HumanLectome - Human Lectin Entry

NCBI Summary

The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions. The encoded protein contains a peptide that displays potent antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria, and fungi. It is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic diseases. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014].

Protein name

Bone marrow proteoglycan 2

Synonym(s)

Bone marrow proteoglycan (BMPG) (Proteoglycan 2) [Cleaved into: Eosinophil granule major basic protein (EMBP) (MBP) (Pregnancy-associated major basic protein)]

HGNC gene name

PRG2

HGNC name

proteoglycan 2, pro eosinophil major basic protein

Protein_CD_name

Undefined

Lectin confidence

Curated

UniLectin class

C-type lectin

C-type classification

Undefined

Known lectin group

C-type - CTLD/acidic neck

Lectin fold

a/b mixed / C-type lectin-like

Glycan specificity

Heparin

RefSeq accession

Gene ID

UniProt accession

Ensembl protein ID

UniRef cluster ID

LectomeXplore score

0.258

Reference

10.1021/bi051112b

Other links

neXtProt, PFAM, InterPro

Protein sequence and protein families (fasta) (222 amino acids) Download

MKLPLLLALLFGAVSALHLRSETSTFETPLGAKTLPEDEETPEQEMEETPCRELEEEEEWGSGSEDASKKDGAVESISVPDMVDKNLTCPEEEDTVKVVGIPGCQTCRYLLVRSLQTFSQAWFTCRRCYRGNLVSIHNFNINYRIQCSVSALNQGQVWIGGRITGSGRCRRFQWVDGSRWNFAYWAAHQPWSRGGHCVALCTRGGHWRRAHCLRRLPFICSY

Mol* PDB structure viewerUniLectin3D

Select a PDB entry:

Structural models

AlphaFold v2: AF-P13727-F1 Download

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Expression

Human Protein Atlas

GeneCards

mRNA expression in normal human tissues for PRG2 Gene

ProteomicsDB

References

NCBI References (10 PubMed Identifiers)

Development and application of novel immunoassays for eosinophil granule major basic proteins to evaluate eosinophilia and myeloproliferative disorders. [33689807]

Mechanism of atopic cataract caused by eosinophil granule major basic protein. [31595373]

Re-Expression of Bone Marrow Proteoglycan-2 by 5-Azacytidine is associated with STAT3 Inactivation and SensitivityResponse to Imatinib in Resistant CML Cells [29936783]

Proteomic characterization of human multiple myeloma bone marrow extracellular matrix. [28344315]

Toxicity of eosinophil MBP is repressed by intracellular crystallization and promoted by extracellular aggregation. [25728769]

Purification and cDNA cloning of a novel factor produced by a human T-cell hybridoma: sequence homology with animal lectins. [1565101]

Cloning and sequence analysis of the human gene encoding eosinophil major basic protein. [2323577]

Antibiotic proteins of human polymorphonuclear leukocytes. [2501794]

Isolation of a complementary DNA clone encoding a precursor to human eosinophil major basic protein. [3199069]

Localization of somatostatin-like immunoreactivity in the pancreatic islets of the hagfish, Myxine glutinosa and the lamprey Lampetra fluviatilis. [319906]

UniProt Main References (21 PubMed Identifiers)

Acidic precursor revealed in human eosinophil granule major basic protein cDNA. [3171483]

Human eosinophil major basic protein, a mediator of allergic inflammation, is expressed by alternative splicing from two promoters. [7531438]

Complete sequencing and characterization of 21,243 full-length human cDNAs. [14702039]

Human chromosome 11 DNA sequence and analysis including novel gene identification. [16554811]

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]

Pro-major basic protein has three types of sugar chains at the pro-portion. [8507662]

Circulating human pregnancy-associated plasma protein-A is disulfide-bridged to the proform of eosinophil major basic protein. [7685339]

Identification of angiotensinogen and complement C3dg as novel proteins binding the proform of eosinophil major basic protein in human pregnancy serum and plasma. [7539791]

Biochemical and amino acid sequence analysis of human eosinophil granule major basic protein. [3410852]

Eosinophil granule cationic proteins: major basic protein is distinct from the smaller subunit of eosinophil peroxidase. [3422083]

All isoforms of this gene containing a lectin domain

NP_001289855.1, NP_001289856.1, NP_002719.3, NP_001230174.1

RNA

RNA (Transcript ID: NM_002728.6)

