NCBI Summary
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The group, designated KLRC (NKG2) are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The KLRC (NKG2) gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. KLRC2 alternative splice variants have been described but their full-length nature has not been determined. [provided by RefSeq, Jul 2008].
Protein
Protein (NP_002251)
Killer cell lectin-like receptor C member 2
NKG2-C type II integral membrane protein (CD159 antigen-like family member C) (NK cell receptor C) (NKG2-C-activating NK receptor) (CD antigen CD159c)
KLRC2
killer cell lectin like receptor C2
Very low evidence
C-type lectin
Undefined
C-type - Natural Killer NK
a/b mixed / C-type lectin-like
Uncharacterised
0.298
Undefined
Protein sequence and protein families (fasta) (231 amino acids) Download
MNKQRGTFSEVSLAQDPKRQQRKPKGNKSSISGTEQEIFQVELNLQNPSLNHQGIDKIYDCQGLLPPPEKLTAEVLGIICIVLMATVLKTIVLIPFLEQNNFSPNTRTQKARHCGHCPEEWITYSNSCYYIGKERRTWEESLLACTSKNSSLLSIDNEEEMKFLASILPSSWIGVFRNSSHHPWVTINGLAFKHKIKDSDNAELNCAVLQVNRLKSAQCGSSMIYHCKHKL
Mol* PDB structure viewer

Either no PDB or existing PDB of non-glycosylated form

Structural models
Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.


