NCBI Summary
This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion. [provided by RefSeq, Feb 2012].
Protein
Protein (NP_003821)
SIGLEC-5
Sialic acid-binding Ig-like lectin 5 (Siglec-5) (CD33 antigen-like 2) (Obesity-binding protein 2) (OB-BP2) (OB-binding protein 2) (CD antigen CD170)
SIGLEC5
sialic acid binding Ig like lectin 5
CD170
Curated
I-type lectin
I-Type Lectins - CD33-related Siglecs
b-sandwich / Ig-like
NeuAc / Neu5Ac(a2-6)GalNAc
NP_003821
8778
O15389
ENSP00000507738.1
O15389
0.55
10.1146/annurev-immunol-102419-035900
neXtProt, PFAM, InterPro, CFG data
Protein sequence and protein families (fasta) (551 amino acids) Download
MLPLLLLPLLWGGSLQEKPVYELQVQKSVTVQEGLCVLVPCSFSYPWRSWYSSPPLYVYWFRDGEIPYYAEVVATNNPDRRVKPETQGRFRLLGDVQKKNCSLSIGDARMEDTGSYFFRVERGRDVKYSYQQNKLNLEVTALIEKPDIHFLEPLESGRPTRLSCSLPGSCEAGPPLTFSWTGNALSPLDPETTRSSELTLTPRPEDHGTNLTCQMKRQGAQVTTERTVQLNVSYAPQTITIFRNGIALEILQNTSYLPVLEGQALRLLCDAPSNPPAHLSWFQGSPALNATPISNTGILELRRVRSAEEGGFTCRAQHPLGFLQIFLNLSVYSLPQLLGPSCSWEAEGLHCRCSFRARPAPSLCWRLEEKPLEGNSSQGSFKVNSSSAGPWANSSLILHGGLSSDLKVSCKAWNIYGSQSGSVLLLQGRSNLGTGVVPAALGGAGVMALLCICLCLIFFLIVKARRKQAAGRPEKMDDEDPIMGTITSGSRKKPWPDSPGDQASPPGDAPPLEEQKELHYASLSFSEMKSREPKDQEAPSTTEYSEIKTSK
Mol* PDB structure viewerUniLectin3D
Structural models
AlphaFold v2: AF-O15389-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

AlphaFold_v2 structural model assessment through SWISS-MODEL tools.

Ligand
Glycan ligands from structural data
aNeuAc26bGal14Glc
NeuAc(a2-6)Gal(b1-4)Glc
2ZG1
2ZG1
GlyConnect Structures
aNeuAc3bGal14Glc
NeuAc(a2-3)Gal(b1-4)Glc
2ZG3
2ZG3
GlyConnect Structures
GeneCards
mRNA expression in normal human tissues for SIGLEC5 Gene
ProteomicsDB
References
NCBI References (10 PubMed Identifiers)
  • A reference map of the human binary protein interactome. [32296183]
  • Soluble siglec-5 is a novel salivary biomarker for primary Sjogren's syndrome. [30922727]
  • Genetic susceptibility of common polymorphisms in NIN and SIGLEC5 to chronic periodontitis. [30765789]
  • Siglec-5 is a novel marker of critical limb ischemia in patients with diabetes. [28900239]
  • Group B Streptococcus suppression of phagocyte functions by protein-mediated engagement of human Siglec-5. [19596804]
