HumanLectome - Human Lectin Entry

NCBI Summary

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jan 2015].

Protein

Protein (NP_002250)

Protein name

Killer cell lectin-like receptor C member 1

Synonym(s)

NKG2-A/NKG2-B type II integral membrane protein (CD159 antigen-like family member A) (NK cell receptor A) (NKG2-A/B-activating NK receptor) (CD antigen CD159a)

HGNC gene name

KLRC1

HGNC name

killer cell lectin like receptor C1

Protein_CD_name

CD159a

Lectin confidence

Very low evidence

UniLectin class

C-type lectin

C-type classification

Undefined

Known lectin group

C-type - Natural Killer NK

Lectin fold

a/b mixed / C-type lectin-like

Glycan specificity

Uncharacterised

RefSeq accession

Gene ID

UniProt accession

Ensembl protein ID

UniRef cluster ID

LectomeXplore score

0.303

Reference

Undefined

Other links

PFAM, InterPro, CPX-2502

Protein sequence and protein families (fasta) (233 amino acids) Download

MDNQGVIYSDLNLPPNPKRQQRKPKGNKNSILATEQEITYAELNLQKASQDFQGNDKTYHCKDLPSAPEKLIVGILGIICLILMASVVTIVVIPSTLIQRHNNSSLNTRTQKARHCGHCPEEWITYSNSCYYIGKERRTWEESLLACTSKNSSLLSIDNEEEMKFLSIISPSSWIGVFRNSSHHPWVTMNGLAFKHEIKDSDNAELNCAVLQVNRLKSAQCGSSIIYHCKHKL

Mol* PDB structure viewerUniLectin3D

Select a PDB entry:

Structural models

AlphaFold v2: AF-P26715-F1 Download

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Oligomerization and Known Interactions

Heterodimer with KLRD1; disulfide-linked (PubMed:18083576, PubMed:18332182, PubMed:18448674). KLRD1-KLRC1 heterodimer interacts with peptide-bound HLA-E-B2M heterotrimeric complex (PubMed:18083576). Competes with KLRC2 for its interaction with HLA-E (PubMed:18083576). Interacts (via ITIM) with INPP5D/SHIP-1 and INPPL1/SHIP-2 (via SH2 domain)

Annotation

Ligand

Glycan ligands from structural data

No crystal structures of complexes with glycan ligand.

Expression

Human Protein Atlas

GeneCards

Functionality temporarily unavailable.

ProteomicsDB

References

NCBI References (10 PubMed Identifiers)

The CD94/NKG2A inhibitory receptor educates uterine NK cells to optimize pregnancy outcomes in humans and mice. [33887202]

Potential prognostic value of PD-L1 and NKG2A expression in Indonesian patients with skin nodular melanoma. [34049578]

Epstein-Barr virus peptides derived from latent cycle proteins alter NKG2A + NK cell effector function. [33203899]

Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains. [32814053]

NKG2A/CD94 Is a New Immune Receptor for HLA-G and Distinguishes Amino Acid Differences in the HLA-G Heavy Chain. [32575403]

NKG2A complexed with CD94 defines a novel inhibitory natural killer cell receptor. [9034158]

Human natural killer cell receptors involved in MHC class I recognition are disulfide-linked heterodimers of CD94 and NKG2 subunits. [8943374]

Genomic structure, chromosome location, and alternative splicing of the human NKG2A gene. [8753859]

A multigene family on human chromosome 12 encodes natural killer-cell lectins. [8436421]

DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells. [2007850]

UniProt Main References (20 PubMed Identifiers)

Sequence analysis of a 62-kb region overlapping the human KLRC cluster of genes. [9598306]

The finished DNA sequence of human chromosome 12. [16541075]

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]

Functionally and structurally distinct NK cell receptor repertoires in the peripheral blood of two human donors. [9430220]

Inhibition of antigen-induced T cell response and antibody-induced NK cell cytotoxicity by NKG2A: association of NKG2A with SHP-1 and SHP-2 protein-tyrosine phosphatases. [9485206]

HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C. [9486650]

Surface expression of HLA-E, an inhibitor of natural killer cells, enhanced by human cytomegalovirus gpUL40. [10669413]

TCR specificity dictates CD94/NKG2A expression by human CTL. [12387742]

Role that each NKG2A immunoreceptor tyrosine-based inhibitory motif plays in mediating the human CD94/NKG2A inhibitory signal. [12165520]

HIV-1 infection leads to increased HLA-E expression resulting in impaired function of natural killer cells. [15751767]

All isoforms of this gene containing a lectin domain

NP_002250.2, NP_998823.1, XP_024304741.1, NP_001291377.1, NP_015567.2, NP_998822.1

RNA

RNA (Transcript ID: NM_002259.5)

