NCBI Summary
The product of this gene belongs to the ficolin family of proteins. This family is characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. This gene is predominantly expressed in the liver, and has been shown to have carbohydrate binding and opsonic activities. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
Protein
Protein (NP_004099)
L-ficolin
Ficolin-2 (37 kDa elastin-binding protein) (Collagen/fibrinogen domain-containing protein 2) (EBP-37) (Ficolin-B) (Ficolin-beta) (Hucolin) (L-ficolin) (Serum lectin p35)
FCN2
ficolin 2
Undefined
Curated
Ficolin-like
Ficolins
a/b mixed with b-sheet / Fibrinogen C-ter like
MELDRAVGVLGAATLLLSFLGMAWALQAADTCPEVKMVGLEGSDKLTILRGCPGLPGAPGPKGEAGTNGKRGERGPPGPPGKAGPPGPNGAPGEPQPCLTGPRTCKDLLDRGHFLSGWHTIYLPDCRPLTVLCDMDTDGGGWTVFQRRVDGSVDFYRDWATYKQGFGSRLGEFWLGNDNIHALTAQGTSELRVDLVDFEDNYQFAKYRSFKVADEAEKYNLVLGAFVEGSAGDSLTFHNNQSFSTKDQDNDLNTGNCAVMFQGAWWYKNCHVSNLNGRYLRGTHGSFANGINWKSGKGYNYSYKVSEMKVRPA
Mol* PDB structure viewerUniLectin3D
Ligand
Glycan ligands from structural data
Glc(b1-3)Glc(b1-3)Glc.png)
References
NCBI References (10 PubMed Identifiers)
- Novel FCN2 Variants and Haplotypes are Associated with Rheumatic Heart Disease. [34529517]
- Associations of ficolins and mannose-binding lectin with acute myeloid leukaemia in adults. [32601370]
- Association of FCN2 polymorphisms and Ficolin-2 levels with dengue fever in Vietnamese patients. [32088336]
- Circulating Ficolin-2 and Ficolin-3 Form Heterocomplexes. [32094208]
- Insufficient serum L-ficolin is associated with disease presence and extent of pulmonary Mycobacterium avium complex disease. [31638993]
- Ficolins and the fibrinogen-like domain. [9777405]
- Purification and binding properties of a human ficolin-like protein. [9202708]
- Cloning and characterization of the human lectin P35 gene and its related gene. [8884275]
- A novel human serum lectin with collagen- and fibrinogen-like domains that functions as an opsonin. [8576206]
- Hucolin, a new corticosteroid-binding protein from human plasma with structural similarities to ficolins, transforming growth factor-beta 1-binding proteins. [7498469]
UniProt Main References (8 PubMed Identifiers)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. [14702039]
- DNA sequence and analysis of human chromosome 9. [15164053]
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
- EBP-37, a new elastin-binding protein in human plasma: structural similarity to ficolins, transforming growth factor-beta 1-binding proteins. [8586615]
- Cutting edge: complement-activating complex of ficolin and mannose-binding lectin-associated serine protease. [10679061]
