HumanLectome - Human Lectin Entry

NCBI Summary

This gene encodes a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. The encoded protein contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeats. The gene product is required for binding and subsequent rolling of leucocytes on endothelial cells, facilitating their migration into secondary lymphoid organs and inflammation sites. Single-nucleotide polymorphisms in this gene have been associated with various diseases including immunoglobulin A nephropathy. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009].

Protein name

L-selectin

Synonym(s)

L-selectin (CD62 antigen-like family member L) (Leukocyte adhesion molecule 1) (LAM-1) (Leukocyte surface antigen Leu-8) (Leukocyte-endothelial cell adhesion molecule 1) (LECAM1) (Lymph node homing receptor) (TQ1) (gp90-MEL) (CD antigen CD62L)

HGNC gene name

SELL

HGNC name

selectin L

Protein_CD_name

CD62L

Lectin confidence

Curated

UniLectin class

C-type lectin

C-type classification

SELL

Known lectin group

C-type - Selectins

Lectin fold

a/b mixed / C-type lectin-like

Glycan specificity

RefSeq accession

Gene ID

UniProt accession

Ensembl protein ID

UniRef cluster ID

LectomeXplore score

0.452

Reference

10.1016/0006-291x(92)90697-j

Other links

neXtProt, PFAM, InterPro, CFG data

Protein sequence and protein families (fasta) (372 amino acids) Download

MIFPWKCQSTQRDLWNIFKLWGWTMLCCDFLAHHGTDCWTYHYSEKPMNWQRARRFCRDNYTDLVAIQNKAEIEYLEKTLPFSRSYYWIGIRKIGGIWTWVGTNKSLTEEAENWGDGEPNNKKNKEDCVEIYIKRNKDAGKWNDDACHKLKAALCYTASCQPWSCSGHGECVEIINNYTCNCDVGYYGPQCQFVIQCEPLEAPELGTMDCTHPLGNFSFSSQCAFSCSEGTNLTGIEETTCGPFGNWSSPEPTCQVIQCEPLSAPDLGIMNCSHPLASFSFTSACTFICSEGTELIGKKKTICESSGIWSNPSPICQKLDKSFSMIKEGDYNPLFIPVAVMVTAFSGLAFIIWLARRLKKGKKSKRSMNDPY

Mol* PDB structure viewerUniLectin3D

Select a PDB entry:

Structural models

AlphaFold v2: AF-P14151-F1 Download

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Expression

Human Protein Atlas

GeneCards

mRNA expression in normal human tissues for SELL Gene

ProteomicsDB

References

NCBI References (10 PubMed Identifiers)

Circulating ILC precursors expressing CD62L exhibit a type 2 signature distinctly decreased in psoriatic patients. [33728641]

An increase in CD62Ldim neutrophils precedes the development of pulmonary embolisms in COVID-19 patients. [33482019]

L-selectin regulates human neutrophil transendothelial migration. [33408247]

Tumors exploit CXCR4hiCD62Llo aged neutrophils to facilitate metastatic spread. [33537175]

L-Selectin P213S and Integrin Alpha 2 C807T Genetic Polymorphisms in Pediatric Sickle Cell Disease Patients. [32433445]

An endothelial ligand for L-selectin is a novel mucin-like molecule. [1376638]

Cell-cell contact mechanisms. [1375831]

Selectins: a family of adhesion receptors. [1717161]

Structure of the gene encoding the human leukocyte adhesion molecule-1 (TQ1, Leu-8) of lymphocytes and neutrophils. [1692315]

Isolation and chromosomal localization of cDNAs encoding a novel human lymphocyte cell surface molecule, LAM-1. Homology with the mouse lymphocyte homing receptor and other human adhesion proteins. [2473156]

UniProt Main References (13 PubMed Identifiers)

Human homologue of mouse lymph node homing receptor: evolutionary conservation at tandem cell interaction domains. [2664786]

