Protein
Protein (NP_001773)
CD72
B-cell differentiation antigen CD72 (Lyb-2) (CD antigen CD72)
CD72
CD72 molecule
CD72
Very low evidence
C-type lectin
Undefined
C-type - Natural Killer NK
a/b mixed / C-type lectin-like
Uncharacterised
NP_001773
971
P21854
ENSP00000259633.4
P21854
0.341
Undefined
PFAM, InterPro
Protein sequence and protein families (fasta) (359 amino acids) Download
MAEAITYADLRFVKAPLKKSISSRLGQDPGADDDGEITYENVQVPAVLGVPSSLASSVLGDKAAVKSEQPTASWRAVTSPAVGRILPCRTTCLRYLLLGLLLTCLLLGVTAICLGVRYLQVSQQLQQTNRVLEVTNSSLRQQLRLKITQLGQSAEDLQGSRRELAQSQEALQVEQRAHQAAEGQLQACQADRQKTKETLQSEEQQRRALEQKLSNMENRLKPFFTCGSADTCCPSGWIMHQKSCFYISLTSKNWQESQKQCETLSSKLATFSEIYPQSHSYYFLNSLLPNGGSGNSYWTGLSSNKDWKLTDDTQRTRTYAQSSKCNKVHKTWSWWTLESESCRSSLPYICEMTAFRFPD
No structure currently available in the PDB RCSB Databank.
Structural models
AlphaFold v2: AF-P21854-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

SWISS-MODEL structural models
SWISS-MODEL structural model
Modeller structural model (Homology modelling pipeline), Error: [1.65, 2.18] ÅDownload
The location of the lectin domain structural model is: 194-354
We infer [1.65, 2.18] Å as the interval of error of this structural model.
Template 1: 3WHD chain: C, Q8WXI8, NP_525126.2, sequence identity: 21.1%, coverage: 84.5%, location in sequence: 63-215, (63-215 in PDB).
Template 2: 6BBD chain: A, Q9N1X4, NP_999275.1, sequence identity: 17.4%, coverage: 86.3%, location in sequence: 225-378, (205-358 in PDB).
Template 3: 4WRE chain: A, P08427, NP_001257574.1, sequence identity: 14.3%, coverage: 80.7%, location in sequence: 108-248, (88-228 in PDB).
Show the alignment used for the construction of the structural model, Download.
Show the plot of DOPE energy score, Download.
Oligomerization and Known Interactions
Homodimer; disulfide-linked. Associates with CD5. Interacts (tyrosine phosphorylated) with PTPN6/SHP-1
Annotation
Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
Expression
Human Protein Atlas
GeneCards
Functionality temporarily unavailable.
ProteomicsDB
References
NCBI References (10 PubMed Identifiers)
  • CD40 and CD72 expression and prognostic values among children with systemic lupus erythematosus: a case-control study. [32700598]
  • A regulatory role for CD72 expression on B cells and increased soluble CD72 in primary Sjogren's syndrome. [32306893]
  • A reference map of the human binary protein interactome. [32296183]
  • Interferon-alpha-induced CD100 on naive CD8+ T cells enhances antiviral responses to hepatitis C infection through CD72 signal transduction. [28222623]
  • Increased soluble CD72 in systemic lupus erythematosus is in association with disease activity and lupus nephritis. [26883681]
  • The B cell surface protein CD72 recruits the tyrosine phosphatase SHP-1 upon tyrosine phosphorylation. [9590210]
  • Native soluble CD5 delivers a costimulatory signal to resting human B lymphocytes. [8806810]
  • The B-cell surface protein CD72/Lyb-2 is the ligand for CD5. [1711157]
  • Identity of human Lyb-2 and CD72 and localization of the gene to chromosome 9. [2044654]
  • Identification of a human protein homologous to the mouse Lyb-2 B cell differentiation antigen and sequence of the corresponding cDNA. [2141045]
UniProt Main References (1 PubMed Identifiers)
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
All isoforms of this gene containing a lectin domain
XP_006716956.1, NP_001773.1
RNA
RNA (Transcript ID: NM_001782.3)
NM_001782.3
CD72 molecule
