NCBI Summary
Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene is a lysophospholipase expressed in eosinophils and basophils. It hydrolyzes lysophosphatidylcholine to glycerophosphocholine and a free fatty acid. This protein may possess carbohydrate or IgE-binding activities. It is both structurally and functionally related to the galectin family of beta-galactoside binding proteins. It may be associated with inflammation and some myeloid leukemias. [provided by RefSeq, Jul 2008].
Protein
Protein (NP_001819)
Galectin 10 / Charcot-Leyden crystal galectin
Galectin-10 (Gal-10) (Charcot-Leyden crystal protein) (CLC) (Eosinophil lysophospholipase) (Lysolecithin acylhydrolase)
CLC
Charcot-Leyden crystal galectin
Undefined
Low evidence
Galectin
S-Type Lectins - Prototypical
b-sandwich / ConA-like
Man
NP_001819
1178
Q05315
ENSP00000221804.3
Q05315
0.455
10.1021/bi990756e
neXtProt, PFAM, InterPro
Protein sequence and protein families (fasta) (142 amino acids) Download
MSLLPVPYTEAASLSTGSTVTIKGRPLACFLNEPYLQVDFHTEMKEESDIVFHFQVCFGRRVVMNSREYGAWKQQVESKNMPFQDGQEFELSISVLPDKYQVMVNGQSSYTFDHRIKPEAVKMVQVWRDISLTKFNVSYLKR
Mol* PDB structure viewerUniLectin3D
Structural models
AlphaFold v2: AF-Q05315-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

AlphaFold_v2 structural model assessment through SWISS-MODEL tools.

Ligand
Glycan ligands from structural data
Gal(b1-4)Glc
6A1T
6A1T
GlyConnect Structures
ribose
Rib
6QRN
6QRN
GlyConnect Structures
Man
Man
1QKQ
1QKQ
GlyConnect Structures
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for CLC Gene
ProteomicsDB
References
NCBI References (10 PubMed Identifiers)
  • Identification of galectin-10 as a biomarker for periodontitis based on proteomic analysis of gingival crevicular fluid. [33300083]
  • [Expression and pathological role of galectin-10 in different types of nasal polyps]. [32911886]
  • Galectin-10, the protein that forms Charcot-Leyden crystals, is not stored in granules but resides in the peripheral cytoplasm of human eosinophils. [32108369]
  • A reference map of the human binary protein interactome. [32296183]
  • Predictive Significance of Charcot-Leyden Crystals for Eosinophilic Chronic Rhinosinusitis With Nasal Polyps. [31269798]
  • Localization of the human eosinophil Charcot-Leyden crystal protein (lysophospholipase) gene (CLC) to chromosome 19 and the human ribonuclease 2 (eosinophil-derived neurotoxin) and ribonuclease 3 (eosinophil cationic protein) genes (RNS2 and RNS3) to chromosome 14. [1577491]
  • Charcot-Leyden crystal protein in the degranulation and recovery of activated basophils. [1373430]
  • Ultrastructural localization of Charcot-Leyden crystal protein (lysophospholipase) to intracytoplasmic crystals in tumor cells of primary solid and papillary epithelial neoplasm of the pancreas. [2160563]
  • Ultrastructural localization of Charcot-Leyden crystal protein (lysophospholipase) and peroxidase in macrophages, eosinophils, and extracellular matrix of the skin in the hypereosinophilic syndrome. [2160562]
  • Comparative properties of the Charcot-Leyden crystal protein and the major basic protein from human eosinophils. [942977]
UniProt Main References (13 PubMed Identifiers)