RNA RefSeq ID

NM_002728.6

RNA name

proteoglycan 2, pro eosinophil major basic protein, transcript variant 1

Isoforms

All isoforms of PRG2 containing a lectin domain

RNA Ensembl ID

ENST00000311862.10

Coding region

68..736 (or 57387475.. 57389944)

mRNA location

57386780.. 57390650

NCBI Matured mRNA sequence 1431 NTP Download

m⁷G-5')ppp(5'-AAAGAAGGACCUGGGCUUUGGGAAGAUCUAAAGACCCAGGAAGGUCUCUGGGUGGGAUAAAGCCAAGAUGAAACUCCCCUUACUUCUGGCUCUUCUAUUUGGGGCAGUUUCUGCUCUUCAUCUAAGGUCUGAGACUUCCACCUUUGAGACCCCUUUGGGUGCUAAGACGCUGCCUGAGGAUGAGGAGACACCAGAGCAGGAGAUGGAGGAGACCCCUUGCAGGGAGCUGGAGGAAGAGGAGGAGUGGGGCUCUGGAAGUGAAGAUGCCUCCAAGAAAGAUGGGGCUGUUGAGUCUAUCUCAGUGCCAGAUAUGGUGGACAAAAACCUUACGUGUCCUGAGGAAGAGGACACAGUAAAAGUGGUGGGCAUCCCUGGGUGCCAGACCUGCCGCUACCUCCUGGUGAGAAGUCUUCAGACGUUUAGUCAAGCUUGGUUUACUUGCCGGAGGUGCUACAGGGGCAACCUGGUUUCCAUCCACAACUUCAAUAUUAAUUAUCGAAUCCAGUGUUCUGUCAGCGCGCUCAACCAGGGUCAAGUCUGGAUUGGAGGCAGGAUCACAGGCUCGGGUCGCUGCAGACGCUUUCAGUGGGUUGACGGCAGCCGCUGGAACUUUGCAUACUGGGCUGCUCACCAGCCCUGGUCCCGCGGUGGUCACUGCGUGGCCCUGUGUACCCGAGGAGGCCACUGGCGUCGAGCCCACUGCCUCAGAAGACUUCCUUUCAUCUGUUCCUACUGAGCUGGUCCCAGCCAGCAGUUCAGAGCUGCCCUCUCCUGGGCAGCUGCCUCCCCUCCUCUGCUUGCCAUCCCUCCCUCCACCUCCCUGCAAUAAAAUGGGUUUUACUGAAAUGGAUUUAUUUUCUCCUCUGAUCGCGGAUCCACUCUGCUUAGCCCUCAUUGAAACUUCUUCCUUAUCAUCUCUCCCCACACCACAACUUUCAUAGAAGUGUCAGAAGCUACUACUCCUUGAGGAGGAGGAUGGAGGGUGGAGUUGGGUCUAUGGAGCCUUUUGGAGAUGGAGGAAUGGGCUCAGCUAGUUCUCUUCAUAGAACACCUGAUUACUGGGCACCUGCAUAGUGCUGCCAGGACCUUUCAAGGUUGUAGGUAGACUCCCAAUGGCCCAGUUUGCAUCUCUGUAACCAAAGGCCUUUUCUCUCUCUCUCUCCAACCCCAGAACUGUGGUUGGUUUUAUAUGUAAGGAAGUUAACAUGUCCCUGGGAACAGUCCACAACAUUCAGGAAUGAAUGUAUAAGUACCGCAAUCCCCGGCCCCUCAAGUGGAAUAAAUCUAACAUGUAUUGGGCACCAUUUCCCAGUGGCCUGCUGUGGUAGUUGGCCUUAUUCCAUGCAUUUUUAUGGGCUGCCUUCCCUUCCUCAACUGCAUUCUCUGCUCCUUCCUACUCUCUGCAACUCCCAAAUAAACACUUGUACGCAA-3'- Poly-A tail

Coding region

NCBI Matured mRNA sequence viewer

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More about the NCBI sViewer.

DNA

DNA (Gene ID: 5553)

HGNC Gene symbol

PRG2

HGNC Gene name

proteoglycan 2, pro eosinophil major basic protein

Chr. RefSeq ID

NC_000011.10

Chromosome N°

11 57387475.. 57389944

CDS location

57387475.. 57389944

DNA strand

strand -

CCDS ID

CCDS7955.1

Mouse ortholog gene

MGI:103294

Gene Variant

ClinVar, dbVar

DNA Ensembl ID

ENSG00000186652

HGNC other symbol

MBP, BMPG, proMBP

UCSC ID

uc001nkc.4

GeneBank

INSDC: BC005929

GeneCards

9362

MIM

605601

VEGA ID

OTTHUMG00000167027

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