SWISS-MODEL structural models
Modeller structural model (Homology modelling pipeline), Error: [1.56, 2.02] ÅDownload
The location of the lectin domain structural model is: 107-229
We infer [1.56, 2.02] Å as the interval of error of this structural model.
Template 1: 2BPE chain: A, Q6QLQ4, NP_0NO0REFSEQ0.0, sequence identity: 27.6%, coverage: 93.5%, location in sequence: 117-244, (117-244 in PDB).
Template 2: 6PWS chain: A, E1BIQ4, XP_005198961.1, sequence identity: 27.6%, coverage: 94.3%, location in sequence: 174-302, (162-290 in PDB).
Template 3: 2YHF chain: A, Q9NY25, NP_037384.1, sequence identity: 25.2%, coverage: 91.9%, location in sequence: 70-187, (70-187 in PDB).
Show the alignment used for the construction of the structural model, Download.
Show the plot of DOPE energy score, Download.
Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
References
NCBI References (10 PubMed Identifiers)
  • Influence of NKG2C Genotypes on HIV Susceptibility and Viral Load Set Point. [34076484]
  • Deletion of the NKG2C receptor encoding KLRC2 gene and HLA-E variants are risk factors for severe COVID-19. [33500568]
  • Surface NKG2C Identifies Differentiated alphabetaT-Cell Clones Expanded in Peripheral Blood. [33664730]
  • Adaptive NKG2C+ natural killer cells are related to exacerbations and nutritional abnormalities in COPD patients. [32131843]
  • Phenotypic and Functional Analysis of Human NK Cell Subpopulations According to the Expression of FcepsilonRIgamma and NKG2C. [31867015]
  • Sequence analysis of a 62-kb region overlapping the human KLRC cluster of genes. [9598306]
  • HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C. [9486650]
  • Natural killer cell cytolytic activity is inhibited by NKG2-A and activated by NKG2-C. [9103421]
  • A multigene family on human chromosome 12 encodes natural killer-cell lectins. [8436421]
  • DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells. [2007850]
UniProt Main References (12 PubMed Identifiers)
  • The genomic organization of NKG2C, E, F, and D receptor genes in the human natural killer gene complex. [9683661]
  • Conservation and variation in human and common chimpanzee CD94 and NKG2 genes. [11751968]
  • The finished DNA sequence of human chromosome 12. [16541075]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
  • HLA-E-bound peptides influence recognition by inhibitory and triggering CD94/NKG2 receptors: preferential response to an HLA-G-derived nonamer. [9754572]
  • Association of DAP12 with activating CD94/NKG2C NK cell receptors. [9655483]
  • The CD94/NKG2C killer lectin-like receptor constitutes an alternative activation pathway for a subset of CD8+ T cells. [15940674]
  • The heterodimeric assembly of the CD94-NKG2 receptor family and implications for human leukocyte antigen-E recognition. [18083576]
  • NKG2A inhibits NKG2C effector functions of gammadelta T cells: implications in health and disease. [20952657]
  • Expansion of a unique CD57+NKG2Chi natural killer cell subset during acute human cytomegalovirus infection. [21825173]
  • Show more
RNA
RNA (Transcript ID: NM_002260.4)
killer cell lectin like receptor C2
m7G-5')ppp(5'-CCCUCACAUCACACAGCUGCAGAGAUGAAUAAACAAAGAGGAACCUUCUCAGAAGUGAGUCUGGCCCAGGACCCAAAGCGGCAGCAAAGGAAACCUAAAGGCAAUAAAAGCUCCAUUUCAGGAACCGAACAGGAAAUAUUCCAAGUAGAAUUAAAUCUUCAAAAUCCUUCCCUGAAUCAUCAAGGGAUUGAUAAAAUAUAUGACUGCCAAGGUUUACUGCCACCUCCAGAGAAGCUCACUGCCGAGGUCCUAGGAAUCAUUUGCAUUGUCCUGAUGGCCACUGUGUUAAAAACAAUAGUUCUUAUUCCUUUCCUGGAGCAGAACAAUUUUUCCCCGAAUACAAGAACGCAGAAAGCACGUCAUUGUGGCCAUUGUCCUGAGGAGUGGAUUACAUAUUCCAACAGUUGUUAUUACAUUGGUAAGGAAAGAAGAACUUGGGAAGAGAGUUUGCUGGCCUGUACUUCGAAGAACUCCAGUCUGCUUUCUAUAGAUAAUGAAGAAGAAAUGAAAUUUCUGGCCAGCAUUUUACCUUCCUCAUGGAUUGGUGUGUUUCGUAACAGCAGUCAUCAUCCAUGGGUGACAAUAAAUGGUUUGGCUUUCAAACAUAAGAUAAAAGACUCAGAUAAUGCUGAACUUAACUGUGCAGUGCUACAAGUAAAUCGACUUAAAUCAGCCCAGUGUGGAUCUUCAAUGAUAUAUCAUUGUAAGCAUAAGCUUUAGAAGUAAAGCAUUUGCGUUUGCAGUGCAUCAGAUACAUUUUAUAUUUCUUAAAAUAGAAAUAUUAUGAUUGCAUAAAUCUGAAAAUGAAUUAUGUUAUUUGCUCUGAUACAAAAAUUCUAAAUCAAUUAUUGAAAUAGGAUGCACACAAUUACUAAAGUACAGACAUCCUAGCAUUUGUGUCGGGCUCAUUUUGCUCAACAUGGUAUUUGUGGUUUUCAGCCUUUCUAAAAGUUGCAUGUUAUGUGAGUCAGCUUAUAGGAAGUACCAAGAACAGUCAAACCCAUGGAGACAGAAAGUAGAAUAGUGGUUGCCAAUGUCUCAGGGAGGUUGAAAUAGGAGAUGACCACUAAUUGAUAGAACGUUUCUUUGUGUCGUGAUGAAAACUUUCUAAAUUUCAGUAGUGGUGAUGGUUGUAACUCUGCGAAUAUACUAAACAUCAUUGAUUUUUAAUCAUUUUAAGUGCAUGAAAUGUAUGCUUUGUACAUGACACUUCAAUAAAGCUAUCCAGAAAAAAAAAA-3'- Poly-A tail
  • Coding region
;
DNA
DNA (Gene ID: 3822)
killer cell lectin like receptor C2
strand -
NKG2-C, CD159c, NKG2C
NCBI CDS gene sequence (696 bp)
5'-ATGAATAAACAAAGAGGAACCTTCTCAGAAGTGAGTCTGGCCCAGGACCCAAAGCGGCAGCAAAGGAAACCTAAAGGCAATAAAAGCTCCATTTCAGGAACCGAACAGGAAATATTCCAAGTAGAATTAAATCTTCAAAATCCTTCCCTGAATCATCAAGGGATTGATAAAATATATGACTGCCAAGGTTTACTGCCACCTCCAGAGAAGCTCACTGCCGAGGTCCTAGGAATCATTTGCATTGTCCTGATGGCCACTGTGTTAAAAACAATAGTTCTTATTCCTTTCCTGGAGCAGAACAATTTTTCCCCGAATACAAGAACGCAGAAAGCACGTCATTGTGGCCATTGTCCTGAGGAGTGGATTACATATTCCAACAGTTGTTATTACATTGGTAAGGAAAGAAGAACTTGGGAAGAGAGTTTGCTGGCCTGTACTTCGAAGAACTCCAGTCTGCTTTCTATAGATAATGAAGAAGAAATGAAATTTCTGGCCAGCATTTTACCTTCCTCATGGATTGGTGTGTTTCGTAACAGCAGTCATCATCCATGGGTGACAATAAATGGTTTGGCTTTCAAACATAAGATAAAAGACTCAGATAATGCTGAACTTAACTGTGCAGTGCTACAAGTAAATCGACTTAAATCAGCCCAGTGTGGATCTTCAATGATATATCATTGTAAGCATAAGCTTTAG-3'
NCBI CDS gene sequence with introns (location: 10431117.. 10435986) (4870 bp)Download
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 10430599.. 10436010) (5412 bp)Download
NCBI gene sequence (location: [10430599.. 10436010 + 1000]) (6412 bp)Download
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