NCBI Summary
This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. This protein can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands. This protein localizes to the extracellular matrix, the cytoplasm and the nucleus. This protein plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell regulation. The protein exhibits antimicrobial activity against bacteria and fungi. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2014].
Protein
Protein (NP_002297)
Galectin 3
Galectin-3 (Gal-3) (35 kDa lectin) (Carbohydrate-binding protein 35) (CBP 35) (Galactose-specific lectin 3) (Galactoside-binding protein) (GALBP) (IgE-binding protein) (L-31) (Laminin-binding protein) (Lectin L-29) (Mac-2 antigen)
LGALS3
galectin 3
Undefined
Curated
Galectin
S-Type Lectins - Chimeric
b-sandwich / ConA-like
Gal / Oligo LacNAc / Blood group A and B
NP_002297
3958
P17931
ENSP00000254301.9
P17931
0.505
10.1016/j.jmb.2013.12.004
neXtProt, PFAM, InterPro, CFG data
Protein sequence and protein families (fasta) (250 amino acids) Download
MADNFSLHDALSGSGNPNPQGWPGAWGNQPAGAGGYPGASYPGAYPGQAPPGAYPGQAPPGAYPGAPGAYPGAPAPGVYPGPPSGPGAYPSSGQPSATGAYPATGPYGAPAGPLIVPYNLPLPGGVVPRMLITILGTVKPNANRIALDFQRGNDVAFHFNPRFNENNRRVIVCNTKLDNNWGREERQSVFPFESGKPFKIQVLVEPDHFKVAVNDAHLLQYNHRVKKLNEISKLGISGDIDLTSASYTMI
Mol* PDB structure viewerUniLectin3D
Structural models
AlphaFold v2: AF-P17931-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

AlphaFold_v2 structural model assessment through SWISS-MODEL tools.

Ligand
Glycan ligands from structural data
galactose derivative (S-enantiomer)
GalA(a1-4)GalA
6KXA
6KXA
GlyConnect Structures
Thio di-galactoside derivative, bGal14Glc, aGalA14GalA
Gal(b1-4)Glc
2NMN, 2NMO, 2NN8, 3AYE, 3ZSJ, 4R9A, 4R9B, 4R9C, 4R9D, 4RL7, 6FOF, 6Y4C
2NMN, 2NMO, 2NN8, 3AYE, 3ZSJ, 4R9A, 4R9B, 4R9C, 4R9D, 4RL7, 6FOF, 6Y4C
GlyConnect Structures
bGal14GlcNAc13bGal14Glc
Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)Glc
4LBK, 4LBN
4LBK, 4LBN
GlyConnect Structures
Gal derivative
GalNAc(b1-4)GlcNAc
7BE3
7BE3
GlyConnect Structures
bGal13aGalNAc-Ser, bGal13aGalNAc-PNP
Gal(b1-3)GalNAc
3AYA, 3AYD
3AYA, 3AYD
GlyConnect Structures
bGal13GlcNAc13bGal14Glc
Gal(b1-3)GlcNAc(b1-3)Gal(b1-4)Glc
4LBJ, 4LBM
4LBJ, 4LBM
GlyConnect Structures
bGal14Glc
Gal(b1-4)Fruf
6B8K
6B8K
GlyConnect Structures
fluoroaryltriazole monothiogalactoside , aGalA14GalAa14GalA, 3-deoxy-3-(4-[m-fluorophenyl]-1H-1, thiodigalactoside, fluoroaryltriazole monothiogalactoside, LacNAc derivative, fluoroaryl triazole monothiogalactoside, bGal14Glc, substituted fluoroaryltriazole monothiogalactoside, LacNAc derivativee, Thio di-galactoside derivative, substituted polyfluoroaryl monothiogalactoside, galactose derivative, thiodigalactoside derivative, fluoroaryltriazole monothiogalactoside
Gal
4JC1, 5E8A, 5E88, 5E89, 5EXO, 5H9P, 5H9R, 4BM8, 4BLJ, 4BLI, 6FK2, 6QLN, 6QLO, 6QLP, 6QLQ, 6QLR, 6QLS, 6QLT, 6QLU, 6RHM, 6RHL, 6Q0Q, 6Q17
4JC1, 5E8A, 5E88, 5E89, 5EXO, 5H9P, 5H9R, 4BM8, 4BLJ, 4BLI, 6FK2, 6QLN, 6QLO, 6QLP, 6QLQ, 6QLR, 6QLS, 6QLT, 6QLU, 6RHM, 6RHL, 6Q0Q, 6Q17
GlyConnect Structures
