HumanLectome - Human Lectin Entry

NCBI Summary

This gene encodes a pancreatic secretory protein that may be involved in cell proliferation or differentiation. It has similarity to the C-type lectin superfamily. The enhanced expression of this gene is observed during pancreatic inflammation and liver carcinogenesis. The mature protein also functions as an antimicrobial protein with antibacterial activity. Alternate splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, Nov 2014].

Protein name

HIP - PAP Regenerating family member 3 alpha

Synonym(s)

Regenerating islet-derived protein 3-alpha (REG-3-alpha) (Hepatointestinal pancreatic protein) (HIP/PAP) (Human proislet peptide) (Pancreatitis-associated protein 1) (Regenerating islet-derived protein III-alpha) (Reg III-alpha) [Cleaved into: Regenerating islet-derived protein 3-alpha 16.5 kDa form; Regenerating islet-derived protein 3-alpha 15 kDa form]

HGNC gene name

REG3A

HGNC name

regenerating family member 3 alpha

Protein_CD_name

Undefined

Lectin confidence

Curated

UniLectin class

C-type lectin

C-type classification

REG3A

Known lectin group

C-type - Free C-type Lectin Domains CTLDs

Lectin fold

a/b mixed / C-type lectin-like

Glycan specificity

Chitin / peptidoglycan

RefSeq accession

Gene ID

UniProt accession

Ensembl protein ID

UniRef cluster ID

LectomeXplore score

0.345

Reference

10.1126/science.1127119

Other links

neXtProt, PFAM, InterPro

Protein sequence and protein families (fasta) (175 amino acids) Download

MLPPMALPSVSWMLLSCLMLLSQVQGEEPQRELPSARIRCPKGSKAYGSHCYALFLSPKSWTDADLACQKRPSGNLVSVLSGAEGSFVSSLVKSIGNSYSYVWIGLHDPTQGTEPNGEGWEWSSSDVMNYFAWERNPSTISSPGHCASLSRSTAFLRWKDYNCNVRLPYVCKFTD

Mol* PDB structure viewerUniLectin3D

Select a PDB entry:

Structural models

AlphaFold v2: AF-Q06141-F1 Download

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Expression

Human Protein Atlas

GeneCards

mRNA expression in normal human tissues for REG3A Gene

ProteomicsDB

References

NCBI References (10 PubMed Identifiers)

Secretome screening reveals immunomodulating functions of IFNalpha-7, PAP and GDF-7 on regulatory T-cells. [34408239]

REG3A/REG3B promotes acinar to ductal metaplasia through binding to EXTL3 and activating the RAS-RAF-MEK-ERK signaling pathway. [34099862]

Myocardial Accumulations of Reg3A, Reg3gamma and Oncostatin M Are Associated with the Formation of Granulomata in Patients with Cardiac Sarcoidosis. [33923774]

Symbiotic bacteria direct expression of an intestinal bactericidal lectin. [16931762]

The human pancreatitis-associated protein (PAP)-encoding gene generates multiple transcripts through alternative use of 5' exons. [7721106]

Structural organization and chromosomal localization of a human gene (HIP/PAP) encoding a C-type lectin overexpressed in primary liver cancer. [8076648]

Molecular cloning, genomic organization, and chromosomal localization of the human pancreatitis-associated protein (PAP) gene. [8188210]

Cloning and tissue-specific expression of cDNAs for the human and mouse homologues of rat pancreatitis-associated protein (PAP). [7679928]

Human pancreatitis-associated protein. Messenger RNA cloning and expression in pancreatic diseases. [1469087]

A novel gene (HIP) activated in human primary liver cancer. [1325291]

UniProt Main References (4 PubMed Identifiers)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]

Proteolytic activation of human pancreatitis-associated protein is required for peptidoglycan binding and bacterial aggregation. [19254208]

The antimicrobial protein REG3A regulates keratinocyte proliferation and differentiation after skin injury. [22727489]

Molecular basis for peptidoglycan recognition by a bactericidal lectin. [20382864]

All isoforms of this gene containing a lectin domain

NP_002571.1, NP_620354.1, NP_620355.1

RNA

RNA (Transcript ID: NM_002580.3)

RNA RefSeq ID

NM_002580.3

RNA name

regenerating family member 3 alpha, transcript variant 1

Isoforms

All isoforms of REG3A containing a lectin domain

RNA Ensembl ID

ENST00000305165.3

Coding region

61..588 (or 79157226.. 79159405)

mRNA location

79157006.. 79159753

NCBI Matured mRNA sequence 808 NTP Download

m⁷G-5')ppp(5'-AAACCAUACCAUAUCCCACCAGAGAGUGACUCCUGAUUGCCUCCUCAAGUCGCAGACACUAUGCUGCCUCCCAUGGCCCUGCCCAGUGUAUCUUGGAUGCUGCUUUCCUGCCUCAUGCUGCUGUCUCAGGUUCAAGGUGAAGAACCCCAGAGGGAACUGCCCUCUGCACGGAUCCGCUGUCCCAAAGGCUCCAAGGCCUAUGGCUCCCACUGCUAUGCCUUGUUUUUGUCACCAAAAUCCUGGACAGAUGCAGAUCUGGCCUGCCAGAAGCGGCCCUCUGGAAACCUGGUGUCUGUGCUCAGUGGGGCUGAGGGAUCCUUCGUGUCCUCCCUGGUGAAGAGCAUUGGUAACAGCUACUCAUACGUCUGGAUUGGGCUCCAUGACCCCACACAGGGCACCGAGCCCAAUGGAGAAGGUUGGGAGUGGAGUAGCAGUGAUGUGAUGAAUUACUUUGCAUGGGAGAGAAAUCCCUCCACCAUCUCAAGCCCCGGCCACUGUGCGAGCCUGUCGAGAAGCACAGCAUUUCUGAGGUGGAAAGAUUAUAACUGUAAUGUGAGGUUACCCUAUGUCUGCAAGUUCACUGACUAGUGCAGGAGGGAAGUCAGCAGCCUGUGUUUGGUGUGCAACUCAUCAUGGGCAUGAGACCAGUGUGAGGACUCACCCUGGAAGAGAAUAUUCGCUUAAUUCCCCCAACCUGACCACCUCAUUCUUAUCUUUCUUCUGUUUCUUCCUCCCCGCUGUCAUUUCAGUCUCUUCAUUUUGUCAUACGGCCUAAGGCUUUAAAGAGCAAUAAAAUUUUUAGUCUGCA-3'- Poly-A tail

Coding region

NCBI Matured mRNA sequence viewer

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More about the NCBI sViewer.

DNA

DNA (Gene ID: 5068)

HGNC Gene symbol

REG3A

HGNC Gene name

regenerating family member 3 alpha

Chr. RefSeq ID

NC_000002.12

Chromosome N°

2 79157226.. 79159405

CDS location

79157226.. 79159405

DNA strand

strand -

CCDS ID

CCDS1965.1

Mouse ortholog gene

MGI:109408;MGI:97478

Gene Variant

ClinVar, dbVar

DNA Ensembl ID

ENSG00000172016

HGNC other symbol

HIP, REG-III, REG3, PBCGF, PAP1

UCSC ID

uc002sof.3

GeneBank

INSDC: S51768

GeneCards

8601

MIM

167805

VEGA ID

OTTHUMG00000130017

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