- Deciphering complement receptor type 1 interactions with recognition proteins of the lectin complement pathway. [23460739]
- Structural insights into the innate immune recognition specificities of L- and H-ficolins. [17215869]
- The consensus coding sequences of human breast and colorectal cancers. [16959974]
All isoforms of this gene containing a lectin domain
RNA
RNA (Transcript ID: NM_004108.3)
m7G-5')ppp(5'-AGACCAGAAGAGAUGGAGCUGGACAGAGCUGUGGGGGUCCUGGGCGCUGCCACCCUGCUGCUCUCUUUCCUGGGCAUGGCCUGGGCUCUCCAGGCGGCAGACACCUGUCCAGAGGUGAAGAUGGUGGGCCUGGAGGGCUCUGACAAGCUCACCAUUCUCCGAGGCUGUCCGGGGCUGCCUGGGGCCCCUGGGCCCAAGGGAGAGGCAGGCACCAAUGGAAAGAGAGGAGAACGUGGCCCCCCUGGACCUCCUGGGAAGGCAGGACCACCUGGGCCCAACGGAGCACCUGGGGAGCCCCAGCCGUGCCUGACAGGCCCGCGUACCUGCAAGGACCUGCUAGACCGAGGGCACUUCCUGAGCGGCUGGCACACCAUCUACCUGCCCGACUGCCGGCCCCUGACUGUGCUCUGUGACAUGGACACGGACGGAGGGGGCUGGACCGUUUUCCAGCGGAGGGUGGAUGGCUCUGUGGACUUCUACCGGGACUGGGCCACGUACAAGCAGGGCUUCGGCAGUCGGCUGGGGGAGUUCUGGCUGGGGAAUGACAACAUCCACGCCCUGACCGCCCAGGGAACCAGCGAGCUCCGUGUAGACCUGGUGGACUUUGAGGACAACUACCAGUUUGCUAAGUACAGAUCAUUCAAGGUGGCCGACGAGGCGGAGAAGUACAAUCUGGUCCUGGGGGCCUUCGUGGAGGGCAGUGCGGGAGAUUCCCUGACGUUCCACAACAACCAGUCCUUCUCCACCAAAGACCAGGACAAUGAUCUUAACACCGGAAAUUGUGCUGUGAUGUUUCAGGGAGCUUGGUGGUACAAAAACUGCCAUGUGUCAAACCUGAAUGGUCGCUACCUCAGGGGGACUCAUGGCAGCUUUGCAAAUGGCAUCAACUGGAAGUCGGGGAAAGGAUACAAUUAUAGCUACAAGGUGUCAGAGAUGAAGGUGCGACCUGCCUAGCCCAGGCCGGCCUCAGGGUCAGGACGCCUCCACACAUAGUUGGUUGGGGGGUAGGGUUGGGAGCUUGGCCCUACGGUUUGUAAAAGAAACACAUGUCGUGAUUCUAAA-3'- Poly-A tail - Coding region
DNA
DNA (Gene ID: 2220)
ficolin 2
strand +
P35, FCNL, EBP-37, ficolin-2
NCBI CDS gene sequence (942 bp)
5'-ATGGAGCTGGACAGAGCTGTGGGGGTCCTGGGCGCTGCCACCCTGCTGCTCTCTTTCCTGGGCATGGCCTGGGCTCTCCAGGCGGCAGACACCTGTCCAGAGGTGAAGATGGTGGGCCTGGAGGGCTCTGACAAGCTCACCATTCTCCGAGGCTGTCCGGGGCTGCCTGGGGCCCCTGGGCCCAAGGGAGAGGCAGGCACCAATGGAAAGAGAGGAGAACGTGGCCCCCCTGGACCTCCTGGGAAGGCAGGACCACCTGGGCCCAACGGAGCACCTGGGGAGCCCCAGCCGTGCCTGACAGGCCCGCGTACCTGCAAGGACCTGCTAGACCGAGGGCACTTCCTGAGCGGCTGGCACACCATCTACCTGCCCGACTGCCGGCCCCTGACTGTGCTCTGTGACATGGACACGGACGGAGGGGGCTGGACCGTTTTCCAGCGGAGGGTGGATGGCTCTGTGGACTTCTACCGGGACTGGGCCACGTACAAGCAGGGCTTCGGCAGTCGGCTGGGGGAGTTCTGGCTGGGGAATGACAACATCCACGCCCTGACCGCCCAGGGAACCAGCGAGCTCCGTGTAGACCTGGTGGACTTTGAGGACAACTACCAGTTTGCTAAGTACAGATCATTCAAGGTGGCCGACGAGGCGGAGAAGTACAATCTGGTCCTGGGGGCCTTCGTGGAGGGCAGTGCGGGAGATTCCCTGACGTTCCACAACAACCAGTCCTTCTCCACCAAAGACCAGGACAATGATCTTAACACCGGAAATTGTGCTGTGATGTTTCAGGGAGCTTGGTGGTACAAAAACTGCCATGTGTCAAACCTGAATGGTCGCTACCTCAGGGGGACTCATGGCAGCTTTGCAAATGGCATCAACTGGAAGTCGGGGAAAGGATACAATTATAGCTACAAGGTGTCAGAGATGAAGGTGCGACCTGCCTAG-3'
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