NCBI Summary
The protein encoded by this gene is part of the innate immune response, protecting the lungs against inhaled microorganisms and chemicals. The encoded protein may also be involved in surfactant metabolism. [provided by RefSeq, Jul 2015].
Protein
Protein (NP_003010)
SP-D - surfactant-associated protein D
Pulmonary surfactant-associated protein D (PSP-D) (SP-D) (Collectin-7) (Lung surfactant protein D)
SFTPD
surfactant protein D
Undefined
Curated
C-type lectin
COLEC7
C-type - Collectins
a/b mixed / C-type lectin-like
MLLFLLSALVLLTQPLGYLEAEMKTYSHRTMPSACTLVMCSSVESGLPGRDGRDGREGPRGEKGDPGLPGAAGQAGMPGQAGPVGPKGDNGSVGEPGPKGDTGPSGPPGPPGVPGPAGREGPLGKQGNIGPQGKPGPKGEAGPKGEVGAPGMQGSAGARGLAGPKGERGVPGERGVPGNTGAAGSAGAMGPQGSPGARGPPGLKGDKGIPGDKGAKGESGLPDVASLRQQVEALQGQVQHLQAAFSQYKKVELFPNGQSVGEKIFKTAGFVKPFTEAQLLCTQAGGQLASPRSAAENAALQQLVVAKNEAAFLSMTDSKTEGKFTYPTGESLVYSNWAPGEPNDDGGSEDCVEIFTNGKWNDRACGEKRLVVCEF
Mol* PDB structure viewerUniLectin3D
Ligand
Glycan ligands from structural data
![](../templates/png/Man(a1-2)Man(a1-2)Man.png)
![](../templates/png/Glc(a1-3)Hep(a1-3)Hep(a1-5)Kdo.png)
![](../templates/png/Glc(a1-4)Glc.png)
![](../templates/png/ManNAc.png)
![](../templates/png/Man(a1-4)Man.png)
![](../templates/png/LDmanHep.png)
![](../templates/png/DDmanHep.png)
![](../templates/png/Glc(a1-4)Glc(a1-4)Glc.png)
![](../templates/png/Hep(a1-3)Hep(a1-5)Kdo.png)
![](../templates/png/Man(a1-2)Man.png)
![](../templates/png/LDmanHep(a1-3)LDmanHep.png)
References
NCBI References (10 PubMed Identifiers)
- Pro-Apoptotic and Immunotherapeutic Effects of Carbon Nanotubes Functionalized with Recombinant Human Surfactant Protein D on Leukemic Cells. [34638783]
- Serum surfactant protein D in COVID-19 is elevated and correlated with disease severity. [34344306]
- Full-Length Recombinant hSP-D Binds and Inhibits SARS-CoV-2. [34439781]
- A Recombinant Fragment of Human Surfactant Protein D Binds Spike Protein and Inhibits Infectivity and Replication of SARS-CoV-2 in Clinical Samples. [33784482]
- Genetic Association With Pseudomonas aeruginosa Acquisition in Cystic Fibrosis: Influence of Surfactant Protein D and Mannose-Binding Lectin. [33679736]
- Molecular structure of pulmonary surfactant protein D (SP-D). [8006040]
- Pulmonary surfactant protein D specifically binds to phosphatidylinositol. [1400434]
- Purification, characterization and cDNA cloning of human lung surfactant protein D. [1339284]
- Characterization of pulmonary surfactant protein D: its copurification with lipids. [1932100]
- Human surfactant protein D: SP-D contains a C-type lectin carbohydrate recognition domain. [1898081]
UniProt Main References (7 PubMed Identifiers)
- Genomic organization of human surfactant protein D (SP-D). SP-D is encoded on chromosome 10q22.2-23.1. [8428971]
- The DNA sequence and comparative analysis of human chromosome 10. [15164054]
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
- Accumulation of surfactant protein D in human pulmonary alveolar proteinosis. [8424457]