  • Molecular cloning and characterization of human eosinophil Charcot-Leyden crystal protein (lysophospholipase). Similarities to IgE binding proteins and the S-type animal lectin superfamily. [8419478]
  • The genomic structure of the human Charcot-Leyden crystal protein gene is analogous to those of the galectin genes. [9119387]
  • A primate subfamily of galectins expressed at the maternal-fetal interface that promote immune cell death. [19497882]
  • The DNA sequence and biology of human chromosome 19. [15057824]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
  • Comparative proteomics of nasal fluid in seasonal allergic rhinitis. [16457599]
  • Human CD4+CD25+ regulatory T cells: proteome analysis identifies galectin-10 as a novel marker essential for their anergy and suppressive function. [17502455]
  • Galectin-10, eosinophils, and celiac disease. [19758173]
  • Galectin-10, a potential biomarker of eosinophilic airway inflammation. [22880030]
  • An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. [24275569]
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RNA
RNA (Transcript ID: NM_001828.6)
NM_001828.6
Charcot-Leyden crystal galectin
All isoforms of CLC containing a lectin domain
ENST00000221804.5
78..506 (or 39731380.. 39737952)
39731255.. 39738029
NCBI Matured mRNA sequence 631 NTPDownload 
m7G-5')ppp(5'-CAUUUAAAUUCUGCAGCUCAGAGAUUCACACAGAAGUCUGGACACAAUUCAGAAGAGCCACCCAGAAGGAGACAACAAUGUCCCUGCUACCCGUGCCAUACACAGAGGCUGCCUCUUUGUCUACUGGUUCUACUGUGACAAUCAAAGGGCGACCACUUGCCUGUUUCUUGAAUGAACCAUAUCUGCAGGUGGAUUUCCACACUGAGAUGAAGGAGGAAUCAGACAUUGUCUUCCAUUUCCAAGUGUGCUUUGGUCGUCGUGUGGUCAUGAACAGCCGUGAGUAUGGGGCCUGGAAGCAGCAGGUGGAAUCCAAGAAUAUGCCCUUUCAGGAUGGCCAAGAAUUUGAACUGAGCAUCUCAGUGCUGCCAGAUAAGUACCAGGUAAUGGUCAAUGGCCAAUCCUCUUACACCUUUGACCAUAGAAUCAAGCCUGAGGCUGUGAAGAUGGUGCAAGUGUGGAGAGAUAUCUCCCUGACCAAAUUUAAUGUCAGCUAUUUAAAGAGAUAACCAGACUUCAUGUUGCCAAGGAAUCCCUGUCUCUACGUGAACUUGGGAUUCCAAAGCCAGCUAACAGCAUGAUCUUUUCUCACUUCAAUCCUUACUCCUGCUCAUUAAAACUUAAUCAAACUUCA-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
;
More about the NCBI sViewer.
DNA
DNA (Gene ID: 1178)
CLC
Charcot-Leyden crystal galectin
NC_000019.10
19  39731380.. 39737952
39731380.. 39737952
strand -
CCDS33025.1
ClinVar, dbVar
ENSG00000105205
LGALS10, MGC149659, Gal-10
uc002omh.4
INSDC: L01664
2014
153310
OTTHUMG00000183144
ENA, DDBJ, Monarch
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (429 bp)
5'-ATGTCCCTGCTACCCGTGCCATACACAGAGGCTGCCTCTTTGTCTACTGGTTCTACTGTGACAATCAAAGGGCGACCACTTGCCTGTTTCTTGAATGAACCATATCTGCAGGTGGATTTCCACACTGAGATGAAGGAGGAATCAGACATTGTCTTCCATTTCCAAGTGTGCTTTGGTCGTCGTGTGGTCATGAACAGCCGTGAGTATGGGGCCTGGAAGCAGCAGGTGGAATCCAAGAATATGCCCTTTCAGGATGGCCAAGAATTTGAACTGAGCATCTCAGTGCTGCCAGATAAGTACCAGGTAATGGTCAATGGCCAATCCTCTTACACCTTTGACCATAGAATCAAGCCTGAGGCTGTGAAGATGGTGCAAGTGTGGAGAGATATCTCCCTGACCAAATTTAATGTCAGCTATTTAAAGAGATAA-3'
NCBI CDS gene sequence with introns (location: 39731380.. 39737952) (6573 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 39731255.. 39738029) (6775 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [39731255.. 39738029 + 1000]) (7775 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
How to cite: Schnider B., M'Rad Y., el Ahmadie J., de Brevern AG., Imberty A., Lisacek F., HumanLectome, an update of UniLectin for the annotation and prediction of human lectins, Nucleic Acids Reasearch doi.org/10.1093/nar/gkad905