NCBI Summary
Calreticulin is a highly conserved chaperone protein which resides primarily in the endoplasmic reticulum, and is involved in a variety of cellular processes, among them, cell adhesion. Additionally, it functions in protein folding quality control and calcium homeostasis. Calreticulin is also found in the nucleus, suggesting that it may have a role in transcription regulation. Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin. Recurrent mutations in calreticulin have been linked to various neoplasms, including the myeloproliferative type.[provided by RefSeq, May 2020].
Protein
Protein (NP_004334)
Calreticulin
Calreticulin (CRP55) (Calregulin) (Endoplasmic reticulum resident protein 60) (ERp60) (HACBP) (grp60)
CALR
calreticulin
Undefined
Curated
calnexin-calreticulin like
L-Type Lectins
b-sandwich / ConA-like
MLLSVPLLLGLLGLAVAEPAVYFKEQFLDGDGWTSRWIESKHKSDFGKFVLSSGKFYGDEEKDKGLQTSQDARFYALSASFEPFSNKGQTLVVQFTVKHEQNIDCGGGYVKLFPNSLDQTDMHGDSEYNIMFGPDICGPGTKKVHVIFNYKGKNVLINKDIRCKDDEFTHLYTLIVRPDNTYEVKIDNSQVESGSLEDDWDFLPPKKIKDPDASKPEDWDERAKIDDPTDSKPEDWDKPEHIPDPDAKKPEDWDEEMDGEWEPPVIQNPEYKGEWKPRQIDNPDYKGTWIHPEIDNPEYSPDPSIYAYDNFGVLGLDLWQVKSGTIFDNFLITNDEAYAEEFGNETWGVTKAAEKQMKDKQDEEQRLKEEEEDKKRKEEEEAEDKEDDEDKDEDEEDEEDKEEDEEEDVPGQAKDEL
Mol* PDB structure viewerUniLectin3D
Ligand
Glycan ligands from structural data
![](../templates/png/Glc(a1-3)Man(a1-2)Man(a1-2)Man.png)
References
NCBI References (10 PubMed Identifiers)
- MPL overexpression induces a high level of mutant-CALR/MPL complex: a novel mechanism of ruxolitinib resistance in myeloproliferative neoplasms with CALR mutations. [34165774]
- Possible Roles of Calreticulin in Uterine Decidualization and Receptivity in Rats and Humans. [34638846]
- A Comparison of Two Molecular Methods for Detecting CALR Mutations in Myeloproliferative Neoplasms. [34542973]
- Clinical and Laboratory Features of JAK2 V617F, CALR, and MPL Mutations in Malaysian Patients with Classical Myeloproliferative Neoplasm (MPN). [34300032]
- Extracellularly Released Calreticulin Induced by Endoplasmic Reticulum Stress Impairs Syncytialization of Cytotrophoblast Model BeWo Cells. [34073978]
- Human liver protein map: a reference database established by microsequencing and gel comparison. [1286669]
- Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes. [1286667]
- The 5'-flanking region of the human calreticulin gene shares homology with the human GRP78, GRP94, and protein disulfide isomerase promoters. [1733953]
