NCBI Summary
Ficolins are a group of proteins which consist of a collagen-like domain and a fibrinogen-like domain. In human serum, there are two types of ficolins, both of which have lectin activity. The protein encoded by this gene is a thermolabile beta-2-macroglycoprotein found in all human serum and is a member of the ficolin/opsonin p35 lectin family. The protein, which was initially identified based on its reactivity with sera from patients with systemic lupus erythematosus, has been shown to have a calcium-independent lectin activity. The protein can activate the complement pathway in association with MASPs and sMAP, thereby aiding in host defense through the activation of the lectin pathway. Alternative splicing occurs at this locus and two variants, each encoding a distinct isoform, have been identified. [provided by RefSeq, Jul 2008].
Protein
Protein (NP_003656)
H-ficolin
Ficolin-3 (Collagen/fibrinogen domain-containing lectin 3 p35) (Collagen/fibrinogen domain-containing protein 3) (Hakata antigen)
FCN3
ficolin 3
Undefined
Curated
Ficolin-like
Ficolins
a/b mixed with b-sheet / Fibrinogen C-ter like
Fuc, Gal
NP_003656
8547
O75636
ENSP00000270879.4
O75636
0.665
10.1038/sj.emboj.7601500
neXtProt, PFAM, InterPro, CFG data
Protein sequence and protein families (fasta) (299 amino acids) Download
MDLLWILPSLWLLLLGGPACLKTQEHPSCPGPRELEASKVVLLPSCPGAPGSPGEKGAPGPQGPPGPPGKMGPKGEPGDPVNLLRCQEGPRNCRELLSQGATLSGWYHLCLPEGRALPVFCDMDTEGGGWLVFQRRQDGSVDFFRSWSSYRAGFGNQESEFWLGNENLHQLTLQGNWELRVELEDFNGNRTFAHYATFRLLGEVDHYQLALGKFSEGTAGDSLSLHSGRPFTTYDADHDSSNSNCAVIVHGAWWYASCYRSNLNGRYAVSEAAAHKYGIDWASGRGVGHPYRRVRMMLR
Mol* PDB structure viewerUniLectin3D
Structural models
AlphaFold v2: AF-O75636-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Ligand
Glycan ligands from structural data
Gal
Gal
2J5Z
2J5Z
GlyConnect Structures
D-Fuc
Fuc
2J60
2J60
GlyConnect Structures
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for FCN3 Gene
ProteomicsDB
References
NCBI References (10 PubMed Identifiers)
  • FCN3 functions as a tumor suppressor of lung adenocarcinoma through induction of endoplasmic reticulum stress. [33859174]
  • Association of ficolin-1 and ficolin-3 gene variation and pulmonary tuberculosis susceptibility in a Chinese population. [33591573]
  • The clinical value of ficolin-3 gene polymorphism in rheumatic heart disease. An Egyptian adolescents study. [33499929]
  • Associations of ficolins and mannose-binding lectin with acute myeloid leukaemia in adults. [32601370]
  • Circulating Ficolin-2 and Ficolin-3 Form Heterocomplexes. [32094208]
  • Activation of the lectin complement pathway by H-ficolin (Hakata antigen). [11907111]
  • Hakata antigen, a new member of the ficolin/opsonin p35 family, is a novel human lectin secreted into bronchus/alveolus and bile. [10330454]
  • Cloning and characterization of the Hakata antigen, a member of the ficolin/opsonin p35 lectin family. [9694814]
  • Isolation and characterization of a thermolabile beta-2 macroglycoprotein ('thermolabile substance' or 'Hakata antigen') detected by precipitating (auto) antibody in sera of patients with systemic lupus erythematosus. [1859827]
  • Serological studies of an SLE-associated antigen-antibody system discovered as a precipitation reaction in agarose gel: the HAKATA antigen-antibody system. [2276712]
UniProt Main References (9 PubMed Identifiers)
  • Complete sequencing and characterization of 21,243 full-length human cDNAs. [14702039]
  • The DNA sequence and biological annotation of human chromosome 1. [16710414]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
