NCBI Summary
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. This gene product may act as an autocrine negative growth factor that regulates cell proliferation. [provided by RefSeq, Jul 2008].
Protein
Protein (NP_002296)
Galectin 1
Galectin-1 (Gal-1) (14 kDa laminin-binding protein) (HLBP14) (14 kDa lectin) (Beta-galactoside-binding lectin L-14-I) (Galaptin) (HBL) (HPL) (Lactose-binding lectin 1) (Lectin galactoside-binding soluble 1) (Putative MAPK-activating protein PM12) (S-Lac lectin 1)
LGALS1
galectin 1
Undefined
Curated
Galectin
S-Type Lectins - Prototypical
b-sandwich / ConA-like
0.434
Protein sequence and protein families (fasta) (135 amino acids) Download
MACGLVASNLNLKPGECLRVRGEVAPDAKSFVLNLGKDSNNLCLHFNPRFNAHGDANTIVCNSKDGGAWGTEQREAVFPFQPGSVAEVCITFDQANLTVKLPDGYEFKFPNRLNLEAINYMAADGDFKIKCVAFD
Mol* PDB structure viewerUniLectin3D
Structural models
Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.


Ligand
Glycan ligands from structural data
lactose, bGal14Glc
Gal(b1-4)Glc
N-Acetyllactosamine
Gal(b1-4)Fruf
lactobionic acid, Gal, thiodigalactoside, 3
Gal
(6OSO3)bGal14GlcNAc, (6OSO3)bGal13GlcNAc, 2, bGal13GlcNAc, (3OSO3)bGal13GlcNAc, bGal14GlcNAc, activated N-acetyllactosamine, bGal14GlcANAc
Gal(b1-4)GlcNAc
aNeuAc23bGal14Glc, 3-triazol-1-yl)-thio-digalactoside, bGal13GlcNAc, 3'deoxy-3
Gal(b1-3)GlcNAc
3'-bis-(4-[m-fluorophenyl]-1H-1
NeuAc(a2-3)Gal(b1-4)Glc
methyl 2-O-acetyl-3-O-(4-methylbenzoyl)-b-D-talopyranoside
Tal
References
NCBI References (10 PubMed Identifiers)
  • Characterizing ligand-induced conformational changes in clinically relevant galectin-1 by HN/H2O (D2O) exchange. [34022292]
  • A novel miR1983-TLR7-IFNbeta circuit licenses NK cells to kill glioma cells, and is under the control of galectin-1. [34249474]
  • Cross-Linking Effects Dictate the Preference of Galectins to Bind LacNAc-Decorated HPMA Copolymers. [34206141]
  • Degraded Arabinogalactans and Their Binding Properties to Cancer-Associated Human Galectins. [33920014]
  • Hypoxia Induces Galectin-1 Expression Via Autoinduction of Placental Growth Factor in Retinal Pigment Epithelium Cells. [33599733]
  • Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin. [1602151]
  • Isolation of a cDNA clone, encoding a human beta-galactoside binding protein, overexpressed during glucocorticoid-induced cell death. [1713454]
  • Genomic sequence and organization of two members of a human lectin gene family. [1988031]
  • Localization of endogenous beta-galactoside-binding lectin in human cells and tissues. [1996404]
  • Human splenic galaptin: physicochemical characterization. [2383549]
UniProt Main References (33 PubMed Identifiers)
  • Cloning and nucleotide sequence of a full-length cDNA for human 14 kDa beta-galactoside-binding lectin. [2719964]
  • Molecular cloning, characterization, and expression of a human 14-kDa lectin. [2910856]
  • Evidence that the 14 kDa soluble beta-galactoside-binding lectin in man is encoded by a single gene. [2719646]
  • Emergence of hormonal and redox regulation of galectin-1 in placental mammals: implication in maternal-fetal immune tolerance. [18824694]
  • Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. [12761501]
  • A genome annotation-driven approach to cloning the human ORFeome. [15461802]
  • Complete sequencing and characterization of 21,243 full-length human cDNAs. [14702039]
  • The DNA sequence of human chromosome 22. [10591208]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
  • Complete amino acid sequence of a beta-galactoside-binding lectin from human placenta. [3065332]
  • Show more
RNA
RNA (Transcript ID: NM_002305.4)
galectin 1
m7G-5')ppp(5'-AUCUCUCUCGGGUGGAGUCUUCUGACAGCUGGUGCGCCUGCCCGGGAACAUCCUCCUGGACUCAAUCAUGGCUUGUGGUCUGGUCGCCAGCAACCUGAAUCUCAAACCUGGAGAGUGCCUUCGAGUGCGAGGCGAGGUGGCUCCUGACGCUAAGAGCUUCGUGCUGAACCUGGGCAAAGACAGCAACAACCUGUGCCUGCACUUCAACCCUCGCUUCAACGCCCACGGCGACGCCAACACCAUCGUGUGCAACAGCAAGGACGGCGGGGCCUGGGGGACCGAGCAGCGGGAGGCUGUCUUUCCCUUCCAGCCUGGAAGUGUUGCAGAGGUGUGCAUCACCUUCGACCAGGCCAACCUGACCGUCAAGCUGCCAGAUGGAUACGAAUUCAAGUUCCCCAACCGCCUCAACCUGGAGGCCAUCAACUACAUGGCAGCUGACGGUGACUUCAAGAUCAAAUGUGUGGCCUUUGACUGAAAUCAGCCAGCCCAUGGCCCCCAAUAAAGGCAGCUGCCUCUGCUCCCUCUGAA-3'- Poly-A tail
  • Coding region
;
DNA
DNA (Gene ID: 3956)
galectin 1
strand +
GBP
NCBI CDS gene sequence (408 bp)
5'-ATGGCTTGTGGTCTGGTCGCCAGCAACCTGAATCTCAAACCTGGAGAGTGCCTTCGAGTGCGAGGCGAGGTGGCTCCTGACGCTAAGAGCTTCGTGCTGAACCTGGGCAAAGACAGCAACAACCTGTGCCTGCACTTCAACCCTCGCTTCAACGCCCACGGCGACGCCAACACCATCGTGTGCAACAGCAAGGACGGCGGGGCCTGGGGGACCGAGCAGCGGGAGGCTGTCTTTCCCTTCCAGCCTGGAAGTGTTGCAGAGGTGTGCATCACCTTCGACCAGGCCAACCTGACCGTCAAGCTGCCAGATGGATACGAATTCAAGTTCCCCAACCGCCTCAACCTGGAGGCCATCAACTACATGGCAGCTGACGGTGACTTCAAGATCAAATGTGTGGCCTTTGACTGA-3'
NCBI CDS gene sequence with introns (location: 37675703.. 37679749) (4047 bp)Download
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 37675636.. 37679802) (4167 bp)Download
NCBI gene sequence (location: [37675636 - 1000].. 37679802) (5167 bp)Download
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