NCBI Summary
The protein encoded by this gene is a type I membrane protein and member of the immunoglobulin superfamily. It is thought to be involved in the process of myelination. It is a lectin that binds to sialylated glycoconjugates and mediates certain myelin-neuron cell-cell interactions. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2010].
Protein
Protein (NP_002352)
SIGLEC-4
Myelin-associated glycoprotein (Siglec-4a)
MAG
myelin associated glycoprotein
Undefined
Curated
I-type lectin
I-Type Lectins - Siglecs common to mammals
b-sandwich / Ig-like
NeuAc / Neu5Ac(a2-3)Gal(b1-3)GalNAc
NP_002352
4099
P20916
ENSP00000376048.2
P20916
0.846
10.1146/annurev-immunol-102419-035900
neXtProt, PFAM, InterPro
Protein sequence and protein families (fasta) (626 amino acids) Download
MIFLTALPLFWIMISASRGGHWGAWMPSSISAFEGTCVSIPCRFDFPDELRPAVVHGVWYFNSPYPKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFRGDLGGYNQYTFSEHSVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTSILTLRGQAQAPPRVICTARNLYGAKSLELPFQGAHRLMWAKIGPVGAVVAFAILIAIVCYITQTRRKKNVTESPSFSAGDNPPVLFSSDFRISGAPEKYESERRLGSERRLLGLRGEPPELDLSYSHSDLGKRPTKDSYTLTEELAEYAEIRVK
No structure currently available in the PDB RCSB Databank.
Structural models
AlphaFold v2: AF-P20916-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

SWISS-MODEL structural models
SWISS-MODEL structural model
Modeller structural model (Homology modelling pipeline), Error: [0.28, 0.77] ÅDownload
The location of the lectin domain structural model is: 20-139
We infer [0.28, 0.77] Å as the interval of error of this structural model.
Template 1: 5LFR chain: A, P20917, NP_001333015.1, sequence identity: 97.5%, coverage: 100.0%, location in sequence: 19-331, (19-331 in PDB).
Template 2: 6D4A chain: B, P20138, NP_001763.3, sequence identity: 30.0%, coverage: 98.3%, location in sequence: 18-141, (18-141 in PDB).
Template 3: 2G5R chain: A, Q9Y286, NP_055200.1, sequence identity: 29.2%, coverage: 98.3%, location in sequence: 24-144, (24-144 in PDB).
Show the alignment used for the construction of the structural model, Download.
Show the plot of DOPE energy score, Download.
Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for MAG Gene
ProteomicsDB
References
NCBI References (10 PubMed Identifiers)
  • Recessive null-allele variants in MAG associated with spastic ataxia, nystagmus, neuropathy, and dystonia. [32629324]
