HumanLectome - Human Lectin Entry

NCBI Summary

The protein encoded by this gene is part of the innate immune response, protecting the lungs against inhaled microorganisms and chemicals. The encoded protein may also be involved in surfactant metabolism. [provided by RefSeq, Jul 2015].

Protein

Protein (NP_003010)

Protein name

SP-D - surfactant-associated protein D

Synonym(s)

Pulmonary surfactant-associated protein D (PSP-D) (SP-D) (Collectin-7) (Lung surfactant protein D)

HGNC gene name

SFTPD

HGNC name

surfactant protein D

Protein_CD_name

Undefined

Lectin confidence

Curated

UniLectin class

C-type lectin

C-type classification

COLEC7

Known lectin group

C-type - Collectins

Lectin fold

a/b mixed / C-type lectin-like

Glycan specificity

Man, Glc, Hept / High mannose N-glycans / Lipopolysaccharide

RefSeq accession

Gene ID

UniProt accession

Ensembl protein ID

UniRef cluster ID

LectomeXplore score

0.45

Reference

10.1016/s0022-2836(03)00761-7

Other links

neXtProt, PFAM, InterPro, CFG data

Protein sequence and protein families (fasta) (375 amino acids) Download

MLLFLLSALVLLTQPLGYLEAEMKTYSHRTMPSACTLVMCSSVESGLPGRDGRDGREGPRGEKGDPGLPGAAGQAGMPGQAGPVGPKGDNGSVGEPGPKGDTGPSGPPGPPGVPGPAGREGPLGKQGNIGPQGKPGPKGEAGPKGEVGAPGMQGSAGARGLAGPKGERGVPGERGVPGNTGAAGSAGAMGPQGSPGARGPPGLKGDKGIPGDKGAKGESGLPDVASLRQQVEALQGQVQHLQAAFSQYKKVELFPNGQSVGEKIFKTAGFVKPFTEAQLLCTQAGGQLASPRSAAENAALQQLVVAKNEAAFLSMTDSKTEGKFTYPTGESLVYSNWAPGEPNDDGGSEDCVEIFTNGKWNDRACGEKRLVVCEF

Mol* PDB structure viewerUniLectin3D

Select a PDB entry:

Structural models

AlphaFold v2: AF-P35247-F1 Download

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Ligand

Glycan ligands from structural data

Name

aMan12aMan12Man

IUPAC

Man(a1-2)Man(a1-2)Man

PDB

4M18

UniLectin3D

4M18

Parent structures

GlyConnect Structures

Name

aGlc13aHep13aHep15Kdof

IUPAC

Glc(a1-3)Hep(a1-3)Hep(a1-5)Kdo

PDB

5OXS

UniLectin3D

5OXS

Parent structures

GlyConnect Structures

Name

aGlc14Glc, p-nitrophenyl maltoside

IUPAC

Glc(a1-4)Glc

PDB

1PWB, 2GGX

UniLectin3D

1PWB, 2GGX

Parent structures

GlyConnect Structures

Name

ManNAc

IUPAC

ManNAc

PDB

2ORJ

UniLectin3D

2ORJ

Parent structures

GlyConnect Structures

Name

aMan14Man

IUPAC

Man(a1-4)Man

PDB

3IKR

UniLectin3D

3IKR

Parent structures

GlyConnect Structures

Name

7-O-carbamoyl-L-glycero-D-manno-heptose, 2-deoxy-L-glycero-D-manno-heptose, aHep1-5anyhdroKdof, L-glycero-D-manno-heptose

IUPAC

LDmanHep

PDB

2RIB, 2RID, 2RIE, 4E52

UniLectin3D

2RIB, 2RID, 2RIE, 4E52

Parent structures

GlyConnect Structures

Name

Gal

IUPAC

Gal

PDB

3IKN

UniLectin3D

3IKN

Parent structures

GlyConnect Structures

Name

D-glycero-D-manno-heptose

IUPAC

DDmanHep

PDB

2RIA

UniLectin3D

2RIA

Parent structures

GlyConnect Structures

Name

aGlc14aGlc14Glc

IUPAC

Glc(a1-4)Glc(a1-4)Glc

PDB

2GGU

UniLectin3D

2GGU

Parent structures

GlyConnect Structures

Name

aHep13aHep15Kdof

IUPAC

Hep(a1-3)Hep(a1-5)Kdo

PDB

5OXR

UniLectin3D

5OXR

Parent structures

GlyConnect Structures

Name

aMan12aMan

IUPAC

Man(a1-2)Man

PDB

3IKQ

UniLectin3D

3IKQ

Parent structures

GlyConnect Structures

Name

aLDmanHep13LLmanHep

IUPAC

LDmanHep(a1-3)LDmanHep

PDB

2RIC

UniLectin3D

2RIC

Parent structures

GlyConnect Structures

Expression

Human Protein Atlas

GeneCards

mRNA expression in normal human tissues for SFTPD Gene

ProteomicsDB

References

NCBI References (10 PubMed Identifiers)

Pro-Apoptotic and Immunotherapeutic Effects of Carbon Nanotubes Functionalized with Recombinant Human Surfactant Protein D on Leukemic Cells. [34638783]

Serum surfactant protein D in COVID-19 is elevated and correlated with disease severity. [34344306]

Full-Length Recombinant hSP-D Binds and Inhibits SARS-CoV-2. [34439781]

A Recombinant Fragment of Human Surfactant Protein D Binds Spike Protein and Inhibits Infectivity and Replication of SARS-CoV-2 in Clinical Samples. [33784482]

Genetic Association With Pseudomonas aeruginosa Acquisition in Cystic Fibrosis: Influence of Surfactant Protein D and Mannose-Binding Lectin. [33679736]

