NCBI Summary
This gene is a type I subclass member of the Reg gene family. The Reg gene family is a multigene family grouped into four subclasses, types I, II, III and IV, based on the primary structures of the encoded proteins. This gene encodes a protein that is secreted by the exocrine pancreas. It is associated with islet cell regeneration and diabetogenesis and may be involved in pancreatic lithogenesis. Reg family members REG1B, REGL, PAP and this gene are tandemly clustered on chromosome 2p12 and may have arisen from the same ancestral gene by gene duplication. [provided by RefSeq, Jul 2008].
Protein (NP_002900)
Regenerating family member 1 alpha
Lithostathine-1-alpha (Islet cells regeneration factor) (ICRF) (Islet of Langerhans regenerating protein) (REG) (Pancreatic stone protein) (PSP) (Pancreatic thread protein) (PTP) (Regenerating islet-derived protein 1-alpha) (REG-1-alpha) (Regenerating protein I alpha)
regenerating family member 1 alpha
Very low evidence
C-type lectin
C-type - Free C-type Lectin Domains CTLDs
a/b mixed / C-type lectin-like
Protein sequence and protein families (fasta) (166 amino acids) Download
Mol* PDB structure viewerUniLectin3D
Structural models
Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
NCBI References (10 PubMed Identifiers)
  • Protective and anti-inflammatory role of REG1A in inflammatory bowel disease induced by JAK/STAT3 signaling axis. [33513463]
  • Carboxypeptidase A1 and regenerating islet-derived 1alpha as new markers for pancreatic acinar cell carcinoma. [32702400]
  • Pancreatic stone protein - sepsis and the riddles of the exocrine pancreas. [32037128]
  • Association of Serum PSP/REG Ialpha with Renal Function in Type 2 Diabetes Mellitus. [32309450]
  • Association of regenerating gene 1A single-nucleotide polymorphisms and nasopharyngeal carcinoma susceptibility in southern Chinese population. [31541294]
  • Isolation and characterization of human reg protein produced in Saccharomyces cerevisiae. [2226837]
  • Enhanced expression of an exocrine pancreatic protein in Alzheimer's disease and the developing human brain. [2394826]
  • Complete nucleotide sequence of human reg gene and its expression in normal and tumoral tissues. The reg protein, pancreatic stone protein, and pancreatic thread protein are one and the same product of the gene. [2332435]
  • Secretory pancreatic stone protein messenger RNA. Nucleotide sequence and expression in chronic calcifying pancreatitis. [2525567]
  • N-terminal sequence extension in the glycosylated forms of human pancreatic stone protein. The 5-oxoproline N-terminal chain is O-glycosylated on the 5th amino acid residue. [2493268]
UniProt Main References (12 PubMed Identifiers)
  • A novel gene activated in regenerating islets. [2963000]
  • Generation and annotation of the DNA sequences of human chromosomes 2 and 4. [15815621]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
  • Complete amino acid sequence of an immunoreactive form of human pancreatic stone protein isolated from pancreatic juice. [3665916]
  • Partial amino acid sequence of human pancreatic stone protein, a novel pancreatic secretory protein. [3541906]
  • Isolation, characterization, and distribution of an unusual pancreatic human secretory protein. [3908481]
  • Cleavage of the Arg-Ile bond in the native polypeptide chain of human pancreatic stone protein. [3108036]
  • Signal peptide prediction based on analysis of experimentally verified cleavage sites. [15340161]
  • The human reg gene encodes pancreatic stone protein. [2764894]
  • Crystal structure of human lithostathine, the pancreatic inhibitor of stone formation. [8654365]
  • Show more
RNA (Transcript ID: NM_002909.5)
regenerating family member 1 alpha
  • Coding region
DNA (Gene ID: 5967)
regenerating family member 1 alpha
strand +
NCBI CDS gene sequence (501 bp)
NCBI CDS gene sequence with introns (location: 79120862.. 79123215) (2354 bp)Download
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 79120488.. 79123409) (2922 bp)Download
NCBI gene sequence (location: [79120488 - 1000].. 79123409) (3922 bp)Download
How to cite: Schnider B., M'Rad Y., el Ahmadie J., de Brevern AG., Imberty A., Lisacek F., HumanLectome, an update of UniLectin for the annotation and prediction of human lectins, Nucleic Acids Reasearch