  • Clinical and laboratory features of anti-MAG neuropathy without monoclonal gammopathy. [30992531]
  • Association between abnormal serum myelin-specific protein levels and white matter integrity in first-episode and drug-naive patients with major depressive disorder. [29477585]
  • Myelin-associated glycoprotein gene mutation causes Pelizaeus-Merzbacher disease-like disorder. [26179919]
  • Heterogeneity of Polyneuropathy Associated with Anti-MAG Antibodies. [26065001]
  • Molecular cloning of human myelin-associated glycoprotein. [2479762]
  • cDNA cloning and amino acid sequence for human myelin-associated glycoprotein. [2476987]
  • Myelin-associated glycoprotein in demyelinating disorders. [2475262]
  • The myelin-associated glycoprotein gene: mapping to human chromosome 19 and mouse chromosome 7 and expression in quivering mice. [2447011]
  • Characterization of binding properties of the myelin-associated glycoprotein to extracellular matrix constituents. [2446864]
UniProt Main References (9 PubMed Identifiers)
  • Complete sequencing and characterization of 21,243 full-length human cDNAs. [14702039]
  • The DNA sequence and biology of human chromosome 19. [15057824]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
  • Reciprocal expression of myelin-associated glycoprotein splice variants in the adult human peripheral and central nervous systems. [9495552]
  • Myelin-associated glycoprotein (MAG) distribution in human central nervous tissue studied immunocytochemically with monoclonal antibody. [6200494]
  • Identification of the glycosylated sequons of human myelin-associated glycoprotein. [7505568]
  • Genetic variants of Nogo-66 receptor with possible association to schizophrenia block myelin inhibition of axon growth. [19052207]
  • Exome sequencing links corticospinal motor neuron disease to common neurodegenerative disorders. [24482476]
  • Neurologic syndrome associated with homozygous mutation at MAG sialic acid binding site. [27606346]
All isoforms of this gene containing a lectin domain
NP_542167.1, NP_002352.1, NP_001186145.1
RNA
RNA (Transcript ID: NM_002361.4)
NM_002361.4
myelin associated glycoprotein, transcript variant 1
All isoforms of MAG containing a lectin domain
ENST00000392213.8
124..2004 (or 35295409.. 35313454)
35292161.. 35313807
NCBI Matured mRNA sequence 2357 NTPDownload 
