Protein
Protein (NP_001773)
CD72
B-cell differentiation antigen CD72 (Lyb-2) (CD antigen CD72)
CD72
CD72 molecule
CD72
Very low evidence
C-type lectin
Undefined
C-type - Natural Killer NK
a/b mixed / C-type lectin-like
Uncharacterised
NP_001773
971
P21854
ENSP00000259633.4
P21854
0.341
Undefined
neXtProt, PFAM, InterPro
Protein sequence and protein families (fasta) (359 amino acids) Download
MAEAITYADLRFVKAPLKKSISSRLGQDPGADDDGEITYENVQVPAVLGVPSSLASSVLGDKAAVKSEQPTASWRAVTSPAVGRILPCRTTCLRYLLLGLLLTCLLLGVTAICLGVRYLQVSQQLQQTNRVLEVTNSSLRQQLRLKITQLGQSAEDLQGSRRELAQSQEALQVEQRAHQAAEGQLQACQADRQKTKETLQSEEQQRRALEQKLSNMENRLKPFFTCGSADTCCPSGWIMHQKSCFYISLTSKNWQESQKQCETLSSKLATFSEIYPQSHSYYFLNSLLPNGGSGNSYWTGLSSNKDWKLTDDTQRTRTYAQSSKCNKVHKTWSWWTLESESCRSSLPYICEMTAFRFPD
No structure currently available in the PDB RCSB Databank.
Structural models
AlphaFold v2: AF-P21854-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

SWISS-MODEL structural models
SWISS-MODEL structural model
Modeller structural model (Homology modelling pipeline), Error: [1.65, 2.18] ÅDownload
The location of the lectin domain structural model is: 194-354
We infer [1.65, 2.18] Å as the interval of error of this structural model.
Template 1: 3WHD chain: C, Q8WXI8, NP_525126.2, sequence identity: 21.1%, coverage: 84.5%, location in sequence: 63-215, (63-215 in PDB).
Template 2: 6BBD chain: A, Q9N1X4, NP_999275.1, sequence identity: 17.4%, coverage: 86.3%, location in sequence: 225-378, (205-358 in PDB).
Template 3: 4WRE chain: A, P08427, NP_001257574.1, sequence identity: 14.3%, coverage: 80.7%, location in sequence: 108-248, (88-228 in PDB).
Show the alignment used for the construction of the structural model, Download.
Show the plot of DOPE energy score, Download.
Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for CD72 Gene
ProteomicsDB
References
NCBI References (10 PubMed Identifiers)
  • CD40 and CD72 expression and prognostic values among children with systemic lupus erythematosus: a case-control study. [32700598]
  • A regulatory role for CD72 expression on B cells and increased soluble CD72 in primary Sjogren's syndrome. [32306893]
  • A reference map of the human binary protein interactome. [32296183]
  • Interferon-alpha-induced CD100 on naive CD8+ T cells enhances antiviral responses to hepatitis C infection through CD72 signal transduction. [28222623]
  • Increased soluble CD72 in systemic lupus erythematosus is in association with disease activity and lupus nephritis. [26883681]
  • The B cell surface protein CD72 recruits the tyrosine phosphatase SHP-1 upon tyrosine phosphorylation. [9590210]
  • Native soluble CD5 delivers a costimulatory signal to resting human B lymphocytes. [8806810]
  • The B-cell surface protein CD72/Lyb-2 is the ligand for CD5. [1711157]
  • Identity of human Lyb-2 and CD72 and localization of the gene to chromosome 9. [2044654]
  • Identification of a human protein homologous to the mouse Lyb-2 B cell differentiation antigen and sequence of the corresponding cDNA. [2141045]
UniProt Main References (1 PubMed Identifiers)
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
All isoforms of this gene containing a lectin domain
XP_006716956.1, NP_001773.1
RNA
RNA (Transcript ID: NM_001782.3)
NM_001782.3
CD72 molecule
All isoforms of CD72 containing a lectin domain
ENST00000259633.9
111..1190 (or 35610624.. 35618303)
35609982.. 35618413
