NCBI Summary
This gene encodes a 140 kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Alternative splice variants may occur but are not well documented. [provided by RefSeq, Jul 2008].
Protein
Protein (NP_002996)
P-selectin
P-selectin (CD62 antigen-like family member P) (Granule membrane protein 140) (GMP-140) (Leukocyte-endothelial cell adhesion molecule 3) (LECAM3) (Platelet activation dependent granule-external membrane protein) (PADGEM) (CD antigen CD62P)
SELP
selectin P
CD62P
Curated
C-type lectin
SELP
C-type - Selectins
a/b mixed / C-type lectin-like
Sialyl Lewis x
NP_002996
6403
P16109
ENSP00000263686.5
P16109
0.458
10.1016/s0092-8674(00)00138-0
neXtProt, PFAM, InterPro, CFG data
Protein sequence and protein families (fasta) (830 amino acids) Download
MANCQIAILYQRFQRVVFGISQLLCFSALISELTNQKEVAAWTYHYSTKAYSWNISRKYCQNRYTDLVAIQNKNEIDYLNKVLPYYSSYYWIGIRKNNKTWTWVGTKKALTNEAENWADNEPNNKRNNEDCVEIYIKSPSAPGKWNDEHCLKKKHALCYTASCQDMSCSKQGECLETIGNYTCSCYPGFYGPECEYVRECGELELPQHVLMNCSHPLGNFSFNSQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQCLAAQCPPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPECQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRPSGQWTAVTPACRAVKCSELHVNKPIAMNCSNLWGNFSYGSICSFHCLEGQLLNGSAQTACQENGHWSTTVPTCQAGPLTIQEALTYFGGAVASTIGLIMGGTLLALLRKRFRQKDDGKCPLNPHSHLGTYGVFTNAAFDPSP
Mol* PDB structure viewerUniLectin3D
Structural models
AlphaFold v2: AF-P16109-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Ligand
Glycan ligands from structural data
aNeuAc23bGal14(aFuc13)GlcNAc
NeuAc(a2-3)Gal(b1-4)[Fuc(a1-3)]GlcNAc
1G1R
1G1R
GlyConnect Structures
Psgl-1 peptide
NeuAc(a2-3)Gal(b1-4)[Fuc(a1-3)]GlcNAc(b1-6)[Gal(b1-3)]GalNAc
1G1S
1G1S
GlyConnect Structures
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for SELP Gene
ProteomicsDB
References
NCBI References (10 PubMed Identifiers)
  • SELP Asp603Asn and severe thrombosis in COVID-19 males. [34399825]
  • Soluble P-selectin as a potential diagnostic and prognostic biomarker for COVID-19 disease: A case-control study. [34015287]
  • A Combined Activity of Thrombin and P-Selectin Is Essential for Platelet Activation by Pancreatic Cancer Cells. [33805059]
  • Fucoidan-coated nanoparticles target radiation-induced P-selectin to enhance chemoradiotherapy in murine colorectal cancer. [33232787]
  • Relationship of Platelet Glycoprotein IIb/IIIa and CD62P With Hypercoagulable State After Oncologic Surgery. [33259230]
  • Platelet dense granule membranes contain both granulophysin and P-selectin (GMP-140). [1377048]
  • Cell-cell contact mechanisms. [1375831]
  • Isolation of dense granules from human platelets. [1435334]
  • Structure of the human gene encoding granule membrane protein-140, a member of the selectin family of adhesion receptors for leukocytes. [1701178]
