HumanLectome - Human Lectin Entry

NCBI Summary

The ficolin family of proteins are characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. The collagen-like and the fibrinogen-like domains are also found separately in other proteins such as complement protein C1q, C-type lectins known as collectins, and tenascins. However, all these proteins recognize different targets, and are functionally distinct. Ficolin 1 encoded by FCN1 is predominantly expressed in the peripheral blood leukocytes, and has been postulated to function as a plasma protein with elastin-binding activity. [provided by RefSeq, Jul 2008].

Protein name

M-ficolin

Synonym(s)

Ficolin-1 (Collagen/fibrinogen domain-containing protein 1) (Ficolin-A) (Ficolin-alpha) (M-ficolin)

HGNC gene name

FCN1

HGNC name

ficolin 1

Protein_CD_name

Undefined

Lectin confidence

Curated

UniLectin class

Ficolin-like

Known lectin group

Ficolins

Lectin fold

a/b mixed with b-sheet / Fibrinogen C-ter like

Glycan specificity

GlcNAc, GalNAc, NeuAc

RefSeq accession

Gene ID

UniProt accession

Ensembl protein ID

UniRef cluster ID

LectomeXplore score

0.819

Reference

10.1074/jbc.M705741200

Other links

neXtProt, PFAM, InterPro, CFG data

Protein sequence and protein families (fasta) (326 amino acids) Download

MELSGATMARGLAVLLVLFLHIKNLPAQAADTCPEVKVVGLEGSDKLTILRGCPGLPGAPGPKGEAGVIGERGERGLPGAPGKAGPVGPKGDRGEKGMRGEKGDAGQSQSCATGPRNCKDLLDRGYFLSGWHTIYLPDCRPLTVLCDMDTDGGGWTVFQRRMDGSVDFYRDWAAYKQGFGSQLGEFWLGNDNIHALTAQGSSELRVDLVDFEGNHQFAKYKSFKVADEAEKYKLVLGAFVGGSAGNSLTGHNNNFFSTKDQDNDVSSSNCAEKFQGAWWYADCHASNLNGLYLMGPHESYANGINWSAAKGYKYSYKVSEMKVRPA

Mol* PDB structure viewerUniLectin3D

Select a PDB entry:

Structural models

AlphaFold v2: AF-O00602-F1 Download

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Expression

Human Protein Atlas

GeneCards

mRNA expression in normal human tissues for FCN1 Gene

ProteomicsDB

References

NCBI References (10 PubMed Identifiers)

Association of ficolin-1 and ficolin-3 gene variation and pulmonary tuberculosis susceptibility in a Chinese population. [33591573]

Association between serum ficolin-1 level and disease progression in primary biliary cholangitis. [32915797]

Associations of ficolins and mannose-binding lectin with acute myeloid leukaemia in adults. [32601370]

Ficolin-1 gene (FCN1) -144 C/A polymorphism is associated with adverse outcome of severe pneumonia in the under-five Egyptian children: A multicenter study. [32142211]

Sickening or Healing the Heart? The Association of Ficolin-1 and Rheumatic Fever. [30619357]

Characterization of ficolins as novel elastin-binding proteins and molecular cloning of human ficolin-1. [8947836]

Cloning and characterization of the human lectin P35 gene and its related gene. [8884275]

A novel human serum lectin with collagen- and fibrinogen-like domains that functions as an opsonin. [8576206]

Human ficolin: cDNA cloning, demonstration of peripheral blood leucocytes as the major site of synthesis and assignment of the gene to chromosome 9. [8573080]

Molecular cloning and characterization of ficolin, a multimeric protein with fibrinogen- and collagen-like domains. [7686157]

UniProt Main References (10 PubMed Identifiers)

Complete sequencing and characterization of 21,243 full-length human cDNAs. [14702039]

DNA sequence and analysis of human chromosome 9. [15164053]

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]

Signal peptide prediction based on analysis of experimentally verified cleavage sites. [15340161]

