NCBI Summary
This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion. [provided by RefSeq, Feb 2012].
Protein
Protein (NP_003821)
SIGLEC-5
Sialic acid-binding Ig-like lectin 5 (Siglec-5) (CD33 antigen-like 2) (Obesity-binding protein 2) (OB-BP2) (OB-binding protein 2) (CD antigen CD170)
SIGLEC5
sialic acid binding Ig like lectin 5
CD170
Curated
I-type lectin
I-Type Lectins - CD33-related Siglecs
b-sandwich / Ig-like
NeuAc / Neu5Ac(a2-6)GalNAc
NP_003821
8778
O15389
ENSP00000507738.1
O15389
0.55
10.1146/annurev-immunol-102419-035900
neXtProt, PFAM, InterPro, CFG data
Protein sequence and protein families (fasta) (551 amino acids) Download
MLPLLLLPLLWGGSLQEKPVYELQVQKSVTVQEGLCVLVPCSFSYPWRSWYSSPPLYVYWFRDGEIPYYAEVVATNNPDRRVKPETQGRFRLLGDVQKKNCSLSIGDARMEDTGSYFFRVERGRDVKYSYQQNKLNLEVTALIEKPDIHFLEPLESGRPTRLSCSLPGSCEAGPPLTFSWTGNALSPLDPETTRSSELTLTPRPEDHGTNLTCQMKRQGAQVTTERTVQLNVSYAPQTITIFRNGIALEILQNTSYLPVLEGQALRLLCDAPSNPPAHLSWFQGSPALNATPISNTGILELRRVRSAEEGGFTCRAQHPLGFLQIFLNLSVYSLPQLLGPSCSWEAEGLHCRCSFRARPAPSLCWRLEEKPLEGNSSQGSFKVNSSSAGPWANSSLILHGGLSSDLKVSCKAWNIYGSQSGSVLLLQGRSNLGTGVVPAALGGAGVMALLCICLCLIFFLIVKARRKQAAGRPEKMDDEDPIMGTITSGSRKKPWPDSPGDQASPPGDAPPLEEQKELHYASLSFSEMKSREPKDQEAPSTTEYSEIKTSK
Mol* PDB structure viewerUniLectin3D
Structural models
AlphaFold v2: AF-O15389-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Ligand
Glycan ligands from structural data
aNeuAc26bGal14Glc
NeuAc(a2-6)Gal(b1-4)Glc
2ZG1
2ZG1
GlyConnect Structures
aNeuAc3bGal14Glc
NeuAc(a2-3)Gal(b1-4)Glc
2ZG3
2ZG3
GlyConnect Structures
GeneCards
mRNA expression in normal human tissues for SIGLEC5 Gene
ProteomicsDB
References
NCBI References (10 PubMed Identifiers)
  • A reference map of the human binary protein interactome. [32296183]
  • Soluble siglec-5 is a novel salivary biomarker for primary Sjogren's syndrome. [30922727]
  • Genetic susceptibility of common polymorphisms in NIN and SIGLEC5 to chronic periodontitis. [30765789]
  • Siglec-5 is a novel marker of critical limb ischemia in patients with diabetes. [28900239]
  • Group B Streptococcus suppression of phagocyte functions by protein-mediated engagement of human Siglec-5. [19596804]
