp-GaNTase 2) (Protein-UDP acetylgalactosaminyltransferase 2) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 2) [Cleaved into: Polypeptide N-acetylgalactosaminyltransferase 2 soluble form]
GALNT2
polypeptide N-acetylgalactosaminyltransferase 2
Undefined
Curated
Ricin-like
R-Type Lectins
b-trefoil
GalNAc / Mucin-type glycopeptide
NP_004472
2590
Q10471
ENSP00000355632.4
Q10471
0.217
10.1074/jbc.M111.273722
neXtProt, PFAM, InterPro
Protein sequence and protein families (fasta) (571 amino acids) Download
MRRRSRMLLCFAFLWVLGIAYYMYSGGGSALAGGAGGGAGRKEDWNEIDPIKKKDLHHSNGEEKAQSMETLPPGKVRWPDFNQEAYVGGTMVRSGQDPYARNKFNQVESDKLRMDRAIPDTRHDQCQRKQWRVDLPATSVVITFHNEARSALLRTVVSVLKKSPPHLIKEIILVDDYSNDPEDGALLGKIEKVRVLRNDRREGLMRSRVRGADAAQAKVLTFLDSHCECNEHWLEPLLERVAEDRTRVVSPIIDVINMDNFQYVGASADLKGGFDWNLVFKWDYMTPEQRRSRQGNPVAPIKTPMIAGGLFVMDKFYFEELGKYDMMMDVWGGENLEISFRVWQCGGSLEIIPCSRVGHVFRKQHPYTFPGGSGTVFARNTRRAAEVWMDEYKNFYYAAVPSARNVPYGNIQSRLELRKKLSCKPFKWYLENVYPELRVPDHQDIAFGALQQGTNCLDTLGHFADGVVGVYECHNAGGNQEWALTKEKSVKHMDLCLTVVDRAPGSLIKLQGCRENDSRQKWEQIEGNSKLRHVGSNLCLDSRTAKSGGLSVEVCGPALSQQWKFTLNLQQ
Mol* PDB structure viewerUniLectin3D
Structural models
AlphaFold v2: AF-Q10471-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Ligand
Glycan ligands from structural data
Glycopeptide with one GalNAc, glycopeptide
GalNAc
5AJN, 5AJO, 5AJP
5AJN, 5AJO, 5AJP
GlyConnect Structures
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for GALNT2 Gene
ProteomicsDB
References
NCBI References (10 PubMed Identifiers)
  • GALNT2/14 overexpression correlate with prognosis and methylation: potential therapeutic targets for lung adenocarcinoma. [33964375]
  • GALNT2 promotes cell proliferation, migration, and invasion by activating the Notch/Hes1-PTEN-PI3K/Akt signaling pathway in lung adenocarcinoma. [33785338]
  • TLR7 in B cells promotes renal inflammation and Gd-IgA1 synthesis in IgA nephropathy. [32699192]
  • Novel congenital disorder of O-linked glycosylation caused by GALNT2 loss of function. [32293671]
  • A reference map of the human binary protein interactome. [32296183]
  • Localization of three human polypeptide GalNAc-transferases in HeLa cells suggests initiation of O-linked glycosylation throughout the Golgi apparatus. [9394011]