NCBI Matured mRNA sequence 1531 NTPDownload 
m7G-5')ppp(5'-GCAGUCACAGAGGGAACACAGAGCCUAGUUGUAAACGGACAGAGACGAGAGGGGCAAGGGAGGACAGUGGAUGACAGGGAAGACGAGUGGGGGCAGAGCUGCUCAGGACCAUGGCUGAGGCCAUCACCUAUGCAGAUCUGAGGUUUGUGAAGGCUCCCCUGAAGAAGAGCAUCUCCAGCCGGUUAGGACAGGACCCAGGGGCUGAUGAUGAUGGGGAAAUCACCUACGAGAAUGUUCAAGUGCCCGCAGUCCUAGGGGUGCCCUCAAGCUUGGCUUCUUCUGUACUAGGGGACAAAGCAGCGGUCAAGUCGGAGCAGCCAACUGCGUCCUGGAGAGCCGUGACGUCACCAGCUGUCGGGCGGAUUCUCCCCUGCCGCACAACCUGCCUGCGAUACCUCCUGCUCGGCCUGCUCCUCACCUGCCUGCUGUUAGGAGUGACCGCCAUCUGCCUGGGAGUGCGCUAUCUGCAGGUGUCUCAGCAGCUCCAGCAGACGAACAGGGUUCUGGAAGUCACUAACAGCAGCCUGAGGCAGCAGCUCCGCCUCAAGAUAACGCAGCUGGGACAGAGUGCAGAGGAUCUGCAGGGGUCCAGGAGAGAGCUGGCGCAGAGUCAGGAAGCACUACAGGUGGAACAGAGGGCUCAUCAGGCGGCCGAAGGGCAGCUACAGGCCUGCCAGGCAGACAGACAGAAGACGAAGGAGACCUUGCAAAGUGAGGAGCAACAGAGGAGGGCCUUGGAGCAGAAGCUGAGCAACAUGGAGAACAGACUGAAGCCCUUCUUCACAUGCGGCUCAGCAGACACCUGCUGUCCGUCGGGAUGGAUAAUGCAUCAGAAAAGCUGCUUUUACAUCUCACUUACUUCAAAAAAUUGGCAGGAGAGCCAAAAACAAUGUGAAACUCUGUCUUCCAAGCUGGCCACAUUCAGUGAAAUUUAUCCACAAUCACACUCUUACUACUUCUUAAAUUCACUGUUGCCAAAUGGUGGUUCAGGGAAUUCAUAUUGGACUGGCCUCAGCUCUAACAAGGAUUGGAAGUUGACUGAUGAUACACAACGCACUAGGACUUAUGCUCAAAGCUCAAAAUGUAACAAGGUACAUAAAACUUGGUCAUGGUGGACACUGGAGUCAGAGUCAUGUAGAAGUUCUCUUCCCUACAUCUGUGAGAUGACAGCUUUCAGGUUUCCAGAUUAGGACAGUCCUUUGCACUGAGUUGACACUCAUGCCAACAAGAACCUGUGCCCCUCCUUCCUAACCUGAGGCCUGGGGUUCCUCAGACCAUCUCCUUCAUUCUGGGCAGUGCCCAGCCACCGGCUGACCCACACCUGACACUUCCAGCCAGUCUGCUGCCUGCUCCCUCUUCCUGAAACUGGACUGUUCCUGGGAAAAGGGUGAAGCCACCUCUAGAAGGGACUUUGGCCUCCCCCCAAGAACUUCCCAUGGUAGAAUGGGGUGGGGGAGGAGGGCGCACGGGCUGAGCGGAUAGGGGCGGCCCGGAGCCAGCCAGGCAGUUUUAUUGAAAUCUUUUUAAAUAA-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
;
More about the NCBI sViewer.
DNA
DNA (Gene ID: 971)
CD72
CD72 molecule
NC_000009.12
9  35610624.. 35618303
35610624.. 35618303
strand -
CCDS6581.1
MGI:88345
ClinVar, dbVar
ENSG00000137101
LYB2, CD72b
uc064sxd.1
INSDC:
1696
107272
OTTHUMG00000019870
ENA, DDBJ, Monarch
CD72
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (1080 bp)
5'-ATGGCTGAGGCCATCACCTATGCAGATCTGAGGTTTGTGAAGGCTCCCCTGAAGAAGAGCATCTCCAGCCGGTTAGGACAGGACCCAGGGGCTGATGATGATGGGGAAATCACCTACGAGAATGTTCAAGTGCCCGCAGTCCTAGGGGTGCCCTCAAGCTTGGCTTCTTCTGTACTAGGGGACAAAGCAGCGGTCAAGTCGGAGCAGCCAACTGCGTCCTGGAGAGCCGTGACGTCACCAGCTGTCGGGCGGATTCTCCCCTGCCGCACAACCTGCCTGCGATACCTCCTGCTCGGCCTGCTCCTCACCTGCCTGCTGTTAGGAGTGACCGCCATCTGCCTGGGAGTGCGCTATCTGCAGGTGTCTCAGCAGCTCCAGCAGACGAACAGGGTTCTGGAAGTCACTAACAGCAGCCTGAGGCAGCAGCTCCGCCTCAAGATAACGCAGCTGGGACAGAGTGCAGAGGATCTGCAGGGGTCCAGGAGAGAGCTGGCGCAGAGTCAGGAAGCACTACAGGTGGAACAGAGGGCTCATCAGGCGGCCGAAGGGCAGCTACAGGCCTGCCAGGCAGACAGACAGAAGACGAAGGAGACCTTGCAAAGTGAGGAGCAACAGAGGAGGGCCTTGGAGCAGAAGCTGAGCAACATGGAGAACAGACTGAAGCCCTTCTTCACATGCGGCTCAGCAGACACCTGCTGTCCGTCGGGATGGATAATGCATCAGAAAAGCTGCTTTTACATCTCACTTACTTCAAAAAATTGGCAGGAGAGCCAAAAACAATGTGAAACTCTGTCTTCCAAGCTGGCCACATTCAGTGAAATTTATCCACAATCACACTCTTACTACTTCTTAAATTCACTGTTGCCAAATGGTGGTTCAGGGAATTCATATTGGACTGGCCTCAGCTCTAACAAGGATTGGAAGTTGACTGATGATACACAACGCACTAGGACTTATGCTCAAAGCTCAAAATGTAACAAGGTACATAAAACTTGGTCATGGTGGACACTGGAGTCAGAGTCATGTAGAAGTTCTCTTCCCTACATCTGTGAGATGACAGCTTTCAGGTTTCCAGATTAG-3'
NCBI CDS gene sequence with introns (location: 35610624.. 35618303) (7680 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 35609982.. 35618413) (8432 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [35609982.. 35618413 + 1000]) (9432 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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