m7G-5')ppp(5'-GAGCUGGGCUGGCGGAGCAGAGGUGCAGAAGCAACUGAGUCCAAGUUGUCUGGCGGCUUCAGGUGGACCCAGAAGACGUCCCCAACUCAGGGAGAUUCAGCGAUCACUCACUCGCUGUACAGAAUGAUAUUCCUCACGGCACUGCCUCUGUUCUGGAUUAUGAUUUCAGCCUCCCGAGGGGGUCACUGGGGUGCCUGGAUGCCCUCGUCCAUCUCGGCCUUCGAAGGCACGUGCGUCUCCAUCCCCUGCCGCUUUGACUUCCCGGAUGAGCUGCGGCCCGCUGUGGUGCAUGGUGUCUGGUACUUCAAUAGCCCCUACCCCAAGAACUACCCCCCGGUGGUCUUCAAGUCGCGCACCCAAGUAGUCCACGAGAGCUUCCAGGGCCGCAGCCGCCUCCUGGGGGACCUGGGCCUGCGAAACUGCACCCUCCUGCUCAGCAACGUCAGCCCCGAGCUGGGCGGGAAGUACUACUUCCGUGGGGACCUGGGCGGCUACAACCAGUACACCUUCUCAGAGCACAGCGUCCUGGAUAUCGUCAACACCCCCAACAUCGUGGUGCCCCCAGAGGUGGUGGCAGGCACGGAGGUGGAGGUCAGCUGCAUGGUGCCGGACAACUGCCCAGAGCUGCGCCCUGAGCUGAGCUGGCUGGGCCACGAGGGGCUGGGGGAGCCCGCUGUGCUGGGCCGGCUGCGGGAGGACGAGGGCACCUGGGUGCAGGUGUCACUGCUGCACUUCGUGCCCACGAGGGAGGCCAACGGCCACAGGCUGGGCUGCCAGGCCUCCUUCCCCAACACCACCCUGCAGUUCGAGGGCUACGCCAGCAUGGACGUCAAGUACCCCCCGGUGAUUGUGGAGAUGAACUCCUCGGUGGAGGCCAUCGAGGGCUCCCACGUGAGCCUGCUCUGUGGGGCUGACAGCAACCCCCCGCCGCUGCUGACCUGGAUGCGGGACGGGACAGUCCUCCGGGAGGCGGUGGCCGAGAGCCUGCUCCUGGAGCUGGAGGAGGUGACCCCCGCCGAAGACGGCGUCUAUGCCUGCCUGGCCGAGAAUGCCUAUGGCCAGGACAACCGCACCGUGGGGCUCAGUGUCAUGUAUGCACCCUGGAAGCCAACAGUGAACGGGACAAUGGUGGCCGUAGAGGGGGAGACGGUCUCUAUCUUGUGCUCCACACAGAGCAACCCGGACCCUAUUCUCACCAUCUUCAAGGAGAAGCAGAUCCUGUCCACGGUCAUCUACGAGAGCGAGCUGCAGCUGGAGCUGCCGGCCGUGUCACCCGAGGAUGAUGGAGAGUACUGGUGUGUGGCUGAGAACCAGUAUGGCCAGAGGGCCACCGCCUUCAACCUGUCUGUGGAGUUCGCCCCUGUGCUCCUCCUGGAGUCCCACUGCGCGGCAGCCCGAGACACGGUGCAGUGCCUGUGCGUGGUGAAGUCCAACCCGGAGCCGUCCGUGGCCUUUGAGCUGCCAUCGCGCAAUGUGACCGUGAACGAGAGCGAGCGGGAGUUCGUGUACUCGGAGCGCAGCGGCCUCGUGCUCACCAGCAUCCUCACGCUGCGGGGGCAGGCCCAGGCCCCGCCCCGCGUCAUCUGCACCGCGAGGAACCUCUAUGGCGCCAAGAGCCUGGAGCUGCCCUUCCAGGGAGCCCAUCGACUGAUGUGGGCCAAGAUCGGGCCUGUGGGCGCCGUGGUCGCCUUUGCCAUCCUGAUUGCCAUCGUCUGCUACAUUACCCAGACACGCAGGAAAAAGAACGUGACAGAGAGCCCCAGCUUCUCGGCAGGGGACAACCCUCCCGUCCUGUUCAGCAGCGACUUCCGCAUCUCUGGGGCACCAGAGAAGUACGAGAGCGAGAGGCGCCUGGGAUCUGAGAGGAGGCUGCUGGGCCUUCGGGGUGAGCCCCCAGAGCUGGACCUGAGCUAUUCUCACUCGGACCUGGGGAAACGGCCCACCAAGGACAGCUACACGCUGACGGAGGAGCUAGCUGAGUAUGCUGAAAUCCGGGUCAAGUGAAGGAGCUGGGGGCAGCCUGCGUGGCUGACCCCCCUCAGGACCCUCGCUGGCCCCCACUGGCUGUGGGCUCCCUUCCUCCCAAAAGUAUCGGGGGCUGGGGCAGGAGGGGAGUGAGGCAGGUGACAGUGAGGUCCUGGGGGCCUGACCUCCCCCUCCUUCCCAGCUGCCCCUCCCUGCCAGCACCCCCACGCCCUCAUUACGGCUCCUCUCUAACCUCCUUUACCCUCAUCUGUCUGGAGGGGAGCUCUGUCUGUCCGUGUUAUUUAUUGCUACUUCCUGCCUGGUCUCCUGCCCCCACACCUGGCCCUGGGGCCUGUACAAAAGGGACAUGAAAUAAAUGCCCCAAAGCCAAA-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
;
More about the NCBI sViewer.