  • Localization of O-glycosylation sites on glycopeptide fragments from lactation-associated MUC1. All putative sites within the tandem repeat are glycosylation targets in vivo. [9312074]
  • Substrate specificities of three members of the human UDP-N-acetyl-alpha-D-galactosamine:Polypeptide N-acetylgalactosaminyltransferase family, GalNAc-T1, -T2, and -T3. [9295285]
  • cDNA cloning and expression of a novel human UDP-N-acetyl-alpha-D-galactosamine. Polypeptide N-acetylgalactosaminyltransferase, GalNAc-t3. [8663203]
  • Purification and cDNA cloning of a human UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase. [7592619]
UniProt Main References (12 PubMed Identifiers)
  • Complete sequencing and characterization of 21,243 full-length human cDNAs. [14702039]
  • The DNA sequence and biological annotation of human chromosome 1. [16710414]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
  • Initiation of O-glycan synthesis in IgA1 hinge region is determined by a single enzyme, UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2. [12438318]
  • Initial characterization of the human central proteome. [21269460]
  • Toward a comprehensive characterization of a human cancer cell phosphoproteome. [23186163]
  • An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. [24275569]
  • N-terminome analysis of the human mitochondrial proteome. [25944712]
  • Dynamic association between the catalytic and lectin domains of human UDP-GalNAc:polypeptide alpha-N-acetylgalactosaminyltransferase-2. [16434399]
  • Substrate-guided front-face reaction revealed by combined structural snapshots and metadynamics for the polypeptide N-acetylgalactosaminyltransferase 2. [24954443]
    • Show more
All isoforms of this gene containing a lectin domain
NP_001278795.1, NP_004472.1
RNA
RNA (Transcript ID: NM_004481.5)
NM_004481.5
polypeptide N-acetylgalactosaminyltransferase 2, transcript variant 1
All isoforms of GALNT2 containing a lectin domain
ENST00000366672.5
44..1759 (or 230067281.. 230279458)
230067238.. 230282122
NCBI Matured mRNA sequence 4423 NTPDownload 
