NCBI Summary
The protein encoded by this gene is a type II membrane receptor with an extracellular C-type lectin-like domain fold. The extracellular portion binds structures with a high mannose content and has been shown to recognize several pathogens, including C. elegans, S. cerevisiae, M. tuberculosis, C. neoformans, and house dust mite. When stimulated, the encoded protein initiates signalling through the CARD9-Bcl10-Malt1 pathway, leading to the induction of cytokines. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015].
Protein
Protein (NP_001007034)
Dectin-2
C-type lectin domain family 6 member A (C-type lectin superfamily member 10) (Dendritic cell-associated C-type lectin 2) (DC-associated C-type lectin 2) (Dectin-2)
CLEC6A
C-type lectin domain containing 6A
Undefined
Curated
C-type lectin
CLEC4N
C-type - Type II transmembrane receptors
a/b mixed / C-type lectin-like
Man / High mannose N-glycans
NP_001007034
93978
Q6EIG7
ENSP00000371505.3
Q6EIG7
0.423
10.1074/jbc.M117.799080
neXtProt, PFAM, InterPro, CFG data
Protein sequence and protein families (fasta) (209 amino acids) Download
MMQEQQPQSTEKRGWLSLRLWSVAGISIALLSACFIVSCVVTYHFTYGETGKRLSELHSYHSSLTCFSEGTKVPAWGCCPASWKSFGSSCYFISSEEKVWSKSEQNCVEMGAHLVVFNTEAEQNFIVQQLNESFSYFLGLSDPQGNNNWQWIDKTPYEKNVRFWHLGEPNHSAEQCASIVFWKPTGWGWNDVICETRRNSICEMNKIYL
Mol* PDB structure viewerUniLectin3D
Structural models
AlphaFold v2: AF-Q6EIG7-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Ligand
Glycan ligands from structural data
aMan12aMan13(aMan12aMan16)bMan
Man(a1-2)Man(a1-3)[Man(a1-2)Man(a1-6)]Man
5VYB
5VYB
GlyConnect Structures
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for CLEC6A Gene
References
NCBI References (10 PubMed Identifiers)
  • Deletion of haematopoietic Dectin-2 or CARD9 does not protect from atherosclerosis development under hyperglycaemic conditions. [31868000]
  • Human thioredoxin, a damage-associated molecular pattern and Malassezia-crossreactive autoallergen, modulates immune responses via the C-type lectin receptors Dectin-1 and Dectin-2. [31371767]
  • Deciphering the molecular basis of mycobacteria and lipoglycan recognition by the C-type lectin Dectin-2. [30443026]
  • Dectin-1/2-induced autocrine PGE2 signaling licenses dendritic cells to prime Th2 responses. [29668708]
  • The Syk-Coupled C-Type Lectin Receptors Dectin-2 and Dectin-3 Are Involved in Paracoccidioides brasiliensis Recognition by Human Plasmacytoid Dendritic Cells. [29616019]
  • The carbohydrate-recognition domain of Dectin-2 is a C-type lectin with specificity for high mannose. [16423983]
  • Identification and expression profiling of a human C-type lectin, structurally homologous to mouse dectin-2. [15810886]
  • Identification of lectin-like receptors expressed by antigen presenting cells and neutrophils and their mapping to a novel gene complex. [15368084]
  • Molecular cloning of human dectin-2. [15175046]
  • Signaling and immune regulatory role of the dendritic cell immunoreceptor (DCIR) family lectins: DCIR, DCAR, dectin-2 and BDCA-2. [15481152]
UniProt Main References (4 PubMed Identifiers)
  • The finished DNA sequence of human chromosome 12. [16541075]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
  • C-type lectin receptors Dectin-3 and Dectin-2 form a heterodimeric pattern-recognition receptor for host defense against fungal infection. [23911656]
  • Mechanism of pathogen recognition by human dectin-2. [28652405]