derivative of LacNAc, LacNAc derivative, 3-triazol-1-yl)-thio-digalactoside, GLYCEROL, benzamido-N-acetyllactosamine, bGal14GlcNAc
Gal(b1-4)GlcNAc
1A3K, 1KJL, 1KJR, 2XG3, 5NFB, 5NFA, 5NF9, 5NF7
1A3K, 1KJL, 1KJR, 2XG3, 5NFB, 5NFA, 5NF9, 5NF7
GlyConnect Structures
bGal13GlcNAc
Gal(b1-3)GlcNAc
4XBN
4XBN
GlyConnect Structures
aNeuAc23bGal14Glc
NeuAc(a2-3)Gal(b1-4)Glc
4LBL, 4LBO
4LBL, 4LBO
GlyConnect Structures
thioditaloside, MQT, DQT
Tal
3T1L, 3T1M, 4JCK
3T1L, 3T1M, 4JCK
GlyConnect Structures
Lactitol
Gal(b1-4)Gal
6F6Y
6F6Y
GlyConnect Structures
galactose derivative (R enantiomer)
GalA(a1-4)GalA(a1-4)GalA
6KXB
6KXB
GlyConnect Structures
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for LGALS3 Gene
ProteomicsDB
References
NCBI References (10 PubMed Identifiers)
  • Predictors of Total Mortality and Serious Arrhythmic Events in Non-Ischemic Heart Failure Patients: The Role of Galectin-3. [34550239]
  • Relationship between Circulating Galectin-3, Systemic Inflammation, and Protein-Energy Wasting in Chronic Hemodialysis Patients. [34444962]
  • The Role of Galectin-3 and ST2 in Cardiology: A Short Review. [34439833]
  • Galectin-3 induces death of Candida species expressing specific beta-1,2-linked mannans. [16982911]
  • Mapping of the galectin-3 gene (LGALS3) to human chromosome 14 at region 14q21-22. [9271684]
  • Mac-2-binding glycoproteins. Putative ligands for a cytosolic beta-galactoside lectin. [1917996]
  • Molecular cloning and chromosomal mapping of a human galactoside-binding protein. [2009535]
  • Human breast carcinoma cDNA encoding a galactoside-binding lectin homologous to mouse Mac-2 antigen. [2022338]
  • Genomic sequence and organization of two members of a human lectin gene family. [1988031]
  • Molecular cloning of a human macrophage lectin specific for galactose. [2402511]
UniProt Main References (19 PubMed Identifiers)
  • Human IgE-binding protein: a soluble lectin exhibiting a highly conserved interspecies sequence and differential recognition of IgE glycoforms. [2261464]
  • Decreased expression of Mac-2 (carbohydrate binding protein 35) and loss of its nuclear localization are associated with the neoplastic progression of colon carcinoma. [7682704]
  • The human LGALS3 (galectin-3) gene: determination of the gene structure and functional characterization of the promoter. [9439577]
  • Complete sequencing and characterization of 21,243 full-length human cDNAs. [14702039]
  • The DNA sequence and analysis of human chromosome 14. [12508121]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
  • L-29, a soluble lactose-binding lectin, is phosphorylated on serine 6 and serine 12 in vivo and by casein kinase I. [8253806]
  • Mac-2 binding protein is a cell-adhesive protein of the extracellular matrix which self-assembles into ring-like structures and binds beta1 integrins, collagens and fibronectin. [9501082]
  • NG2 proteoglycan promotes endothelial cell motility and angiogenesis via engagement of galectin-3 and alpha3beta1 integrin. [15181153]
  • The regulation of inflammation by galectin-3. [19594635]
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All isoforms of this gene containing a lectin domain
NP_002297.2, NP_001344607.1
RNA
RNA (Transcript ID: NM_002306.4)
NM_002306.4
galectin 3, transcript variant 1
All isoforms of LGALS3 containing a lectin domain
ENST00000254301.14
54..806 (or 55137374.. 55145271)
55129252.. 55145423
NCBI Matured mRNA sequence 958 NTPDownload 
m7G-5')ppp(5'-GCCCGCAGCACCUCCUCGCCAGCAGCCGUCCGGAGCCAGCCAACGAGCGGAAAAUGGCAGACAAUUUUUCGCUCCAUGAUGCGUUAUCUGGGUCUGGAAACCCAAACCCUCAAGGAUGGCCUGGCGCAUGGGGGAACCAGCCUGCUGGGGCAGGGGGCUACCCAGGGGCUUCCUAUCCUGGGGCCUACCCCGGGCAGGCACCCCCAGGGGCUUAUCCUGGACAGGCACCUCCAGGCGCCUACCCUGGAGCACCUGGAGCUUAUCCCGGAGCACCUGCACCUGGAGUCUACCCAGGGCCACCCAGCGGCCCUGGGGCCUACCCAUCUUCUGGACAGCCAAGUGCCACCGGAGCCUACCCUGCCACUGGCCCCUAUGGCGCCCCUGCUGGGCCACUGAUUGUGCCUUAUAACCUGCCUUUGCCUGGGGGAGUGGUGCCUCGCAUGCUGAUAACAAUUCUGGGCACGGUGAAGCCCAAUGCAAACAGAAUUGCUUUAGAUUUCCAAAGAGGGAAUGAUGUUGCCUUCCACUUUAACCCACGCUUCAAUGAGAACAACAGGAGAGUCAUUGUUUGCAAUACAAAGCUGGAUAAUAACUGGGGAAGGGAAGAAAGACAGUCGGUUUUCCCAUUUGAAAGUGGGAAACCAUUCAAAAUACAAGUACUGGUUGAACCUGACCACUUCAAGGUUGCAGUGAAUGAUGCUCACUUGUUGCAGUACAAUCAUCGGGUUAAAAAACUCAAUGAAAUCAGCAAACUGGGAAUUUCUGGUGACAUAGACCUCACCAGUGCUUCAUAUACCAUGAUAUAAUCUGAAAGGGGCAGAUUAAAAAAAAAAAAAGAAUCUAAACCUUACAUGUGUAAAGGUUUCAUGUUCACUGUGAGUGAAAAUUUUUACAUUCAUCAAUAUCCCUCUUGUAAGUCAUCUACUUAAUAAAUAUUACAGUGAAUUACCUGUCUCAA-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
;
More about the NCBI sViewer.
DNA
DNA (Gene ID: 3958)
LGALS3
galectin 3
NC_000014.9
14  55137374.. 55145271
55137374.. 55145271
strand +
CCDS41956.1
MGI:96778
ClinVar, dbVar
ENSG00000131981
MAC-2, GALIG
uc001xbr.4
INSDC: M64303
6563
153619
OTTHUMG00000171030
ENA, DDBJ, Monarch
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (753 bp)
5'-ATGGCAGACAATTTTTCGCTCCATGATGCGTTATCTGGGTCTGGAAACCCAAACCCTCAAGGATGGCCTGGCGCATGGGGGAACCAGCCTGCTGGGGCAGGGGGCTACCCAGGGGCTTCCTATCCTGGGGCCTACCCCGGGCAGGCACCCCCAGGGGCTTATCCTGGACAGGCACCTCCAGGCGCCTACCCTGGAGCACCTGGAGCTTATCCCGGAGCACCTGCACCTGGAGTCTACCCAGGGCCACCCAGCGGCCCTGGGGCCTACCCATCTTCTGGACAGCCAAGTGCCACCGGAGCCTACCCTGCCACTGGCCCCTATGGCGCCCCTGCTGGGCCACTGATTGTGCCTTATAACCTGCCTTTGCCTGGGGGAGTGGTGCCTCGCATGCTGATAACAATTCTGGGCACGGTGAAGCCCAATGCAAACAGAATTGCTTTAGATTTCCAAAGAGGGAATGATGTTGCCTTCCACTTTAACCCACGCTTCAATGAGAACAACAGGAGAGTCATTGTTTGCAATACAAAGCTGGATAATAACTGGGGAAGGGAAGAAAGACAGTCGGTTTTCCCATTTGAAAGTGGGAAACCATTCAAAATACAAGTACTGGTTGAACCTGACCACTTCAAGGTTGCAGTGAATGATGCTCACTTGTTGCAGTACAATCATCGGGTTAAAAAACTCAATGAAATCAGCAAACTGGGAATTTCTGGTGACATAGACCTCACCAGTGCTTCATATACCATGATATAA-3'
NCBI CDS gene sequence with introns (location: 55137374.. 55145271) (7898 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 55129252.. 55145423) (16172 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [55129252 - 1000].. 55145423) (17172 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
How to cite: Schnider B., M'Rad Y., el Ahmadie J., de Brevern AG., Imberty A., Lisacek F., HumanLectome, an update of UniLectin for the annotation and prediction of human lectins, Nucleic Acids Reasearch doi.org/10.1093/nar/gkad905