m7G-5')ppp(5'-ACUCGCGAGCAGCGGCGGCCCCGCCGGCGGCCGAGUUGGGAGAAUGCGGCGGCGCUCGCGGAUGCUGCUCUGCUUCGCCUUCCUGUGGGUGCUGGGCAUCGCCUACUACAUGUACUCGGGGGGCGGCUCUGCGCUGGCCGGGGGCGCGGGCGGCGGCGCCGGCAGGAAGGAGGACUGGAAUGAAAUUGACCCCAUUAAAAAGAAAGACCUUCAUCACAGCAAUGGAGAAGAGAAAGCACAAAGCAUGGAGACCCUCCCUCCAGGGAAAGUACGGUGGCCAGACUUUAACCAGGAAGCUUAUGUUGGAGGGACGAUGGUCCGCUCCGGGCAGGACCCUUACGCCCGCAACAAGUUCAACCAGGUGGAGAGUGAUAAGCUUCGAAUGGACAGAGCCAUCCCUGACACCCGGCAUGACCAGUGUCAGCGGAAGCAGUGGCGGGUGGAUCUGCCGGCCACCAGCGUGGUGAUCACGUUUCACAAUGAAGCCAGGUCGGCCCUACUCAGGACCGUGGUCAGCGUGCUUAAGAAAAGCCCGCCCCAUCUCAUAAAAGAAAUCAUCUUGGUGGAUGACUACAGCAAUGAUCCUGAGGACGGGGCUCUCUUGGGGAAAAUUGAGAAAGUGCGAGUUCUUAGAAAUGAUCGACGAGAAGGCCUCAUGCGCUCACGGGUUCGGGGGGCCGAUGCUGCCCAAGCCAAGGUCCUGACCUUCCUGGACAGUCACUGCGAGUGUAAUGAGCACUGGCUGGAGCCCCUCCUGGAAAGGGUGGCGGAGGACAGGACUCGGGUUGUGUCACCCAUCAUCGAUGUCAUUAAUAUGGACAACUUUCAGUAUGUGGGGGCAUCUGCUGACUUGAAGGGCGGUUUUGAUUGGAACUUGGUAUUCAAGUGGGAUUACAUGACGCCUGAGCAGAGAAGGUCCCGGCAGGGGAACCCAGUCGCCCCUAUAAAAACCCCCAUGAUUGCUGGUGGGCUGUUUGUGAUGGAUAAGUUCUAUUUUGAAGAACUGGGGAAGUACGACAUGAUGAUGGAUGUGUGGGGAGGAGAGAACCUAGAGAUCUCGUUCCGCGUGUGGCAGUGUGGUGGCAGCCUGGAGAUCAUCCCGUGCAGCCGUGUGGGACACGUGUUCCGGAAGCAGCACCCCUACACGUUCCCGGGUGGCAGUGGCACUGUCUUUGCCCGAAACACCCGCCGGGCAGCAGAGGUCUGGAUGGAUGAAUACAAAAAUUUCUAUUAUGCAGCAGUGCCUUCUGCUAGAAACGUUCCUUAUGGAAAUAUUCAGAGCAGAUUGGAGCUUAGGAAGAAACUCAGCUGCAAGCCUUUCAAAUGGUACCUUGAAAAUGUCUAUCCAGAGUUAAGGGUUCCAGACCAUCAGGAUAUAGCUUUUGGGGCCUUGCAGCAGGGAACUAACUGCCUCGACACUUUGGGACACUUUGCUGAUGGUGUGGUUGGAGUUUAUGAAUGUCACAAUGCUGGGGGAAACCAGGAAUGGGCCUUGACGAAGGAGAAGUCGGUGAAGCACAUGGAUUUGUGCCUUACUGUGGUGGACCGGGCACCGGGCUCUCUUAUAAAGCUGCAGGGCUGCCGAGAAAAUGACAGCAGACAGAAAUGGGAACAGAUCGAGGGCAACUCCAAGCUGAGGCACGUGGGCAGCAACCUGUGCCUGGACAGUCGCACGGCCAAGAGCGGGGGCCUAAGCGUGGAGGUGUGUGGCCCGGCCCUUUCGCAGCAGUGGAAGUUCACGCUCAACCUGCAGCAGUAGGAGGGUCCGGGAGGCCCUGCCGUCCUGUCUCCUGCACCAUUGGGUGGAGUCUGGUGAUCACAUUAUUGAUUAUGUUUCUUAAACUUUCCGCGAAACUAAUAUACCUCAGUAUUCCAUCAUGGUCUGAAAGUCAAACUUCGGCAAGGCACGGACGACUGUGCAGACACAGCAGCGGCAAGAAGCGAGAACUGCCCUCCCCCUCCUCUCGGUGCAGCCCAGCCGGGCCCCCUUCCCCAGGCCGGAGCGCCCCUCUUCCUUCCAGCUUUCACUUCUGCCGGCUCCGCAACUGAGUGACACCCAGCGACAACCGACUGGGGAGUGGUAGAAGCAACUGAACGGAUGCGUGCGAGCUGAGGACAGGGCGGGAGGAGGGGGCACACAUGCCCCAGGGGAGCGAGGAGAACUCUUGAAAUCUCCAUUUUCAAUCCCUUCGAAAUCACGUAUGGUUUCCACAAAGCCGAGUCGUGUCACGUGGCAGGUUUACGUCAAUAGUCCCUCUCUCUGCUCCUCCAUUCGCAAGUGUCUUCCUGGGCCAGACUCCCCUCCACCUCAUGUACUUGCUAUAUUGAGGAUGAAGUUUUCUAUGGUGGGACACUAAAUAUAAAGCUAUAUAGAGAAAGAAUGUACGGUCAGUUCCCUAUGGUUUCUGUAGAUCAUCGUCAUCUUGUAUAUUCCCCACAAAGCCGUUCGCAGCUUCCGGGAGAAGGGGCCAGAGCCCGGUGGGGCCAGUUUCUCACAGAGGGAGGAGGUGGCCUUUGUCCCCUGGAGCCCGAUCAGCCAGUUGGUGCUACUGCUGUGGCCAGCUGGGGGGCUUCCUCCAGACCACCGGCCUCGGCCCCGGCAUCCCUGUUGGGCGUCAGCCUGAGAGUCCCUACUGUGCGUCAGAAUCCACCUUGCGUGCUGUGCGUAUCUGUGAACCUGGAGCGGUUACUUAUUUUGACAGAUAUCACUUUGGGUCUUUUUACAUUAAAUUUCUUUUCUCUAAGGAAUAUAAGACAUACCCCAUAGCUCUGUGUGAGCCAGCAAUACCGCUGCCCCCUGGCGACAGGGCAGACCAAUGAUGCCAGGCAGCUGUCACACGCUAGUAUUGGCUUCAUUGUGAUCUGAGCCCUGCACGCUGGGCCUUCAGAAUUAAUGGCCAGCAGUGUCAGGGAUGAGCCCGUCAGCCAGGGCACAGGCCUGGCUCACAGUCCUGCACACCUGCUGGCCUGGGGAGCUCCAGCCAGGCAGCGAGUCCUGCCCCGCCCGCAGCUCCCUCCCACACCCCGCCUGGCCAAGAUGACUGCUUCAGGGGGCUUUGGGGAAAGAAUUAGGAAGGGUCAGAACCAAACAAUACCUGCUCAUUUACACUGAGGAUUCAGGGCGGGAGACAGGAGCCUUGGGGUCCUGUUAAACCACAGACAGUUAUGAACUGAAAGUCAUAACGGGGAGAGGUGCCUGGCUUCUACCUGGGUGCUCAGGAAUGUUCCUCGUCACCCCUGCCACUCUGUGGUCGGUGCCCUGCUUCCUCCUCCACUCCUGGCCGCCUUCUCCAGCGCCGCACACACAGAUGCUCAGUCUCAGAGAGGCUGGCACGGCCUGGCAGUCUGAGAAAAGCGUCAGUUAGGCACACCUGCAGGCCCCUCGGUGGGACAGCGGCGGCCUUGGAGUUAGGAGCCACCCUGGGAGGUUGUGCCGGUGCCAUGCUCCUCCCUGUGUCUUGUAUGAAAGGGGCCACUGUGUGUCUUCCUCCCCGGCGGGAGCCCCACAUGUGUGCACUGUAGGACAGCGGCCCCGAGGUGGAAGCCUGGCUGGAGGGCUGCCCUAUAGGUCUUCUCUUCCCGCCUCCCCUGCCAUGCAACCAGAUGUGUUGUGAGUGGGCAGCGUGCCCCCACGCUGGAGUAACUCCGCACGCUUCUGUCUUUCACGGUGGGCGCUCGGGGGGAGCCUGAGGAAAACCCCCUUAGGUACCUGUGCGAGGCUGUGGAGUGCAGGCCAGAGCAGGGUGUGCGUAGCCCCCAGCACCCAGGUUCUUCUGUCAGACCCUGUGACCUGCGAGCUGCUACUACUGUAAGGAGGGAAAUGGAUGAAUCUGGCUCGUUUUAAAAUCACGUUUUCUGACGAAUCCUUUGCCCCUUCACCUUUACCCCGCCCGCACCCCUAGGCCCUCUCAGCCUUCCUAUCAUCCCACGUGUCUACCCAGACCCUUGUGCGGCCCAUGCCCUGGGGGCGGCGUCCUGUCCCUGAGCUGGGAGGCGGCUUUGGAUGGUCCGGGCGUCAAGAGCAGGGGUGGGCCGGGGAGGGGUCCUUUGCGGUGAGCUAUGUUUACAUGACACAGUGUGCCAAAGUGACUUACUGCGGUUGCGUUAGUUUUUAAUCAUCAGGACUAUCUCACCCUCCCACUCCUGUUUUUAAAACUCAGAAUUCUUUCCUAAGAGCCCUUCGAGCAAAGCGUGCCGAAGUUAGUUGUCUUCUCUGUGCUGGUCCUUUCUUAUGUCCUCAUAAAAGCUCAGAUGAUGGUAUCUGUGAGUAUGUUUUGCAAAUUCAAAAUAUAGUUUGGUAAUUUUUUUUUCCAGUUGAUUUUUAAAAAGAACUGCUGUACAGAGCUUGUACUUUGUCCAUUUUAUAGAUGGAAACCAUCCUUGAAAAUUGUUUAACUUAAAUAAAGAGAAGAUACUUUCUAGA-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
;
More about the NCBI sViewer.