  • Genomic organization of the selectin family of leukocyte adhesion molecules on human and mouse chromosome 1. [1694218]
UniProt Main References (17 PubMed Identifiers)
  • Cloning of GMP-140, a granule membrane protein of platelets and endothelium: sequence similarity to proteins involved in cell adhesion and inflammation. [2466574]
  • The DNA sequence and biological annotation of human chromosome 1. [16710414]
  • P-selectin is acylated with palmitic acid and stearic acid at cysteine 766 through a thioester linkage. [7684381]
  • A sulfated peptide segment at the amino terminus of PSGL-1 is critical for P-selectin binding. [7585949]
  • PSGL-1 recognition of P-selectin is controlled by a tyrosine sulfation consensus at the PSGL-1 amino terminus. [7585950]
  • Tyrosine sulfation of P-selectin glycoprotein ligand-1 is required for high affinity binding to P-selectin. [7559387]
  • A new member of the sorting nexin family interacts with the C-terminus of P-selectin. [11237770]
  • Functions of sorting nexin 17 domains and recognition motif for P-selectin trafficking. [15769472]
  • Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach. [16263699]
  • Endoglycan, a member of the CD34 family of sialomucins, is a ligand for the vascular selectins. [18606703]
    • Show more
All isoforms of this gene containing a lectin domain
XP_005245497.1, XP_005245495.1, XP_005245496.1, NP_002996.2, XP_005245492.1, XP_005245493.1
RNA
RNA (Transcript ID: NM_003005.4)
NM_003005.4
selectin P
All isoforms of SELP containing a lectin domain
ENST00000263686.11
51..2543 (or 169590148.. 169630074)
169588849.. 169630124
NCBI Matured mRNA sequence 3157 NTPDownload 
m7G-5')ppp(5'-AGCAGUCUGGGUUGGGCAGAAGGCAGAAAACCAGCAGAGUCACAGAGGAGAUGGCCAACUGCCAAAUAGCCAUCUUGUACCAGAGAUUCCAGAGAGUGGUCUUUGGAAUUUCCCAACUCCUUUGCUUCAGUGCCCUGAUCUCUGAACUAACAAACCAGAAAGAAGUGGCAGCAUGGACUUAUCAUUACAGCACAAAAGCAUACUCAUGGAAUAUUUCCCGUAAAUACUGCCAGAAUCGCUACACAGACUUAGUGGCCAUCCAGAAUAAAAAUGAAAUUGAUUACCUCAAUAAGGUCCUACCCUACUACAGCUCCUACUACUGGAUUGGGAUCCGAAAGAACAAUAAGACAUGGACAUGGGUGGGAACCAAAAAGGCUCUCACCAACGAGGCUGAGAACUGGGCUGAUAAUGAACCUAACAACAAAAGGAACAACGAGGACUGCGUGGAGAUAUACAUCAAGAGUCCGUCAGCCCCUGGCAAGUGGAAUGAUGAGCACUGCUUGAAGAAAAAGCACGCAUUGUGUUACACAGCCUCCUGCCAGGACAUGUCCUGCAGCAAACAAGGAGAGUGCCUCGAGACCAUCGGGAACUACACCUGCUCCUGUUACCCUGGAUUCUAUGGGCCAGAAUGUGAAUACGUGAGAGAGUGUGGAGAACUUGAGCUCCCUCAACACGUGCUCAUGAACUGCAGCCACCCUCUGGGAAACUUCUCUUUUAACUCGCAGUGCAGCUUCCACUGCACUGACGGGUACCAAGUAAAUGGGCCCAGCAAGCUGGAAUGCUUGGCUUCUGGAAUCUGGACAAAUAAGCCUCCACAGUGUUUAGCUGCCCAGUGCCCACCCCUGAAGAUUCCUGAACGAGGAAACAUGACCUGCCUUCAUUCUGCAAAAGCAUUCCAGCAUCAGUCUAGCUGCAGCUUCAGUUGUGAAGAGGGAUUUGCAUUAGUUGGACCGGAAGUGGUGCAAUGCACAGCCUCGGGGGUAUGGACAGCCCCAGCCCCAGUGUGUAAAGCUGUGCAGUGUCAGCACCUGGAAGCCCCCAGUGAAGGAACCAUGGACUGUGUUCAUCCGCUCACUGCUUUUGCCUAUGGCUCCAGCUGUAAAUUUGAGUGCCAGCCCGGCUACAGAGUGAGGGGCUUGGACAUGCUCCGCUGCAUUGACUCUGGACACUGGUCUGCACCCUUGCCAACCUGUGAGGCUAUUUCGUGUGAGCCGCUGGAGAGUCCUGUCCACGGAAGCAUGGAUUGCUCUCCAUCCUUGAGAGCGUUUCAGUAUGACACCAACUGUAGCUUCCGCUGUGCUGAAGGUUUCAUGCUGAGAGGAGCCGAUAUAGUUCGGUGUGAUAACUUGGGACAGUGGACAGCACCAGCCCCAGUCUGUCAAGCUUUGCAGUGCCAGGAUCUCCCAGUUCCAAAUGAGGCCCGGGUGAACUGCUCCCACCCCUUCGGUGCCUUUAGGUACCAGUCAGUCUGCAGCUUCACCUGCAAUGAAGGCUUGCUCCUGGUGGGAGCAAGUGUGCUACAGUGCUUGGCUACUGGAAACUGGAAUUCUGUUCCUCCAGAAUGCCAAGCCAUUCCCUGCACACCUUUGCUAAGCCCUCAGAAUGGAACAAUGACCUGUGUUCAACCUCUUGGAAGUUCCAGUUAUAAAUCCACAUGUCAAUUCAUCUGUGACGAGGGAUAUUCUUUGUCUGGACCAGAAAGAUUGGAUUGUACUCGAUCGGGACGCUGGACAGACUCCCCACCAAUGUGUGAAGCCAUCAAGUGCCCAGAACUCUUUGCCCCAGAGCAGGGCAGCCUGGAUUGUUCUGACACUCGUGGAGAAUUCAAUGUUGGCUCCACCUGCCAUUUCUCUUGUGACAACGGCUUUAAGCUGGAGGGGCCCAAUAAUGUGGAAUGCACAACUUCUGGAAGAUGGUCAGCUACUCCACCAACCUGCAAAGGCAUAGCAUCACUUCCUACUCCAGGGGUGCAAUGUCCAGCCCUCACCACUCCUGGGCAGGGAACCAUGUACUGUAGGCAUCAUCCGGGAACCUUUGGUUUUAAUACCACUUGUUACUUUGGCUGCAACGCUGGAUUCACACUCAUAGGAGACAGCACUCUCAGCUGCAGACCUUCAGGACAAUGGACAGCAGUAACUCCAGCAUGCAGAGCUGUGAAAUGCUCAGAACUACAUGUUAAUAAGCCAAUAGCGAUGAACUGCUCCAACCUCUGGGGAAACUUCAGUUAUGGAUCAAUCUGCUCUUUCCAUUGUCUAGAGGGCCAGUUACUUAAUGGCUCUGCACAAACAGCAUGCCAAGAGAAUGGCCACUGGUCAACUACCGUGCCAACCUGCCAAGCAGGACCAUUGACUAUCCAGGAAGCCCUGACUUACUUUGGUGGAGCGGUGGCUUCUACGAUAGGUCUGAUAAUGGGUGGGACGCUCCUGGCUUUGCUAAGAAAGCGUUUCAGACAAAAAGAUGAUGGGAAAUGCCCCUUGAAUCCUCACAGCCACCUAGGAACAUAUGGAGUUUUUACAAACGCUGCAUUUGACCCGAGUCCUUAAGGUUUCCAUAAACACCCAUGAAUCAAAGACAUGGAAUUACCUUAGAUUAGCUCUGGACCAGCCUGUUGGACCCGCUCUGGACCAACCCUGUUUCCUGAGUUUGGGAUUGUGGUACAAUCUCAAAUUCUCAACCUACCACCCCUUCCUGUCCCACCUCUUCUCUUCCUGUAACACAAGCCACAGAAGCCAGGAGCAAAUGUUUCUGCAGUAGUCUCUGUGCUUUGACUCACCUGUUACUUGAAAUACCAGUGAACCAAAGAGACUGGAGCAUCUGACUCACAAGAAGACCAGACUGUGGAGAAAUAAAAAUACCUCUUUAUUUUUUGAUUGAAGGAAGGUUUUCUCCACUUUGUUGGAAAGCAGGUGGCAUCUCUAAUUGGAAGAAAUUCCUGUAGCAUCUUCUGGAGUCUCCAGUGGUUGCUGUUGAUGAGGCCUCUUGGACCUCUGCUCUGAGGCUUCCAGAGAGUCCUCUGGAUGGCACCAGAGGCUGCAGAAGGCCAAGAAUCAAGCUAGAAGGCCACAUGUCACCGUGGACCUUCCUGCCACCAGUCACUGUCCCUCAAAUGACCCAAAGACCAAUAUUCAAAUGCGUAAUUAAAAGAAUUUUCCCCAAA-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
;
More about the NCBI sViewer.
DNA
DNA (Gene ID: 6403)
SELP
selectin P
NC_000001.11
1  169590148.. 169630074
169590148.. 169630074
strand -
CCDS1282.1
MGI:98280
ClinVar, dbVar
ENSG00000174175
CD62, PSEL, PADGEM, GMP140, CD62P
uc001ggi.5
INSDC: BC068533
10721
173610
OTTHUMG00000034685
ENA, DDBJ, Monarch
CD62P
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (2493 bp)