Leu-8/TQ1 is the human equivalent of the Mel-14 lymph node homing receptor. [2509939]

Characterization of a human homologue of the murine peripheral lymph node homing receptor. [2663882]

Complete sequencing and characterization of 21,243 full-length human cDNAs. [14702039]

The DNA sequence and biological annotation of human chromosome 1. [16710414]

Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. [16335952]

Molecular basis of leukocyte rolling on PSGL-1. Predominant role of core-2 O-glycans and of tyrosine sulfate residue 51. [12403782]

Model glycosulfopeptides from P-selectin glycoprotein ligand-1 require tyrosine sulfation and a core 2-branched O-glycan to bind to L-selectin. [12736247]

Endoglycan, a member of the CD34 family of sialomucins, is a ligand for the vascular selectins. [18606703]

Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins. [19349973]

RNA

RNA (Transcript ID: NM_000655.5)

RNA RefSeq ID

NM_000655.5

RNA name

selectin L, transcript variant 1

Isoforms

All isoforms of SELL containing a lectin domain

RNA Ensembl ID

ENST00000236147.6

Coding region

123..1241 (or 169691784.. 169711498)

mRNA location

169690667.. 169711620

NCBI Matured mRNA sequence 2358 NTP Download

m⁷G-5')ppp(5'-GACAUUCAGUGCAGUCUACCUGCAGCACAGCACACUCCCUUUGGGCAAGGACCUGAGACCCUUGUGCUAAGUCAAGAGGCUCAAUGGGCUGCAGAAGAACUAGAGAAGGACCAAGCAAAGCCAUGAUAUUUCCAUGGAAAUGUCAGAGCACCCAGAGGGACUUAUGGAACAUCUUCAAGUUGUGGGGGUGGACAAUGCUCUGUUGUGAUUUCCUGGCACAUCAUGGAACCGACUGCUGGACUUACCAUUAUUCUGAAAAACCCAUGAACUGGCAAAGGGCUAGAAGAUUCUGCCGAGACAAUUACACAGAUUUAGUUGCCAUACAAAACAAGGCGGAAAUUGAGUAUCUGGAGAAGACUCUGCCUUUCAGUCGUUCUUACUACUGGAUAGGAAUCCGGAAGAUAGGAGGAAUAUGGACGUGGGUGGGAACCAACAAAUCUCUUACUGAAGAAGCAGAGAACUGGGGAGAUGGUGAGCCCAACAACAAGAAGAACAAGGAGGACUGCGUGGAGAUCUAUAUCAAGAGAAACAAAGAUGCAGGCAAAUGGAACGAUGACGCCUGCCACAAACUAAAGGCAGCCCUCUGUUACACAGCUUCUUGCCAGCCCUGGUCAUGCAGUGGCCAUGGAGAAUGUGUAGAAAUCAUCAAUAAUUACACCUGCAACUGUGAUGUGGGGUACUAUGGGCCCCAGUGUCAGUUUGUGAUUCAGUGUGAGCCUUUGGAGGCCCCAGAGCUGGGUACCAUGGACUGUACUCACCCUUUGGGAAACUUCAGCUUCAGCUCACAGUGUGCCUUCAGCUGCUCUGAAGGAACAAACUUAACUGGGAUUGAAGAAACCACCUGUGGACCAUUUGGAAACUGGUCAUCUCCAGAACCAACCUGUCAAGUGAUUCAGUGUGAGCCUCUAUCAGCACCAGAUUUGGGGAUCAUGAACUGUAGCCAUCCCCUGGCCAGCUUCAGCUUUACCUCUGCAUGUACCUUCAUCUGCUCAGAAGGAACUGAGUUAAUUGGGAAGAAGAAAACCAUUUGUGAAUCAUCUGGAAUCUGGUCAAAUCCUAGUCCAAUAUGUCAAAAAUUGGACAAAAGUUUCUCAAUGAUUAAGGAGGGUGAUUAUAACCCCCUCUUCAUUCCAGUGGCAGUCAUGGUUACUGCAUUCUCUGGGUUGGCAUUUAUCAUUUGGCUGGCAAGGAGAUUAAAAAAAGGCAAGAAAUCCAAGAGAAGUAUGAAUGACCCAUAUUAAAUCGCCCUUGGUGAAAGAAAAUUCUUGGAAUACUAAAAAUCAUGAGAUCCUUUAAAUCCUUCCAUGAAACGUUUUGUGUGGUGGCACCUCCUACGUCAAACAUGAAGUGUGUUUCCUUCAGUGCAUCUGGGAAGAUUUCUACCUGACCAACAGUUCCUUCAGCUUCCAUUUCGCCCCUCAUUUAUCCCUCAACCCCCAGCCCACAGGUGUUUAUACAGCUCAGCUUUUUGUCUUUUCUGAGGAGAAACAAAUAAGACCAUAAAGGGAAAGGAUUCAUGUGGAAUAUAAAGAUGGCUGACUUUGCUCUUUCUUGACUCUUGUUUUCAGUUUCAAUUCAGUGCUGUACUUGAUGACAGACACUUCUAAAUGAAGUGCAAAUUUGAUACAUAUGUGAAUAUGGACUCAGUUUUCUUGCAGAUCAAAUUUCACGUCGUCUUCUGUAUACUGUGGAGGUACACUCUUAUAGAAAGUUCAAAAAGUCUACGCUCUCCUUUCUUUCUAACUCCAGUGAAGUAAUGGGGUCCUGCUCAAGUUGAAAGAGUCCUAUUUGCACUGUAGCCUCGCCGUCUGUGAAUUGGACCAUCCUAUUUAACUGGCUUCAGCCUCCCCACCUUCUUCAGCCACCUCUCUUUUUCAGUUGGCUGACUUCCACACCUAGCAUCUCAUGAGUGCCAAGCAAAAGGAGAGAAGAGAGAAAUAGCCUGCGCUGUUUUUUAGUUUGGGGGUUUUGCUGUUUCCUUUUAUGAGACCCAUUCCUAUUUCUUAUAGUCAAUGUUUCUUUUAUCACGAUAUUAUUAGUAAGAAAACAUCACUGAAAUGCUAGCUGCAAGUGACAUCUCUUUGAUGUCAUAUGGAAGAGUUAAAACAGGUGGAGAAAUUCCUUGAUUCACAAUGAAAUGCUCUCCUUUCCCCUGCCCCCAGACCUUUUAUCCACUUACCUAGAUUCUACAUAUUCUUUAAAUUUCAUCUCAGGCCUCCCUCAACCCCACCACUUCUUUUAUAACUAGUCCUUUACUAAUCCAACCCAUGAUGAGCUCCUCUUCCUGGCUUCUUACUGAAAGGUUACCCUGUAACAUGCAAUUUUGCAUUUGAAUAAAGCCUGCUUUUUAAGUGUUAA-3'- Poly-A tail

Coding region

NCBI Matured mRNA sequence viewer

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More about the NCBI sViewer.

DNA

DNA (Gene ID: 6402)

HGNC Gene symbol

SELL

HGNC Gene name

selectin L

Chr. RefSeq ID

NC_000001.11

Chromosome N°

1 169691784.. 169711498

CDS location

169691784.. 169711498

DNA strand

strand -

CCDS ID

CCDS53427.1

Mouse ortholog gene

MGI:98279

Gene Variant

ClinVar, dbVar

DNA Ensembl ID

ENSG00000188404

HGNC other symbol

LSEL, LAM1, LAM-1, hLHRc, Leu-8, Lyam-1, PLNHR, CD62L

UCSC ID

uc001ggk.4

GeneBank

INSDC: M25280

GeneCards

10720

MIM

153240

VEGA ID

OTTHUMG00000034809

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