- Characterization of the autoantigen calreticulin. [1919005]
- In vitro interaction of a polypeptide homologous to human Ro/SS-A antigen (calreticulin) with a highly conserved amino acid sequence in the cytoplasmic domain of integrin alpha subunits. [1911778]
UniProt Main References (31 PubMed Identifiers)
- Molecular cloning, expression, and chromosome 19 localization of a human Ro/SS-A autoantigen. [2332496]
- Human protein factory for converting the transcriptome into an in vitro-expressed proteome,. [19054851]
- The DNA sequence and biology of human chromosome 19. [15057824]
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
- Human placental calreticulin: purification, characterization and association with other proteins. [7841019]
- Molecular characterization of human Ro/SS-A antigen. Amino terminal sequence of the protein moiety of human Ro/SS-A antigen and immunological activity of a corresponding synthetic peptide. [3260607]
- Sequence similarity of calreticulin with a Ca2(+)-binding protein that co-purifies with an Ins(1,4,5)P3-sensitive Ca2+ store in HL-60 cells. [2400400]
- The calcium-binding protein calreticulin is a major constituent of lytic granules in cytolytic T lymphocytes. [8418194]
- A two-dimensional gel database of human colon carcinoma proteins. [9150948]
- Calreticulin functions as a molecular chaperone in the biosynthesis of myeloperoxidase. [7876246] Show more
RNA
RNA (Transcript ID: NM_004343.4)
m7G-5')ppp(5'-GUCCGUACUGCAGAGCCGCUGCCGGAGGGUCGUUUUAAAGGGCCCGCGCGUUGCCGCCCCCUCGGCCCGCCAUGCUGCUAUCCGUGCCGCUGCUGCUCGGCCUCCUCGGCCUGGCCGUCGCCGAGCCUGCCGUCUACUUCAAGGAGCAGUUUCUGGACGGAGACGGGUGGACUUCCCGCUGGAUCGAAUCCAAACACAAGUCAGAUUUUGGCAAAUUCGUUCUCAGUUCCGGCAAGUUCUACGGUGACGAGGAGAAAGAUAAAGGUUUGCAGACAAGCCAGGAUGCACGCUUUUAUGCUCUGUCGGCCAGUUUCGAGCCUUUCAGCAACAAAGGCCAGACGCUGGUGGUGCAGUUCACGGUGAAACAUGAGCAGAACAUCGACUGUGGGGGCGGCUAUGUGAAGCUGUUUCCUAAUAGUUUGGACCAGACAGACAUGCACGGAGACUCAGAAUACAACAUCAUGUUUGGUCCCGACAUCUGUGGCCCUGGCACCAAGAAGGUUCAUGUCAUCUUCAACUACAAGGGCAAGAACGUGCUGAUCAACAAGGACAUCCGUUGCAAGGAUGAUGAGUUUACACACCUGUACACACUGAUUGUGCGGCCAGACAACACCUAUGAGGUGAAGAUUGACAACAGCCAGGUGGAGUCCGGCUCCUUGGAAGACGAUUGGGACUUCCUGCCACCCAAGAAGAUAAAGGAUCCUGAUGCUUCAAAACCGGAAGACUGGGAUGAGCGGGCCAAGAUCGAUGAUCCCACAGACUCCAAGCCUGAGGACUGGGACAAGCCCGAGCAUAUCCCUGACCCUGAUGCUAAGAAGCCCGAGGACUGGGAUGAAGAGAUGGACGGAGAGUGGGAACCCCCAGUGAUUCAGAACCCUGAGUACAAGGGUGAGUGGAAGCCCCGGCAGAUCGACAACCCAGAUUACAAGGGCACUUGGAUCCACCCAGAAAUUGACAACCCCGAGUAUUCUCCCGAUCCCAGUAUCUAUGCCUAUGAUAACUUUGGCGUGCUGGGCCUGGACCUCUGGCAGGUCAAGUCUGGCACCAUCUUUGACAACUUCCUCAUCACCAACGAUGAGGCAUACGCUGAGGAGUUUGGCAACGAGACGUGGGGCGUAACAAAGGCAGCAGAGAAACAAAUGAAGGACAAACAGGACGAGGAGCAGAGGCUUAAGGAGGAGGAAGAAGACAAGAAACGCAAAGAGGAGGAGGAGGCAGAGGACAAGGAGGAUGAUGAGGACAAAGAUGAGGAUGAGGAGGAUGAGGAGGACAAGGAGGAAGAUGAGGAGGAAGAUGUCCCCGGCCAGGCCAAGGACGAGCUGUAGAGAGGCCUGCCUCCAGGGCUGGACUGAGGCCUGAGCGCUCCUGCCGCAGAGCUGGCCGCGCCAAAUAAUGUCUCUGUGAGACUCGAGAACUUUCAUUUUUUUCCAGGCUGGUUCGGAUUUGGGGUGGAUUUUGGUUUUGUUCCCCUCCUCCACUCUCCCCCACCCCCUCCCCGCCCUUUUUUUUUUUUUUUUUUAAACUGGUAUUUUAUCUUUGAUUCUCCUUCAGCCCUCACCCCUGGUUCUCAUCUUUCUUGAUCAACAUCUUUUCUUGCCUCUGUCCCCUUCUCUCAUCUCUUAGCUCCCCUCCAACCUGGGGGGCAGUGGUGUGGAGAAGCCACAGGCCUGAGAUUUCAUCUGCUCUCCUUCCUGGAGCCCAGAGGAGGGCAGCAGAAGGGGGUGGUGUCUCCAACCCCCCAGCACUGAGGAAGAACGGGGCUCUUCUCAUUUCACCCCUCCCUUUCUCCCCUGCCCCCAGGACUGGGCCACUUCUGGGUGGGGCAGUGGGUCCCAGAUUGGCUCACACUGAGAAUGUAAGAACUACAAACAAAAUUUCUAUUAAAUUAAAUUUUGUGUCUC-3'- Poly-A tail
- Coding region
DNA
DNA (Gene ID: 811)
calreticulin
strand +
RO, SSA, cC1qR, CRT, FLJ26680
NCBI CDS gene sequence (1254 bp)
5'-ATGCTGCTATCCGTGCCGCTGCTGCTCGGCCTCCTCGGCCTGGCCGTCGCCGAGCCTGCCGTCTACTTCAAGGAGCAGTTTCTGGACGGAGACGGGTGGACTTCCCGCTGGATCGAATCCAAACACAAGTCAGATTTTGGCAAATTCGTTCTCAGTTCCGGCAAGTTCTACGGTGACGAGGAGAAAGATAAAGGTTTGCAGACAAGCCAGGATGCACGCTTTTATGCTCTGTCGGCCAGTTTCGAGCCTTTCAGCAACAAAGGCCAGACGCTGGTGGTGCAGTTCACGGTGAAACATGAGCAGAACATCGACTGTGGGGGCGGCTATGTGAAGCTGTTTCCTAATAGTTTGGACCAGACAGACATGCACGGAGACTCAGAATACAACATCATGTTTGGTCCCGACATCTGTGGCCCTGGCACCAAGAAGGTTCATGTCATCTTCAACTACAAGGGCAAGAACGTGCTGATCAACAAGGACATCCGTTGCAAGGATGATGAGTTTACACACCTGTACACACTGATTGTGCGGCCAGACAACACCTATGAGGTGAAGATTGACAACAGCCAGGTGGAGTCCGGCTCCTTGGAAGACGATTGGGACTTCCTGCCACCCAAGAAGATAAAGGATCCTGATGCTTCAAAACCGGAAGACTGGGATGAGCGGGCCAAGATCGATGATCCCACAGACTCCAAGCCTGAGGACTGGGACAAGCCCGAGCATATCCCTGACCCTGATGCTAAGAAGCCCGAGGACTGGGATGAAGAGATGGACGGAGAGTGGGAACCCCCAGTGATTCAGAACCCTGAGTACAAGGGTGAGTGGAAGCCCCGGCAGATCGACAACCCAGATTACAAGGGCACTTGGATCCACCCAGAAATTGACAACCCCGAGTATTCTCCCGATCCCAGTATCTATGCCTATGATAACTTTGGCGTGCTGGGCCTGGACCTCTGGCAGGTCAAGTCTGGCACCATCTTTGACAACTTCCTCATCACCAACGATGAGGCATACGCTGAGGAGTTTGGCAACGAGACGTGGGGCGTAACAAAGGCAGCAGAGAAACAAATGAAGGACAAACAGGACGAGGAGCAGAGGCTTAAGGAGGAGGAAGAAGACAAGAAACGCAAAGAGGAGGAGGAGGCAGAGGACAAGGAGGATGATGAGGACAAAGATGAGGATGAGGAGGATGAGGAGGACAAGGAGGAAGATGAGGAGGAAGATGTCCCCGGCCAGGCCAAGGACGAGCTGTAG-3'
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