  • Characterization of Siglec-5 (CD170) expression and functional activity of anti-Siglec-5 antibodies on human phagocytes. [12763136]
  • Genomic organization of the siglec gene locus on chromosome 19q13.4 and cloning of two new siglec pseudogenes. [11943481]
  • OB-BP1/Siglec-6. a leptin- and sialic acid-binding protein of the immunoglobulin superfamily. [10428856]
  • Assignment of the human OB binding protein-2 gene (CD33L2) to chromosome 19q13.3 by radiation hybrid mapping. [10343116]
  • Characterization of siglec-5, a novel glycoprotein expressed on myeloid cells related to CD33. [9731071]
UniProt Main References (3 PubMed Identifiers)
  • The DNA sequence and biology of human chromosome 19. [15057824]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
  • Structural implications of Siglec-5-mediated sialoglycan recognition. [18022638]
All isoforms of this gene containing a lectin domain
NP_001371638.1, NP_001371637.1, NP_003821.1, XP_016882908.1
RNA
RNA (Transcript ID: NM_003830.4)
NM_003830.4
sialic acid binding Ig like lectin 5, transcript variant 1
All isoforms of SIGLEC5 containing a lectin domain
ENST00000683636.1
67..1722 (or 51612231.. 51630335)
51610960.. 51630401
NCBI Matured mRNA sequence 2993 NTPDownload 
m7G-5')ppp(5'-AUUUGGAGCAUUUCCUUCCCUGACAGCCGGACCUGGGACUGGGCUGGGGCCCUGGCGGAUGGAGACAUGCUGCCCCUGCUGCUGCUGCCCCUGCUGUGGGGGGGGUCCCUGCAGGAGAAGCCAGUGUACGAGCUGCAAGUGCAGAAGUCGGUGACGGUGCAGGAGGGCCUGUGCGUCCUUGUGCCCUGCUCCUUCUCUUACCCCUGGAGAUCCUGGUAUUCCUCUCCCCCACUCUACGUCUACUGGUUCCGGGACGGGGAGAUCCCAUACUACGCUGAGGUUGUGGCCACAAACAACCCAGACAGAAGAGUGAAGCCAGAGACCCAGGGCCGAUUCCGCCUCCUUGGGGAUGUCCAGAAGAAGAACUGCUCCCUGAGCAUCGGAGAUGCCAGAAUGGAGGACACGGGAAGCUAUUUCUUCCGCGUGGAGAGAGGAAGGGAUGUAAAAUAUAGCUACCAACAGAAUAAGCUGAACUUGGAGGUGACAGCCCUGAUAGAGAAACCCGACAUCCACUUUCUGGAGCCUCUGGAGUCCGGCCGCCCCACAAGGCUGAGCUGCAGCCUUCCAGGAUCCUGUGAAGCGGGACCACCUCUCACAUUCUCCUGGACGGGGAAUGCCCUCAGCCCCCUGGACCCCGAGACCACCCGCUCCUCGGAGCUCACCCUCACCCCCAGGCCCGAGGACCAUGGCACCAACCUCACCUGUCAGAUGAAACGCCAAGGAGCUCAGGUGACCACGGAGAGAACUGUCCAGCUCAAUGUCUCCUAUGCUCCACAGACCAUCACCAUCUUCAGGAACGGCAUAGCCCUAGAGAUCCUGCAAAACACCUCAUACCUUCCGGUCCUGGAGGGCCAGGCUCUGCGGCUGCUCUGUGAUGCUCCCAGCAACCCCCCUGCACACCUGAGCUGGUUCCAGGGCUCCCCUGCCCUGAACGCCACCCCCAUCUCCAAUACCGGGAUCUUGGAGCUUCGUCGAGUAAGGUCUGCAGAAGAAGGAGGCUUCACCUGCCGCGCUCAGCACCCGCUGGGCUUCCUGCAAAUUUUUCUGAAUCUCUCAGUUUACUCCCUCCCACAGUUGCUGGGCCCCUCCUGCUCCUGGGAGGCUGAGGGUCUGCACUGCAGAUGCUCCUUUCGAGCCCGGCCGGCCCCCUCCCUGUGCUGGCGGCUUGAGGAGAAGCCGCUGGAGGGGAACAGCAGCCAGGGCUCAUUCAAGGUCAACUCCAGCUCAGCUGGGCCCUGGGCCAACAGCUCCCUGAUCCUCCACGGGGGGCUCAGCUCCGACCUCAAAGUCAGCUGCAAGGCCUGGAACAUCUAUGGGUCCCAGAGCGGCUCUGUCCUGCUGCUGCAAGGGAGAUCGAACCUCGGGACAGGAGUGGUUCCUGCAGCCCUUGGUGGUGCUGGUGUCAUGGCCCUGCUCUGUAUCUGUCUGUGCCUCAUCUUCUUUUUAAUAGUGAAAGCCCGCAGGAAGCAAGCAGCUGGGAGACCAGAGAAAAUGGAUGAUGAAGACCCCAUUAUGGGUACCAUCACCUCGGGUUCCAGGAAGAAGCCCUGGCCAGACAGCCCCGGAGAUCAAGCAUCUCCUCCUGGGGAUGCCCCUCCCUUGGAAGAACAAAAGGAGCUCCAUUAUGCCUCCCUUAGUUUUUCUGAGAUGAAGUCGAGGGAGCCUAAGGACCAGGAGGCCCCAAGCACCACGGAGUACUCGGAGAUCAAGACAAGCAAGUGAGGAUUUGCCCAGAGUUCAGUCCUGGCUGGAGGAGCCACAGCCUGUCUGGGGGAAAGGACAAGUCAGGGACCACUUGCUGAAGCACGAAGAGCCCUUGUGGCAAUGUUAACAUUAACUGAUGUUUAAGUGCUCCAAGCAGAUGGAAUUAGAGAGGUGGGCUCAAAUCUAGGCCCUGGCACUGUCAUCAAGCAAUUCACUGCAUCCCUCUGUGCCUCAGUUUCCCAUUCUGUAAAUCAGAGAUCAUGCAUGCUACCUCAAAGGUUGUUGUGAACAUUAAAGAAAUCAACACAUGGAAAUCAACCAACAUGGGUCCUGGAACAGGGCGUUGUGCUCAGUGCUUUCUGGUCUCUCUUCCUUGAAUAGAAAGGUCCUGCUGGCAAGUUCUCUCAAGGCUGGGGAUGACCAGGCACAAAAAACAGGGCAGCAAUAUGUUGGUGUCACUCCCCUUCCCAAAACUCUUCGAAGACUCCCUAGGAAAGACCAGCCCCUCAGCCUGGCACUUGGUUCAUGAUGUGGGAUCUUAUAUCCUUGCCAGAGUCAUAUCUUUGCCCACUUUUACCUGCAAUCCUUGCAUCAUAUUCCUUUGGCUCCAGUCCUUCAUUUAUGAGACCCAUAGGAAUCCUUCCAACAGCCAAAGAGUUGAGUCUAACUCUUUCCUGCCCAAACCCAUUCACGGCCCCCUGGCCUUAGACAAUAUAUCACAAGCAUCUCCCCUGACACAUAAAGUCCUUCAUGAUCUCCCUGCUAUCUAUUCAUUUAUACUUUCCUCUUGCCUAACCCUUCCUUAAGCCUUUCAUGCUGGUUCAUACCACACUGUCUUUGCAAUUUGAGAUUCCUCCUCCUGGAAGCCAUGCCUCCUUGCUUUCAUCUGGCUUACACUAUCUUUUCCUCCAAACAUGAGUUAAUGGGUGGUCUUGAGUUGGAAGAGUGGACUGAAGAAAGAACUUAUACUCUCCCUCCUCUAAAAUUGAACUAAUUUAUUUUUUAAAAUGCUAAACCAAAAGCAGCUAAAAAUUCUCCAGUUACUUAUCUAGGGUAUCUCCAAACCCAGAUAAAUGACAAUGUUAGAAACUUCAGCAAGUGGUCAUGAGGAAAUGAGUGGAUAAUUCCAGUGGAGUACUGGGAGGACAUUGAUUCUCAAUAUCUACCACCCAAACUUCAUUUUCAUCACUGUAAAGAAGGUGAAUUGUGACUACUGUUUUGGUUAUGACAGGUUAGAUAAUUUUGAUCAAGCCUUGUGUUGAAAAUAAUAAAAUCUUUUGGGGAAAAAA-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
;
More about the NCBI sViewer.