DNA
DNA (Gene ID: 2590)
GALNT2
polypeptide N-acetylgalactosaminyltransferase 2
NC_000001.11
1  230067281.. 230279458
230067281.. 230279458
strand +
CCDS1582.1
MGI:894694
ClinVar, dbVar
ENSG00000143641
GalNAc-T2
uc010pwa.2
INSDC: BC041120
4124
602274
OTTHUMG00000037771
ENA, DDBJ, Monarch
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (1716 bp)
5'-ATGCGGCGGCGCTCGCGGATGCTGCTCTGCTTCGCCTTCCTGTGGGTGCTGGGCATCGCCTACTACATGTACTCGGGGGGCGGCTCTGCGCTGGCCGGGGGCGCGGGCGGCGGCGCCGGCAGGAAGGAGGACTGGAATGAAATTGACCCCATTAAAAAGAAAGACCTTCATCACAGCAATGGAGAAGAGAAAGCACAAAGCATGGAGACCCTCCCTCCAGGGAAAGTACGGTGGCCAGACTTTAACCAGGAAGCTTATGTTGGAGGGACGATGGTCCGCTCCGGGCAGGACCCTTACGCCCGCAACAAGTTCAACCAGGTGGAGAGTGATAAGCTTCGAATGGACAGAGCCATCCCTGACACCCGGCATGACCAGTGTCAGCGGAAGCAGTGGCGGGTGGATCTGCCGGCCACCAGCGTGGTGATCACGTTTCACAATGAAGCCAGGTCGGCCCTACTCAGGACCGTGGTCAGCGTGCTTAAGAAAAGCCCGCCCCATCTCATAAAAGAAATCATCTTGGTGGATGACTACAGCAATGATCCTGAGGACGGGGCTCTCTTGGGGAAAATTGAGAAAGTGCGAGTTCTTAGAAATGATCGACGAGAAGGCCTCATGCGCTCACGGGTTCGGGGGGCCGATGCTGCCCAAGCCAAGGTCCTGACCTTCCTGGACAGTCACTGCGAGTGTAATGAGCACTGGCTGGAGCCCCTCCTGGAAAGGGTGGCGGAGGACAGGACTCGGGTTGTGTCACCCATCATCGATGTCATTAATATGGACAACTTTCAGTATGTGGGGGCATCTGCTGACTTGAAGGGCGGTTTTGATTGGAACTTGGTATTCAAGTGGGATTACATGACGCCTGAGCAGAGAAGGTCCCGGCAGGGGAACCCAGTCGCCCCTATAAAAACCCCCATGATTGCTGGTGGGCTGTTTGTGATGGATAAGTTCTATTTTGAAGAACTGGGGAAGTACGACATGATGATGGATGTGTGGGGAGGAGAGAACCTAGAGATCTCGTTCCGCGTGTGGCAGTGTGGTGGCAGCCTGGAGATCATCCCGTGCAGCCGTGTGGGACACGTGTTCCGGAAGCAGCACCCCTACACGTTCCCGGGTGGCAGTGGCACTGTCTTTGCCCGAAACACCCGCCGGGCAGCAGAGGTCTGGATGGATGAATACAAAAATTTCTATTATGCAGCAGTGCCTTCTGCTAGAAACGTTCCTTATGGAAATATTCAGAGCAGATTGGAGCTTAGGAAGAAACTCAGCTGCAAGCCTTTCAAATGGTACCTTGAAAATGTCTATCCAGAGTTAAGGGTTCCAGACCATCAGGATATAGCTTTTGGGGCCTTGCAGCAGGGAACTAACTGCCTCGACACTTTGGGACACTTTGCTGATGGTGTGGTTGGAGTTTATGAATGTCACAATGCTGGGGGAAACCAGGAATGGGCCTTGACGAAGGAGAAGTCGGTGAAGCACATGGATTTGTGCCTTACTGTGGTGGACCGGGCACCGGGCTCTCTTATAAAGCTGCAGGGCTGCCGAGAAAATGACAGCAGACAGAAATGGGAACAGATCGAGGGCAACTCCAAGCTGAGGCACGTGGGCAGCAACCTGTGCCTGGACAGTCGCACGGCCAAGAGCGGGGGCCTAAGCGTGGAGGTGTGTGGCCCGGCCCTTTCGCAGCAGTGGAAGTTCACGCTCAACCTGCAGCAGTAG-3'
NCBI CDS gene sequence with introns (location: 230067281.. 230279458) (212178 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 230067238.. 230282122) (214885 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [230067238 - 1000].. 230282122) (215885 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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