HumanLectome - Human Lectin Entry

NCBI Summary

The ficolin family of proteins are characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. The collagen-like and the fibrinogen-like domains are also found separately in other proteins such as complement protein C1q, C-type lectins known as collectins, and tenascins. However, all these proteins recognize different targets, and are functionally distinct. Ficolin 1 encoded by FCN1 is predominantly expressed in the peripheral blood leukocytes, and has been postulated to function as a plasma protein with elastin-binding activity. [provided by RefSeq, Jul 2008].

Protein name

M-ficolin

Synonym(s)

Ficolin-1 (Collagen/fibrinogen domain-containing protein 1) (Ficolin-A) (Ficolin-alpha) (M-ficolin)

HGNC gene name

FCN1

HGNC name

ficolin 1

Protein_CD_name

Undefined

Lectin confidence

Curated

UniLectin class

Ficolin-like

Known lectin group

Ficolins

Lectin fold

a/b mixed with b-sheet / Fibrinogen C-ter like

Glycan specificity

GlcNAc, GalNAc, NeuAc

RefSeq accession

Gene ID

UniProt accession

Ensembl protein ID

UniRef cluster ID

LectomeXplore score

0.819

Reference

10.1074/jbc.M705741200

Other links

neXtProt, PFAM, InterPro, CFG data

Protein sequence and protein families (fasta) (326 amino acids) Download

MELSGATMARGLAVLLVLFLHIKNLPAQAADTCPEVKVVGLEGSDKLTILRGCPGLPGAPGPKGEAGVIGERGERGLPGAPGKAGPVGPKGDRGEKGMRGEKGDAGQSQSCATGPRNCKDLLDRGYFLSGWHTIYLPDCRPLTVLCDMDTDGGGWTVFQRRMDGSVDFYRDWAAYKQGFGSQLGEFWLGNDNIHALTAQGSSELRVDLVDFEGNHQFAKYKSFKVADEAEKYKLVLGAFVGGSAGNSLTGHNNNFFSTKDQDNDVSSSNCAEKFQGAWWYADCHASNLNGLYLMGPHESYANGINWSAAKGYKYSYKVSEMKVRPA

Mol* PDB structure viewerUniLectin3D

Select a PDB entry:

Structural models

AlphaFold v2: AF-O00602-F1 Download

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

AlphaFold_v2 structural model assessment through SWISS-MODEL tools.

Expression

Human Protein Atlas

GeneCards

mRNA expression in normal human tissues for FCN1 Gene

ProteomicsDB

References

NCBI References (10 PubMed Identifiers)

Association of ficolin-1 and ficolin-3 gene variation and pulmonary tuberculosis susceptibility in a Chinese population. [33591573]

Association between serum ficolin-1 level and disease progression in primary biliary cholangitis. [32915797]

Associations of ficolins and mannose-binding lectin with acute myeloid leukaemia in adults. [32601370]

Ficolin-1 gene (FCN1) -144 C/A polymorphism is associated with adverse outcome of severe pneumonia in the under-five Egyptian children: A multicenter study. [32142211]

Sickening or Healing the Heart? The Association of Ficolin-1 and Rheumatic Fever. [30619357]

Characterization of ficolins as novel elastin-binding proteins and molecular cloning of human ficolin-1. [8947836]

Cloning and characterization of the human lectin P35 gene and its related gene. [8884275]

A novel human serum lectin with collagen- and fibrinogen-like domains that functions as an opsonin. [8576206]

Human ficolin: cDNA cloning, demonstration of peripheral blood leucocytes as the major site of synthesis and assignment of the gene to chromosome 9. [8573080]

Molecular cloning and characterization of ficolin, a multimeric protein with fibrinogen- and collagen-like domains. [7686157]

UniProt Main References (10 PubMed Identifiers)

Complete sequencing and characterization of 21,243 full-length human cDNAs. [14702039]

DNA sequence and analysis of human chromosome 9. [15164053]

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]

Signal peptide prediction based on analysis of experimentally verified cleavage sites. [15340161]