DNA
DNA (Gene ID: 4099)
MAG
myelin associated glycoprotein
NC_000019.10
19  35295409.. 35313454
35295409.. 35313454
strand +
CCDS12455.1
MGI:96912
ClinVar, dbVar
ENSG00000105695
SIGLEC4A, SIGLEC-4A, S-MAG
uc002nyy.3
INSDC: M29273
6783
159460
OTTHUMG00000183296
ENA, DDBJ, Monarch
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (1881 bp)
5'-ATGATATTCCTCACGGCACTGCCTCTGTTCTGGATTATGATTTCAGCCTCCCGAGGGGGTCACTGGGGTGCCTGGATGCCCTCGTCCATCTCGGCCTTCGAAGGCACGTGCGTCTCCATCCCCTGCCGCTTTGACTTCCCGGATGAGCTGCGGCCCGCTGTGGTGCATGGTGTCTGGTACTTCAATAGCCCCTACCCCAAGAACTACCCCCCGGTGGTCTTCAAGTCGCGCACCCAAGTAGTCCACGAGAGCTTCCAGGGCCGCAGCCGCCTCCTGGGGGACCTGGGCCTGCGAAACTGCACCCTCCTGCTCAGCAACGTCAGCCCCGAGCTGGGCGGGAAGTACTACTTCCGTGGGGACCTGGGCGGCTACAACCAGTACACCTTCTCAGAGCACAGCGTCCTGGATATCGTCAACACCCCCAACATCGTGGTGCCCCCAGAGGTGGTGGCAGGCACGGAGGTGGAGGTCAGCTGCATGGTGCCGGACAACTGCCCAGAGCTGCGCCCTGAGCTGAGCTGGCTGGGCCACGAGGGGCTGGGGGAGCCCGCTGTGCTGGGCCGGCTGCGGGAGGACGAGGGCACCTGGGTGCAGGTGTCACTGCTGCACTTCGTGCCCACGAGGGAGGCCAACGGCCACAGGCTGGGCTGCCAGGCCTCCTTCCCCAACACCACCCTGCAGTTCGAGGGCTACGCCAGCATGGACGTCAAGTACCCCCCGGTGATTGTGGAGATGAACTCCTCGGTGGAGGCCATCGAGGGCTCCCACGTGAGCCTGCTCTGTGGGGCTGACAGCAACCCCCCGCCGCTGCTGACCTGGATGCGGGACGGGACAGTCCTCCGGGAGGCGGTGGCCGAGAGCCTGCTCCTGGAGCTGGAGGAGGTGACCCCCGCCGAAGACGGCGTCTATGCCTGCCTGGCCGAGAATGCCTATGGCCAGGACAACCGCACCGTGGGGCTCAGTGTCATGTATGCACCCTGGAAGCCAACAGTGAACGGGACAATGGTGGCCGTAGAGGGGGAGACGGTCTCTATCTTGTGCTCCACACAGAGCAACCCGGACCCTATTCTCACCATCTTCAAGGAGAAGCAGATCCTGTCCACGGTCATCTACGAGAGCGAGCTGCAGCTGGAGCTGCCGGCCGTGTCACCCGAGGATGATGGAGAGTACTGGTGTGTGGCTGAGAACCAGTATGGCCAGAGGGCCACCGCCTTCAACCTGTCTGTGGAGTTCGCCCCTGTGCTCCTCCTGGAGTCCCACTGCGCGGCAGCCCGAGACACGGTGCAGTGCCTGTGCGTGGTGAAGTCCAACCCGGAGCCGTCCGTGGCCTTTGAGCTGCCATCGCGCAATGTGACCGTGAACGAGAGCGAGCGGGAGTTCGTGTACTCGGAGCGCAGCGGCCTCGTGCTCACCAGCATCCTCACGCTGCGGGGGCAGGCCCAGGCCCCGCCCCGCGTCATCTGCACCGCGAGGAACCTCTATGGCGCCAAGAGCCTGGAGCTGCCCTTCCAGGGAGCCCATCGACTGATGTGGGCCAAGATCGGGCCTGTGGGCGCCGTGGTCGCCTTTGCCATCCTGATTGCCATCGTCTGCTACATTACCCAGACACGCAGGAAAAAGAACGTGACAGAGAGCCCCAGCTTCTCGGCAGGGGACAACCCTCCCGTCCTGTTCAGCAGCGACTTCCGCATCTCTGGGGCACCAGAGAAGTACGAGAGCGAGAGGCGCCTGGGATCTGAGAGGAGGCTGCTGGGCCTTCGGGGTGAGCCCCCAGAGCTGGACCTGAGCTATTCTCACTCGGACCTGGGGAAACGGCCCACCAAGGACAGCTACACGCTGACGGAGGAGCTAGCTGAGTATGCTGAAATCCGGGTCAAGTGA-3'
NCBI CDS gene sequence with introns (location: 35295409.. 35313454) (18046 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 35292161.. 35313807) (21647 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [35292161 - 1000].. 35313807) (22647 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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