Secreted M-ficolin anchors onto monocyte transmembrane G protein-coupled receptor 43 and cross talks with plasma C-reactive protein to mediate immune signaling and regulate host defense. [21037097]

Tethering of Ficolin-1 to cell surfaces through recognition of sialic acid by the fibrinogen-like domain. [20400674]

Trivalent recognition unit of innate immunity system: crystal structure of trimeric human M-ficolin fibrinogen-like domain. [17148457]

Structural basis for innate immune sensing by M-ficolin and its control by a pH-dependent conformational switch. [17897951]

Carbohydrate recognition properties of human ficolins: glycan array screening reveals the sialic acid binding specificity of M-ficolin. [20032467]

The consensus coding sequences of human breast and colorectal cancers. [16959974]

RNA

RNA (Transcript ID: NM_002003.5)

RNA RefSeq ID

NM_002003.5

RNA name

ficolin 1

Isoforms

All isoforms of FCN1 containing a lectin domain

RNA Ensembl ID

ENST00000371806.4

Coding region

42..1022 (or 134909798.. 134917871)

mRNA location

134903232.. 134917912

NCBI Matured mRNA sequence 7588 NTP Download

m⁷G-5')ppp(5'-GUUAGAGCUGGGGGACUCUUCAGAGUCAAAGGCCAGAGAGCAUGGAGCUGAGUGGAGCCACCAUGGCCCGGGGGCUCGCUGUCCUGCUAGUCUUGUUCCUGCAUAUCAAGAACCUGCCUGCCCAGGCUGCGGACACAUGUCCAGAGGUGAAGGUGGUGGGCCUGGAGGGCUCUGACAAGCUCACCAUUCUCCGAGGCUGCCCGGGGCUGCCCGGGGCCCCAGGGCCAAAGGGAGAGGCAGGUGUCAUUGGAGAGAGAGGAGAACGCGGUCUCCCUGGAGCCCCUGGAAAGGCAGGACCAGUGGGGCCCAAAGGAGACCGAGGAGAGAAGGGGAUGCGUGGAGAGAAAGGAGACGCUGGGCAGUCUCAGUCGUGUGCGACAGGCCCACGCAACUGCAAGGACCUGCUAGACCGGGGGUAUUUCCUGAGCGGCUGGCACACCAUCUACCUGCCCGACUGCCGGCCCCUGACUGUGCUCUGUGACAUGGACACGGACGGAGGGGGCUGGACCGUUUUCCAGCGGAGGAUGGAUGGCUCUGUGGACUUCUAUCGGGACUGGGCCGCAUACAAGCAGGGCUUCGGCAGUCAGCUGGGGGAGUUCUGGCUGGGGAAUGACAACAUCCACGCCCUGACUGCCCAGGGAAGCAGCGAGCUCCGUGUAGACCUGGUGGACUUUGAGGGCAACCACCAGUUUGCUAAGUACAAAUCAUUCAAGGUGGCUGACGAGGCAGAGAAGUACAAGCUGGUACUGGGAGCCUUUGUCGGGGGCAGUGCGGGUAAUUCUCUAACGGGCCACAACAACAACUUCUUCUCCACCAAAGACCAAGACAAUGAUGUGAGUUCUUCGAAUUGUGCUGAGAAGUUCCAAGGAGCCUGGUGGUACGCCGACUGUCAUGCUUCAAACCUCAAUGGUCUCUACCUCAUGGGACCCCAUGAGAGCUAUGCCAAUGGUAUCAACUGGAGUGCGGCGAAGGGGUACAAAUAUAGCUACAAGGUGUCAGAGAUGAAGGUGCGGCCCGCCUAGACGGGCCAGGACCCCUCCACAUGCACCUGCUAGUGGGGAGGCCACACCCACAAGCGCUGCGUCGUGGAAGUCACCCCAUUUCCCCAGCCAGACACACUCCCAUGACGCCCACAGCUGCCCCUUUGCCCCCAGCUCAGUCAAGCCGCCACAUGCCCACAACCUCACCAGAGGGAGAAUUAUGUUUCUAAAUAUGUUUACUUUGGGACAGAAAAGUUUUACCAGUUUCAAUGUGUGUUUCUUGAACACCAGUGGUUUUGAUCACUUUCCUGUGUCUGUUGCACGGCAGGUCUUUCCCUGGAAUUUGGUAAGUCGGGAAGAGUCAGGACCCUUAUUUAGCAGAUGGCACUACCGAUGUUCAGGGAGGUUGAGUGACUUUUGCGAGGAUUUUCCACCUCCAGUAAUUGACACAGGGCGAUCCUCACCUCCACCCCCAAGCCUCCCCCAUCCCCCCAUGCCUCACUCACAACACUUCACACUUCUUGAAAAAGGUCACUUUGGGGUCCAGAAAACACUUACUAAAAAGGGGGAAAGUUUAGUAGGAACUUUUCUGCUUCCCACCACGGCAGAGUUCAUGCUUUGGGCUGGCUGGCUGCUGGGAAGAGAUAAACACUUAGCACUCACUAAGUGAGCGCCUGGUCAGCCACCUGCACAGAGAAGAUUCCGAAGAGGCCUUCCUCCCACACACAGACCUCAGCUAGAGGGGACCGCGGACCUCAGUGGGAAAAGCUGCACAAGGCUUCUAGGAGAUGAUGGAGAAGGGGCUUCUCCAGCUCCCAGGCCAGGGGAGAUUUCUCAACCACGACCUAAGAAGCAUCAAAGGGAAUGUGGCAAGUGUGACUCCAUUCAAAUCAAGAGCUCCCACUUACCGAAGGACACUAAGGGAACCAAAGGAAGGCCAGAGGGGCAGAAUCAACGUGCGGCACACAAAUCUUUAGUUUUCUACUAUUGCCGCAACCAGUCACCACAAAUGGAGUGGCUUGAAACAACAAGAACUCGCCACCUCCUGGCUCAGUAGAUCUGGAGUCCCUGGGCCUUACUGGGCCAGCAGGCAGGACUCAGCAGUGGUGGCUCCUUCCAGGGUUCUAGGGGAGAACCUGCUUCCUUGCCUUUUCCAGCCCCAGGGGUCACUGGCAUUCAUUGGCCCGGACUCCUUCCCCCAACCCCAAAGCCAGCAGCACCACAUCUCUCUGACCCUUCAUCCGUUGUCCCCUCUCCCCCCAAGCCCCAUGGGACAGGGUCUCCACUCCUGAGACUCAUGGGAUUAGACUAGGCCUACCUGGAUGAUCUGGGAUCCUCUCCCAUGUCCAGGUCUCUAUCCCUAACCACAUCAGCAAAGUCUCUUUUGCCAUGGAAGGUAUUUGCAGGCUCUGACUUUGUGUGUAUUAGGGCAGGACAUUUUUGGCGGGGCAGUGGUGGGGGCAGGGAAUUAUUCUGCCUACCAUGCCUUAUACAAAAAUAAAUAAAUCACAGGCUUAUACCUGAAAGAAUUCCUGCAAAUAAUAAAAGAAUUAGAGCAGCUCAGUUAAAUAAAAAAAGGUAUGAGAUGUGAACAGACACUUCACAGAAGAUGACAUGCAGGGGAGCAAGGUAUUUAUCAAAAAGUGCUCCACUUUUCACUUACCAGAGAAAUGCAAAUCAGCACCCAAAGGAGUCACUGCGGCACCCUCAUCUGAGCCUCAGAAGUUAGAAAGAUGGAUAGCACCAGUGUCAAAGGUGACUGUGGGAGGGAGAUUUGCAUACACUGCUAGUAACAAUGCGAAUUGAUGGAACCAACCUGGAAAAUGGCUUGGCAUCAACUGUUGGAGAAGAAGACACACAGUCCUCUAACCUGCCAGUCCCACAUCAGGGCCUGGAUAUGGCCGUCAUGUGUACCAGGGAGCAUGGCCAGGAAUCUUUACAGCCAAAUACUCACCAUAGCACCAAACUGGAAUCAGCCGACAUACCCAUCAGGAAGAGAAUGGAUGUUAAAAAAUGCAAGGAUAGCCAUUGGGUAGAACGCCAUACAGCCAUGACAAUUACACAGUGACACCUACACACAAGGAGCAUGAGUCUCACAAACAUGGCAGCAAAAGGAGCCUGUUCAAGAGGGUAUGUGCUAUGGAUUCCAUUGUAGAUAAAGUUUUUCAAAAGCAAAAGUAGCCAAUGGUAUUUUGGAUGCAUAUUUAGGUGGUAAAUGUAUACAGGAAAAAUAAGAAAGUGAUUGUAUUUGAGGGUGGGACCACAUGGUGACUGGGAAGGGACAGGGACAAGCCUCUGGGGUUCUGGCAAUGCUCUGUUUCUUGACCCAGGUGGUGAUUGUAAGGAUGUUUGUUAACUAGUGAUGAAAAUAAUUAAGCUGUACUUUUGCUUUAUACACUUUUGAGUACAUGUUAUGUUCCACAAUUUAAAAACUACUUAUAAAGAAACUGCACAUGCUUGGAUCCAGGAACAUGAGCUACAGGCACAUCCUCCACUGAUGCCCAGUGUUCUUGACUCAAUACCUGUAAGGAGAGGUCCUUGUAGCCCAUUGGGGGCUGACCAGACCCUACUACGCCCCUGCCACAAUCUCUAGUCCAUCACAAAAUCCACUAUUGGGAUAGUACUUUCGUCCCUCAGUAGGUAAGCAUUUUUACAACCUAGGAAGACUUAGCUUUAAGUCUAGAAAUGAUUAGUAUAAAUAUAAAAUAUAAAUAUGAUUAAUAUAAAUAUAAAAUAGCCAUAGAAAUAUGCCUUUUAGUUUGUUUUUUGAGACAGAGUUUUACUCUGCCACCCAGGCUGGAGUGCAGUGGCGUGAUCUCAGCUCACUGCAAUCUCCACCUCCCAGGUUCAAGAGAUUCUCAUGCUUCAGCCUCCCAAGUAGCUGGGAUCACAGGCACACACAACCAUGCCCAGCAAUUUUUUUGUAUUUUUAGUAGAGAUGGGGUUUCGCCGUGUUGGCCAGGCUGGUCUUGAACUCCCGACCUCAAGUGAUCCACCCGCCUCUGCCUCCCAAAUUGCUGAGAUUACAGGCGUGAGACACUGUGCCUGGCCAAAAUAUGCCUUUUGUAUUAAGGAAUCUGGACAGGUUUGAUUUUUCACAGUCUUGUAAUGUUUAAAUAAUUUGGCCUAUUAUGAAGAAUCUCACAAAUCCAAUAUAAAAUGUGGAACUAACUAAUCAAAAUCAUCUUGUAAUAUUACAUGGAAAUCUUAGUGCGUUUAUACACGGUAUUGGCAUAUUUAAGAGACUUUGAGCUCAUUGCAUUUCUAAGUUAAAUUAUUAGAUUUCUUAAGAUUUAAGUUAAAUUAUUAGAUUUUUAAAGAUUAAUUAGUGCUAAGGAGGGUUUUCUCAUUAGACAGCUGAAAUGCCGCAGGAGAAAUUUGAGUGUAUUCCACUUCUUAUUGCAAUUUUAAAUGUUUGAAGUUAUUUAAAGAACUAAAUUUAUGGUAUCCAAAAGCUCUAAAAAGGUGACUCUUAAGAUUUGCAGGUCUUAUAAAUAGAAAAACAAGAACUGUAAGCCAAACUUAAAAUAUUCAGGAUGAAUUGAGUUUUUGAAUUUGUAGCUUUCAGAAACUGAACAUUAAUUUUAAGAAGCAAAGCAGGCUGGGCACAGUGGCUCACGCCUGUAAUCCUAGCACUUUAGGAGGCUGAAGUGGGUGGAUCACUUGAGAUCAGGAGUUCAAGACCAGCCUGGCCAACAUGAUGAAACCUCCUCUCUACUAAAAAUACAAAACUCCGCCAGAAAUCGCUUGAUCCCGGGAGGUGGAGGUUGCAGUGAGCUGAGAUCGUGCCACUGCACUCCAGCCUGGGGAACAGAGCGAGAUUCCGCCUCAAAAAAAAAAUAAAAAUAAAAAGAAGAAGAAGAAGAAGGAGAAAGAGGGAGAGGGAGAGGGAGAGGGAGAGGGAGAGGGAGAGGGAGAAGAAGAAGAAGAAGAAGAAGAAGAAGAAGAAGAAGAAGAAGAAGAAGAAGAAGAAGAGGAAGAGGAAGAGGAAGAGGAAGAGGAAGAGGAAGAGGAAGAAGAAGAAGAAGAGGAAGAAGAAGAAGAAGCAGCAGCAGCGGCCAGGCGCGGUGGCUCACGCUUGUAAUCCCAGCACUUUGGGAGGCCGAGGCGGGCGGAUCACAAGGUCAGGAGAUCAAGACCAUCCUGGCUAACAUGAUGAAACCCCGUCUCUACUAAAAAUACAAAAAAAUUAGCCGUUCAUGGUGGGGGAUGCCUAUCGUCCCAGCUACUCGAGAAGCUGAGGCAGGAGAAUGGCGUGAACCCAGGAGGCAGAGGUUGAAGUGAGCCGAGAUCGCACCACUGCACUCCAGCCUGGGCGACAGAGCGAGACUCUGUCUCAAAAUAAAAGAAGCAAAGCAAGCUUAUGAAGAGAUGAAGAGUCUUUUCCCAUCACCAAUUCCUCCCCAACUCACAUCAGCAGAACUGAGAGAGCUUUUGUGAUUUGAGGGAUAAAGCUGAAUGGGUGAAAAGAAAUCAAGCCCUCCUCCUCUUGGGCCAGUGCUCUUCUUCCUGGCCAUGGGACCUCUCAAGUAGGAGUGUAGGCGUGGGCCCAUCCAGCAACAUUUGGGCAUUCGUGGACAUCCACAUAGUGUUGUUUCUGUUCUUUUCCUCUCCUUCCUCAUCUUCUCUCGUCUUUGUUGAAUAUUUUUAUUAUCCCGUCACCUCCUCUAUCAGCUUAUAACUUGUUCAUUCUUUUCCUAUCUUUUGGUGUUUAUGCUUGCGAUUGCAAUAUAUAGCCUUGAUUUUUUACGGUAUACUAUAAAUUAUUCCUUCUACCACUUUACCAAUGAAGACUUUGAAACACCUCUAACUACAUUCACUCCCUUCUGCUUUUUAUGCCAUUCUUGCCGCCAUGCUAUGAUACAUUUAUUUAAAGUCCUGCAAGAAAUGGCUAUUAGUAUUGUUUUGUGCAGUCCGUAUUCAUUUUUACCACAUUUUUACACUUUAUGUUGCCCUUUAUUCCUUCUUCUAUUUUAUUAUUAUUAUUAUUUUUGGUGUGAGAUCAUCUUCUUGCUGCCUGACAAACUCCCUUUCAUAUAUAUUUUUUAUUUUUAUUUUUUGAAACAGGGUCUCACUCUGUCCCCCAGGCUGGAGUGCAGCGGUAUGACCUUAGCUCACUGCAACCUCCACCUCCUGGGCUCAAACAAUUCUCCUGCCUCAGCUUCCCGUGUAGCUGGGACUACAGGUGUGCACCACUACGCUGGGCUAAUUUUUGUAUUUUUUGGUAGAGAUGGGGUUUCGCCAUGUUAGCCAGGCUGCUCUUGAACUCCUGACCUCAAGUGAUCCACCCGCCUCAGCCUCCCAAAGUGCUAGGAUUACAGAUGUGAGACACCGUGCCCAGCCUCAUAUAUUUUUUGAUGAAAGUCUGCUGAGGAUGAAUUCUGUCCACUUUUAUUAUCUGAAAACAUCUUUAUUUUGCCUCAUUUUAAAUAGUAUUUAGAUUGGGUGUAGACUUCUAUAUUGCCAAUUAGUUUCUUUUAGCACUGUAAAUACAGAUGUCCAGUAUUUUCAGAUUCAGUUAUUUCAGCUGAAAAGCUAGCUGAAAGUCUUGUUGCUCCUCUGAAGGUAAUAUGACUUUUUUCAAAAAAUACAUUUAUAAAAUUUUUUUUCUUUGCCUUGAUAGUUUUACUACAAGGUGCCUGGAUGAGACUUUCUCUGAAUUUGUCUUGCUUGGGGUUCAUAGAAUCUGUGACUUGAUGUCUUUCAUGAGUUUUGAAAAAUGCUAGCCAUUAUCUCUUAAAUAUUGCUAUUACUCUACUCCCUCUUCUCUUUCAGAUAUUUCAGUUACACCAAUGGCCAAUGUUUGCUCGUGUCUCAUAUGUCUCUUGUUCUAGUUUCUGGAUUUGUAUUCUUUUUUCCUUUUCACAUUCAGUCUGGAUAUUUUCUGCUGACCUAUAUUCCAGUUCACUAAUAAUGCUUUUCACUGUAUCUAAUUUGCUUAUAAAUAGAAAACCAUUGAUUGAGUUAUUAAUUUCAGUUAUAGAAUAGCCAGUGUAGACUCCAAUGCUUGGCUCCACUUCUCCACUUUUUCACCUAUUUUUUUCACCAUCUUCCAUUUUCUUCAACACACCAGUCAGAGUCGUUUUUAAAGACAUUUUAAACACCUCAGUGGCCUGUAGAUCUUAUCUUCUGUUUUUUGUUUCUUUUUAAUCUUAGUUUUUUGGCACACUUGGAGGGUUUUGAUUGAAUGCUAGACAUAGUAUUCAGGAAGGCAGAGAGGAUUUUUUUUUAAGUCAGAUUUUUUGAGGUAUAAUUUAAUACAGUAAAAUUCACCUAUUUUAGUUCAGUUCUAAGAGUUUCCUCUGUGACUUUUCCUUUGGCCCAUGGUUUAUUUAAAAUUGUGUUCUUUUACUUCCAAAUUAUUUGGGAUUUUUCUAGAUAUCUUUCUGUUCUUGAUUUCUGGCUUACCUCUAUCAGGGUCAGAGAACAAACUUAAUAUGAUUUCAAUUAUUUUAAAUUUGCCAAUGUUUAUUUUAUGGCCCAGAAUAUGGUCUAUGUUGGUGAAAGUUCAAUUUGAACUUGAAAAGAAUAUGUUUUAUGCUGUUGUCUACUGAAAAGUCUAUAUAUAAAAAAUAGAUUAAUAAACUGAUUAAUAGCCUGGUUCACCA-3'- Poly-A tail

Coding region

NCBI Matured mRNA sequence viewer

;

More about the NCBI sViewer.

DNA

DNA (Gene ID: 2219)

HGNC Gene symbol

FCN1

HGNC Gene name

ficolin 1

Chr. RefSeq ID

NC_000009.12

Chromosome N°

9 134909798.. 134917871

CDS location

134909798.. 134917871

DNA strand

strand -

CCDS ID

CCDS6985.1

Mouse ortholog gene

MGI:1341158

Gene Variant

ClinVar, dbVar

DNA Ensembl ID

ENSG00000085265

HGNC other symbol

FCNM

UCSC ID

uc004cfi.4

GeneBank

INSDC: D83920

GeneCards

3623

MIM

601252

VEGA ID

OTTHUMG00000020895

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