All isoforms of CD72 containing a lectin domain
ENST00000259633.9
111..1190 (or 35610624.. 35618303)
35609982.. 35618413
NCBI Matured mRNA sequence 1531 NTPDownload 
m7G-5')ppp(5'-GCAGUCACAGAGGGAACACAGAGCCUAGUUGUAAACGGACAGAGACGAGAGGGGCAAGGGAGGACAGUGGAUGACAGGGAAGACGAGUGGGGGCAGAGCUGCUCAGGACCAUGGCUGAGGCCAUCACCUAUGCAGAUCUGAGGUUUGUGAAGGCUCCCCUGAAGAAGAGCAUCUCCAGCCGGUUAGGACAGGACCCAGGGGCUGAUGAUGAUGGGGAAAUCACCUACGAGAAUGUUCAAGUGCCCGCAGUCCUAGGGGUGCCCUCAAGCUUGGCUUCUUCUGUACUAGGGGACAAAGCAGCGGUCAAGUCGGAGCAGCCAACUGCGUCCUGGAGAGCCGUGACGUCACCAGCUGUCGGGCGGAUUCUCCCCUGCCGCACAACCUGCCUGCGAUACCUCCUGCUCGGCCUGCUCCUCACCUGCCUGCUGUUAGGAGUGACCGCCAUCUGCCUGGGAGUGCGCUAUCUGCAGGUGUCUCAGCAGCUCCAGCAGACGAACAGGGUUCUGGAAGUCACUAACAGCAGCCUGAGGCAGCAGCUCCGCCUCAAGAUAACGCAGCUGGGACAGAGUGCAGAGGAUCUGCAGGGGUCCAGGAGAGAGCUGGCGCAGAGUCAGGAAGCACUACAGGUGGAACAGAGGGCUCAUCAGGCGGCCGAAGGGCAGCUACAGGCCUGCCAGGCAGACAGACAGAAGACGAAGGAGACCUUGCAAAGUGAGGAGCAACAGAGGAGGGCCUUGGAGCAGAAGCUGAGCAACAUGGAGAACAGACUGAAGCCCUUCUUCACAUGCGGCUCAGCAGACACCUGCUGUCCGUCGGGAUGGAUAAUGCAUCAGAAAAGCUGCUUUUACAUCUCACUUACUUCAAAAAAUUGGCAGGAGAGCCAAAAACAAUGUGAAACUCUGUCUUCCAAGCUGGCCACAUUCAGUGAAAUUUAUCCACAAUCACACUCUUACUACUUCUUAAAUUCACUGUUGCCAAAUGGUGGUUCAGGGAAUUCAUAUUGGACUGGCCUCAGCUCUAACAAGGAUUGGAAGUUGACUGAUGAUACACAACGCACUAGGACUUAUGCUCAAAGCUCAAAAUGUAACAAGGUACAUAAAACUUGGUCAUGGUGGACACUGGAGUCAGAGUCAUGUAGAAGUUCUCUUCCCUACAUCUGUGAGAUGACAGCUUUCAGGUUUCCAGAUUAGGACAGUCCUUUGCACUGAGUUGACACUCAUGCCAACAAGAACCUGUGCCCCUCCUUCCUAACCUGAGGCCUGGGGUUCCUCAGACCAUCUCCUUCAUUCUGGGCAGUGCCCAGCCACCGGCUGACCCACACCUGACACUUCCAGCCAGUCUGCUGCCUGCUCCCUCUUCCUGAAACUGGACUGUUCCUGGGAAAAGGGUGAAGCCACCUCUAGAAGGGACUUUGGCCUCCCCCCAAGAACUUCCCAUGGUAGAAUGGGGUGGGGGAGGAGGGCGCACGGGCUGAGCGGAUAGGGGCGGCCCGGAGCCAGCCAGGCAGUUUUAUUGAAAUCUUUUUAAAUAA-3'- Poly-A tail
  • Coding region
mRNA-related data
DNA
DNA (Gene ID: 971)
CD72
CD72 molecule
NC_000009.12
9  35610624.. 35618303
35610624.. 35618303
strand -
CCDS6581.1
MGI:88345
ClinVar, dbVar
ENSG00000137101
LYB2, CD72b
uc064sxd.1
INSDC:
1696
107272
OTTHUMG00000019870
ENA, DDBJ, Monarch
CD72
Gene-related data
NCBI CDS gene sequence (1080 bp)
5'-ATGGCTGAGGCCATCACCTATGCAGATCTGAGGTTTGTGAAGGCTCCCCTGAAGAAGAGCATCTCCAGCCGGTTAGGACAGGACCCAGGGGCTGATGATGATGGGGAAATCACCTACGAGAATGTTCAAGTGCCCGCAGTCCTAGGGGTGCCCTCAAGCTTGGCTTCTTCTGTACTAGGGGACAAAGCAGCGGTCAAGTCGGAGCAGCCAACTGCGTCCTGGAGAGCCGTGACGTCACCAGCTGTCGGGCGGATTCTCCCCTGCCGCACAACCTGCCTGCGATACCTCCTGCTCGGCCTGCTCCTCACCTGCCTGCTGTTAGGAGTGACCGCCATCTGCCTGGGAGTGCGCTATCTGCAGGTGTCTCAGCAGCTCCAGCAGACGAACAGGGTTCTGGAAGTCACTAACAGCAGCCTGAGGCAGCAGCTCCGCCTCAAGATAACGCAGCTGGGACAGAGTGCAGAGGATCTGCAGGGGTCCAGGAGAGAGCTGGCGCAGAGTCAGGAAGCACTACAGGTGGAACAGAGGGCTCATCAGGCGGCCGAAGGGCAGCTACAGGCCTGCCAGGCAGACAGACAGAAGACGAAGGAGACCTTGCAAAGTGAGGAGCAACAGAGGAGGGCCTTGGAGCAGAAGCTGAGCAACATGGAGAACAGACTGAAGCCCTTCTTCACATGCGGCTCAGCAGACACCTGCTGTCCGTCGGGATGGATAATGCATCAGAAAAGCTGCTTTTACATCTCACTTACTTCAAAAAATTGGCAGGAGAGCCAAAAACAATGTGAAACTCTGTCTTCCAAGCTGGCCACATTCAGTGAAATTTATCCACAATCACACTCTTACTACTTCTTAAATTCACTGTTGCCAAATGGTGGTTCAGGGAATTCATATTGGACTGGCCTCAGCTCTAACAAGGATTGGAAGTTGACTGATGATACACAACGCACTAGGACTTATGCTCAAAGCTCAAAATGTAACAAGGTACATAAAACTTGGTCATGGTGGACACTGGAGTCAGAGTCATGTAGAAGTTCTCTTCCCTACATCTGTGAGATGACAGCTTTCAGGTTTCCAGATTAG-3'
NCBI CDS gene sequence with introns (location: 35610624.. 35618303) (7680 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 35609982.. 35618413) (8432 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [35609982.. 35618413 + 1000]) (9432 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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