Molecular structure of pulmonary surfactant protein D (SP-D). [8006040]

Pulmonary surfactant protein D specifically binds to phosphatidylinositol. [1400434]

Purification, characterization and cDNA cloning of human lung surfactant protein D. [1339284]

Characterization of pulmonary surfactant protein D: its copurification with lipids. [1932100]

Human surfactant protein D: SP-D contains a C-type lectin carbohydrate recognition domain. [1898081]

UniProt Main References (7 PubMed Identifiers)

Genomic organization of human surfactant protein D (SP-D). SP-D is encoded on chromosome 10q22.2-23.1. [8428971]

The DNA sequence and comparative analysis of human chromosome 10. [15164054]

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]

Accumulation of surfactant protein D in human pulmonary alveolar proteinosis. [8424457]

The lung innate immune gene surfactant protein-D is expressed in adipose tissue and linked to obesity status. [23478426]

Crystal structure of the trimeric alpha-helical coiled-coil and the three lectin domains of human lung surfactant protein D. [10368295]

Genetic defects in surfactant protein A2 are associated with pulmonary fibrosis and lung cancer. [19100526]

All isoforms of this gene containing a lectin domain

XP_011538390.1, NP_003010.4, XP_011538389.1

RNA

RNA (Transcript ID: NM_003019.5)

RNA RefSeq ID

NM_003019.5

RNA name

surfactant protein D

Isoforms

All isoforms of SFTPD containing a lectin domain

RNA Ensembl ID

ENST00000372292.8

Coding region

44..1171 (or 79937852.. 79946659)

mRNA location

79937740.. 79949105

NCBI Matured mRNA sequence 1283 NTP Download

m⁷G-5')ppp(5'-AGUUUGCUUGGAGCUCCUGGGGCCUAACAAAAAGAAACCUGCCAUGCUGCUCUUCCUCCUCUCUGCACUGGUCCUGCUCACACAGCCCCUGGGCUACCUGGAAGCAGAAAUGAAGACCUACUCCCACAGAACAAUGCCCAGUGCUUGCACCCUGGUCAUGUGUAGCUCAGUGGAGAGUGGCCUGCCUGGUCGCGAUGGACGGGAUGGGAGAGAGGGCCCUCGGGGCGAGAAGGGGGACCCAGGUUUGCCAGGAGCUGCAGGGCAAGCAGGGAUGCCUGGACAAGCUGGCCCAGUUGGGCCCAAAGGGGACAAUGGCUCUGUUGGAGAACCUGGACCAAAGGGAGACACUGGGCCAAGUGGACCUCCAGGACCUCCCGGUGUGCCUGGUCCAGCUGGAAGAGAAGGUCCCCUGGGGAAGCAGGGGAACAUAGGACCUCAGGGCAAGCCAGGCCCAAAAGGAGAAGCUGGGCCCAAAGGAGAAGUAGGUGCCCCAGGCAUGCAGGGCUCGGCAGGGGCAAGAGGCCUCGCAGGCCCUAAGGGAGAGCGAGGUGUCCCUGGUGAGCGUGGAGUCCCUGGAAACACAGGGGCAGCAGGGUCUGCUGGAGCCAUGGGUCCCCAGGGAAGUCCAGGUGCCAGGGGACCCCCGGGAUUGAAGGGGGACAAAGGCAUUCCUGGAGACAAAGGAGCAAAGGGAGAAAGUGGGCUUCCAGAUGUUGCUUCUCUGAGGCAGCAGGUUGAGGCCUUACAGGGACAAGUACAGCACCUCCAGGCUGCUUUCUCUCAGUAUAAGAAAGUUGAGCUCUUCCCAAAUGGCCAAAGUGUCGGGGAGAAGAUUUUCAAGACAGCAGGCUUUGUAAAACCAUUUACGGAGGCACAGCUGCUGUGCACACAGGCUGGUGGACAGUUGGCCUCUCCACGCUCUGCCGCUGAGAAUGCCGCCUUGCAACAGCUGGUCGUAGCUAAGAACGAGGCUGCUUUCCUGAGCAUGACUGAUUCCAAGACAGAGGGCAAGUUCACCUACCCCACAGGAGAGUCCCUGGUCUAUUCCAACUGGGCCCCAGGGGAGCCCAACGAUGAUGGCGGGUCAGAGGACUGUGUGGAGAUCUUCACCAAUGGCAAGUGGAAUGACAGGGCUUGUGGAGAAAAGCGUCUUGUGGUCUGCGAGUUCUGAGCCAACUGGGGUGGGUGGGGCAGUGCUUGGCCCAGGAGUUUGGCCAGAAGUCAAGGCUUAGACCCUCAUGCUGCCAAUAUCCUAAUAAAAAGGUGACCAUCUGUGCCGGGAA-3'- Poly-A tail

Coding region

NCBI Matured mRNA sequence viewer

;

More about the NCBI sViewer.

DNA

DNA (Gene ID: 6441)

HGNC Gene symbol

SFTPD

HGNC Gene name

surfactant protein D

Chr. RefSeq ID

NC_000010.11

Chromosome N°

10 79937852.. 79946659

CDS location

79937852.. 79946659

DNA strand

strand -

CCDS ID

CCDS7362.1

Mouse ortholog gene

MGI:109515

Gene Variant

ClinVar, dbVar

DNA Ensembl ID

ENSG00000133661

HGNC other symbol

SP-D, COLEC7

UCSC ID

uc001kbh.4

GeneBank

INSDC: L05485

GeneCards

10803

MIM

178635

VEGA ID

OTTHUMG00000018590

How to cite: