HumanLectome - Human Lectin Entry

NCBI Summary

The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. This gene product may act as an autocrine negative growth factor that regulates cell proliferation. [provided by RefSeq, Jul 2008].

Protein

Protein (NP_002296)

Protein name

Galectin 1

Synonym(s)

Galectin-1 (Gal-1) (14 kDa laminin-binding protein) (HLBP14) (14 kDa lectin) (Beta-galactoside-binding lectin L-14-I) (Galaptin) (HBL) (HPL) (Lactose-binding lectin 1) (Lectin galactoside-binding soluble 1) (Putative MAPK-activating protein PM12) (S-Lac lectin 1)

HGNC gene name

LGALS1

HGNC name

galectin 1

Protein_CD_name

Undefined

Lectin confidence

Curated

UniLectin class

galectin-like

Known lectin group

S-Type Lectins - Prototypical

Lectin fold

b-sandwich / ConA-like

Glycan specificity

Gal / Gal(b1-4)GlcNAc / poly LacNAc

RefSeq accession

Gene ID

UniProt accession

Ensembl protein ID

UniRef cluster ID

LectomeXplore score

0.434

Reference

10.1074/jbc.M709545200

Other links

neXtProt, PFAM, InterPro, CFG data

Protein sequence and protein families (fasta) (135 amino acids) Download

MACGLVASNLNLKPGECLRVRGEVAPDAKSFVLNLGKDSNNLCLHFNPRFNAHGDANTIVCNSKDGGAWGTEQREAVFPFQPGSVAEVCITFDQANLTVKLPDGYEFKFPNRLNLEAINYMAADGDFKIKCVAFD

Mol* PDB structure viewerUniLectin3D

Select a PDB entry:

Structural models

AlphaFold v2: AF-P09382-F1 Download

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Ligand

Glycan ligands from structural data

Name

lactose, bGal14Glc

IUPAC

Gal(b1-4)Glc

PDB

1GZW, 1W6O, 2ZKN

UniLectin3D

1GZW, 1W6O, 2ZKN

Parent structures

GlyConnect Structures

Name

N-Acetyllactosamine

IUPAC

Gal(b1-4)Fruf

PDB

6B94

UniLectin3D

6B94

Parent structures

GlyConnect Structures

Name

lactobionic acid, Gal, thiodigalactoside, 3

IUPAC

Gal

PDB

1W6M, 3OY8, 3OYW, 4Y24

UniLectin3D

1W6M, 3OY8, 3OYW, 4Y24

Parent structures

GlyConnect Structures

Name

(6OSO3)bGal14GlcNAc, (6OSO3)bGal13GlcNAc, 2, bGal13GlcNAc, (3OSO3)bGal13GlcNAc, bGal14GlcNAc, activated N-acetyllactosamine, bGal14GlcANAc

IUPAC

Gal(b1-4)GlcNAc

PDB

1W6P, 4Y1Z, 4Y1X, 4Y1U, 4Q27, 4Q26, 4Q2F, 4Q1R, 4Q1P

UniLectin3D

1W6P, 4Y1Z, 4Y1X, 4Y1U, 4Q27, 4Q26, 4Q2F, 4Q1R, 4Q1P

Parent structures

GlyConnect Structures

Name

aNeuAc23bGal14Glc, 3-triazol-1-yl)-thio-digalactoside, bGal13GlcNAc, 3'deoxy-3

IUPAC

Gal(b1-3)GlcNAc

PDB

4XBL, 4Y22, 4Y1Y, 4Y1V

UniLectin3D

4XBL, 4Y22, 4Y1Y, 4Y1V

Parent structures

GlyConnect Structures

Name

3'-bis-(4-[m-fluorophenyl]-1H-1

IUPAC

NeuAc(a2-3)Gal(b1-4)Glc

PDB

4Y20

UniLectin3D

4Y20

Parent structures

GlyConnect Structures

Name

methyl 2-O-acetyl-3-O-(4-methylbenzoyl)-b-D-talopyranoside

IUPAC

Tal

PDB

3T2T

UniLectin3D

3T2T

Parent structures

GlyConnect Structures

Expression

Human Protein Atlas

GeneCards

mRNA expression in normal human tissues for LGALS1 Gene

ProteomicsDB

References

NCBI References (10 PubMed Identifiers)

Characterizing ligand-induced conformational changes in clinically relevant galectin-1 by HN/H2O (D2O) exchange. [34022292]

A novel miR1983-TLR7-IFNbeta circuit licenses NK cells to kill glioma cells, and is under the control of galectin-1. [34249474]

Cross-Linking Effects Dictate the Preference of Galectins to Bind LacNAc-Decorated HPMA Copolymers. [34206141]

Degraded Arabinogalactans and Their Binding Properties to Cancer-Associated Human Galectins. [33920014]

Hypoxia Induces Galectin-1 Expression Via Autoinduction of Placental Growth Factor in Retinal Pigment Epithelium Cells. [33599733]

Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin. [1602151]

Isolation of a cDNA clone, encoding a human beta-galactoside binding protein, overexpressed during glucocorticoid-induced cell death. [1713454]

Genomic sequence and organization of two members of a human lectin gene family. [1988031]

Localization of endogenous beta-galactoside-binding lectin in human cells and tissues. [1996404]