RNA RefSeq ID

NM_002259.5

RNA name

killer cell lectin like receptor C1, transcript variant 1

Isoforms

All isoforms of KLRC1 containing a lectin domain

RNA Ensembl ID

ENST00000359151.8

Coding region

212..913 (or 10446551.. 10451156)

mRNA location

10446028.. 10453377

NCBI Matured mRNA sequence 1436 NTP Download

m⁷G-5')ppp(5'-CCACUCUUGACUCACUCUGAGCCUUCACAGGGCAGUCUGCGAAGAUUGCAGGCAUUGUUUGUUCUUGUCUUGGAUUUAUGCCUUUAAAUUUCACCUUUUAUUACACAGCUAUAGCAGGCCUUUUUAUGAGACUAACCUGGCCUCUCCACUAAAGGAUGUGUGACUUUCUGGGGACAGAAGAGUACAGUCCCUGACAUCACACACUGCAGAGAUGGAUAACCAAGGAGUAAUCUACUCAGACCUGAAUCUGCCCCCAAACCCAAAGAGGCAGCAACGAAAACCUAAAGGCAAUAAAAACUCCAUUUUAGCAACUGAACAGGAAAUAACCUAUGCGGAAUUAAACCUUCAAAAAGCUUCUCAGGAUUUUCAAGGGAAUGACAAAACCUAUCACUGCAAAGAUUUACCAUCAGCUCCAGAGAAGCUCAUUGUUGGGAUCCUGGGAAUUAUCUGUCUUAUCUUAAUGGCCUCUGUGGUAACGAUAGUUGUUAUUCCCUCUACAUUAAUACAGAGGCACAACAAUUCUUCCCUGAAUACAAGAACUCAGAAAGCACGUCAUUGUGGCCAUUGUCCUGAGGAGUGGAUUACAUAUUCCAACAGUUGUUACUACAUUGGUAAGGAAAGAAGAACUUGGGAAGAGAGUUUGCUGGCCUGUACUUCGAAGAACUCCAGUCUGCUUUCUAUAGAUAAUGAAGAAGAAAUGAAAUUUCUGUCCAUCAUUUCACCAUCCUCAUGGAUUGGUGUGUUUCGUAACAGCAGUCAUCAUCCAUGGGUGACAAUGAAUGGUUUGGCUUUCAAACAUGAGAUAAAAGACUCAGAUAAUGCUGAACUUAACUGUGCAGUGCUACAAGUAAAUCGACUUAAAUCAGCCCAGUGUGGAUCUUCAAUAAUAUAUCAUUGUAAGCAUAAGCUUUAGAGGUAAAGCGUUUGCAUUUGCAGUGCAUCAGAUAAAUUGUAUAUUUCUUAAAAUAGAAAUAUAUUAUGAUUGCAUAAAUCUUAAAAUGAAUUAUGUUAUUUGCUCUAAUAAGAAAAUUCUAAAUCAAUUAUUGAAACAGGAUACACACAAUUACUAAAGUACAGACAUCCUAGCAUUUGUGUCGGGCUCAUUUUGCUCAACAUGGUAUUUGUGGUUUUCAGCCUUUCUAAAAGUUGCAUGUUAUGUGAGUCAGCUUAUAGGAAGUACCAAGAACAGUCAAACCCAUGGAGACAGAAAGUAGAAUAGUGGUUGCCAAUGUCUGAGGGAGGUUGAAAUAGGAGAUGACCUCUAACUGAUAGAACGUUACUUUGUGUCGUGAUGAAAACUUUCUAAAUUUCAGUAGUGGUGAUGGUUGUAACUCUGCGAAUAUACUAAACAUCAUUGAUUUUUAAUCAUUUUAAGUGCAUGAAAUGUAUGCUUUGUACACGACACUUCAAUAAAGCUAUCCAGAAAAAAAAAAAAA-3'- Poly-A tail

Coding region

mRNA-related data

DNA

DNA (Gene ID: 3821)

HGNC Gene symbol

KLRC1

HGNC Gene name

killer cell lectin like receptor C1

Chr. RefSeq ID

NC_000012.12

Chromosome N°

12 10446551.. 10451156

CDS location

10446551.. 10451156

DNA strand

strand -

CCDS ID

CCDS8625.1

Mouse ortholog gene

MGI:1336161

Gene Variant

ClinVar, dbVar

DNA Ensembl ID

ENSG00000134545

HGNC other symbol

NKG2-A, NKG2-B, CD159a

UCSC ID

uc001qyn.5

GeneBank

INSDC: U54782

GeneCards

6374

MIM

161555

VEGA ID

OTTHUMG00000168584

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