Secreted M-ficolin anchors onto monocyte transmembrane G protein-coupled receptor 43 and cross talks with plasma C-reactive protein to mediate immune signaling and regulate host defense. [21037097]

Tethering of Ficolin-1 to cell surfaces through recognition of sialic acid by the fibrinogen-like domain. [20400674]

Trivalent recognition unit of innate immunity system: crystal structure of trimeric human M-ficolin fibrinogen-like domain. [17148457]

Structural basis for innate immune sensing by M-ficolin and its control by a pH-dependent conformational switch. [17897951]

Carbohydrate recognition properties of human ficolins: glycan array screening reveals the sialic acid binding specificity of M-ficolin. [20032467]

The consensus coding sequences of human breast and colorectal cancers. [16959974]

RNA

RNA (Transcript ID: NM_002003.5)

RNA RefSeq ID

NM_002003.5

RNA name

ficolin 1

Isoforms

All isoforms of FCN1 containing a lectin domain

RNA Ensembl ID

ENST00000371806.4

Coding region

42..1022 (or 134909798.. 134917871)

mRNA location

134903232.. 134917912

NCBI Matured mRNA sequence 7588 NTP Download

m⁷G-5')ppp(5'-GUUAGAGCUGGGGGACUCUUCAGAGUCAAAGGCCAGAGAGCAUGGAGCUGAGUGGAGCCACCAUGGCCCGGGGGCUCGCUGUCCUGCUAGUCUUGUUCCUGCAUAUCAAGAACCUGCCUGCCCAGGCUGCGGACACAUGUCCAGAGGUGAAGGUGGUGGGCCUGGAGGGCUCUGACAAGCUCACCAUUCUCCGAGGCUGCCCGGGGCUGCCCGGGGCCCCAGGGCCAAAGGGAGAGGCAGGUGUCAUUGGAGAGAGAGGAGAACGCGGUCUCCCUGGAGCCCCUGGAAAGGCAGGACCAGUGGGGCCCAAAGGAGACCGAGGAGAGAAGGGGAUGCGUGGAGAGAAAGGAGACGCUGGGCAGUCUCAGUCGUGUGCGACAGGCCCACGCAACUGCAAGGACCUGCUAGACCGGGGGUAUUUCCUGAGCGGCUGGCACACCAUCUACCUGCCCGACUGCCGGCCCCUGACUGUGCUCUGUGACAUGGACACGGACGGAGGGGGCUGGACCGUUUUCCAGCGGAGGAUGGAUGGCUCUGUGGACUUCUAUCGGGACUGGGCCGCAUACAAGCAGGGCUUCGGCAGUCAGCUGGGGGAGUUCUGGCUGGGGAAUGACAACAUCCACGCCCUGACUGCCCAGGGAAGCAGCGAGCUCCGUGUAGACCUGGUGGACUUUGAGGGCAACCACCAGUUUGCUAAGUACAAAUCAUUCAAGGUGGCUGACGAGGCAGAGAAGUACAAGCUGGUACUGGGAGCCUUUGUCGGGGGCAGUGCGGGUAAUUCUCUAACGGGCCACAACAACAACUUCUUCUCCACCAAAGACCAAGACAAUGAUGUGAGUUCUUCGAAUUGUGCUGAGAAGUUCCAAGGAGCCUGGUGGUACGCCGACUGUCAUGCUUCAAACCUCAAUGGUCUCUACCUCAUGGGACCCCAUGAGAGCUAUGCCAAUGGUAUCAACUGGAGUGCGGCGAAGGGGUACAAAUAUAGCUACAAGGUGUCAGAGAUGAAGGUGCGGCCCGCCUAGACGGGCCAGGACCCCUCCACAUGCACCUGCUAGUGGGGAGGCCACACCCACAAGCGCUGCGUCGUGGAAGUCACCCCAUUUCCCCAGCCAGACACACUCCCAUGACGCCCACAGCUGCCCCUUUGCCCCCAGCUCAGUCAAGCCGCCACAUGCCCACAACCUCACCAGAGGGAGAAUUAUGUUUCUAAAUAUGUUUACUUUGGGACAGAAAAGUUUUACCAGUUUCAAUGUGUGUUUCUUGAACACCAGUGGUUUUGAUCACUUUCCUGUGUCUGUUGCACGGCAGGUCUUUCCCUGGAAUUUGGUAAGUCGGGAAGAGUCAGGACCCUUAUUUAGCAGAUGGCACUACCGAUGUUCAGGGAGGUUGAGUGACUUUUGCGAGGAUUUUCCACCUCCAGUAAUUGACACAGGGCGAUCCUCACCUCCACCCCCAAGCCUCCCCCAUCCCCCCAUGCCUCACUCACAACACUUCACACUUCUUGAAAAAGGUCACUUUGGGGUCCAGAAAACACUUACUAAAAAGGGGGAAAGUUUAGUAGGAACUUUUCUGCUUCCCACCACGGCAGAGUUCAUGCUUUGGGCUGGCUGGCUGCUGGGAAGAGAUAAACACUUAGCACUCACUAAGUGAGCGCCUGGUCAGCCACCUGCACAGAGAAGAUUCCGAAGAGGCCUUCCUCCCACACACAGACCUCAGCUAGAGGGGACCGCGGACCUCAGUGGGAAAAGCUGCACAAGGCUUCUAGGAGAUGAUGGAGAAGGGGCUUCUCCAGCUCCCAGGCCAGGGGAGAUUUCUCAACCACGACCUAAGAAGCAUCAAAGGGAAUGUGGCAAGUGUGACUCCAUUCAAAUCAAGAGCUCCCACUUACCGAAGGACACUAAGGGAACCAAAGGAAGGCCAGAGGGGCAGAAUCAACGUGCGGCACACAAAUCUUUAGUUUUCUACUAUUGCCGCAACCAGUCACCACAAAUGGAGUGGCUUGAAACAACAAGAACUCGCCACCUCCUGGCUCAGUAGAUCUGGAGUCCCUGGGCCUUACUGGGCCAGCAGGCAGGACUCAGCAGUGGUGGCUCCUUCCAGGGUUCUAGGGGAGAACCUGCUUCCUUGCCUUUUCCAGCCCCAGGGGUCACUGGCAUUCAUUGGCCCGGACUCCUUCCCCCAACCCCAAAGCCAGCAGCACCACAUCUCUCUGACCCUUCAUCCGUUGUCCCCUCUCCCCCCAAGCCCCAUGGGACAGGGUCUCCACUCCUGAGACUCAUGGGAUUAGACUAGGCCUACCUGGAUGAUCUGGGAUCCUCUCCCAUGUCCAGGUCUCUAUCCCUAACCACAUCAGCAAAGUCUCUUUUGCCAUGGAAGGUAUUUGCAGGCUCUGACUUUGUGUGUAUUAGGGCAGGACAUUUUUGGCGGGGCAGUGGUGGGGGCAGGGAAUUAUUCUGCCUACCAUGCCUUAUACAAAAAUAAAUAAAUCACAGGCUUAUACCUGAAAGAAUUCCUGCAAAUAAUAAAAGAAUUAGAGCAGCUCAGUUAAAUAAAAAAAGGUAUGAGAUGUGAACAGACACUUCACAGAAGAUGACAUGCAGGGGAGCAAGGUAUUUAUCAAAAAGUGCUCCACUUUUCACUUACCAGAGAAAUGCAAAUCAGCACCCAAAGGAGUCACUGCGGCACCCUCAUCUGAGCCUCAGAAGUUAGAAAGAUGGAUAGCACCAGUGUCAAAGGUGACUGUGGGAGGGAGAUUUGCAUACACUGCUAGUAACAAUGCGAAUUGAUGGAACCAACCUGGAAAAUGGCUUGGCAUCAACUGUUGGAGAAGAAGACACACAGUCCUCUAACCUGCCAGUCCCACAUCAGGGCCUGGAUAUGGCCGUCAUGUGUACCAGGGAGCAUGGCCAGGAAUCUUUACAGCCAAAUACUCACCAUAGCACCAAACUGGAAUCAGCCGACAUACCCAUCAGGAAGAGAAUGGAUGUUAAAAAAUGCAAGGAUAGCCAUUGGGUAGAACGCCAUACAGCCAUGACAAUUACACAGUGACACCUACACACAAGGAGCAUGAGUCUCACAAACAUGGCAGCAAAAGGAGCCUGUUCAAGAGGGUAUGUGCUAUGGAUUCCAUUGUAGAUAAAGUUUUUCAAAAGCAAAAGUAGCCAAUGGUAUUUUGGAUGCAUAUUUAGGUGGUAAAUGUAUACAGGAAAAAUAAGAAAGUGAUUGUAUUUGAGGGUGGGACCACAUGGUGACUGGGAAGGGACAGGGACAAGCCUCUGGGGUUCUGGCAAUGCUCUGUUUCUUGACCCAGGUGGUGAUUGUAAGGAUGUUUGUUAACUAGUGAUGAAAAUAAUUAAGCUGUACUUUUGCUUUAUACACUUUUGAGUACAUGUUAUGUUCCACAAUUUAAAAACUACUUAUAAAGAAACUGCACAUGCUUGGAUCCAGGAACAUGAGCUACAGGCACAUCCUCCACUGAUGCCCAGUGUUCUUGACUCAAUACCUGUAAGGAGAGGUCCUUGUAGCCCAUUGGGGGCUGACCAGACCCUACUACGCCCCUGCCACAAUCUCUAGUCCAUCACAAAAUCCACUAUUGGGAUAGUACUUUCGUCCCUCAGUAGGUAAGCAUUUUUACAACCUAGGAAGACUUAGCUUUAAGUCUAGAAAUGAUUAGUAUAAAUAUAAAAUAUAAAUAUGAUUAAUAUAAAUAUAAAAUAGCCAUAGAAAUAUGCCUUUUAGUUUGUUUUUUGAGACAGAGUUUUACUCUGCCACCCAGGCUGGAGUGCAGUGGCGUGAUCUCAGCUCACUGCAAUCUCCACCUCCCAGGUUCAAGAGAUUCUCAUGCUUCAGCCUCCCAAGUAGCUGGGAUCACAGGCACACACAACCAUGCCCAGCAAUUUUUUUGUAUUUUUAGUAGAGAUGGGGUUUCGCCGUGUUGGCCAGGCUGGUCUUGAACUCCCGACCUCAAGUGAUCCACCCGCCUCUGCCUCCCAAAUUGCUGAGAUUACAGGCGUGAGACACUGUGCCUGGCCAAAAUAUGCCUUUUGUAUUAAGGAAUCUGGACAGGUUUGAUUUUUCACAGUCUUGUAAUGUUUAAAUAAUUUGGCCUAUUAUGAAGAAUCUCACAAAUCCAAUAUAAAAUGUGGAACUAACUAAUCAAAAUCAUCUUGUAAUAUUACAUGGAAAUCUUAGUGCGUUUAUACACGGUAUUGGCAUAUUUAAGAGACUUUGAGCUCAUUGCAUUUCUAAGUUAAAUUAUUAGAUUUCUUAAGAUUUAAGUUAAAUUAUUAGAUUUUUAAAGAUUAAUUAGUGCUAAGGAGGGUUUUCUCAUUAGACAGCUGAAAUGCCGCAGGAGAAAUUUGAGUGUAUUCCACUUCUUAUUGCAAUUUUAAAUGUUUGAAGUUAUUUAAAGAACUAAAUUUAUGGUAUCCAAAAGCUCUAAAAAGGUGACUCUUAAGAUUUGCAGGUCUUAUAAAUAGAAAAACAAGAACUGUAAGCCAAACUUAAAAUAUUCAGGAUGAAUUGAGUUUUUGAAUUUGUAGCUUUCAGAAACUGAACAUUAAUUUUAAGAAGCAAAGCAGGCUGGGCACAGUGGCUCACGCCUGUAAUCCUAGCACUUUAGGAGGCUGAAGUGGGUGGAUCACUUGAGAUCAGGAGUUCAAGACCAGCCUGGCCAACAUGAUGAAACCUCCUCUCUACUAAAAAUACAAAACUCCGCCAGAAAUCGCUUGAUCCCGGGAGGUGGAGGUUGCAGUGAGCUGAGAUCGUGCCACUGCACUCCAGCCUGGGGAACAGAGCGAGAUUCCGCCUCAAAAAAAAAAUAAAAAUAAAAAGAAGAAGAAGAAGAAGGAGAAAGAGGGAGAGGGAGAGGGAGAGGGAGAGGGAGAGGGAGAGGGAGAAGAAGAAGAAGAAGAAGAAGAAGAAGAAGAAGAAGAAGAAGAAGAAGAAGAAGAAGAGGAAGAGGAAGAGGAAGAGGAAGAGGAAGAGGAAGAGGAAGAAGAAGAAGAAGAGGAAGAAGAAGAAGAAGCAGCAGCAGCGGCCAGGCGCGGUGGCUCACGCUUGUAAUCCCAGCACUUUGGGAGGCCGAGGCGGGCGGAUCACAAGGUCAGGAGAUCAAGACCAUCCUGGCUAACAUGAUGAAACCCCGUCUCUACUAAAAAUACAAAAAAAUUAGCCGUUCAUGGUGGGGGAUGCCUAUCGUCCCAGCUACUCGAGAAGCUGAGGCAGGAGAAUGGCGUGAACCCAGGAGGCAGAGGUUGAAGUGAGCCGAGAUCGCACCACUGCACUCCAGCCUGGGCGACAGAGCGAGACUCUGUCUCAAAAUAAAAGAAGCAAAGCAAGCUUAUGAAGAGAUGAAGAGUCUUUUCCCAUCACCAAUUCCUCCCCAACUCACAUCAGCAGAACUGAGAGAGCUUUUGUGAUUUGAGGGAUAAAGCUGAAUGGGUGAAAAGAAAUCAAGCCCUCCUCCUCUUGGGCCAGUGCUCUUCUUCCUGGCCAUGGGACCUCUCAAGUAGGAGUGUAGGCGUGGGCCCAUCCAGCAACAUUUGGGCAUUCGUGGACAUCCACAUAGUGUUGUUUCUGUUCUUUUCCUCUCCUUCCUCAUCUUCUCUCGUCUUUGUUGAAUAUUUUUAUUAUCCCGUCACCUCCUCUAUCAGCUUAUAACUUGUUCAUUCUUUUCCUAUCUUUUGGUGUUUAUGCUUGCGAUUGCAAUAUAUAGCCUUGAUUUUUUACGGUAUACUAUAAAUUAUUCCUUCUACCACUUUACCAAUGAAGACUUUGAAACACCUCUAACUACAUUCACUCCCUUCUGCUUUUUAUGCCAUUCUUGCCGCCAUGCUAUGAUACAUUUAUUUAAAGUCCUGCAAGAAAUGGCUAUUAGUAUUGUUUUGUGCAGUCCGUAUUCAUUUUUACCACAUUUUUACACUUUAUGUUGCCCUUUAUUCCUUCUUCUAUUUUAUUAUUAUUAUUAUUUUUGGUGUGAGAUCAUCUUCUUGCUGCCUGACAAACUCCCUUUCAUAUAUAUUUUUUAUUUUUAUUUUUUGAAACAGGGUCUCACUCUGUCCCCCAGGCUGGAGUGCAGCGGUAUGACCUUAGCUCACUGCAACCUCCACCUCCUGGGCUCAAACAAUUCUCCUGCCUCAGCUUCCCGUGUAGCUGGGACUACAGGUGUGCACCACUACGCUGGGCUAAUUUUUGUAUUUUUUGGUAGAGAUGGGGUUUCGCCAUGUUAGCCAGGCUGCUCUUGAACUCCUGACCUCAAGUGAUCCACCCGCCUCAGCCUCCCAAAGUGCUAGGAUUACAGAUGUGAGACACCGUGCCCAGCCUCAUAUAUUUUUUGAUGAAAGUCUGCUGAGGAUGAAUUCUGUCCACUUUUAUUAUCUGAAAACAUCUUUAUUUUGCCUCAUUUUAAAUAGUAUUUAGAUUGGGUGUAGACUUCUAUAUUGCCAAUUAGUUUCUUUUAGCACUGUAAAUACAGAUGUCCAGUAUUUUCAGAUUCAGUUAUUUCAGCUGAAAAGCUAGCUGAAAGUCUUGUUGCUCCUCUGAAGGUAAUAUGACUUUUUUCAAAAAAUACAUUUAUAAAAUUUUUUUUCUUUGCCUUGAUAGUUUUACUACAAGGUGCCUGGAUGAGACUUUCUCUGAAUUUGUCUUGCUUGGGGUUCAUAGAAUCUGUGACUUGAUGUCUUUCAUGAGUUUUGAAAAAUGCUAGCCAUUAUCUCUUAAAUAUUGCUAUUACUCUACUCCCUCUUCUCUUUCAGAUAUUUCAGUUACACCAAUGGCCAAUGUUUGCUCGUGUCUCAUAUGUCUCUUGUUCUAGUUUCUGGAUUUGUAUUCUUUUUUCCUUUUCACAUUCAGUCUGGAUAUUUUCUGCUGACCUAUAUUCCAGUUCACUAAUAAUGCUUUUCACUGUAUCUAAUUUGCUUAUAAAUAGAAAACCAUUGAUUGAGUUAUUAAUUUCAGUUAUAGAAUAGCCAGUGUAGACUCCAAUGCUUGGCUCCACUUCUCCACUUUUUCACCUAUUUUUUUCACCAUCUUCCAUUUUCUUCAACACACCAGUCAGAGUCGUUUUUAAAGACAUUUUAAACACCUCAGUGGCCUGUAGAUCUUAUCUUCUGUUUUUUGUUUCUUUUUAAUCUUAGUUUUUUGGCACACUUGGAGGGUUUUGAUUGAAUGCUAGACAUAGUAUUCAGGAAGGCAGAGAGGAUUUUUUUUUAAGUCAGAUUUUUUGAGGUAUAAUUUAAUACAGUAAAAUUCACCUAUUUUAGUUCAGUUCUAAGAGUUUCCUCUGUGACUUUUCCUUUGGCCCAUGGUUUAUUUAAAAUUGUGUUCUUUUACUUCCAAAUUAUUUGGGAUUUUUCUAGAUAUCUUUCUGUUCUUGAUUUCUGGCUUACCUCUAUCAGGGUCAGAGAACAAACUUAAUAUGAUUUCAAUUAUUUUAAAUUUGCCAAUGUUUAUUUUAUGGCCCAGAAUAUGGUCUAUGUUGGUGAAAGUUCAAUUUGAACUUGAAAAGAAUAUGUUUUAUGCUGUUGUCUACUGAAAAGUCUAUAUAUAAAAAAUAGAUUAAUAAACUGAUUAAUAGCCUGGUUCACCA-3'- Poly-A tail

Coding region

NCBI Matured mRNA sequence viewer

;

More about the NCBI sViewer.

DNA

DNA (Gene ID: 2219)

HGNC Gene symbol

FCN1

HGNC Gene name

ficolin 1

Chr. RefSeq ID

NC_000009.12

Chromosome N°

9 134909798.. 134917871

CDS location

134909798.. 134917871

DNA strand

strand -

CCDS ID

CCDS6985.1

Mouse ortholog gene

MGI:1341158

Gene Variant

ClinVar, dbVar

DNA Ensembl ID

ENSG00000085265

HGNC other symbol

FCNM

UCSC ID

uc004cfi.4

GeneBank

INSDC: D83920

GeneCards

3623

MIM

601252

VEGA ID

OTTHUMG00000020895