Human splenic galaptin: physicochemical characterization. [2383549]

UniProt Main References (33 PubMed Identifiers)

Cloning and nucleotide sequence of a full-length cDNA for human 14 kDa beta-galactoside-binding lectin. [2719964]

Molecular cloning, characterization, and expression of a human 14-kDa lectin. [2910856]

Evidence that the 14 kDa soluble beta-galactoside-binding lectin in man is encoded by a single gene. [2719646]

Emergence of hormonal and redox regulation of galectin-1 in placental mammals: implication in maternal-fetal immune tolerance. [18824694]

Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. [12761501]

A genome annotation-driven approach to cloning the human ORFeome. [15461802]

Complete sequencing and characterization of 21,243 full-length human cDNAs. [14702039]

The DNA sequence of human chromosome 22. [10591208]

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]

Complete amino acid sequence of a beta-galactoside-binding lectin from human placenta. [3065332]

Further characterization and structural studies on human placenta lectin. [3611046]

Identification of a 14-kDa laminin binding protein (HLBP14) in human melanoma cells that is identical to the 14-kDa galactoside binding lectin. [1386213]

Apoptosis of T cells mediated by galectin-1. [7501023]

Galectin-1, a natural ligand for the receptor-type protein tyrosine phosphatase CD45. [10369126]

Regulation of CD45-induced signaling by galectin-1 in Burkitt lymphoma B cells. [10764829]

Glycoprotein 90K/MAC-2BP interacts with galectin-1 and mediates galectin-1-induced cell aggregation. [11146440]

Presentation of galectin-1 by extracellular matrix triggers T cell death. [14617626]

A primate subfamily of galectins expressed at the maternal-fetal interface that promote immune cell death. [19497882]

Lysine acetylation targets protein complexes and co-regulates major cellular functions. [19608861]

Initial characterization of the human central proteome. [21269460]

Resveratrol-induced changes of the human adipocyte secretion profile. [22905912]

Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-alpha-acetylation features. [22223895]

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. [22814378]

Multiple functions of sushi domain containing 2 (SUSD2) in breast tumorigenesis. [23131994]

Modulation of CD6 function through interaction with Galectin-1 and -3. [24945728]

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. [24275569]

A Single Kinase Generates the Majority of the Secreted Phosphoproteome. [26091039]

N-terminome analysis of the human mitochondrial proteome. [25944712]

A Translocation Pathway for Vesicle-Mediated Unconventional Protein Secretion. [32272059]

Growth-regulatory human galectin-1: crystallographic characterisation of the structural changes induced by single-site mutations and their impact on the thermodynamics of ligand binding. [15476813]

Functional and structural bases of a cysteine-less mutant as a long-lasting substitute for galectin-1. [18796645]

Critical role of the solvent environment in galectin-1 binding to the disaccharide lactose. [19128029]

RNA

RNA (Transcript ID: NM_002305.4)

RNA RefSeq ID

NM_002305.4

RNA name

galectin 1

Isoforms

All isoforms of LGALS1 containing a lectin domain

RNA Ensembl ID

ENST00000215909.10

Coding region

68..475 (or 37675703.. 37679749)

mRNA location

37675636.. 37679802

NCBI Matured mRNA sequence 528 NTP Download

m⁷G-5')ppp(5'-AUCUCUCUCGGGUGGAGUCUUCUGACAGCUGGUGCGCCUGCCCGGGAACAUCCUCCUGGACUCAAUCAUGGCUUGUGGUCUGGUCGCCAGCAACCUGAAUCUCAAACCUGGAGAGUGCCUUCGAGUGCGAGGCGAGGUGGCUCCUGACGCUAAGAGCUUCGUGCUGAACCUGGGCAAAGACAGCAACAACCUGUGCCUGCACUUCAACCCUCGCUUCAACGCCCACGGCGACGCCAACACCAUCGUGUGCAACAGCAAGGACGGCGGGGCCUGGGGGACCGAGCAGCGGGAGGCUGUCUUUCCCUUCCAGCCUGGAAGUGUUGCAGAGGUGUGCAUCACCUUCGACCAGGCCAACCUGACCGUCAAGCUGCCAGAUGGAUACGAAUUCAAGUUCCCCAACCGCCUCAACCUGGAGGCCAUCAACUACAUGGCAGCUGACGGUGACUUCAAGAUCAAAUGUGUGGCCUUUGACUGAAAUCAGCCAGCCCAUGGCCCCCAAUAAAGGCAGCUGCCUCUGCUCCCUCUGAA-3'- Poly-A tail

Coding region

NCBI Matured mRNA sequence viewer

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More about the NCBI sViewer.

DNA

DNA (Gene ID: 3956)

HGNC Gene symbol

LGALS1

HGNC Gene name

galectin 1

Chr. RefSeq ID

NC_000022.11

Chromosome N°

22 37675703.. 37679749

CDS location

37675703.. 37679749

DNA strand

strand +

CCDS ID

CCDS13954.1

Mouse ortholog gene

MGI:96777

Gene Variant

ClinVar, dbVar

DNA Ensembl ID

ENSG00000100097

HGNC other symbol

GBP

UCSC ID

uc003atn.4

GeneBank

INSDC:

GeneCards

6561

MIM

150570

VEGA ID

OTTHUMG00000150661

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