- The lung innate immune gene surfactant protein-D is expressed in adipose tissue and linked to obesity status. [23478426]
- Crystal structure of the trimeric alpha-helical coiled-coil and the three lectin domains of human lung surfactant protein D. [10368295]
- Genetic defects in surfactant protein A2 are associated with pulmonary fibrosis and lung cancer. [19100526]
All isoforms of this gene containing a lectin domain
RNA
RNA (Transcript ID: NM_003019.5)
m7G-5')ppp(5'-AGUUUGCUUGGAGCUCCUGGGGCCUAACAAAAAGAAACCUGCCAUGCUGCUCUUCCUCCUCUCUGCACUGGUCCUGCUCACACAGCCCCUGGGCUACCUGGAAGCAGAAAUGAAGACCUACUCCCACAGAACAAUGCCCAGUGCUUGCACCCUGGUCAUGUGUAGCUCAGUGGAGAGUGGCCUGCCUGGUCGCGAUGGACGGGAUGGGAGAGAGGGCCCUCGGGGCGAGAAGGGGGACCCAGGUUUGCCAGGAGCUGCAGGGCAAGCAGGGAUGCCUGGACAAGCUGGCCCAGUUGGGCCCAAAGGGGACAAUGGCUCUGUUGGAGAACCUGGACCAAAGGGAGACACUGGGCCAAGUGGACCUCCAGGACCUCCCGGUGUGCCUGGUCCAGCUGGAAGAGAAGGUCCCCUGGGGAAGCAGGGGAACAUAGGACCUCAGGGCAAGCCAGGCCCAAAAGGAGAAGCUGGGCCCAAAGGAGAAGUAGGUGCCCCAGGCAUGCAGGGCUCGGCAGGGGCAAGAGGCCUCGCAGGCCCUAAGGGAGAGCGAGGUGUCCCUGGUGAGCGUGGAGUCCCUGGAAACACAGGGGCAGCAGGGUCUGCUGGAGCCAUGGGUCCCCAGGGAAGUCCAGGUGCCAGGGGACCCCCGGGAUUGAAGGGGGACAAAGGCAUUCCUGGAGACAAAGGAGCAAAGGGAGAAAGUGGGCUUCCAGAUGUUGCUUCUCUGAGGCAGCAGGUUGAGGCCUUACAGGGACAAGUACAGCACCUCCAGGCUGCUUUCUCUCAGUAUAAGAAAGUUGAGCUCUUCCCAAAUGGCCAAAGUGUCGGGGAGAAGAUUUUCAAGACAGCAGGCUUUGUAAAACCAUUUACGGAGGCACAGCUGCUGUGCACACAGGCUGGUGGACAGUUGGCCUCUCCACGCUCUGCCGCUGAGAAUGCCGCCUUGCAACAGCUGGUCGUAGCUAAGAACGAGGCUGCUUUCCUGAGCAUGACUGAUUCCAAGACAGAGGGCAAGUUCACCUACCCCACAGGAGAGUCCCUGGUCUAUUCCAACUGGGCCCCAGGGGAGCCCAACGAUGAUGGCGGGUCAGAGGACUGUGUGGAGAUCUUCACCAAUGGCAAGUGGAAUGACAGGGCUUGUGGAGAAAAGCGUCUUGUGGUCUGCGAGUUCUGAGCCAACUGGGGUGGGUGGGGCAGUGCUUGGCCCAGGAGUUUGGCCAGAAGUCAAGGCUUAGACCCUCAUGCUGCCAAUAUCCUAAUAAAAAGGUGACCAUCUGUGCCGGGAA-3'- Poly-A tail
- Coding region
DNA
DNA (Gene ID: 6441)
surfactant protein D
strand -
SP-D, COLEC7
NCBI CDS gene sequence (1128 bp)
5'-ATGCTGCTCTTCCTCCTCTCTGCACTGGTCCTGCTCACACAGCCCCTGGGCTACCTGGAAGCAGAAATGAAGACCTACTCCCACAGAACAATGCCCAGTGCTTGCACCCTGGTCATGTGTAGCTCAGTGGAGAGTGGCCTGCCTGGTCGCGATGGACGGGATGGGAGAGAGGGCCCTCGGGGCGAGAAGGGGGACCCAGGTTTGCCAGGAGCTGCAGGGCAAGCAGGGATGCCTGGACAAGCTGGCCCAGTTGGGCCCAAAGGGGACAATGGCTCTGTTGGAGAACCTGGACCAAAGGGAGACACTGGGCCAAGTGGACCTCCAGGACCTCCCGGTGTGCCTGGTCCAGCTGGAAGAGAAGGTCCCCTGGGGAAGCAGGGGAACATAGGACCTCAGGGCAAGCCAGGCCCAAAAGGAGAAGCTGGGCCCAAAGGAGAAGTAGGTGCCCCAGGCATGCAGGGCTCGGCAGGGGCAAGAGGCCTCGCAGGCCCTAAGGGAGAGCGAGGTGTCCCTGGTGAGCGTGGAGTCCCTGGAAACACAGGGGCAGCAGGGTCTGCTGGAGCCATGGGTCCCCAGGGAAGTCCAGGTGCCAGGGGACCCCCGGGATTGAAGGGGGACAAAGGCATTCCTGGAGACAAAGGAGCAAAGGGAGAAAGTGGGCTTCCAGATGTTGCTTCTCTGAGGCAGCAGGTTGAGGCCTTACAGGGACAAGTACAGCACCTCCAGGCTGCTTTCTCTCAGTATAAGAAAGTTGAGCTCTTCCCAAATGGCCAAAGTGTCGGGGAGAAGATTTTCAAGACAGCAGGCTTTGTAAAACCATTTACGGAGGCACAGCTGCTGTGCACACAGGCTGGTGGACAGTTGGCCTCTCCACGCTCTGCCGCTGAGAATGCCGCCTTGCAACAGCTGGTCGTAGCTAAGAACGAGGCTGCTTTCCTGAGCATGACTGATTCCAAGACAGAGGGCAAGTTCACCTACCCCACAGGAGAGTCCCTGGTCTATTCCAACTGGGCCCCAGGGGAGCCCAACGATGATGGCGGGTCAGAGGACTGTGTGGAGATCTTCACCAATGGCAAGTGGAATGACAGGGCTTGTGGAGAAAAGCGTCTTGTGGTCTGCGAGTTCTGA-3'
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