All isoforms of this gene containing a lectin domain
NP_001304928.1, NP_001007034.1
RNA
RNA (Transcript ID: NM_001007033.2)
NM_001007033.2
C-type lectin domain containing 6A, transcript variant 1
All isoforms of CLEC6A containing a lectin domain
ENST00000382073.4
151..780 (or 8456112.. 8477464)
8455962.. 8478330
NCBI Matured mRNA sequence 1646 NTPDownload 
m7G-5')ppp(5'-AAUGUUGGAAGUCUCUUAGUCCUAUAAGAGUGUGUAGCAGUUUGUCCCUGAGCUCUAGCUUCUUUAAAUGAAGCUGAGUCUCUGGGCAACAUCUUUAGGGAGAGAGGUACAAAAGGUUCCUGGACCUUCUCAACACAGGGAGCCUGCAUAAUGAUGCAAGAGCAGCAACCUCAAAGUACAGAGAAAAGAGGCUGGUUGUCCCUGAGACUCUGGUCUGUGGCUGGGAUUUCCAUUGCACUCCUCAGUGCUUGCUUCAUUGUGAGCUGUGUAGUAACUUACCAUUUUACAUAUGGUGAAACUGGCAAAAGGCUGUCUGAACUACACUCAUAUCAUUCAAGUCUCACCUGCUUCAGUGAAGGGACAAAGGUGCCAGCCUGGGGAUGUUGCCCAGCUUCUUGGAAGUCAUUUGGUUCCAGUUGCUACUUCAUUUCCAGUGAAGAGAAGGUUUGGUCUAAGAGUGAGCAGAACUGUGUUGAGAUGGGAGCACAUUUGGUUGUGUUCAACACAGAAGCAGAGCAGAAUUUCAUUGUCCAGCAGCUGAAUGAGUCAUUUUCUUAUUUUCUGGGGCUUUCAGACCCACAAGGUAAUAAUAAUUGGCAAUGGAUUGAUAAGACACCUUAUGAGAAAAAUGUCAGAUUUUGGCACCUAGGUGAGCCCAAUCAUUCUGCAGAGCAAUGUGCUUCAAUAGUCUUCUGGAAACCUACAGGAUGGGGCUGGAAUGAUGUUAUCUGUGAAACUAGAAGGAAUUCAAUAUGUGAGAUGAAUAAGAUUUACCUAUGAGUAGAAGCUUAAUUGGAAAGAAGAGAAGAAUUACUGACGUAAUUUUUUCCCUGACGUCUUUAAAAUUGAACCCUAUCAUGAAAUGAUAAUUUCUUCCUGAAUUUACACAUAAUCCUUAUGUUAUAGAGGUUCACAGAAAUGGAAAGAUACCUGUUUCCCUUUAAUCAAUCUUCUCGUUUCCUCUUUUCCAUUAAUGAUAGAAUGCACCCUUCCUCUCUUUGUUCCAUUCUUUCACUUGUUAUUCAUUUUUUUCUUUCUUCACACUUCAUUACACAAAUAUUUAUUGUUUCAGAGACUGUACUAUUUUGUUUGUUAGAAGAUUUAUAAGGCAGUAUCUUUUGAAAAUUAUGACUUUCCUUCCUCAAUAUACCAUAAAGAAAUCUUUUUGGUCAAGAUGGUAGUUGGAACUACAAUCAUCUGAAGGCCUGACAAGAGUUGAAAGACAUGUUUUCUAGAUGGCUCACUCACAUGGCUGGCAACUUGGUGUUGGCUAUUAAUGUAACCUGGAAAUAAAUUUUAUUCUGCAGUUAGGGAUUUGGCAUUUUAUAUAUGUUGAUUCAAUCAAGUUUGGCAAGCAGGGUGUUCGAUACUGCUAUAUCCUGUAUUCUUGGUUUAUUUGUUUUAUUUCUGAGAAAUAUGUGUUAAGAUCUCUCGCUGAUUGGGAAUUUGUCUAUUUCUCAUUUAAAUUUUGUCAAAUCUUUCUUUGCUUGCAAGCAUUUCUUGUUACCCAAAUCUAAUCUAUUCCUGAAAAUAUGAUGGUUAGCAAAGUUUGAGAUAACUAGAGCCUGUAAUCCAUCAUUUUAAAUGGCAAUGAUAAUGACAGUUUAUUUUUAUGUUAUAUAAAAACCUCAACAAAUUUUCCAAAC-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
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More about the NCBI sViewer.
DNA
DNA (Gene ID: 93978)
CLEC6A
C-type lectin domain containing 6A
NC_000012.12
12  8456112.. 8477464
8456112.. 8477464
strand +
CCDS31739.1
MGI:1861231
ClinVar, dbVar
ENSG00000205846
dectin-2, hDECTIN-2
uc001qum.2
INSDC: AY321309
14556
613579
OTTHUMG00000168672
ENA, DDBJ, Monarch
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (630 bp)
5'-ATGATGCAAGAGCAGCAACCTCAAAGTACAGAGAAAAGAGGCTGGTTGTCCCTGAGACTCTGGTCTGTGGCTGGGATTTCCATTGCACTCCTCAGTGCTTGCTTCATTGTGAGCTGTGTAGTAACTTACCATTTTACATATGGTGAAACTGGCAAAAGGCTGTCTGAACTACACTCATATCATTCAAGTCTCACCTGCTTCAGTGAAGGGACAAAGGTGCCAGCCTGGGGATGTTGCCCAGCTTCTTGGAAGTCATTTGGTTCCAGTTGCTACTTCATTTCCAGTGAAGAGAAGGTTTGGTCTAAGAGTGAGCAGAACTGTGTTGAGATGGGAGCACATTTGGTTGTGTTCAACACAGAAGCAGAGCAGAATTTCATTGTCCAGCAGCTGAATGAGTCATTTTCTTATTTTCTGGGGCTTTCAGACCCACAAGGTAATAATAATTGGCAATGGATTGATAAGACACCTTATGAGAAAAATGTCAGATTTTGGCACCTAGGTGAGCCCAATCATTCTGCAGAGCAATGTGCTTCAATAGTCTTCTGGAAACCTACAGGATGGGGCTGGAATGATGTTATCTGTGAAACTAGAAGGAATTCAATATGTGAGATGAATAAGATTTACCTATGA-3'
NCBI CDS gene sequence with introns (location: 8456112.. 8477464) (21353 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 8455962.. 8478330) (22369 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [8455962 - 1000].. 8478330) (23369 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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