  • Signal peptide prediction based on analysis of experimentally verified cleavage sites. [15340161]
  • Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. [16335952]
  • Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. [19159218]
  • A strategy for precise and large scale identification of core fucosylated glycoproteins. [19139490]
  • Immunodeficiency associated with FCN3 mutation and ficolin-3 deficiency. [19535802]
  • Structural insights into the innate immune recognition specificities of L- and H-ficolins. [17215869]
All isoforms of this gene containing a lectin domain
NP_003656.2, NP_775628.1
RNA
RNA (Transcript ID: NM_003665.4)
NM_003665.4
ficolin 3, transcript variant 1
All isoforms of FCN3 containing a lectin domain
ENST00000270879.9
7..906 (or 27369236.. 27374818)
27369110.. 27374824
NCBI Matured mRNA sequence 1032 NTPDownload 
m7G-5')ppp(5'-AGCAAGAUGGAUCUACUGUGGAUCCUGCCCUCCCUGUGGCUUCUCCUGCUUGGGGGGCCUGCCUGCCUGAAGACCCAGGAACACCCCAGCUGCCCAGGACCCAGGGAACUGGAAGCCAGCAAAGUUGUCCUCCUGCCCAGUUGUCCCGGAGCUCCAGGAAGUCCUGGGGAGAAGGGAGCCCCAGGUCCUCAAGGGCCACCUGGACCACCAGGCAAGAUGGGCCCCAAGGGUGAGCCAGGAGAUCCAGUGAACCUGCUCCGGUGCCAGGAAGGCCCCAGAAACUGCCGGGAGCUGUUGAGCCAGGGCGCCACCUUGAGCGGCUGGUACCAUCUGUGCCUACCUGAGGGCAGGGCCCUCCCAGUCUUUUGUGACAUGGACACCGAGGGGGGCGGCUGGCUGGUGUUUCAGAGGCGCCAGGAUGGUUCUGUGGAUUUCUUCCGCUCUUGGUCCUCCUACAGAGCAGGUUUUGGGAACCAAGAGUCUGAAUUCUGGCUGGGAAAUGAGAAUUUGCACCAGCUUACUCUCCAGGGUAACUGGGAGCUGCGGGUAGAGCUGGAAGACUUUAAUGGUAACCGUACUUUCGCCCACUAUGCGACCUUCCGCCUCCUCGGUGAGGUAGACCACUACCAGCUGGCACUGGGCAAGUUCUCAGAGGGCACUGCAGGGGAUUCCCUGAGCCUCCACAGUGGGAGGCCCUUUACCACCUAUGACGCUGACCACGAUUCAAGCAACAGCAACUGUGCAGUGAUUGUCCACGGUGCCUGGUGGUAUGCAUCCUGUUACCGAUCAAAUCUCAAUGGUCGCUAUGCAGUGUCUGAGGCUGCCGCCCACAAAUAUGGCAUUGACUGGGCCUCAGGCCGUGGUGUGGGCCACCCCUACCGCAGGGUUCGGAUGAUGCUUCGAUAGGGCACUCUGGCAGCCAGUGCCCUUAUCUCUCCUGUACAGCUUCCGGAUCGUCAGCCACCUUGCCUUUGCCAACCACCUCUGCUUGCCUGUCCACAUUUAAAAAUAAAAUCAUUUUAGCCCUUUCAA-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
;
More about the NCBI sViewer.
DNA
DNA (Gene ID: 8547)
FCN3
ficolin 3
NC_000001.11
1  27369236.. 27374818
27369236.. 27374818
strand -
CCDS300.1
ClinVar, dbVar
ENSG00000142748
FCNH, HAKA1
uc001boa.4
INSDC: D88587
3625
604973
OTTHUMG00000005722
ENA, DDBJ, Monarch
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (900 bp)
5'-ATGGATCTACTGTGGATCCTGCCCTCCCTGTGGCTTCTCCTGCTTGGGGGGCCTGCCTGCCTGAAGACCCAGGAACACCCCAGCTGCCCAGGACCCAGGGAACTGGAAGCCAGCAAAGTTGTCCTCCTGCCCAGTTGTCCCGGAGCTCCAGGAAGTCCTGGGGAGAAGGGAGCCCCAGGTCCTCAAGGGCCACCTGGACCACCAGGCAAGATGGGCCCCAAGGGTGAGCCAGGAGATCCAGTGAACCTGCTCCGGTGCCAGGAAGGCCCCAGAAACTGCCGGGAGCTGTTGAGCCAGGGCGCCACCTTGAGCGGCTGGTACCATCTGTGCCTACCTGAGGGCAGGGCCCTCCCAGTCTTTTGTGACATGGACACCGAGGGGGGCGGCTGGCTGGTGTTTCAGAGGCGCCAGGATGGTTCTGTGGATTTCTTCCGCTCTTGGTCCTCCTACAGAGCAGGTTTTGGGAACCAAGAGTCTGAATTCTGGCTGGGAAATGAGAATTTGCACCAGCTTACTCTCCAGGGTAACTGGGAGCTGCGGGTAGAGCTGGAAGACTTTAATGGTAACCGTACTTTCGCCCACTATGCGACCTTCCGCCTCCTCGGTGAGGTAGACCACTACCAGCTGGCACTGGGCAAGTTCTCAGAGGGCACTGCAGGGGATTCCCTGAGCCTCCACAGTGGGAGGCCCTTTACCACCTATGACGCTGACCACGATTCAAGCAACAGCAACTGTGCAGTGATTGTCCACGGTGCCTGGTGGTATGCATCCTGTTACCGATCAAATCTCAATGGTCGCTATGCAGTGTCTGAGGCTGCCGCCCACAAATATGGCATTGACTGGGCCTCAGGCCGTGGTGTGGGCCACCCCTACCGCAGGGTTCGGATGATGCTTCGATAG-3'
NCBI CDS gene sequence with introns (location: 27369236.. 27374818) (5583 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 27369110.. 27374824) (5715 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [27369110.. 27374824 + 1000]) (6715 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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