HumanLectome - Human Lectin Entry

NCBI Summary

This gene encodes a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. The encoded protein contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeats. The gene product is required for binding and subsequent rolling of leucocytes on endothelial cells, facilitating their migration into secondary lymphoid organs and inflammation sites. Single-nucleotide polymorphisms in this gene have been associated with various diseases including immunoglobulin A nephropathy. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009].

Protein name

L-selectin

Synonym(s)

L-selectin (CD62 antigen-like family member L) (Leukocyte adhesion molecule 1) (LAM-1) (Leukocyte surface antigen Leu-8) (Leukocyte-endothelial cell adhesion molecule 1) (LECAM1) (Lymph node homing receptor) (TQ1) (gp90-MEL) (CD antigen CD62L)

HGNC gene name

SELL

HGNC name

selectin L

Protein_CD_name

CD62L

Lectin confidence

Curated

UniLectin class

C-type lectin

C-type classification

SELL

Known lectin group

C-type - Selectins

Lectin fold

a/b mixed / C-type lectin-like

Glycan specificity

RefSeq accession

Gene ID

UniProt accession

Ensembl protein ID

UniRef cluster ID

LectomeXplore score

0.452

Reference

10.1016/0006-291x(92)90697-j

Other links

neXtProt, PFAM, InterPro, CFG data

Protein sequence and protein families (fasta) (372 amino acids) Download

MIFPWKCQSTQRDLWNIFKLWGWTMLCCDFLAHHGTDCWTYHYSEKPMNWQRARRFCRDNYTDLVAIQNKAEIEYLEKTLPFSRSYYWIGIRKIGGIWTWVGTNKSLTEEAENWGDGEPNNKKNKEDCVEIYIKRNKDAGKWNDDACHKLKAALCYTASCQPWSCSGHGECVEIINNYTCNCDVGYYGPQCQFVIQCEPLEAPELGTMDCTHPLGNFSFSSQCAFSCSEGTNLTGIEETTCGPFGNWSSPEPTCQVIQCEPLSAPDLGIMNCSHPLASFSFTSACTFICSEGTELIGKKKTICESSGIWSNPSPICQKLDKSFSMIKEGDYNPLFIPVAVMVTAFSGLAFIIWLARRLKKGKKSKRSMNDPY

Mol* PDB structure viewerUniLectin3D

Select a PDB entry:

Structural models

AlphaFold v2: AF-P14151-F1 Download

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

AlphaFold_v2 structural model assessment through SWISS-MODEL tools.

Expression

Human Protein Atlas

GeneCards

mRNA expression in normal human tissues for SELL Gene

ProteomicsDB

References

NCBI References (10 PubMed Identifiers)

Circulating ILC precursors expressing CD62L exhibit a type 2 signature distinctly decreased in psoriatic patients. [33728641]

An increase in CD62Ldim neutrophils precedes the development of pulmonary embolisms in COVID-19 patients. [33482019]

L-selectin regulates human neutrophil transendothelial migration. [33408247]

Tumors exploit CXCR4hiCD62Llo aged neutrophils to facilitate metastatic spread. [33537175]

L-Selectin P213S and Integrin Alpha 2 C807T Genetic Polymorphisms in Pediatric Sickle Cell Disease Patients. [32433445]

An endothelial ligand for L-selectin is a novel mucin-like molecule. [1376638]

Cell-cell contact mechanisms. [1375831]

Selectins: a family of adhesion receptors. [1717161]

Structure of the gene encoding the human leukocyte adhesion molecule-1 (TQ1, Leu-8) of lymphocytes and neutrophils. [1692315]

Isolation and chromosomal localization of cDNAs encoding a novel human lymphocyte cell surface molecule, LAM-1. Homology with the mouse lymphocyte homing receptor and other human adhesion proteins. [2473156]

UniProt Main References (13 PubMed Identifiers)

Human homologue of mouse lymph node homing receptor: evolutionary conservation at tandem cell interaction domains. [2664786]

