NCBI Summary
This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion. [provided by RefSeq, Feb 2012].
Protein
Protein (NP_003821)
SIGLEC-5
Sialic acid-binding Ig-like lectin 5 (Siglec-5) (CD33 antigen-like 2) (Obesity-binding protein 2) (OB-BP2) (OB-binding protein 2) (CD antigen CD170)
SIGLEC5
sialic acid binding Ig like lectin 5
Curated
I-type lectin
I-Type Lectins - CD33-related Siglecs
b-sandwich / Ig-like
MLPLLLLPLLWGGSLQEKPVYELQVQKSVTVQEGLCVLVPCSFSYPWRSWYSSPPLYVYWFRDGEIPYYAEVVATNNPDRRVKPETQGRFRLLGDVQKKNCSLSIGDARMEDTGSYFFRVERGRDVKYSYQQNKLNLEVTALIEKPDIHFLEPLESGRPTRLSCSLPGSCEAGPPLTFSWTGNALSPLDPETTRSSELTLTPRPEDHGTNLTCQMKRQGAQVTTERTVQLNVSYAPQTITIFRNGIALEILQNTSYLPVLEGQALRLLCDAPSNPPAHLSWFQGSPALNATPISNTGILELRRVRSAEEGGFTCRAQHPLGFLQIFLNLSVYSLPQLLGPSCSWEAEGLHCRCSFRARPAPSLCWRLEEKPLEGNSSQGSFKVNSSSAGPWANSSLILHGGLSSDLKVSCKAWNIYGSQSGSVLLLQGRSNLGTGVVPAALGGAGVMALLCICLCLIFFLIVKARRKQAAGRPEKMDDEDPIMGTITSGSRKKPWPDSPGDQASPPGDAPPLEEQKELHYASLSFSEMKSREPKDQEAPSTTEYSEIKTSK
Mol* PDB structure viewerUniLectin3D
Ligand
Glycan ligands from structural data
![](../templates/png/NeuAc(a2-6)Gal(b1-4)Glc.png)
![](../templates/png/NeuAc(a2-3)Gal(b1-4)Glc.png)
References
NCBI References (10 PubMed Identifiers)
- A reference map of the human binary protein interactome. [32296183]
- Soluble siglec-5 is a novel salivary biomarker for primary Sjogren's syndrome. [30922727]
- Genetic susceptibility of common polymorphisms in NIN and SIGLEC5 to chronic periodontitis. [30765789]
- Siglec-5 is a novel marker of critical limb ischemia in patients with diabetes. [28900239]
- Group B Streptococcus suppression of phagocyte functions by protein-mediated engagement of human Siglec-5. [19596804]
- Characterization of Siglec-5 (CD170) expression and functional activity of anti-Siglec-5 antibodies on human phagocytes. [12763136]
- Genomic organization of the siglec gene locus on chromosome 19q13.4 and cloning of two new siglec pseudogenes. [11943481]
- OB-BP1/Siglec-6. a leptin- and sialic acid-binding protein of the immunoglobulin superfamily. [10428856]
- Assignment of the human OB binding protein-2 gene (CD33L2) to chromosome 19q13.3 by radiation hybrid mapping. [10343116]
- Characterization of siglec-5, a novel glycoprotein expressed on myeloid cells related to CD33. [9731071]
UniProt Main References (3 PubMed Identifiers)
- The DNA sequence and biology of human chromosome 19. [15057824]
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
- Structural implications of Siglec-5-mediated sialoglycan recognition. [18022638]