DNA
DNA (Gene ID: 8778)
SIGLEC5
sialic acid binding Ig like lectin 5
NC_000019.10
19  51612231.. 51630335
51612231.. 51630335
strand -
CCDS33088.1
MGI:2681107
ClinVar, dbVar
ENSG00000105501
OB-BP2, SIGLEC-5, CD170
uc061byd.1
INSDC: U71383
10874
604200
OTTHUMG00000165510
ENA, DDBJ, Monarch
CD170
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (1656 bp)
5'-ATGCTGCCCCTGCTGCTGCTGCCCCTGCTGTGGGGGGGGTCCCTGCAGGAGAAGCCAGTGTACGAGCTGCAAGTGCAGAAGTCGGTGACGGTGCAGGAGGGCCTGTGCGTCCTTGTGCCCTGCTCCTTCTCTTACCCCTGGAGATCCTGGTATTCCTCTCCCCCACTCTACGTCTACTGGTTCCGGGACGGGGAGATCCCATACTACGCTGAGGTTGTGGCCACAAACAACCCAGACAGAAGAGTGAAGCCAGAGACCCAGGGCCGATTCCGCCTCCTTGGGGATGTCCAGAAGAAGAACTGCTCCCTGAGCATCGGAGATGCCAGAATGGAGGACACGGGAAGCTATTTCTTCCGCGTGGAGAGAGGAAGGGATGTAAAATATAGCTACCAACAGAATAAGCTGAACTTGGAGGTGACAGCCCTGATAGAGAAACCCGACATCCACTTTCTGGAGCCTCTGGAGTCCGGCCGCCCCACAAGGCTGAGCTGCAGCCTTCCAGGATCCTGTGAAGCGGGACCACCTCTCACATTCTCCTGGACGGGGAATGCCCTCAGCCCCCTGGACCCCGAGACCACCCGCTCCTCGGAGCTCACCCTCACCCCCAGGCCCGAGGACCATGGCACCAACCTCACCTGTCAGATGAAACGCCAAGGAGCTCAGGTGACCACGGAGAGAACTGTCCAGCTCAATGTCTCCTATGCTCCACAGACCATCACCATCTTCAGGAACGGCATAGCCCTAGAGATCCTGCAAAACACCTCATACCTTCCGGTCCTGGAGGGCCAGGCTCTGCGGCTGCTCTGTGATGCTCCCAGCAACCCCCCTGCACACCTGAGCTGGTTCCAGGGCTCCCCTGCCCTGAACGCCACCCCCATCTCCAATACCGGGATCTTGGAGCTTCGTCGAGTAAGGTCTGCAGAAGAAGGAGGCTTCACCTGCCGCGCTCAGCACCCGCTGGGCTTCCTGCAAATTTTTCTGAATCTCTCAGTTTACTCCCTCCCACAGTTGCTGGGCCCCTCCTGCTCCTGGGAGGCTGAGGGTCTGCACTGCAGATGCTCCTTTCGAGCCCGGCCGGCCCCCTCCCTGTGCTGGCGGCTTGAGGAGAAGCCGCTGGAGGGGAACAGCAGCCAGGGCTCATTCAAGGTCAACTCCAGCTCAGCTGGGCCCTGGGCCAACAGCTCCCTGATCCTCCACGGGGGGCTCAGCTCCGACCTCAAAGTCAGCTGCAAGGCCTGGAACATCTATGGGTCCCAGAGCGGCTCTGTCCTGCTGCTGCAAGGGAGATCGAACCTCGGGACAGGAGTGGTTCCTGCAGCCCTTGGTGGTGCTGGTGTCATGGCCCTGCTCTGTATCTGTCTGTGCCTCATCTTCTTTTTAATAGTGAAAGCCCGCAGGAAGCAAGCAGCTGGGAGACCAGAGAAAATGGATGATGAAGACCCCATTATGGGTACCATCACCTCGGGTTCCAGGAAGAAGCCCTGGCCAGACAGCCCCGGAGATCAAGCATCTCCTCCTGGGGATGCCCCTCCCTTGGAAGAACAAAAGGAGCTCCATTATGCCTCCCTTAGTTTTTCTGAGATGAAGTCGAGGGAGCCTAAGGACCAGGAGGCCCCAAGCACCACGGAGTACTCGGAGATCAAGACAAGCAAGTGA-3'
NCBI CDS gene sequence with introns (location: 51612231.. 51630335) (18105 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 51610960.. 51630401) (19442 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [51610960.. 51630401 + 1000]) (20442 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
How to cite: Schnider B., M'Rad Y., el Ahmadie J., de Brevern AG., Imberty A., Lisacek F., HumanLectome, an update of UniLectin for the annotation and prediction of human lectins, Nucleic Acids Reasearch doi.org/10.1093/nar/gkad905