Leu-8/TQ1 is the human equivalent of the Mel-14 lymph node homing receptor. [2509939]

Characterization of a human homologue of the murine peripheral lymph node homing receptor. [2663882]

Complete sequencing and characterization of 21,243 full-length human cDNAs. [14702039]

The DNA sequence and biological annotation of human chromosome 1. [16710414]

Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. [16335952]

Molecular basis of leukocyte rolling on PSGL-1. Predominant role of core-2 O-glycans and of tyrosine sulfate residue 51. [12403782]

Model glycosulfopeptides from P-selectin glycoprotein ligand-1 require tyrosine sulfation and a core 2-branched O-glycan to bind to L-selectin. [12736247]

Endoglycan, a member of the CD34 family of sialomucins, is a ligand for the vascular selectins. [18606703]

Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins. [19349973]

RNA

RNA (Transcript ID: NM_000655.5)

RNA RefSeq ID

NM_000655.5

RNA name

selectin L, transcript variant 1

Isoforms

All isoforms of SELL containing a lectin domain

RNA Ensembl ID

ENST00000236147.6

Coding region

123..1241 (or 169691784.. 169711498)

mRNA location

169690667.. 169711620

NCBI Matured mRNA sequence 2358 NTP Download

m⁷G-5')ppp(5'-GACAUUCAGUGCAGUCUACCUGCAGCACAGCACACUCCCUUUGGGCAAGGACCUGAGACCCUUGUGCUAAGUCAAGAGGCUCAAUGGGCUGCAGAAGAACUAGAGAAGGACCAAGCAAAGCCAUGAUAUUUCCAUGGAAAUGUCAGAGCACCCAGAGGGACUUAUGGAACAUCUUCAAGUUGUGGGGGUGGACAAUGCUCUGUUGUGAUUUCCUGGCACAUCAUGGAACCGACUGCUGGACUUACCAUUAUUCUGAAAAACCCAUGAACUGGCAAAGGGCUAGAAGAUUCUGCCGAGACAAUUACACAGAUUUAGUUGCCAUACAAAACAAGGCGGAAAUUGAGUAUCUGGAGAAGACUCUGCCUUUCAGUCGUUCUUACUACUGGAUAGGAAUCCGGAAGAUAGGAGGAAUAUGGACGUGGGUGGGAACCAACAAAUCUCUUACUGAAGAAGCAGAGAACUGGGGAGAUGGUGAGCCCAACAACAAGAAGAACAAGGAGGACUGCGUGGAGAUCUAUAUCAAGAGAAACAAAGAUGCAGGCAAAUGGAACGAUGACGCCUGCCACAAACUAAAGGCAGCCCUCUGUUACACAGCUUCUUGCCAGCCCUGGUCAUGCAGUGGCCAUGGAGAAUGUGUAGAAAUCAUCAAUAAUUACACCUGCAACUGUGAUGUGGGGUACUAUGGGCCCCAGUGUCAGUUUGUGAUUCAGUGUGAGCCUUUGGAGGCCCCAGAGCUGGGUACCAUGGACUGUACUCACCCUUUGGGAAACUUCAGCUUCAGCUCACAGUGUGCCUUCAGCUGCUCUGAAGGAACAAACUUAACUGGGAUUGAAGAAACCACCUGUGGACCAUUUGGAAACUGGUCAUCUCCAGAACCAACCUGUCAAGUGAUUCAGUGUGAGCCUCUAUCAGCACCAGAUUUGGGGAUCAUGAACUGUAGCCAUCCCCUGGCCAGCUUCAGCUUUACCUCUGCAUGUACCUUCAUCUGCUCAGAAGGAACUGAGUUAAUUGGGAAGAAGAAAACCAUUUGUGAAUCAUCUGGAAUCUGGUCAAAUCCUAGUCCAAUAUGUCAAAAAUUGGACAAAAGUUUCUCAAUGAUUAAGGAGGGUGAUUAUAACCCCCUCUUCAUUCCAGUGGCAGUCAUGGUUACUGCAUUCUCUGGGUUGGCAUUUAUCAUUUGGCUGGCAAGGAGAUUAAAAAAAGGCAAGAAAUCCAAGAGAAGUAUGAAUGACCCAUAUUAAAUCGCCCUUGGUGAAAGAAAAUUCUUGGAAUACUAAAAAUCAUGAGAUCCUUUAAAUCCUUCCAUGAAACGUUUUGUGUGGUGGCACCUCCUACGUCAAACAUGAAGUGUGUUUCCUUCAGUGCAUCUGGGAAGAUUUCUACCUGACCAACAGUUCCUUCAGCUUCCAUUUCGCCCCUCAUUUAUCCCUCAACCCCCAGCCCACAGGUGUUUAUACAGCUCAGCUUUUUGUCUUUUCUGAGGAGAAACAAAUAAGACCAUAAAGGGAAAGGAUUCAUGUGGAAUAUAAAGAUGGCUGACUUUGCUCUUUCUUGACUCUUGUUUUCAGUUUCAAUUCAGUGCUGUACUUGAUGACAGACACUUCUAAAUGAAGUGCAAAUUUGAUACAUAUGUGAAUAUGGACUCAGUUUUCUUGCAGAUCAAAUUUCACGUCGUCUUCUGUAUACUGUGGAGGUACACUCUUAUAGAAAGUUCAAAAAGUCUACGCUCUCCUUUCUUUCUAACUCCAGUGAAGUAAUGGGGUCCUGCUCAAGUUGAAAGAGUCCUAUUUGCACUGUAGCCUCGCCGUCUGUGAAUUGGACCAUCCUAUUUAACUGGCUUCAGCCUCCCCACCUUCUUCAGCCACCUCUCUUUUUCAGUUGGCUGACUUCCACACCUAGCAUCUCAUGAGUGCCAAGCAAAAGGAGAGAAGAGAGAAAUAGCCUGCGCUGUUUUUUAGUUUGGGGGUUUUGCUGUUUCCUUUUAUGAGACCCAUUCCUAUUUCUUAUAGUCAAUGUUUCUUUUAUCACGAUAUUAUUAGUAAGAAAACAUCACUGAAAUGCUAGCUGCAAGUGACAUCUCUUUGAUGUCAUAUGGAAGAGUUAAAACAGGUGGAGAAAUUCCUUGAUUCACAAUGAAAUGCUCUCCUUUCCCCUGCCCCCAGACCUUUUAUCCACUUACCUAGAUUCUACAUAUUCUUUAAAUUUCAUCUCAGGCCUCCCUCAACCCCACCACUUCUUUUAUAACUAGUCCUUUACUAAUCCAACCCAUGAUGAGCUCCUCUUCCUGGCUUCUUACUGAAAGGUUACCCUGUAACAUGCAAUUUUGCAUUUGAAUAAAGCCUGCUUUUUAAGUGUUAA-3'- Poly-A tail

Coding region

NCBI Matured mRNA sequence viewer

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More about the NCBI sViewer.

DNA

DNA (Gene ID: 6402)

HGNC Gene symbol

SELL

HGNC Gene name

selectin L

Chr. RefSeq ID

NC_000001.11

Chromosome N°

1 169691784.. 169711498

CDS location

169691784.. 169711498

DNA strand

strand -

CCDS ID

CCDS53427.1

Mouse ortholog gene

MGI:98279

Gene Variant

ClinVar, dbVar

DNA Ensembl ID

ENSG00000188404

HGNC other symbol

LSEL, LAM1, LAM-1, hLHRc, Leu-8, Lyam-1, PLNHR, CD62L

UCSC ID

uc001ggk.4

GeneBank

INSDC: M25280

GeneCards

10720

MIM

153240

VEGA ID

OTTHUMG00000034809