5'-ATGGCCAACTGCCAAATAGCCATCTTGTACCAGAGATTCCAGAGAGTGGTCTTTGGAATTTCCCAACTCCTTTGCTTCAGTGCCCTGATCTCTGAACTAACAAACCAGAAAGAAGTGGCAGCATGGACTTATCATTACAGCACAAAAGCATACTCATGGAATATTTCCCGTAAATACTGCCAGAATCGCTACACAGACTTAGTGGCCATCCAGAATAAAAATGAAATTGATTACCTCAATAAGGTCCTACCCTACTACAGCTCCTACTACTGGATTGGGATCCGAAAGAACAATAAGACATGGACATGGGTGGGAACCAAAAAGGCTCTCACCAACGAGGCTGAGAACTGGGCTGATAATGAACCTAACAACAAAAGGAACAACGAGGACTGCGTGGAGATATACATCAAGAGTCCGTCAGCCCCTGGCAAGTGGAATGATGAGCACTGCTTGAAGAAAAAGCACGCATTGTGTTACACAGCCTCCTGCCAGGACATGTCCTGCAGCAAACAAGGAGAGTGCCTCGAGACCATCGGGAACTACACCTGCTCCTGTTACCCTGGATTCTATGGGCCAGAATGTGAATACGTGAGAGAGTGTGGAGAACTTGAGCTCCCTCAACACGTGCTCATGAACTGCAGCCACCCTCTGGGAAACTTCTCTTTTAACTCGCAGTGCAGCTTCCACTGCACTGACGGGTACCAAGTAAATGGGCCCAGCAAGCTGGAATGCTTGGCTTCTGGAATCTGGACAAATAAGCCTCCACAGTGTTTAGCTGCCCAGTGCCCACCCCTGAAGATTCCTGAACGAGGAAACATGACCTGCCTTCATTCTGCAAAAGCATTCCAGCATCAGTCTAGCTGCAGCTTCAGTTGTGAAGAGGGATTTGCATTAGTTGGACCGGAAGTGGTGCAATGCACAGCCTCGGGGGTATGGACAGCCCCAGCCCCAGTGTGTAAAGCTGTGCAGTGTCAGCACCTGGAAGCCCCCAGTGAAGGAACCATGGACTGTGTTCATCCGCTCACTGCTTTTGCCTATGGCTCCAGCTGTAAATTTGAGTGCCAGCCCGGCTACAGAGTGAGGGGCTTGGACATGCTCCGCTGCATTGACTCTGGACACTGGTCTGCACCCTTGCCAACCTGTGAGGCTATTTCGTGTGAGCCGCTGGAGAGTCCTGTCCACGGAAGCATGGATTGCTCTCCATCCTTGAGAGCGTTTCAGTATGACACCAACTGTAGCTTCCGCTGTGCTGAAGGTTTCATGCTGAGAGGAGCCGATATAGTTCGGTGTGATAACTTGGGACAGTGGACAGCACCAGCCCCAGTCTGTCAAGCTTTGCAGTGCCAGGATCTCCCAGTTCCAAATGAGGCCCGGGTGAACTGCTCCCACCCCTTCGGTGCCTTTAGGTACCAGTCAGTCTGCAGCTTCACCTGCAATGAAGGCTTGCTCCTGGTGGGAGCAAGTGTGCTACAGTGCTTGGCTACTGGAAACTGGAATTCTGTTCCTCCAGAATGCCAAGCCATTCCCTGCACACCTTTGCTAAGCCCTCAGAATGGAACAATGACCTGTGTTCAACCTCTTGGAAGTTCCAGTTATAAATCCACATGTCAATTCATCTGTGACGAGGGATATTCTTTGTCTGGACCAGAAAGATTGGATTGTACTCGATCGGGACGCTGGACAGACTCCCCACCAATGTGTGAAGCCATCAAGTGCCCAGAACTCTTTGCCCCAGAGCAGGGCAGCCTGGATTGTTCTGACACTCGTGGAGAATTCAATGTTGGCTCCACCTGCCATTTCTCTTGTGACAACGGCTTTAAGCTGGAGGGGCCCAATAATGTGGAATGCACAACTTCTGGAAGATGGTCAGCTACTCCACCAACCTGCAAAGGCATAGCATCACTTCCTACTCCAGGGGTGCAATGTCCAGCCCTCACCACTCCTGGGCAGGGAACCATGTACTGTAGGCATCATCCGGGAACCTTTGGTTTTAATACCACTTGTTACTTTGGCTGCAACGCTGGATTCACACTCATAGGAGACAGCACTCTCAGCTGCAGACCTTCAGGACAATGGACAGCAGTAACTCCAGCATGCAGAGCTGTGAAATGCTCAGAACTACATGTTAATAAGCCAATAGCGATGAACTGCTCCAACCTCTGGGGAAACTTCAGTTATGGATCAATCTGCTCTTTCCATTGTCTAGAGGGCCAGTTACTTAATGGCTCTGCACAAACAGCATGCCAAGAGAATGGCCACTGGTCAACTACCGTGCCAACCTGCCAAGCAGGACCATTGACTATCCAGGAAGCCCTGACTTACTTTGGTGGAGCGGTGGCTTCTACGATAGGTCTGATAATGGGTGGGACGCTCCTGGCTTTGCTAAGAAAGCGTTTCAGACAAAAAGATGATGGGAAATGCCCCTTGAATCCTCACAGCCACCTAGGAACATATGGAGTTTTTACAAACGCTGCATTTGACCCGAGTCCTTAA-3'
NCBI CDS gene sequence with introns (location: 169590148.. 169630074) (39927 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 169588849.. 169630124) (41276 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [169588849.. 169630124 + 1000]) (42276 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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