All isoforms of this gene containing a lectin domain
RNA
RNA (Transcript ID: NM_003830.4)
sialic acid binding Ig like lectin 5, transcript variant 1
m7G-5')ppp(5'-AUUUGGAGCAUUUCCUUCCCUGACAGCCGGACCUGGGACUGGGCUGGGGCCCUGGCGGAUGGAGACAUGCUGCCCCUGCUGCUGCUGCCCCUGCUGUGGGGGGGGUCCCUGCAGGAGAAGCCAGUGUACGAGCUGCAAGUGCAGAAGUCGGUGACGGUGCAGGAGGGCCUGUGCGUCCUUGUGCCCUGCUCCUUCUCUUACCCCUGGAGAUCCUGGUAUUCCUCUCCCCCACUCUACGUCUACUGGUUCCGGGACGGGGAGAUCCCAUACUACGCUGAGGUUGUGGCCACAAACAACCCAGACAGAAGAGUGAAGCCAGAGACCCAGGGCCGAUUCCGCCUCCUUGGGGAUGUCCAGAAGAAGAACUGCUCCCUGAGCAUCGGAGAUGCCAGAAUGGAGGACACGGGAAGCUAUUUCUUCCGCGUGGAGAGAGGAAGGGAUGUAAAAUAUAGCUACCAACAGAAUAAGCUGAACUUGGAGGUGACAGCCCUGAUAGAGAAACCCGACAUCCACUUUCUGGAGCCUCUGGAGUCCGGCCGCCCCACAAGGCUGAGCUGCAGCCUUCCAGGAUCCUGUGAAGCGGGACCACCUCUCACAUUCUCCUGGACGGGGAAUGCCCUCAGCCCCCUGGACCCCGAGACCACCCGCUCCUCGGAGCUCACCCUCACCCCCAGGCCCGAGGACCAUGGCACCAACCUCACCUGUCAGAUGAAACGCCAAGGAGCUCAGGUGACCACGGAGAGAACUGUCCAGCUCAAUGUCUCCUAUGCUCCACAGACCAUCACCAUCUUCAGGAACGGCAUAGCCCUAGAGAUCCUGCAAAACACCUCAUACCUUCCGGUCCUGGAGGGCCAGGCUCUGCGGCUGCUCUGUGAUGCUCCCAGCAACCCCCCUGCACACCUGAGCUGGUUCCAGGGCUCCCCUGCCCUGAACGCCACCCCCAUCUCCAAUACCGGGAUCUUGGAGCUUCGUCGAGUAAGGUCUGCAGAAGAAGGAGGCUUCACCUGCCGCGCUCAGCACCCGCUGGGCUUCCUGCAAAUUUUUCUGAAUCUCUCAGUUUACUCCCUCCCACAGUUGCUGGGCCCCUCCUGCUCCUGGGAGGCUGAGGGUCUGCACUGCAGAUGCUCCUUUCGAGCCCGGCCGGCCCCCUCCCUGUGCUGGCGGCUUGAGGAGAAGCCGCUGGAGGGGAACAGCAGCCAGGGCUCAUUCAAGGUCAACUCCAGCUCAGCUGGGCCCUGGGCCAACAGCUCCCUGAUCCUCCACGGGGGGCUCAGCUCCGACCUCAAAGUCAGCUGCAAGGCCUGGAACAUCUAUGGGUCCCAGAGCGGCUCUGUCCUGCUGCUGCAAGGGAGAUCGAACCUCGGGACAGGAGUGGUUCCUGCAGCCCUUGGUGGUGCUGGUGUCAUGGCCCUGCUCUGUAUCUGUCUGUGCCUCAUCUUCUUUUUAAUAGUGAAAGCCCGCAGGAAGCAAGCAGCUGGGAGACCAGAGAAAAUGGAUGAUGAAGACCCCAUUAUGGGUACCAUCACCUCGGGUUCCAGGAAGAAGCCCUGGCCAGACAGCCCCGGAGAUCAAGCAUCUCCUCCUGGGGAUGCCCCUCCCUUGGAAGAACAAAAGGAGCUCCAUUAUGCCUCCCUUAGUUUUUCUGAGAUGAAGUCGAGGGAGCCUAAGGACCAGGAGGCCCCAAGCACCACGGAGUACUCGGAGAUCAAGACAAGCAAGUGAGGAUUUGCCCAGAGUUCAGUCCUGGCUGGAGGAGCCACAGCCUGUCUGGGGGAAAGGACAAGUCAGGGACCACUUGCUGAAGCACGAAGAGCCCUUGUGGCAAUGUUAACAUUAACUGAUGUUUAAGUGCUCCAAGCAGAUGGAAUUAGAGAGGUGGGCUCAAAUCUAGGCCCUGGCACUGUCAUCAAGCAAUUCACUGCAUCCCUCUGUGCCUCAGUUUCCCAUUCUGUAAAUCAGAGAUCAUGCAUGCUACCUCAAAGGUUGUUGUGAACAUUAAAGAAAUCAACACAUGGAAAUCAACCAACAUGGGUCCUGGAACAGGGCGUUGUGCUCAGUGCUUUCUGGUCUCUCUUCCUUGAAUAGAAAGGUCCUGCUGGCAAGUUCUCUCAAGGCUGGGGAUGACCAGGCACAAAAAACAGGGCAGCAAUAUGUUGGUGUCACUCCCCUUCCCAAAACUCUUCGAAGACUCCCUAGGAAAGACCAGCCCCUCAGCCUGGCACUUGGUUCAUGAUGUGGGAUCUUAUAUCCUUGCCAGAGUCAUAUCUUUGCCCACUUUUACCUGCAAUCCUUGCAUCAUAUUCCUUUGGCUCCAGUCCUUCAUUUAUGAGACCCAUAGGAAUCCUUCCAACAGCCAAAGAGUUGAGUCUAACUCUUUCCUGCCCAAACCCAUUCACGGCCCCCUGGCCUUAGACAAUAUAUCACAAGCAUCUCCCCUGACACAUAAAGUCCUUCAUGAUCUCCCUGCUAUCUAUUCAUUUAUACUUUCCUCUUGCCUAACCCUUCCUUAAGCCUUUCAUGCUGGUUCAUACCACACUGUCUUUGCAAUUUGAGAUUCCUCCUCCUGGAAGCCAUGCCUCCUUGCUUUCAUCUGGCUUACACUAUCUUUUCCUCCAAACAUGAGUUAAUGGGUGGUCUUGAGUUGGAAGAGUGGACUGAAGAAAGAACUUAUACUCUCCCUCCUCUAAAAUUGAACUAAUUUAUUUUUUAAAAUGCUAAACCAAAAGCAGCUAAAAAUUCUCCAGUUACUUAUCUAGGGUAUCUCCAAACCCAGAUAAAUGACAAUGUUAGAAACUUCAGCAAGUGGUCAUGAGGAAAUGAGUGGAUAAUUCCAGUGGAGUACUGGGAGGACAUUGAUUCUCAAUAUCUACCACCCAAACUUCAUUUUCAUCACUGUAAAGAAGGUGAAUUGUGACUACUGUUUUGGUUAUGACAGGUUAGAUAAUUUUGAUCAAGCCUUGUGUUGAAAAUAAUAAAAUCUUUUGGGGAAAAAA-3'- Poly-A tail
- Coding region
DNA
DNA (Gene ID: 8778)
sialic acid binding Ig like lectin 5
strand -
OB-BP2, SIGLEC-5, CD170
NCBI CDS gene sequence (1656 bp)
5'-ATGCTGCCCCTGCTGCTGCTGCCCCTGCTGTGGGGGGGGTCCCTGCAGGAGAAGCCAGTGTACGAGCTGCAAGTGCAGAAGTCGGTGACGGTGCAGGAGGGCCTGTGCGTCCTTGTGCCCTGCTCCTTCTCTTACCCCTGGAGATCCTGGTATTCCTCTCCCCCACTCTACGTCTACTGGTTCCGGGACGGGGAGATCCCATACTACGCTGAGGTTGTGGCCACAAACAACCCAGACAGAAGAGTGAAGCCAGAGACCCAGGGCCGATTCCGCCTCCTTGGGGATGTCCAGAAGAAGAACTGCTCCCTGAGCATCGGAGATGCCAGAATGGAGGACACGGGAAGCTATTTCTTCCGCGTGGAGAGAGGAAGGGATGTAAAATATAGCTACCAACAGAATAAGCTGAACTTGGAGGTGACAGCCCTGATAGAGAAACCCGACATCCACTTTCTGGAGCCTCTGGAGTCCGGCCGCCCCACAAGGCTGAGCTGCAGCCTTCCAGGATCCTGTGAAGCGGGACCACCTCTCACATTCTCCTGGACGGGGAATGCCCTCAGCCCCCTGGACCCCGAGACCACCCGCTCCTCGGAGCTCACCCTCACCCCCAGGCCCGAGGACCATGGCACCAACCTCACCTGTCAGATGAAACGCCAAGGAGCTCAGGTGACCACGGAGAGAACTGTCCAGCTCAATGTCTCCTATGCTCCACAGACCATCACCATCTTCAGGAACGGCATAGCCCTAGAGATCCTGCAAAACACCTCATACCTTCCGGTCCTGGAGGGCCAGGCTCTGCGGCTGCTCTGTGATGCTCCCAGCAACCCCCCTGCACACCTGAGCTGGTTCCAGGGCTCCCCTGCCCTGAACGCCACCCCCATCTCCAATACCGGGATCTTGGAGCTTCGTCGAGTAAGGTCTGCAGAAGAAGGAGGCTTCACCTGCCGCGCTCAGCACCCGCTGGGCTTCCTGCAAATTTTTCTGAATCTCTCAGTTTACTCCCTCCCACAGTTGCTGGGCCCCTCCTGCTCCTGGGAGGCTGAGGGTCTGCACTGCAGATGCTCCTTTCGAGCCCGGCCGGCCCCCTCCCTGTGCTGGCGGCTTGAGGAGAAGCCGCTGGAGGGGAACAGCAGCCAGGGCTCATTCAAGGTCAACTCCAGCTCAGCTGGGCCCTGGGCCAACAGCTCCCTGATCCTCCACGGGGGGCTCAGCTCCGACCTCAAAGTCAGCTGCAAGGCCTGGAACATCTATGGGTCCCAGAGCGGCTCTGTCCTGCTGCTGCAAGGGAGATCGAACCTCGGGACAGGAGTGGTTCCTGCAGCCCTTGGTGGTGCTGGTGTCATGGCCCTGCTCTGTATCTGTCTGTGCCTCATCTTCTTTTTAATAGTGAAAGCCCGCAGGAAGCAAGCAGCTGGGAGACCAGAGAAAATGGATGATGAAGACCCCATTATGGGTACCATCACCTCGGGTTCCAGGAAGAAGCCCTGGCCAGACAGCCCCGGAGATCAAGCATCTCCTCCTGGGGATGCCCCTCCCTTGGAAGAACAAAAGGAGCTCCATTATGCCTCCCTTAGTTTTTCTGAGATGAAGTCGAGGGAGCCTAAGGACCAGGAGGCCCCAAGCACCACGGAGTACTCGGAGATCAAGACAAGCAAGTGA-3'
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