  • Characterization of Siglec-5 (CD170) expression and functional activity of anti-Siglec-5 antibodies on human phagocytes. [12763136]
  • Genomic organization of the siglec gene locus on chromosome 19q13.4 and cloning of two new siglec pseudogenes. [11943481]
  • OB-BP1/Siglec-6. a leptin- and sialic acid-binding protein of the immunoglobulin superfamily. [10428856]
  • Assignment of the human OB binding protein-2 gene (CD33L2) to chromosome 19q13.3 by radiation hybrid mapping. [10343116]
  • Characterization of siglec-5, a novel glycoprotein expressed on myeloid cells related to CD33. [9731071]
UniProt Main References (3 PubMed Identifiers)
  • The DNA sequence and biology of human chromosome 19. [15057824]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
  • Structural implications of Siglec-5-mediated sialoglycan recognition. [18022638]
All isoforms of this gene containing a lectin domain
NP_001371638.1, NP_001371637.1, NP_003821.1, XP_016882908.1
RNA
RNA (Transcript ID: NM_003830.4)
NM_003830.4
sialic acid binding Ig like lectin 5, transcript variant 1
All isoforms of SIGLEC5 containing a lectin domain
ENST00000683636.1
67..1722 (or 51612231.. 51630335)
51610960.. 51630401
NCBI Matured mRNA sequence 2993 NTPDownload 
m7G-5')ppp(5'-AUUUGGAGCAUUUCCUUCCCUGACAGCCGGACCUGGGACUGGGCUGGGGCCCUGGCGGAUGGAGACAUGCUGCCCCUGCUGCUGCUGCCCCUGCUGUGGGGGGGGUCCCUGCAGGAGAAGCCAGUGUACGAGCUGCAAGUGCAGAAGUCGGUGACGGUGCAGGAGGGCCUGUGCGUCCUUGUGCCCUGCUCCUUCUCUUACCCCUGGAGAUCCUGGUAUUCCUCUCCCCCACUCUACGUCUACUGGUUCCGGGACGGGGAGAUCCCAUACUACGCUGAGGUUGUGGCCACAAACAACCCAGACAGAAGAGUGAAGCCAGAGACCCAGGGCCGAUUCCGCCUCCUUGGGGAUGUCCAGAAGAAGAACUGCUCCCUGAGCAUCGGAGAUGCCAGAAUGGAGGACACGGGAAGCUAUUUCUUCCGCGUGGAGAGAGGAAGGGAUGUAAAAUAUAGCUACCAACAGAAUAAGCUGAACUUGGAGGUGACAGCCCUGAUAGAGAAACCCGACAUCCACUUUCUGGAGCCUCUGGAGUCCGGCCGCCCCACAAGGCUGAGCUGCAGCCUUCCAGGAUCCUGUGAAGCGGGACCACCUCUCACAUUCUCCUGGACGGGGAAUGCCCUCAGCCCCCUGGACCCCGAGACCACCCGCUCCUCGGAGCUCACCCUCACCCCCAGGCCCGAGGACCAUGGCACCAACCUCACCUGUCAGAUGAAACGCCAAGGAGCUCAGGUGACCACGGAGAGAACUGUCCAGCUCAAUGUCUCCUAUGCUCCACAGACCAUCACCAUCUUCAGGAACGGCAUAGCCCUAGAGAUCCUGCAAAACACCUCAUACCUUCCGGUCCUGGAGGGCCAGGCUCUGCGGCUGCUCUGUGAUGCUCCCAGCAACCCCCCUGCACACCUGAGCUGGUUCCAGGGCUCCCCUGCCCUGAACGCCACCCCCAUCUCCAAUACCGGGAUCUUGGAGCUUCGUCGAGUAAGGUCUGCAGAAGAAGGAGGCUUCACCUGCCGCGCUCAGCACCCGCUGGGCUUCCUGCAAAUUUUUCUGAAUCUCUCAGUUUACUCCCUCCCACAGUUGCUGGGCCCCUCCUGCUCCUGGGAGGCUGAGGGUCUGCACUGCAGAUGCUCCUUUCGAGCCCGGCCGGCCCCCUCCCUGUGCUGGCGGCUUGAGGAGAAGCCGCUGGAGGGGAACAGCAGCCAGGGCUCAUUCAAGGUCAACUCCAGCUCAGCUGGGCCCUGGGCCAACAGCUCCCUGAUCCUCCACGGGGGGCUCAGCUCCGACCUCAAAGUCAGCUGCAAGGCCUGGAACAUCUAUGGGUCCCAGAGCGGCUCUGUCCUGCUGCUGCAAGGGAGAUCGAACCUCGGGACAGGAGUGGUUCCUGCAGCCCUUGGUGGUGCUGGUGUCAUGGCCCUGCUCUGUAUCUGUCUGUGCCUCAUCUUCUUUUUAAUAGUGAAAGCCCGCAGGAAGCAAGCAGCUGGGAGACCAGAGAAAAUGGAUGAUGAAGACCCCAUUAUGGGUACCAUCACCUCGGGUUCCAGGAAGAAGCCCUGGCCAGACAGCCCCGGAGAUCAAGCAUCUCCUCCUGGGGAUGCCCCUCCCUUGGAAGAACAAAAGGAGCUCCAUUAUGCCUCCCUUAGUUUUUCUGAGAUGAAGUCGAGGGAGCCUAAGGACCAGGAGGCCCCAAGCACCACGGAGUACUCGGAGAUCAAGACAAGCAAGUGAGGAUUUGCCCAGAGUUCAGUCCUGGCUGGAGGAGCCACAGCCUGUCUGGGGGAAAGGACAAGUCAGGGACCACUUGCUGAAGCACGAAGAGCCCUUGUGGCAAUGUUAACAUUAACUGAUGUUUAAGUGCUCCAAGCAGAUGGAAUUAGAGAGGUGGGCUCAAAUCUAGGCCCUGGCACUGUCAUCAAGCAAUUCACUGCAUCCCUCUGUGCCUCAGUUUCCCAUUCUGUAAAUCAGAGAUCAUGCAUGCUACCUCAAAGGUUGUUGUGAACAUUAAAGAAAUCAACACAUGGAAAUCAACCAACAUGGGUCCUGGAACAGGGCGUUGUGCUCAGUGCUUUCUGGUCUCUCUUCCUUGAAUAGAAAGGUCCUGCUGGCAAGUUCUCUCAAGGCUGGGGAUGACCAGGCACAAAAAACAGGGCAGCAAUAUGUUGGUGUCACUCCCCUUCCCAAAACUCUUCGAAGACUCCCUAGGAAAGACCAGCCCCUCAGCCUGGCACUUGGUUCAUGAUGUGGGAUCUUAUAUCCUUGCCAGAGUCAUAUCUUUGCCCACUUUUACCUGCAAUCCUUGCAUCAUAUUCCUUUGGCUCCAGUCCUUCAUUUAUGAGACCCAUAGGAAUCCUUCCAACAGCCAAAGAGUUGAGUCUAACUCUUUCCUGCCCAAACCCAUUCACGGCCCCCUGGCCUUAGACAAUAUAUCACAAGCAUCUCCCCUGACACAUAAAGUCCUUCAUGAUCUCCCUGCUAUCUAUUCAUUUAUACUUUCCUCUUGCCUAACCCUUCCUUAAGCCUUUCAUGCUGGUUCAUACCACACUGUCUUUGCAAUUUGAGAUUCCUCCUCCUGGAAGCCAUGCCUCCUUGCUUUCAUCUGGCUUACACUAUCUUUUCCUCCAAACAUGAGUUAAUGGGUGGUCUUGAGUUGGAAGAGUGGACUGAAGAAAGAACUUAUACUCUCCCUCCUCUAAAAUUGAACUAAUUUAUUUUUUAAAAUGCUAAACCAAAAGCAGCUAAAAAUUCUCCAGUUACUUAUCUAGGGUAUCUCCAAACCCAGAUAAAUGACAAUGUUAGAAACUUCAGCAAGUGGUCAUGAGGAAAUGAGUGGAUAAUUCCAGUGGAGUACUGGGAGGACAUUGAUUCUCAAUAUCUACCACCCAAACUUCAUUUUCAUCACUGUAAAGAAGGUGAAUUGUGACUACUGUUUUGGUUAUGACAGGUUAGAUAAUUUUGAUCAAGCCUUGUGUUGAAAAUAAUAAAAUCUUUUGGGGAAAAAA-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
;
More about the NCBI sViewer.
DNA
DNA (Gene ID: 8778)
SIGLEC5
sialic acid binding Ig like lectin 5
NC_000019.10
19  51612231.. 51630335
51612231.. 51630335
strand -
CCDS33088.1
MGI:2681107
ClinVar, dbVar
ENSG00000105501
OB-BP2, SIGLEC-5, CD170
uc061byd.1
INSDC: U71383
10874
604200
OTTHUMG00000165510
ENA, DDBJ, Monarch
CD170
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (1656 bp)
5'-ATGCTGCCCCTGCTGCTGCTGCCCCTGCTGTGGGGGGGGTCCCTGCAGGAGAAGCCAGTGTACGAGCTGCAAGTGCAGAAGTCGGTGACGGTGCAGGAGGGCCTGTGCGTCCTTGTGCCCTGCTCCTTCTCTTACCCCTGGAGATCCTGGTATTCCTCTCCCCCACTCTACGTCTACTGGTTCCGGGACGGGGAGATCCCATACTACGCTGAGGTTGTGGCCACAAACAACCCAGACAGAAGAGTGAAGCCAGAGACCCAGGGCCGATTCCGCCTCCTTGGGGATGTCCAGAAGAAGAACTGCTCCCTGAGCATCGGAGATGCCAGAATGGAGGACACGGGAAGCTATTTCTTCCGCGTGGAGAGAGGAAGGGATGTAAAATATAGCTACCAACAGAATAAGCTGAACTTGGAGGTGACAGCCCTGATAGAGAAACCCGACATCCACTTTCTGGAGCCTCTGGAGTCCGGCCGCCCCACAAGGCTGAGCTGCAGCCTTCCAGGATCCTGTGAAGCGGGACCACCTCTCACATTCTCCTGGACGGGGAATGCCCTCAGCCCCCTGGACCCCGAGACCACCCGCTCCTCGGAGCTCACCCTCACCCCCAGGCCCGAGGACCATGGCACCAACCTCACCTGTCAGATGAAACGCCAAGGAGCTCAGGTGACCACGGAGAGAACTGTCCAGCTCAATGTCTCCTATGCTCCACAGACCATCACCATCTTCAGGAACGGCATAGCCCTAGAGATCCTGCAAAACACCTCATACCTTCCGGTCCTGGAGGGCCAGGCTCTGCGGCTGCTCTGTGATGCTCCCAGCAACCCCCCTGCACACCTGAGCTGGTTCCAGGGCTCCCCTGCCCTGAACGCCACCCCCATCTCCAATACCGGGATCTTGGAGCTTCGTCGAGTAAGGTCTGCAGAAGAAGGAGGCTTCACCTGCCGCGCTCAGCACCCGCTGGGCTTCCTGCAAATTTTTCTGAATCTCTCAGTTTACTCCCTCCCACAGTTGCTGGGCCCCTCCTGCTCCTGGGAGGCTGAGGGTCTGCACTGCAGATGCTCCTTTCGAGCCCGGCCGGCCCCCTCCCTGTGCTGGCGGCTTGAGGAGAAGCCGCTGGAGGGGAACAGCAGCCAGGGCTCATTCAAGGTCAACTCCAGCTCAGCTGGGCCCTGGGCCAACAGCTCCCTGATCCTCCACGGGGGGCTCAGCTCCGACCTCAAAGTCAGCTGCAAGGCCTGGAACATCTATGGGTCCCAGAGCGGCTCTGTCCTGCTGCTGCAAGGGAGATCGAACCTCGGGACAGGAGTGGTTCCTGCAGCCCTTGGTGGTGCTGGTGTCATGGCCCTGCTCTGTATCTGTCTGTGCCTCATCTTCTTTTTAATAGTGAAAGCCCGCAGGAAGCAAGCAGCTGGGAGACCAGAGAAAATGGATGATGAAGACCCCATTATGGGTACCATCACCTCGGGTTCCAGGAAGAAGCCCTGGCCAGACAGCCCCGGAGATCAAGCATCTCCTCCTGGGGATGCCCCTCCCTTGGAAGAACAAAAGGAGCTCCATTATGCCTCCCTTAGTTTTTCTGAGATGAAGTCGAGGGAGCCTAAGGACCAGGAGGCCCCAAGCACCACGGAGTACTCGGAGATCAAGACAAGCAAGTGA-3'
NCBI CDS gene sequence with introns (location: 51612231.. 51630335) (18105 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 51610960.. 51630401) (19442 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [51610960.. 51630401 + 1000]) (20442 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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